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Post Info TOPIC: Be careful using Crestor post DAA treatment


Guru

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RE: Be careful using Crestor post DAA treatment
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Me too lamassu, I experienced profound fatigue that was exponentially increasing (for a long time) before I even got diagnosed and then it just increased/continued in this direction as i neared treatment, it was even thicker when I got on treatment, the fatigue stayed after treatment too. On treatment the sof/vel/vox certainly did nothing to improve this situ (understatement), rather, the fatigue was never so thick as when i was on treatment. It existed for a long time before treatment and for quite some time after treatment - it was a very inconvenient/restricting, if not a downright debilitating situ (to say the least)! It was actually boggling and unbelievable how one can be so fatigued without finding any relief for it! I think it was Iris who recently spoke of waking up feeling exhausted - lots of us have known the feeling! Poor Obs humourously (not!) describes how she used to accomplish getting her house vacuumed between naps (took weeks apparently!). On treatment my mind and body were affected by fog and fatigue. But, thank goodness, after treatment, slowly, things started to turn around. I too lost ground, physically, with fatigue/energy affecting my exercise time/ability, in all ways. Things, such as you mention ... stamina, loss of physical abilites, inability to exercise due to restrictions - we manage to work ourselves around them as best we can. I was weak after treatment. I slowly rebuilt - and that came in fits and starts as well, but always in a corrective direction. I am certainly waaaybetter now than I was, it took a while, and I am still improving!

No wonder you found that trial of statin especially unwanted, due to the similar feeling of fatigue you experienced during your HCV tretament.

You have a lot of things to juggle, and to work around with your joint things, but you are a smart diligent guy and i know you will figure out ways to gain/regain your exercise/stamina while managing the joint pain control. Did you ever get any more opinions on the use of kratom versus other things for pain control?

It is early days yet, since your HCV cure - be patient, take some time, keep working slowly, steadily and carefully at the rebuilding/re-couping of your health/stamina. : ) C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

(SEE UPDATES IN BIO)



Veteran Member

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Hi Canuck,

I am feeling fine now thanks after stopping the Crestor. Due to the side effects I had from Epclusa I got very little exercise during the three months of treatment so stamina is low but improving as I walk as much daily as my osteoarthritis can handle. I have been told to expect a right knee replacement sometime in the next few years. When is up to me but I am going to postpone as long as possible.

Right now I can manage the osteo discomfort with a low dose of tramadol daily. The three months on Epclusa was not easy for me (heavy fatigue) so I have zero interest in any invasive procedures this year and certainly not until I see SVR at EOT plus 6 months.

I don't have the labs you asked for. I was finally fatigue free at EOT so was alarmed that after only less than two weeks on Crestor fatigue was returning which prompted a literature search that showed me significant side effects from statins are more common than I expected. I'll discuss with my cardiologist next visit.



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Male, 65, Dx 1990, GT 2a/2c. Pre-treatment VL 11,500,000, ALT 10, AST 18, Fibroscan F3, 12.4 kPa. Rx 12 weeks Epclusa, SOT Mar 8, 2018, EOT May 30, 2018. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19.



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Oh dear, it's really too bad you didn't like the way crestor made you feel, as statins can be such a good thing (and a fairly easy way) for people to reduce their lipid-related problems! Some people find it difficult to reduce their LDL/lipid-related problems (lipid related risks) on their own, without a statin, people can derive a lot of good from statin therapy.

So, you had fatigue and then fatigue+, after being on statins for only about a week?, but, you also said your "liver" didn't like the statins? ... what were your LFT's before and after the statin use? - it could be you were simply of the group who have experienced feelings of fatigue as a side of taking a statin drug new to you, versus the drug actually doing any harm to your liver?

Did your LFT's show any evidence of a protesting change/any increase as an effect of this short course of statins, or was it more a case of you didn't feel well while you were on it? Too bad you could not tolerate the fatigue or see if the fatigue dissipated in a while, over time, as some people have difficulty reducing their lipid problems on their own. Some people are just built funny, it seems, like they have an unfortunate set of built-in circumstances which makes it hard for them to get a handle on reducing lipid related problems/risks.

How out of wack have your lipids been in the past and for how long?, you never did elaborate.

Been wondering how you have been doing and feeling. I am glad you did at least give the statins a try. How are your sore joints feeling, are you still back on the same pain control things now, as you were before your HCV cure?

I recall you were due to see a rhumy guy soon? Let us know how everything else has been going. :) C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

(SEE UPDATES IN BIO)

Tig


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Im sorry you experienced issues with a statin, but I know many, many people that do without difficulty. I would hesitate giving the warning about statins and all DAAs however. There are several medications that are hard on our livers and caution is advised when using any of them. Better to discuss the addition of any drug regimen during or after significant liver disease with the prescribing physician. Im glad youre feeling better.



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Veteran Member

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My cardiologist had wanted me on Crestor but it was contraindicated during treatment with Epclusa. After completing treatment and enough time had passed for the sofosbuvir and velpatasvir to be metabolized completely I asked my hepatologist if taking Crestor was OK to which he said yes.

Within a few days of starting only 5 mg/day of Crestor I noticed symptoms of mild fatigue which got worse after a week. I researched Crestor on line and read many reports of significant side effects which prompted me to stop the Crestor immediately. After about a week I was feeling fine again. I was surprised that my hepatologist actually approved use of Crestor; I won't take a statin again. I'll manage my cholesterol with diet. One thing I know is my damaged liver does not like Crestor. Even physicians have reported significant side effects from taking statins.



-- Edited by lamassu on Thursday 5th of July 2018 03:27:35 PM

__________________

Male, 65, Dx 1990, GT 2a/2c. Pre-treatment VL 11,500,000, ALT 10, AST 18, Fibroscan F3, 12.4 kPa. Rx 12 weeks Epclusa, SOT Mar 8, 2018, EOT May 30, 2018. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19.

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