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Post Info TOPIC: "I'M IN!! - The 8 week SOF/VEL/GS-9857 Trial"


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RE: "I'M IN!! - Started the 8 week SOF/VEL/GS-9857 Trial"
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Hi MommaT,

Welcome to the forum, glad you found us.

I'm sure others will chime in on Epclusa and it's availability as they see your post.

Make yourself at home, we'll do our best to help you get the information that you need.

 

Linux

 



__________________

63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 



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Hi MommaT,

I can imagine your frustration. 

I will ponder your problem a bit.

Pablito is correct. I think, that sof/vel (Epclusa) and/or any of the recent sof/vel/vox trials (the trial Pabilto and I were on, for instance) are not recruiting new subjects (as far as I know) there are no "currently recruiting" Epclusa trials  - but I will have a look again.

I just noticed a recent post from "CandaceV". You and she live in dif. states, but might be an idea to touch base with her, to find out how they got their Epclusa.

Will get back to you. C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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I got on via the Royal London Hospital in UK as part of the POLRIS trial. I believe they've closed recruitment for the trial I was in but there are other versions of the trial going on. It's multi-centre so there are centres in the US.  Google it and there should be links.

I think Eclupsa is coming to market soon. 

You are G2, which is the easiest genotype to treat so you'd do fine with sof/dac, which you could get now.



-- Edited by Pablito on Friday 5th of August 2016 02:35:24 PM

__________________

44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.



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HI! I HAVE A Dr SCRIPT For Epclusa and Insurance but, Not Gilead or Amerihealth will do anything for me. I am Hep c 2b Naive-just got Fibroscan results Compensated Cirrhosis. How do you get on a trial? thanks!



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Thanks all, and thanks for your support along the way.  I know I'm not quite there yet but, as mentioned, I'd have to be exceptionally unlucky at the stage not to go on to SVR.

Canuck - I just get a single line email when I email them about the VL.  It's not quite of the level of getting blood out of the proverbial stone but it's a bit of a struggle so I keep it simple and ask for the most important result.   My LFTs were normal after one week on sof/vel/vox so I assume they have been normal for the last few months.

Pablo



__________________

44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.



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Sydhanrahan wrote:
 Evidently it's very uncommon to be virus free at post week 4 and to relapse in the final 8 weeks. 

Syd


 98% of folks clear at 4 weeks do not go on to relapse. But who's counting eh? wink



__________________

Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."



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Pablito wrote:

Got my EOT+4 bloods today= UND.

One step closer to SVR.


 EXCELLENT NEWS BROTHER!

Time to change that sig line!

JimmyK



__________________

Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."



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Hi Pablo,

you must be feeling pretty darn good round about now. Evidently it's very uncommon to be virus free at post week 4 and to relapse in the final 8 weeks. 

I have been meaning to post a few of my favourite tv series. One US one I really liked was Six Feet Under. It's far from new now but still great to watch. I'm going through a Scandinavian phase at the moment but most of what I watch is via one of our government channels which focuses on multicultural content. Let me know if you can access that sort of stuff and I'll go back and see if I can make a list.

Take care,

Syd



__________________

Contracted Hep C 1969. Genome Type 2, treatment naive. Began 12 week RIBA/sof/Dac on 12/11/15. Cirrhosis. VL before treatment 4m. Treatment extended another 12 weeks without Riba. No virus detected at 9 weeks.



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YAY Pablo!



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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THAT'S the way we do it!! You and me bud! We are BIG FAT ZERO's now! Well... we also have to include calling our sof/vel (with and/or without vox) buddies tkflex 36 and webtomas BIG FAT ZERO"S too.

So nice you and I have those EOT+4 results behind us eh? Onward, in lockstep fellow warrior, to our EOT+12 results!! Feels good doesn't it - are you sure (now) that you still feel quite so strongly that you would have been satisfied NOT knowing ANY of your VL's until EOT+12?? I will always feel very lucky and grateful to have had the opportunity to know every single one of my VL's (so frequently) via the trial regime.

