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Post Info TOPIC: MAVYRET Ziggy Starting in April 2018


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RE: MAVYRET Ziggy Starting in April 2018
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Glad you doing great. Glad the itch is no biggy.  : )

Yesterday, I mentioned the "monograph" in relation to "sides".

Also (when you first arrived here), we were trying to guide you around a bit, and put this in a very early post to you - just so you could suss whatever drug you happened to get (below, from that post, this link was an area where drug info (and monographs) are found, ie for Mav, etc. As well, there should have been a monograph that came WITH your drugs, or, at least an abbreviated version of a monograph (package insert). 

... If you want to explore drugs, try the "search" function button above ... just type in a drug name (or subject) and you will pull up many different informational threads. Or, just go to ... Hep C News ... where you will find monographs for "Epclusa" or "Mavyret" for example ...

Reading the FULL monograph, with all it's technical info, is where you might find the "lower" incidence of "sides" (that are common across many of the new Daa's) and as well you can compare one DAA regime against another (should you wish to), to see that Mav has slightly less incidences of certain sides than other DAAs. smile C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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 ...

This is something I found re:  Mav Side Effects and figured my itching skin was from Mav.  Trying to find the original site I got this from.

No biggy.  Doing great.



-- Edited by Ziggy65 on Monday 16th of April 2018 09:49:10 PM

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__________________
  • 52 yrs female.  USA.  DX 2007. GT1b
  • Pre-Treatment:  VL 9,400,000
  • Fibrosis F2.   Ferritin Level 360
  • High Iron.  Fatty Liver. 
  • ALT 136    AST 64
  • First Treatment:  Mavyret April 11th, 2018.

See Pre-Treatment Test Results in Bio



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Blue poo! Where have you two been! Never heard of such a thing! (blood blood, maybe). OH Tig yer such a teaser. But ... now that we are on the fun topic of poo, and colors, well ...  there IS such a thing a red, yellow, green, beige, brown, black and white poo (although ... technically, white and black aren't colors, are they?) hee hee ... oh my, I am wasting typing here (but I'm havin' fun!). Just ask me and Jaggles all about white poo, we could tell ya horror stories! 

Well, it kinda sounds like the "energy" drink might have been a wee bit too energizing alright. Interesting product! (as a pick-me-ups go) if hours later, you are still up on the toilet! Oh dear. (..."pick me ups go"... is that a pun)? hee hee

Really, it's NOT funny or fun (what happened to you last night), I hate getting rid of objectionable items via either end of my digestive system like that. I would try to put up with just about any amount of impending feelings of up-chucking, than to actually up-chuck! With diarrhea though, there can be less choice in the matter.

Glad to NOT hear of any further episodes of it today. Whew, hope that was the end of it for you.

It can be noted that Mav and many of DAA's can cause some (I think - most often initial and transient) GI symptoms, Mav seems to boast a lesser incidence of this than some of the other DAA's. In the monograph.

Itchy skin? - lukewarm bathing, not hot water, less bathing, minimal soap use (and skin care products), use only the gentlest variety of product, if you have to use any, aveeno/oatmeal based things are sometimes helpful, if it continues bothersome, you could try some calomile lotion on your skin. 

Hey, hey! alllll-most one week done! biggrin C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hey Tigs, 

OH WAIT, I GET IT.  You were just making it up.  

Forgive ME, cause I am a dork !!!!!

I thought it was something I was unaware of and that there really was something as blue diarrhea.

lol too funny.


Thank you for all your support !!!!!!!!!!



-- Edited by Ziggy65 on Sunday 15th of April 2018 10:16:01 PM

__________________
  • 52 yrs female.  USA.  DX 2007. GT1b
  • Pre-Treatment:  VL 9,400,000
  • Fibrosis F2.   Ferritin Level 360
  • High Iron.  Fatty Liver. 
  • ALT 136    AST 64
  • First Treatment:  Mavyret April 11th, 2018.

See Pre-Treatment Test Results in Bio

Tig


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Hey Ziggy,

I told you my humor wasn’t very good! I was trying to bring a laugh to your clearly bad evening last night. You said:

OMG....It's 2:30am and I just had an outburst of a major, all of the sudden, out if the blue, diarrhea attack”

Forgive me! 



__________________

Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR52:12/04/14

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...

