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Post Info TOPIC: Epclusa for gt3 - Started May 27


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RE: Epclusa for gt3 - Started May 27
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Thanks, Hoodie, you little bundle of Joy!



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 

Tig


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Hoodietree wrote:

Happy holidays to you JB! Happy holidays to all of us!  

I am so grateful to all of you for sharing your courage, your vulnerability, and ultimately your STRENGTH publicly on this forum.

2019 is going to be a great year for all of us. Many happy thoughts and wishes for good health, peace, and prosperity for every person on this forum.


 Hoodie, I love the way you think! You’re truly a blessing and we love ya! It’s so nice to know how much you care. People like you, make this a great refuge from the storms life sends our way. Thank you for being you!



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Happy holidays to you JB! Happy holidays to all of us!  

I am so grateful to all of you for sharing your courage, your vulnerability, and ultimately your STRENGTH publicly on this forum.

2019 is going to be a great year for all of us. Many happy thoughts and wishes for good health, peace, and prosperity for every person on this forum.



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 

JB


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Thank you all so much. It means a lot. Who knows what they saw the first time in the MRI. Like many have said, they can do an MRI on anyone and likely see something all the time. Our bodies are weird. Ive also heard that fatty liver and even fibrosis can improve over time. Ive really been working on my diet and exercise. It would be great to see my fibroscore drop as well next year. Hope everyone is having a good weekend and staying warm. Happy holiday season!!

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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 

Tig


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Hi Iris,

Yes! Fatty liver (steatosis) does improve over time. The articles I have read, give clear indication that fatty infiltrates, secondary to CHC and the many manifestations it presents, can lessen. Sometimes rapidly, but typically shows continued reductions via ultrasound and Fibroscan. Very good news!



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Those darn floating artifacts, confuse wonder what they were?

In any case HORRAY!! Things are looking good. CONGRATULATIONS!!!!!

I think the fatty liver is pretty typical for us, that should  improve over time? Is that correct Tig?

Keep us posted, so happy for you. 

Bb, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)



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Hey JB.

Now that's what we like to hear, and that attitude, too. I'm happy to see you keeping things checked out and are taking care of yourself.  Keep up the good work and let us how your new year progresses. 

Cheddy



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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such good news JB. yay



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND



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Wonderful news JB, about NO artifact seen this time around via MRI! I know you were worried, darn thingies, why do these extra events happen to us just to worry us more! All that fretting over that artifact, not fair. But doesn't this feel good, to get a nice clean "negative" MRI, that (basically) only imaged a liver that is now trying to smile back at the camera for us!

I was kinda like you, GT3, some fatty liver, F3 and then F4, but look at me now, right shortly, starting quite soon after cure, super-quick my Fscore started to drop, my fatty liver is no longer mentioned anymore, tidbits seen on a CAT (thought-lymph thingie), funnies on my U/S (granuloma), left and were never see again.

I bet your Fscores and fatty liver will be improving too. You can look forward to seeing many improvements.

Sounds like a very good follow-up plan, i am glad you are on it. We can all rest easy now, now that you are OK! 

How are you feeling generally, comparatively, pre-treatment compared to now for instance? 

I am very pleased, my fellow 3, for your very good news on all fronts! C. biggrin



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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That’s great news, JB! It really sounds like you’ve had good luck and blessings along the way. Seems like you‘ve got all the stars lined up right. So much to celebrate!



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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HOORAY!! Thanks for the update JB. What a relief that must be. Really happy to hear this good news



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 

JB


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Just an update on the MRI.... all good! The thing they saw 6 months ago may have just been an artifact floating around. They didnt see anything this time around! Im due for a physical in March, so Im thinking at that time, Ill just ask them to run a viral load test. Just to be sure. Thatll be about 28 weeks after treatment. Doctor also suggested another fibroscan since my first one in March was borderline. She said maybe wait until May. Thatll be enough time since my cure date. Aside from that she said maybe an ultrasound next year to check on things as I also originally was told I had some fatty liver. So thankful for everyone here. You made this journey so comforting.

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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



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Great big congrats on your lovely SVR12 JB! A lot happened to you in 2018, this cure being crucial and such a good thing, you've gone through a lot. Good on you, for toughing it all out so well. None of this stuff is easy, we know. You have a lot behind you now. Good you had your MRi done, that will soon be behind you as well. Keep us posted. Maybe glucose was just a one off thingy. Sorry about the slo toe, they can notoriously take time to heal, and they remind you of it all the time! C.  