I sure wish the flux of sof/vel treatment people we expect, would soon start appearing and posting here! It will be so exciting to see even more folk joining the already astounding number of cured we are seeing, in all of us, who are now getting all the new daa regimes. WE are the ZERO generation! I am so happy for you Pablo, and I have been loving reading your posts, you are doing SO good, all round!!

Don't you get your ALT, AST, Alk. Phos., bilirubin, etc. results given to you? Just curious. 

Lovely to hear your news. biggrin C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Yay Pablo!

With results like that, you're golden ... SVR next stop!

Congrats, I know that you're over the moon right now, LOL smile

Glad to hear the news.

 

Dave



__________________

63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 



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Pablito,  

That is really good news.  I hear that's a pretty good predictor of what you will hear in another 8 weeks.  

I'm between EOT and SVR 12, and am feeling more like Syd all of the time.  Ahhhh.  I didn't even know I was sick and life is grand again.

 

Cheddy



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Got my EOT+4 bloods today= UND.

One step closer to SVR.



__________________

44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.



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Syd said the following--


I feel as though I have spent two thirds of my life under par - tired, depressed and out of sorts. Yesterday I had another day where I just felt like "normal" people do. You know - that sky's an amazing colour, I love the smell of pavements after rain, this tastes good, how amazing I'm spending time with two friends who remember a day we shared 46 years ago. And I'm not even sad that so much if my life has been spent under this filthy cloud. Just glad and lucky I've crawled out the other end in time to find out what's it's all been about.

Syd, you said it all. How did you get into my head like that??

C,Tkflex36, Webtomass,Syd---I would put my helmet on and jump into any spaceship with you all.  You guys are great!!      RC



__________________

 M-61 (3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017) On my way to SVR.    SVR-12. 3-13-18



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Hi Canuck,

 

Aren't computers grand? This virtual stuff is mind boggling!, for instance, yall may not realize it, but almost all of you, as my most important personal trainers and good travel companions, often come right along with me!, to attend each one of these appointments - trippy eh?! And I must say, it is quite a gangly crowd of you I drag along with me for company, but nice, and (mostly) real well behaved! heehee  biggrin C.

__________________________________

I was trying to write about this very issue on another thread where it had no relevance whatever, but without your imagery capabilities. But yes, you have all been so important to me too and finding out  your positive news made my day.

My 4 week EOT blood draw should be next week but doubt I'll see the results for a loooong time. Then the week 12 one will be end of August.

 I feel as though it's gone. I feel as though I have spent two thirds of my life under par - tired, depressed and out of sorts. Yesterday I had another day where I just felt like "normal" people do. You know - that sky's an amazing colour, I love the smell of pavements after rain, this tastes good, how amazing I'm spending time with two friends who remember a day we shared 46 years ago. And I'm not even sad that so much if my life has been spent under this filthy cloud. Just glad and lucky I've crawled out the other end in time to find out what's it's all been about.

Syd.

ps. Canuck, in case you're turning all cynical on me - no I'm still a teetotaller and didn't find any mushrooms in my garden rake up.



__________________

Contracted Hep C 1969. Genome Type 2, treatment naive. Began 12 week RIBA/sof/Dac on 12/11/15. Cirrhosis. VL before treatment 4m. Treatment extended another 12 weeks without Riba. No virus detected at 9 weeks.



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Pablo, 

My dear fellow astronaut! What a trip we are having with these drugs eh??!! You, me, and my other brothers, webtomass and tkflex36, all of us with same taste in drugs, same sense of direction, no wonder we're going places, fast and having a real good time of it getting there!

No idea whats up with my glucose, they seem completely unconcerned about them, so, is likely unimportant. Immediately pre-trial Gilead did hgb A1C on all of us (as well as regular blood glucoses through out trial). My pre-trial A1C was up a tiny bit but still within normal limits, so that showed no indication of my sugars historically spiking around, over time, prior.

During trial, so far, my glucoses have shown as (barely) overlimit, 5 out of 7 tests. (Norm. ref. 70-100 mg/dl), mine were as follows: 108, 107, 94, 115, 104, 86, 104 - all done fasting, 2 were well within limits and other 5 highs were not very high over at all. No rhyme or reason for it, it seems. Altho you hear talk of treatments temporarily affecting BS's, bilirubins and such, I really don't know why my glucose has been a tad over.

