One of the points that I have been seeing out of some of these studys is that the baseline reading on Rav's before treatment with these newer DAA's has no consequence on outcome.
Which could mean retreatment with similar protease inhibitor but newer/better will be possible.
Matt
-- Edited by Matt Chris on Saturday 9th of November 2013 02:27:52 PM
marktrux said
Nov 6, 2013
I think this another article about the same thing but it's still interesting.
Right on Zlik, were all gonna beat this soon. I am guessing within 5 years.
Zlikster said
Nov 6, 2013
:) so soon it will be time to say goodbye to HCV.
Loopy Lisa said
Nov 6, 2013
I am so happy for you guys, death to Hep C for you all would be amazing, now to find a innoculation for the unstable RNA virus! x
Matt Chris said
Nov 6, 2013
Hey Bills
I felt the same way when I read this report.
It made my day and filled up my hope cup for the week.
Between this news about Gilead and Mercks new combo there will be a lot of new treatments than will not involve Interferon in the coming months and for you Bill its a very good chance that a phase III trial for cirrhotic patients that have failed other triply therapy will be available this coming next 12 months. Especially because these results were based on a small study group
A great day for all HCV treatment waiters.
Matt
ucbgal said
Nov 5, 2013
wow!!!! this is great news for nonresponders to triple. less sx, shorter duration of treatment and quicker svr.
there was an article in the nytimes this past weekend discussing "compassionate plea " to drug companies . evidently one can write a personal plea/letter requesting a new drug that's not fda approved for their condition. reading the article was an eye opener. perhaps this can be an option for those who aren't in clinical trials.
the article was in either the health or business section of sunday november 3,2013.
sandy,ucbgal
Bills said
Nov 5, 2013
WOW
That's what I'm waiting for too.
All I can say is When and When and When ???
Just hearing this is a relief Hope is really on its way now
BillS
tonib said
Nov 5, 2013
This is what I have been hoping for!!
lauralou57 said
Nov 5, 2013
These are outstanding results.
Thank you for posting this.
SVR 100% for everyone!
Terry said
Nov 4, 2013
Those appear to be great results for that trial. It's looking like Gilead is going to become the leader is the race for getting rid of this virus once and for all. And I like the idea of the GS-9669 not causing the anaemia that the ribavirin does. I am five weeks after treatment and yet still very tired and unmotivated.
suziq said
Nov 4, 2013
Hi Matt,
They are achieving great results in the latest trials, aren't they?? I am very hopeful after Merck released my trial data. Down with Hep C--the new meds are gonna kill you!!!
SuziQ
Matt Chris said
Nov 4, 2013
Hey All
Great news from Gilead's presentation at the AASLD about cirrhotic patient treatments.
Here is a small excerpt from the article
In the first comparison, 100% of people with cirrhosis treated with sofosbuvir/ledipasvir plus ribavirin achieved SVR12, compared to only 70% of those treated with sofosbuvir/ledipasvir alone. Presence of resistance-associated mutations at baseline did not appear to reduce treatment efficacy.
In the second comparison, 100% of patients with advanced fibrosis or cirrhosis achieved SVR12 when treated with sofosbuvir/ledipasvir plus either ribavirin or GS-9669. While response rates were the same in both arms, haemoglobin levels dropped significantly amongst people taking ribavirin but remained stable amongst GS-9669 recipients.
Hey all
This link is about the same electron study but a whole lot easy to read
http://hivandhepatitis.com/hcv-treatment/experimental-hcv-drugs/4387-100-of-hard-to-treat-patients-cured-with-sofosbuvirledipasvir-plus-ribavirin-or-gs-9669
One of the points that I have been seeing out of some of these studys is that the baseline reading on Rav's before treatment with these newer DAA's has no consequence on outcome.
Which could mean retreatment with similar protease inhibitor but newer/better will be possible.
Matt
-- Edited by Matt Chris on Saturday 9th of November 2013 02:27:52 PM
I think this another article about the same thing but it's still interesting.
http://www.everydayhealth.com/hepatitis/drug-combo-cures-high-percent-of-hep-c-patients-6209.aspx?xid=aol_eh-news_6_20131104_&aolcat=HLT
Right on Zlik, were all gonna beat this soon. I am guessing within 5 years.
:) so soon it will be time to say goodbye to HCV.
I am so happy for you guys, death to Hep C for you all would be amazing, now to find a innoculation for the unstable RNA virus! x
Hey Bills
I felt the same way when I read this report.
It made my day and filled up my hope cup for the week.
Between this news about Gilead and Mercks new combo there will be a lot of new treatments than will not involve Interferon in the coming months and for you Bill its a very good chance that a phase III trial for cirrhotic patients that have failed other triply therapy will be available this coming next 12 months. Especially because these results were based on a small study group
A great day for all HCV treatment waiters.
Matt
wow!!!! this is great news for nonresponders to triple. less sx, shorter duration of treatment and quicker svr.
there was an article in the nytimes this past weekend discussing "compassionate plea " to drug companies . evidently one can write a personal plea/letter requesting a new drug that's not fda approved for their condition. reading the article was an eye opener. perhaps this can be an option for those who aren't in clinical trials.
the article was in either the health or business section of sunday november 3,2013.
sandy,ucbgal
WOW
That's what I'm waiting for too.
All I can say is When and When and When ???
Just hearing this is a relief Hope is really on its way now
BillS
This is what I have been hoping for!!
These are outstanding results.
Thank you for posting this.
SVR 100% for everyone!
Those appear to be great results for that trial. It's looking like Gilead is going to become the leader is the race for getting rid of this virus once and for all. And I like the idea of the GS-9669 not causing the anaemia that the ribavirin does. I am five weeks after treatment and yet still very tired and unmotivated.
Hi Matt,
They are achieving great results in the latest trials, aren't they?? I am very hopeful after Merck released my trial data. Down with Hep C--the new meds are gonna kill you!!!
SuziQ
Hey All
Great news from Gilead's presentation at the AASLD about cirrhotic patient treatments.
Here is a small excerpt from the article
In the first comparison, 100% of people with cirrhosis treated with sofosbuvir/ledipasvir plus ribavirin achieved SVR12, compared to only 70% of those treated with sofosbuvir/ledipasvir alone. Presence of resistance-associated mutations at baseline did not appear to reduce treatment efficacy.
In the second comparison, 100% of patients with advanced fibrosis or cirrhosis achieved SVR12 when treated with sofosbuvir/ledipasvir plus either ribavirin or GS-9669. While response rates were the same in both arms, haemoglobin levels dropped significantly amongst people taking ribavirin but remained stable amongst GS-9669 recipients.
checkout the article fromHCV NEWS BLOG link -http://mobile.aidsmap.com/page/2787227
matt