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Yes, the quantity says "not detected"

that's the magic test...:clapping:

yes you can relax and a have a great sigh of relief

5



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND

JB


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Thanks, Tig and Cheddy and everyone else. All is well. Toe is much better, but believe it or not, still not 100%. Doc says just to be patient and let it slowly heal. I had my second abdominal MRI last week to take a look at the spot they saw the first time. Nothing back from doc yet. To be honest, The past 12 weeks have been hard (well 24 actually). Lots of worrying about toe, the labs and MRI. I've been thinking of y'all a lot, but just needed to keep my mind off this for a bit. I'm ready for 2019 and ready For 2018 to be in the rear view mirror! I'll keep you posted on MRI.



-- Edited by JB on Monday 26th of November 2018 10:15:17 PM

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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



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Hi JB.  

It sounds like you've reached the sweet spot - undetected, SVR12, normal bilirubin, good ALT and AST, all good functioning numbers. As I understand it, the scary red marks on returns just show that you have this history and will show antibodies. We've had enough of scary, right? It sounds like your biggest worry is your big toe.  Congratulations, JB.  

Did I miss the report on the MRI?  How is the toe?  How are you feeling these days.

All the best to you, JB.

Cheddy



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 

Tig


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Yep, the antibody will forever be positive. It’s the quantitative PCR that we never want to see detectable again! Good to hear from you, JB. Hope all is going well!



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Yes you are cured no problem. Relax, sleep well tonight. Labs are confusing sometimes. My liver doc does not even bother with the EOT+24 week viral load anymore as there is less than a one percent chance someone who reaches SVR12 will not still be undetected at EOT+24 weeks. I insisted so he laughed, wrote the lab order for the viral load test and told me I would still be undetected. He was right of course:)



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Male, 65, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24.

JB


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lamassu wrote:

Do you have a result for the Hepatitis C Viral RNA, Quantitative, Real Time PCR test yet? That one should be undetected.


 Yes, the quantity says "not detected". All numbers, ALT, AST, etc are normal. From what I've been reading tonight online, I'm good! Having not talked to the doc yet, I freak myself out and need someone to tell me that! Lol



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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



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JB wrote:

Hi Everyone! It's been a while. I've been very busy with work and other things. I had my EOT + 12 week blood work and just had a slight panic attack when I saw the color red on the results for my HCV Ab coming in as positive >11. But then I remember reading this was normal and it'll always test positive as long as my HCV quantitation comes back as not detected. I'm good, Right? Please help calm me down.... All other numbers were normal (except my glucose).


AFAIK after a successful course of treatment for hepatitis C, the hepatitis C antibody remains detectable, but the hepatitis C RNA will be undetectable. Do you have a result for the Hepatitis C Viral RNA, Quantitative, Real Time PCR test yet? That one should be undetected.



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Male, 65, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24.

JB


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Hi Everyone! It's been a while. I've been very busy with work and other things. I had my EOT + 12 week blood work and just had a slight panic attack when I saw the color red on the results for my HCV Ab coming in as positive >11. But then I remember reading this was normal and it'll always test positive as long as my HCV quantitation comes back as not detected. I'm good, Right? Please help calm me down.... All other numbers were normal (except my glucose).

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 

Tig


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Hey JB,

Your Bilirubin is normal. The result is within normal limits. These tests fluctuate inside of normal parameters, so nothing to worry about.

Bilirubin, Total   Normal: 0.1-1.2 mg/dL

 



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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JB


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Canuck - Aside from the VL, the doctor ran a comprehensive metabolic panel, CBC w/Plat Automated Diff and Protime INR. There may be others, but these are the results I got back so far from the web portal. Everything seemed normal, but one thing stood out to me -- the Total Bilirubin was 1.0 mg/dl. The last time I had blood drawn it was .07. Should this be concerning? If I get any other results, I'll keep you posted. Anything else I should look out for with all these results that I don't understand?

JB

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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



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Great to hear, JB!  I'll bet that brought on a big SIGH.  How are you feeling, besides the toe.  It will be good to get the meds flushed out, too.  Onward and upward!

 



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Ah! Welcome to Club Zero JB! biggrin We've all been awaiting your arrival to this exclusive club for some time now. Armed with your UNDs, and you already have that nice beach umbrella, you've got every important thing you need right now. All you got to to is put your feet up a bit. Celebrate! Rest that toe a little. You're UND and done. More milestones coming your way, SVR12 party coming up next, and, boring MRI's are in store for you. Now, what were the other bloods they took along with this last VL (and ALT/AST, of which you said both were normal)? - I am interested in all the bloods they took, what bloods did they test for aside from VL/ALT/AST? And what was your ALT/AST result BTW? Congrats on being a Club 0 member bro. wink C. 

 

Image result for on beach with feet up

 



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Great news, JB! It was never in doubt On to SVR12!

 



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Awesome JB! Good luck with your liver MRI we will keep our fingers crossed and pray for the very best!