I have no prior comparables really. In my life I don't think I had more than a few fasting blood sugars done, and none of these must have been out of wack enough to warrant further discussion.

Historically, I have practiced bad eating habits, maybe causing my sugars to spike and crash regularly (that's what I guess, and that's kinda what it has often chronically felt like before), but I have NO idea if I have some kind of tendency to maintain a higher (or on the high end of normal) BS, when tested in a fasting state or not! My pancreas looked unremarkable on U/S, and of all the lipase testing Gilead routinely did on me, all were normal.

My trial sugars are barely over limit, NOT high, so, probably means nothing of any consequence to anyone in the long run. I have no idea really. But it's a good thing, that makes me think, about how I should try to eat better to avoid BS up's and downs. That is always a good thing!

I keep wondering about your ALT's, AST's - you don't get your bloods given to you? What counts most is getting that big zero - that's the most important telling one! biggrin C.

 



-- Edited by Canuck on Friday 24th of June 2016 04:31:23 AM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Wendy/Lisa,

I used to be in the 3 club - now, I'm just a great big zero! heehee C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Shadowfax wrote:

I am so happy for you Canuck and in this case boring is welcomed.

Great results and it occurs to me that I have never seen a hard copy of my VL since that report is different than the one I get online. I was told B und and C und but I don't know if C <15 und or just GONE ... I think I should call but then again, June 25th will be my EOT+12 so I suppose I can wait until then since we all know, nothing really counts until then... well.. yes, It sort of counts because it could be DET.

What is next? When is the next check? It all looks so good! I think you deserve a DQ .. and have one for me smile


uh, oh! - SF's gone all potty mouth Syd!! Saying bad words like DET and DQ!! But ... I can handle it - I love ALL words ! - ALL the ones I receive from ALL my friends here (from poetry to well wishes). I might not be able to handle another DQ celebratory treat right now tho, the last one was TOO much! Linux has got me on some kind of dietary rehab/clean-up prorammme! syd and wendy have me on that move yer butt program. Tig, wmlj, jimmyk, and RC are making sure my brain still gets a work out, and all of you, explain the rules, keep me on the straight and narrow, and babysit me so well. It seems that EVERYONE is looking out for my welfare!! Man, this is nice! So many personal trainers! SF, if you get your draw on Jun 25, how long after until you get the results? THAT one will NOT be boring, it's gunna feel reeaaal good! You too syd, your next one is going to be SO GOOD to have, when is it again? ... you have to remind me!  My EOT+12 will be drawn the end of July. If I was Gilead I would be letting magic stardust fall all over the earth, thick and even, in every hemisphere! I am sure WE are cured, and will have no further need of it, but, there are many more out there who really need this sprinkle.

I differ from the "norm" (ha!, so what's new!), if I could have had a mainline installed so as to monitor my VL every blinking minute of the day over the 8 week treatment, and maybe over the next few years, I would have!) Weeelll, maybe that's a wee bit of an exaggeration, but I have appreciated knowing every bit, every molecule of data, and feedback over the course, but that's just me. Every VL I have ever had or will have will always remain very important to me, some more than others, but I was VERY glad for every single one.

Aren't computers grand? This virtual stuff is mind boggling!, for instance, yall may not realize it, but almost all of you, as my most important personal trainers and good travel companions, often come right along with me!, to attend each one of these appointments - trippy eh?! And I must say, it is quite a gangly crowd of you I drag along with me for company, but nice, and (mostly) real well behaved! heehee  biggrin C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Canuck wrote:
At one point I tried and tried, for days to get a poem I had banging around inside my head, out of me and onto the keyboard, it was at that moment, one with you and syd, and Jimmy in mind about the tides of riba - but it would not cooperate - you inspire me to try again. C.

 LOL, Oh please do my Cascadian, Canadian and most Charming Canuck and Northern friend.

