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Post Info TOPIC: No Critical Interactions Between Ledipasvir/Sofosbuvir and Certain Key Antiretrovirals


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No Critical Interactions Between Ledipasvir/Sofosbuvir and Certain Key Antiretrovirals
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From the 15th International Workshop on Clinical Pharmacology of HIV and Hepatitis Therapy, May 19- 21, 2014, Washington, DC.

"Ledipasvir/sofosbuvir, a fixed-dose coformulation of two direct-acting antivirals (DAAs) for HCV infection, did not have a clinically significant impact on five frequently used antiretrovirals--raltegravir, efavirenz, rilpivirine, and tenofovir/emtricitabine (TDF/FTC)--according to results of three studies in healthy volunteers. Atripla had an affect on ledipasvir deemed not clinically relevant by the Gilead team".

Full article...

http://www.natap.org/2014/Pharm/Pharm_06.htm



__________________

Jill 

(68 yo, lives in UK)

Was Gen 3a, 

24wks Peg/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 

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