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 



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yeehaw JB biggrinbiggrinbiggrin



-- Edited by 5-1-18 on Friday 24th of August 2018 07:48:34 PM

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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND

JB


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My EOT blood work came back undetected again! Thank goodness! ALT/AST and everything else were normal, the doc said. Now I've just got to pray that the "thing" they saw on on my liver is nothing. I'll be doing another MRI in November, along with EOT + 12 week blood work. I'm very thankful for this treatment and all the support and my new friends on this message board. Thank you!

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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



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Amen, JT!

Perfect quote.  I hope you are wearing a smug little smile.



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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//With a new day comes new strength and new thoughts//

 Thank you JB and thank you Eleanor Roosevelt for that one Im going to hold onto it during this new phase of my treatment. 



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 

Tig


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Great and appropriate quote, JB! It was an unusual but welcome feeling waking up to no more medication and no more fire breathing Dragon!



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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JB


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Saw this quote today and had to share it on my social media. Perfect for today. My alarm went off at 9:30am as it had for the past 12 weeks - and I just smiled. ”With the new day comes new strength and new thoughts.“ -Eleanor Roosevelt



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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



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awesome news jb.. enjoy



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND



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Glad youre finished your treatment, JB...    

I hope your toe heals quickly and you can get back to your walking. 

I still drink a lot of water... almost 3 years after my treatment, its a great habit/practice to stay in.

 



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2.5years...post tx... successful dragon slayer 



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Congrats JB!

 



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 

Tig


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Congrats on reaching the end of the line, JB! It always seems like a mile away when you start, but when you finish, it seems like it went by in a blink of the eye. That’s another one of the benefits of these new DAA’s, rapid action and short treatment times. So many improvements, thank goodness!

The EOT testing generally includes the LFT’s, a CBC and a viral load. Same thing at EOT+12. Please let us know when you get them back. I know the anxiety, but these new drugs are miraculous and it‘s rarer than worm teeth that the results are anything but great. 

Good luck with the toe/foot. It’ll be nice to get back to those 10K steps per day. Just get back into easy and build your strength and endurance back up gradually. I’m sure your foot will remind you if you overdo it. You’ll get there in no time, I’m certain of it!



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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That is wonderful JB, the last pill.

As Master Tig pointed out, there is a period of adjustment.  I hope your wheels are greased.  You probably have not been "normal" for some time.  First the disease, the ensuing trauma, and the bombardment of antivirals.  

And now the damn toe!  Don't push that! It makes it take longer.  I just got over one of those foot things.

 

Best to you.  Please keep the updates coming.

 

 



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 

JB


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Thanks, Canuck. I think I need to update my signature. Sorry for the confusion. I have had blood work done at 4 weeks and 8 weeks. I'll get blood work again on Wednesday for 12 weeks and then again in 12 more weeks. Make sense? Do I need to specifically tell the doctor that I want LFT's AND a VL, or is that assumed?

Tig - I've also kept the empty pill bottles. I'll probably hold onto them for a little while as a reminder.

I am so thankful for the new drugs and the ease of this process. I can't say it enough. I just pray now that my followup MRI in November shows that the "thing" on my liver is nothing (or gone for that matter). That's my big worry now.

As far as my toe goes... It is my big toe, Canuck. An important one. Haha. It is still hard to walk on and and I still am walking with a limp. I went to a different doctor last week to get another x-ray and get a second opinion. I thought that after 4 weeks I would be walking a little better, but I wasn't. The new doctor told me that things are healing nicely and that it is normal for the toe to still be stiff and difficult to walk. He said in another week or so, I'll start to see a big difference. It is generally a 6-week healing process. I am wearing the walking boot only when I am going to be on my feet for a while and have to walk a lot.

I'm just bummed because when I started on Epclusa I was walking 8,000 to 10,000 steps per day. Heck, as you know, I even participated in a 10K . I feel like I've been a lazy bum for the past 5 weeks. It stinks, but as soon as I can start walking well again, I'm going to get back into it. I want to keep my body healthy and active. And yes, I've already told myself I'll continue to drink water. I lacked that prior to treatment.

The final pill is in my stomach as I type this.

Thanks guys!

JB

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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



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Oh Yeah!!! That's probably going to take a moment to get to be used to. But refreshingly so biggrin

Down the HATCH ! 

Blessings, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)



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Ah lovely JB, just one more sleep, and just one more pill, and hoo-rah you're done!

I thought you got an "early" optional VL done at 8 weeks (and then you would not be getting another VL done until EOT+12 weeks, but, i must not have understood you before - I do hope it is true that you will be getting LFT's AND a VL (again) at EOT - I always fnd the lab feedback SO rewarding. You deserve more and more rewards (and you will keep getting them) your liver has already starting to thank you, and we can all thank Gilead for making things right. smile 

So, toe-man, how is that toe now, is it still hurtin'?, did you wear the boot long and did it help? (are you still wearing the boot?) I hope it is healing OK, if not, please do go back for another xray and opinion. BTW,  I don't think you ever said ...WHICH toe was it? 