 

D

 



-- Edited by Linuxter on Wednesday 22nd of June 2016 08:24:36 PM

__________________

63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 



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robertsamx wrote:

Ground Control to Major Canuck, You took your Gilead pills and put your helmet on

Commencing countdown,with triple engines on

Check your Viral load and may gods love be with you

10-9-8-7-6-5-4-3-2-NONE DETECTED

This is Ground Control to Major Canuck

You really made the grade and the people want to know whose treatment regime to use

Now it's time to leave the treatment behind if you dare

Your stepping through the door and floating in a most peculiar way

And the stars look very different today

Your feeling very still and your spaceship knows which way to go

Tell your son you love him so, he knows

Ground Control to Major Canuck

Your Liver alive there's nothing wrong

Your no longer floating around in a tin cup far above the moon

Planet earth is blue and there's always something to do

Go out tonight-look up and thank your lucky stars

Words cannot express what I'm feeling right now. Inner peace and rest come close!!

 


RC!!!

OMG, who knew! Secret poets abound! You made laugh and go all aw, all at the same time - I love this, YOU KNOW plagiarism is my VERY favourite kind of poetry of all time EVER, but it does have to be done well, and you have done it amazing justice - I could never have attempted that and made it so good. But poetry has to be backed with inspiration and sometimes hard work, doesn't it, so you and Linux and some of our other poets are obviously very well qualified. You and Linux's poems to me (AND everyone else's really kind comments today) are a real treat for me. Thank you to say the least. C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Linuxter wrote:

On what a happy day this is.

How wonderful the news Canuck!

So very happy for you, UND @ EOT+4 is HUGE and most certainly an express ticket straight to SVR.

 

The Dragon ne'er stood a chance with Canuck at the helm

She stands o'er the beast, shining sword held high

Before her stands a new and better realm

Where ne'er a Dragon shall be.

 

D smile

Hey Linux,

WHAT a lovely one - many thanks for that - some of us now know YOU really DO have it in ya - that poetry gene. You know I love poetry! Isn't this lovely to be able to glimpse in and see each others talents and attributes, of which you have many, including all your artistic sides. At one point I tried and tried, for days to get a poem I had banging around inside my head, out of me and onto the keyboard, it was at that moment, one with you and syd, and Jimmy in mind about the tides of riba - but it would not cooperate - you inspire me to try again. C.

 


 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Congrats Canuck.

As you stated, we all expected it to be UND but it's nice to have the official confirmation.

Can you fill me in a bit more about your glucose please?  The reason I ask is that my week 4 glucose was raised.  I've never had a raised glucose in my life.  To be fair it wasn't a fasting one,  I fasted for my week 8 bloods but it wasn't my priority tracking down results-wise, the VL obviously being the one I was keen to find out.  I'll get the fasting glucose result when I go to my EOT+4 appointment...

...but I do need something to worry about now that I can't worry about not being undetected anymore ;)

Pablo



-- Edited by Pablito on Wednesday 22nd of June 2016 05:18:04 PM

__________________

44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.



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On what a happy day this is.

How wonderful the news Canuck!

So very happy for you, UND @ EOT+4 is HUGE and most certainly an express ticket straight to SVR.

 

The Dragon ne'er stood a chance with Canuck at the helm

She stands o'er the beast, shining sword held high

Before her stands a new and better realm

Where ne'er a Dragon shall be.

 

D smile

 

 



__________________

63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 



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Way to go Canuck! It looks like your on your way to a Hep C free life. That's awesome!!!



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57 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52,+115wks = SVR-115

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Hi Canuck, 

staying up too late but something made me look at the forum before I turned the light out. Wow!!! I am so very happy for you. Those alt numbers are amazing too aren't they? 

Just as Jimmy said, you have been a very special part of this journey for me and I'm going to go to sleep now dreaming of the special star dust sprinkled on you and hoping that a bit floats down to the Southern Hemisphere too. 

What a fine, shiny day it must be in Canada today. 

Syd



__________________

Contracted Hep C 1969. Genome Type 2, treatment naive. Began 12 week RIBA/sof/Dac on 12/11/15. Cirrhosis. VL before treatment 4m. Treatment extended another 12 weeks without Riba. No virus detected at 9 weeks.