Canuck

I'm not worried about the  Big Train Vanilla Chai Tea.   biggrin  I only drink it the 4 days I go to work instead of coffee.  biggrin

What I am more worried about was the vitamin drink I had that (I believe) gave me an episode of diarrhea last night.  evileye  I had run to Costco on my lunch brake at work and one of the freebie snack demonstrator ladies gave me a whole bottle of http://www.zipfizz.com/  just because I had listened to her whole speech.  I told her I had been drinking a whole gallon of water today and it was nice to drink something else that tasted like koolaid.  I have never been known to drink this kind of stuff before, but assumed it was healthy due to vitamins and etc... in it???  I am assuming this is what gave me my Niagara Falls outburst of diarrhea in the wee hours of last night and into this morning.  What ever it was, my body rebuked it.  First I thought it was a side effect of Mavyret.  Well, will I ever Know?  I just know it was not fun.  I think it was the vitamin drink.  NEVER AGAIN will I eat or drink something I don't know what it is while I am on Mavyret.  lol

 

Tig

I have NO IDEA what blue diarrhea is.  I think you misunderstood me.  I meant that the diarrhea attack came at me out of the blue sky.  With no warning.  Not, that it was the "color" blue.  lol.  I have never heard of that before.  What is it?  confuse

The only side effect so far I think I am having is minor itchy skin.

I check back in soon.  Almost done with my first week.  WOW !!!



-- Edited by Ziggy65 on Sunday 15th of April 2018 10:10:37 PM

__________________
  • 52 yrs female.  USA.  DX 2007. GT1b
  • Pre-Treatment:  VL 9,400,000
  • Fibrosis F2.   Ferritin Level 360
  • High Iron.  Fatty Liver. 
  • ALT 136    AST 64
  • First Treatment:  Mavyret April 11th, 2018.

See Pre-Treatment Test Results in Bio

Tig


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OMG, Ziggy! Blue diarrhea in the middle of the night must’ve been terrible... Even normal diarrhea at 2:30 am isn’t much fun! wink

I hope you’re back on track and feeling better today. How did work go? As Canuck mentioned, it’s not uncommon to have an initial adjustment period as you system adjusts to the new medication. That should happen quickly and if the meds were the cause of the blue goose syndrome, it should ease up soon. Excuse the blue humor, see, there I go again!

Keep up the hydration, especially now. Good luck, Warrior, you’re on your way!



__________________

Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR52:12/04/14

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Nah, I don't think it will be some kind of "regular" event (due to the Mav). An "outburst", such as yours, may just be a one-off bit-o-bad luck, caused by who knows? But rule out all the likely things - such as this "vit" drink you had? If that is what is sticking out in your mind as a suspect culprit or a "likely" .. but it could be anything! Food(s), or anything you have taken in to you. Review everything you have eaten/drunk/consumed today, to make sure nothing was "off" or something you have never had before. Perhaps you have just consumed something that did not agree with your digestive tract and you are probably near rid of it now. Hopefully it has all passed, or will very quickly. Mild diet tomorrow, no spicey, bland, soft, applesauce, rice, toast, porrige, cooked soft mild foods. Don't let yourself get dehydrated, make up for the water loss from the diarrhea first, gently, and then pick up where you left off and continue with your regular water intake in a regular sippy ongoing fashion all day long. 

What heck was in this "vitamin drink"?? Are you on vitamins or supplements?? Are you making exotic vit smoothies or something? I wouldn't for now, and if you are partaking of supplements in some way, you better check it out with the doc first. Just a regular good diet is all that is really required (as far as i know) for you for the next couple months. Maybe save for (as I mentioned on your first thread) perhaps not loading yourself up with too much iron content foods (given your mild iron load).

Now having said that, (I hate to suggest it) but "rule out" that you are not coming down with an ordinary unlucky stomache bug - that can happen to anyone! doesn't really sound like it, if you are not really feeling unwell otherwise. This bout will probably just pass.

All the anti-virals do have the ablity to create "some" gastro-intestinal effects, some people never notice a single thing that way, some do experience some GI complaints, nausea and such, if it happens it is often just an early passing thing, a few here have had a bout of runs, or loose bowels, or just softer bowel movements for a bit, but with almost ALL who did, they only had a passing period of it, short-lived, perhaps occurring for most mostly in the initial (beginning period) of the therapy - this too will pass! IF it is the Mav that is caused a small intial revolt in your bowel - look at it this way, Mav has just announced to your virus - "now I've got you"! If it is sign of Mav, then it is a good sign, it's a brief victory war flag being waved by Mav heralding the beginning of the end of your virus. 