Soon, no more middle of the night urgency trips (and tangled up in the bed clothes foot trips!) to the bathroom for you due to all the water drinking you had to do - you can drink much more conveniently as soon as you finish your epclusa, but still, do keep the water drinking up, I found I needed to even after I finished my Vosevi,  it was like my body was insisting that i still needed to keep flushing things out of me with enough water.  

Nice the sound of that last lonely pill rattling around in the bottle and then ... the blessed silence of none - and virus gone! biggrin C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Well done, JB! EOT is a very special day and one I’ll never forget. I still keep a photo of my last Interferon injection and even kept the empty auto injector for a few years, just as a reminder of that special day. I had an alarm on my iPhone, the one that sounds like Crickets. To this day, I can’t stand the sound of that alarm, even as a reminder of that occasion.

Enjoy your achievement, it’s well earned and well deserved!

 



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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JB


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Tomorrow is the big day. Last pill... Thank goodness this was a pretty easy ride for me. I go to the doctor on Wednesday for followup and EOT blood work. It'll be weird when the alarm on my phone doesn't go off anymore at 9:30 a.m. reminding me to take my meds.

Hope everyone has a good weekend.

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



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i had a few weird things , nothing i couldn't handle. just make a note of what goes on. 

the weirdest thing for me was canker sore on my gums and they were sore....... when i took the antibiotic for the sinus infection the gums healed along with it.

just let us know and we someone here might have a story for you about that.

so far so good for me a cpl weeks in a row .



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND

Tig


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There can be a similar adjustment period, as your body readjusts to life without a powerful anti-viral floating around killing Dragon spawn. Some people that have noticed a surge of energy while on the medication, come back down over time. Don’t confuse that with fatigue, it’s just a normalization of sorts, if that is ever a question. You may notice a change in your sleep habits, better or worse, again during this brief period of adjustment. That said, nothing will be cause for concern. Continue to hydrate and don’t add any supplements to your routine. Wait until your EOT+12 bloodwork before adding anything that can alter those test results. You shouldn’t have anything unusual, just adjusting to being healthy again! wink



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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JB


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As I wind down treatment (only 11 pills left), I am curious. Do some experience side effects when they stop taking the drugs? I'm wondering if one's body becomes "used" to the medicine that when they stop they may experience something.

Thanks!

JB

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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



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Ah, I git ya now, only the week 8 one will happen (with no "additional" week 12 one happening). Nice your doc is giving you a fairly full compliment of VL testing, I like that. (4 weeks/8 weeks, then EOT+12 and EOT+24). smile  I hope you do not have to pay out of pocket for this 8 week one! That he agreed with you. That the week 8 would be covered as standard testing? 

Well hop-along, aside from the toe, how has the rest of the body been feeling? Hope you're feeling as good as your labs are looking! wink C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

JB


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Hey Canuck - My doctor said if I wanted to do 8-week blood work, it was up to me. It was not necessary. Because it was still detectible after 4-weeks, I decided to get it done at 8. I'll also do EOT+12 and EOT+24.

JB

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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



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Great News JB biggrin.gif and glad you are finally getting some relief with the toe. That will certainly be some story to tell in the years to come. "How I broke my toe" lmao.gif



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66/F Contracted Early 80's First Diagnosed Early 2000's 2017 re diagnosis and referral for treatment Gen 3a Fibroscan 8.7

Epclusa 12 weeks commenced 1 May 2018 ALT 72 AST 67

28 May 2018 4 weeks ALT 16 AST 23 ...... 23 July 2018 EOT ALT 23 AST 30 .....Oct 16 2018 SVR12 UND



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Bloodwork at EOT+12 weeks and EOT+24 weeks is what would usually be your "Sustained virological response", (your "official" SVR12 and SVR24)  - the UND you have acquired while on treatment, it will be retested and ascertained again  (via taking VL's) at EOT+12 weeks and EOT+24 weeks. In all likelyhood they will do LFT's at those times too. (I think you and your doc had previously discussed doing labs at EOT+12 and EOT+24, right?)

What I was really asking/getting at, was why you had a VL done at 8 weeks, versus (more commonly) a VL done at 12 weeks (nearer to the EOT) - perhaps it was just your docs preference/choice/planning/managing/timing. I wondered if he might STILL do a EOT VL on you, even though you had one done at 8 weeks (perhaps your 8 week VL was an extra one for some reason or as is his preference), or maybe the 8 week one will just suffice to be considered your EOT one (basically). 

Aug 18 EOT is not far away, your toe should be feeling way better by then, and I think your liver is already feeling waaay better right now. biggrin C. 



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

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