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Ground Control to Major Canuck, You took your Gilead pills and put your helmet on

Commencing countdown,with triple engines on

Check your Viral load and may gods love be with you

10-9-8-7-6-5-4-3-2-NONE DETECTED

This is Ground Control to Major Canuck

You really made the grade and the people want to know whose treatment regime to use

Now it's time to leave the treatment behind if you dare

Your stepping through the door and floating in a most peculiar way

And the stars look very different today

Your feeling very still and your spaceship knows which way to go

Tell your son you love him so, he knows

Ground Control to Major Canuck

Your Liver alive there's nothing wrong

Your no longer floating around in a tin cup far above the moon

Planet earth is blue and there's always something to do

Go out tonight-look up and thank your lucky stars

Words cannot express what I'm feeling right now. Inner peace and rest come close!!

 



__________________

 M-61 (3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017) On my way to SVR.    SVR-12. 3-13-18



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Hiya Sis to The North.

It has been very cool to have walked this path with you. To be able to exchange thoughts, before, while waiting for and during treatment has added to my life.

I am extremely happy for you and it is an honor to be part of your happy celebration.

 

Your Brother

JimmyK



__________________

Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."

Tig


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Hey Canuck,

HOORAY!!!!   CONGRATULATION PARTY UNDERWAY!!!!  

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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Canuck is in the ZERO club

 

So happy for this day to have arrived.



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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Wooohooooo, great news Canuck and well deserved, its official, you are released from that demon. Wow, that was a really fast treatment too, impressive!!! Great stats as well. I love when a 3 cures, everyone else too, but 3's have the most troublesome one. :D

Well the cyber celebratory chocolate cake is on me!

CONGRATULATIONS -ballons everywhere! :D



__________________

Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 



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Awesome report Canuck.... we are so happy for you.  Polaris is the bright shinning star for so many out there.   It was the ticket to your  new life.  Best Wishes with your new journey.   CC



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F 63,  1b  1974, no cirrhosis, fibro scan 5.8 F0-F1,fibro test .37 ,V/L 702987, ALT 90, AST 75.  ABBVIE Topaz II on 10-30-14 Viekira Pak no RIBA , EOT 1-22-15 SVR, ALT 37, AST 29, 4-15-15 SVR12 - fibro test .22,  1-21-16 SVR 52 ,  1-21-17 SVR 104!



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I am so happy for you Canuck and in this case boring is welcomed.

Great results and it occurs to me that I have never seen a hard copy of my VL since that report is different than the one I get online. I was told B und and C und but I don't know if C <15 und or just GONE ... I think I should call but then again, June 25th will be my EOT+12 so I suppose I can wait until then since we all know, nothing really counts until then... well.. yes, It sort of counts because it could be DET.

What is next? When is the next check? It all looks so good! I think you deserve a DQ .. and have one for me smile



__________________

65 yo, GT1A, , Cirrhosis, F-Scan F4 33.5, TX Naive Harvoni 12 wks

SOT 2/9/16 / ALT 187 AST 114 VL 2.3M.    POSTS

EOT 5/2/16  ALT 35/ AST/25  platlets 126 C/B VL UND

EOT +12 7/26/16  ALT 25 /AST 22/ ALP 83  platlets 129 C/B VL UND

EOT + 24 10/18/16 ALT 27/ AST 20/ ALP 71 platlets 153 C UND

 * SVR *



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Hey all,

Posting my "official" (sof/vel/vox 8 week trial) EOT+4week result drawn Jun3 - as:  VL = UND (or in other words) ZERO!! biggrin

 

And my other lab lovelies that came with it: ALT 20, AST 24 - almost everything else was also (yawn) boringly normal, save the glucose and C&G Crt&Clr. 

Boy!, THAT was a long time coming - I don't mean the achieving of the "Zero", which I did long ago, halfway through, at week 4, but rather getting the actual "paper" confirmation - it was like pulling teeth to get the lab work results released to me this time! Argh! Just got it, today (Tues. Jun 21)!

Prior ones have been much easier to obtain, and much quicker too - this one required MANY communications - I really don't know exactly why this one seemed so hard for them to convey - I thought I practiced great restraint waiting until Jun 10 to request copies of all the lab work drawn! They initially said - "if it wasn't good news we would have notified you", uh ... then they gave me a telephone "verbal" only that I was UND, but no paper!! And I do not post until I can see the whites of their little viral eyes for myself! 