Lamassu - maybe your doc had more to do with you getting Mav than you think (maybe). 12 weeks of epclusa is more costly than 8 weeks of Mav (for one thing) when considering insurance, and, with you being a GT2 perhaps doc (and insurance) felt epclusa was quite suitable for you as a GT2a/c, just like Mav might have been deemed quite suitable or more appropriate for Zig as a GT1b (even though both drug regimes are quite "pan"). Your docs and insurance may have considered each of your certain individual nuances (your parameters, taken into account).

Hope all is finished for tomorrow Zig, that you didn't loose out on any of your quota of sleep with your bathroom need, and don't feel too "washed-out" in the AM. Get re-hydrated, and continue to hydrate and feed yourself carefully tomorrow, and all should soon be better. smile C.          



-- Edited by Canuck on Monday 16th of April 2018 02:46:22 AM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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OMG....It's 2:30am and I just had an outburst of a major, all of the sudden, out if the blue, diarrhea attack.

It may have been something I drank today that had vitamins in it. But, hoping its not a regular side effect of Mav and something I am going to be dealing with on a daily basis.

Yikes... Got to go to work in the morn.... Night all.

__________________
  • 52 yrs female.  USA.  DX 2007. GT1b
  • Pre-Treatment:  VL 9,400,000
  • Fibrosis F2.   Ferritin Level 360
  • High Iron.  Fatty Liver. 
  • ALT 136    AST 64
  • First Treatment:  Mavyret April 11th, 2018.

See Pre-Treatment Test Results in Bio



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...

Canuk:

Wow, you really went out of your way just to answer my little tea question. I am glad you guys are here to answer my little noob questions. Thank you. You Rock.


lamassu:

I assume that is good news about Epclusa? How are you doing? Looks like you may be done soon? Hope all is well.


...

Today is my 4th day on Mav and so far so good. No headaches or nausea. I have a bit of itchy skin but there are no rashes nor evidence of any skin irritation. Minor so far. Also, today I am very tired but I think that's cause it was my first day back to work since I started the treatment. I was on my feet all day plus, I had to train a new employee. I feel very tired tonight.

I will come back soon to update more. Have a great rest of your weekend everyone.

Ziggy

__________________
  • 52 yrs female.  USA.  DX 2007. GT1b
  • Pre-Treatment:  VL 9,400,000
  • Fibrosis F2.   Ferritin Level 360
  • High Iron.  Fatty Liver. 
  • ALT 136    AST 64
  • First Treatment:  Mavyret April 11th, 2018.

See Pre-Treatment Test Results in Bio



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My Medicare advantage plan would not pay for Mavyret but did for Epclusa.



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Male, 65, Dx 1990, GT 2a/2c. Pre-treatment VL 11,500,000, ALT 10, AST 18, Fibroscan F3, 12.4 kPa. Rx 12 weeks Epclusa, SOT Mar 8, 2018, EOT predicted May 31, 2018. Week 2 VL 50, ALT 12, AST 21.



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If it is just one large chai tea per day, then I can't see what the harm would be - so, I tried to google up what ingredients (really) comprize chai teas, and (of course) there are SO many variations! Healthy (most are thought) some not so healthy (if they use lots of commercially convenient chemical based things to create them). But the individual natural ingredients they list in a lot of the chai teas (from spices to coconut milks, etc.), do not sound harmful, rather they exclaim about the anti-oxidant and anti-inflammatory properties these teas supposedly boast! And less caffeine than coffee.

There is no easy way to answer whether a simple chai tea could interact with your drugs, I think not. But if you were worried then just simply separate the drug away from the tea by hours. I would think that no matter how "powerful" the anti-inflammatory effects of a simple chai tea might brag of, I could'nt imagine how many you would have to consume to be reflected in your ALT!

Just thinking out loud, as I couldn't give a firm answer, except, for that I think chances are that chai teas would not interfere with anything. 

YOU ARE amazing - with these "days" - 3 days on Mav! biggrin and 16 days with out a cig! biggrin Yay! C. Good on the water - water helps everything. wink



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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...

Day three and doing GREAT!!! No side effects as of yet.

Been drinking a gallon of water, but today might end up being (almost) a gallon.

Tomorrow is my first day back to work. I'm working part time Sats thru Tues.

Gonna be different and more difficult to eat full meals at 930am on the way to work. Been cooking a full breakfast my last three days off. But this is the most consistent time for me to eat everyday.