We all knew I was going to have ZERO VL anyway!, but still, it would have been nice to have been provided the confirmation and copies of all the labs sooner, as most of these routine labs often come back within just a few days, and the longest VL result took about 10 days, some were shorter! Oh well.

Yes indeedy, this IS magic star-dust that Gilead has made for us. I am a happy Velparized/Polaris-ed camper. Along with my enchanted fellow passengers (who were also sprinkled by Polaris star-dust), we grabbed the same tail end of the velpa comet as it sped by, and what a ride it has been with tkflex36, webtomass, Pabilto, and me - it has been a very nice trip, feels more like we are rocket ship astronauts returning from outer space explorations of the North Star! Hey, hum along, I'm doing a happy rendition of my Velpa National Anthem! We got your helmet ready RC. biggrin C.

______________________________________________________________

 Update(s) as follows:

 Signature Line update : March 10, 2016 - accepted for and started DAY ONE of 8 week SOF/VEL/GS-9857 trial.  (SOF/VEL/VOX)

March 10 labs taken just before starting treatment - VL 844,000, ALT 86, AST 64,  (my VL in last 6 months, before treatment, decreased from being over 10 millions to under 1 million!)

Other pre-treatment labs: IL28B - CC. Ferritin 541 (ref. 15-300), Iron 37 (ref.9-32), Iron Sat. Index .71 (ref.15-.45).  PT 13.6 (ref. 9.7-12.3 sec), INR 1.3 (ref.0.8-1.2). C&G Crt&clr 58.6 (ref.75-115.0). Glucose 107 (70-100). Urine ph 5.0.  

March 18 labs - WEEK ONE - VL 247, ALT 29, AST 23, C&G Crt&clr 60, Glucose 94, Urine ph 6.

March 29 labs - WEEK TWO - VL <15 detected, ALT 20, AST 23, C&G Crt&clr 58.7, Glucose 115, Urine ph 6.3

April 7 labs - WEEK 4 - VL UND, ALT 21, AST 23, C&G Crt&clr 63.2, Glucose 104

May 5 labs - WEEK 8 - EOT - VL UND, ALT 20, AST 24, C&G Crt&clr 64.2, Glucose 86

June 3 labs - EOT + 4 WEEKS -VL UND, ALT 20, AST 24, C&G Crt&clr 59.3, Glucose 101 

(Just in case anyone is curious to see all my ALT's and their fluctuations, from my initial diagnosis of HCV July 2015, through treatment start of March 10, 2016, to EOT May 5):  86, 89, 75, 78, 87, 83. 65, 86, 29, 20, 21, 20, 20

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hey Pablo... congratulations on your undetected result!!  smile

I remember how concerned you were about whether 8 weeks would be enough, and this is really excellent news.

I`m very happy for you, now onwards to SVR!!



__________________

Jill 

(68 yo, lives in UK)

Was Gen 3a, 

24wks Peg/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Pab,

Maybe you have already looked at tkflex36's thread (sof/vel 12 weeks) and webtomass's thread (sof/vel/vox 12 weeks) before, and just did not recall that webtomass "was" also a 4! Don't be feelin lonely!

But I am in complete agreement - 4's and 3b's ARE special, and us 3a's too! (tkflex36 "was" a 3a like me.)

You should have a read of their interesting threads if you haven't.

I can't figure out the dates (exactly) but webtomass's (sof/vel/vox) EOT+12 weeks should be coming up right soon - possibly drawn the second week of July I think? I sure hope he posts his results again! 

And tkflex's (sof/vel) EOT+12weeks should be drawn at the end of June (I think).

I am looking forward to knowing both of their results and of their joy!

All of us, sprinkled with Gileads magic star dust! - first there were millions ... and then ... there were none! Getting "velparized" - it's real magic!

I just love writing in the past tense - using that word - "was". hee hee biggrin C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Pablito wrote:

Thanks Lisa.  It's lonely being a G4.  I've never met anyone else with this genotype. And having to reply on extrapolated data from G1 studies.


 It means you are special :D

I've never met another 3b either, everyone seems to be 3a. :)



__________________

Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 



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Pab,

YES!! Good going!!, I did note that wonderful tidbit about your arranged fibroscan. Will be REALLY nice to have that feedback. Nice she agreed, and good on you that you got that bagged now.

Oh gee, I AM JUST SO SCREAMINGLY HAPPY FOR YOU (and for me) - we did it - we really do feel like pioneers, don't we! Well ... you and me (and webtomass and tkflex56, all of us, playing astronauts in virus space - kinda scary, but, a very nice feeling being in this ZERO gravity.

Don't ja just love Gilead!

3's and 4's are orphans NO MORE! 

BTW - do you have some other labs, I would be interested to know what your "other parameters" looked like, before treatment, during and after - just an aside.

Oh, it is such a lovely day, isn't it! biggrin C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Canuck - did I mention that one of the nice nurses on the trial has agreed to do a repeat fibroscan at my EOT+24 appointment even though it's not part of the trial protocol?



__________________

44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.



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Thanks Lisa.  It's lonely being a G4.  I've never met anyone else with this genotype. And having to reply on extrapolated data from G1 studies.



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44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.



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Pablito wrote:

Mike, Robert, Wendy, Linuxter, Jimmy, Wimj1960 and Lisa and Cinnamon Girl too...

...a big thanks to all of you.  You have been of great support.  And, of course, when I had my wobble at week 4 when I was still detected you all knew what I didn't....well, I did intellectually but emotionally I was terrified.

And a special thought for Robert and your ongoing battle.

I'm so happy.

Pablo


That is fantastic news, I am so happy for you wooohoooo!!!!!!
It is so fantastic that being a G4, you've been able to treat so fast and effectively. I think you deserve a huge bar of chocolate, and a big sigh of relief. I don't doubt you'll remain UND!!!!
You are soon to be hung in the Dragon Slayer hall of fame! :D x

 



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Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 



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Mike, Robert, Wendy, Linuxter, Jimmy, Wimj1960 and Lisa and Cinnamon Girl too...

...a big thanks to all of you.  You have been of great support.  And, of course, when I had my wobble at week 4 when I was still detected you all knew what I didn't....well, I did intellectually but emotionally I was terrified.

And a special thought for Robert and your ongoing battle.

I'm so happy.

Pablo



__________________

44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.



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Nuff said!

wink



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."



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Very good to hear Pablo!

Congrats! You deserve it smile

Very happy for you ... this time the dragon is gone.

 

Dave



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63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 



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Way to go Pablito! That dragon is history now and 3 months time will prove it. Job well done!!!



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57 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52,+115wks = SVR-115

Mike

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THAT'S THE WAY WE DO IT!!!!

yay,yay,yay

Soooo good. biggrinbiggrin C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Hey Pablo!

Outstanding news, congratulations my friend! I was just reading an article on GT4 success rates on 12 and 16 week treatments being so high. Now you come along with the willingness to pioneer an 8 week protocol and look what you've proven, it works! You're paving the way to reduce treatment time and costs to half in some cases. These are the trials that will help prove effective treatment opportunities to twice as many people, at half the cost. You have earned your merit badge Pablo, good job! EOT = UND  Time to change your signature line!

264.png



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Another one for the zero club!



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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That's great news Pablito. We are all in this together, so when one of us gets this GREAT news  it's good for all of us.  Thank you for sharing your  journey with us.   I can't get this big grin off my face, man you made my day!!   EOT UND.  IT DOSENT GET ANY BETTER! RC



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 M-61 (3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017) On my way to SVR.    SVR-12. 3-13-18



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I've re-read the email from the trial nurse and it says "no HCV detected" so I'm taking that as totally UND but I've emailed her back just to confirm. 



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44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.



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Boom. Undetected EOT 8 weeks of wonder drug Sof/vel/vox!

Got the results via an email so I'm trying now to establish whether this is totally UND, or UND <15 with an indeterminable amount of viral RNA present.  

Either way great news.  

Pablo 



__________________

44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.

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