Can we drink Chai Tea while on Mav? I don't drink coffee but do get my Chai every morn on the way to work. Just wondering. I know I posted this question somewheres else but cant find what thread.

16 days I have not smoked a cigg and kind of freaking out over that, in a good way I guess.  eeeekkkkkkkk....


Have a great weekend all.....It's my Monday.



-- Edited by Ziggy65 on Friday 13th of April 2018 11:29:58 PM

__________________
  • 52 yrs female.  USA.  DX 2007. GT1b
  • Pre-Treatment:  VL 9,400,000
  • Fibrosis F2.   Ferritin Level 360
  • High Iron.  Fatty Liver. 
  • ALT 136    AST 64
  • First Treatment:  Mavyret April 11th, 2018.

See Pre-Treatment Test Results in Bio



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Hey Zig, 

How goes it today! All good I hope. Good on you for the water consumption efforts! mm chia tea! smile

Another link for you: https://www.fibrometer.com/images/fibrometer/Interpr%C3%A9tation_FicheResultat_Virus_ENG.pdf

I am glad you stated today that you think you did NOT have a fibroscan, that has been something I have been wondering about ever since you first posted your F2 status, I was trying to ascertain whether you HAD had a fibroscan, way back in a March 22 post, where I was asking IF your F2 was deduced by blood test OR fibroscan, but then, when you posted your labs a couple days ago I could at least see that you DID have named a "FibroMeter" test - so, that's good to know now, that you did NOT additionally have a fibroscan. That answers my curiosity. If you are not familiar with fibroscans, they are easy to do.

I had been guessing that you have probably been looking around and reading threads on the site here - especially all of the other Mav-takers threads here, but that's great that you know about the search button - it's a handy tool alright.

Glad you clarified it will be an 8 week course - I did note you mentioned that length of course, a couple times, but did not know for sure whether your doc might have left it open to possibly change it up to 12 weeks, or not. SOT Apr 11 makes your EOT Jun 6 - so, nice and short and sweet your Mav will be! biggrin 

What dates did you get booked for your first, and ongoing on-treatment blood draws? C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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WOOHOO!!  Good luck, Zigs! Onward to victory....

F098049F-C387-4F74-8742-981C793F6438.jpeg



__________________

Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR52:12/04/14

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8 weeks.  biggrin



__________________
  • 52 yrs female.  USA.  DX 2007. GT1b
  • Pre-Treatment:  VL 9,400,000
  • Fibrosis F2.   Ferritin Level 360
  • High Iron.  Fatty Liver. 
  • ALT 136    AST 64
  • First Treatment:  Mavyret April 11th, 2018.

See Pre-Treatment Test Results in Bio



Guru

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Oh what a lovely mornin'! A nice new "spring" day to start your Mav. smile Good choice!, if you decided to take your Mav with breakfast, if (as you said) breakfast is your most convenient, consistant, reliable, repeatable time of day to take your dose! Everyone is dif, we had one  lady say she prefered to take it in the evening, there are thousands of folk out there who are taking Mav, and everyone should just choose their best time of day to take it, based on what suits them, AND in being able to continue taking it at the same time every day with a meal - so you have chosen wisely

I chose my time of day dosing (just like you) based on the priority of same reliable time every day with a meal, that just happened to be lunch, as breakfast and suppers we very unreliable for me. 

Hey nice you have a few days off, celebrate your day one! - take a little walk out in the fresh air, have a bubble bath, catch up on some good book or movie you have been wanting to - treat/reward and soothe yourself, for all your hard work getting here, to this good day! 

So, IS it 8 weeks for sure, or 12?

Cheers. wink C. 

Image result for glass of water

 

 

 



-- Edited by Canuck on Wednesday 11th of April 2018 05:14:33 PM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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...

Good Morning,

I have the next three days off from work.  Getting ready to make my breakfast of the day and take my first three MAVYRET pills of this first new ride journey of my first Hep C treatment ever.  Drinking my ice water already.

This was not the way I wanted to do my spring fever.  lol

I'll keep you all posted.

Ziggy

4-11-18



-- Edited by Ziggy65 on Wednesday 11th of April 2018 11:49:27 AM

__________________
  • 52 yrs female.  USA.  DX 2007. GT1b
  • Pre-Treatment:  VL 9,400,000
  • Fibrosis F2.   Ferritin Level 360
  • High Iron.  Fatty Liver. 
  • ALT 136    AST 64
  • First Treatment:  Mavyret April 11th, 2018.

See Pre-Treatment Test Results in Bio

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