Fig. 4. 

Comparison of the envelope proteins and their structural organization in TBEV and HCV. (A) Genomes of TBEV and HCV, with homologous coding domains in the envelope proteins indicated by dotted lines (Yagnik et al., 2000). (B) Structural components of the virus' outer shells: TBEV E-protein dimer and HCV E1E2 tetramer. (C) Construction of the HCV outer shell from the E1E2 tetramer. For clarity, only a facet of the icosahedral shell is shown, and the 3- and 5-fold symmetry axes are indicated.

Figure options

Huey,

Thanks for bringing up the topic- yes, with the advent of super computing and the use of Open Source(non-proprietary) software it has been possible to conduct computer modeling in pursuing "the cure" in all sorts of medical research.

For 10 years I've participated in, and donated computing time for a project at Stanford University called Folding@home.

1. • Folding@home

     Project
   • Folding@home is a distributed computing project for disease research that simulates protein folding, computational drug design, and other types of molecular dynamics. Wikipedia
   • Related topics
     . . . Stanford University's Folding@home distributed computingprotein research project keeps track of how much computer power is donated by users, and currently 6 of the top 100 teams are organized by Apple community-related websites. Wikipedia

     Explore: Stanford University, Distributed computing

     Its [Folding@home] primary purpose is to determine the mechanisms ofprotein folding, which is the process by which proteins reach their final three-dimensional structure, and to examine the causes of protein misfolding. Wikipedia

     Explore: Protein folding

     Vijay S. Pande is the Director of the Biophysics Program and is best known for orchestrating the disease research project called Folding@home distributed computing. Wikipedia

     Explore: Vijay Pande, Distributed computing
2.  

Huey wrote:

---

  Science has not had this kind of upset since the Boson partial.  Advances in Hep-c treatment and HIV are due in part to the use of super computers like the famous KARKEN to model a single three dimensional virus core and mapping it.  With the HIV virus floating around in a modal on the screen we can see things that we never have seen before.  Scientist have now taken on the challenge of studying the behaviour of the virus at different stages in the replication process.  Now comes the hard part, when I say hard I mean near impossible.  What they found is that it unfolded it's self to form a kind of armour and if we could somehow cripple this process or prevent it all together.  But how does it unfold?  To figure this out science turns to Open Source.  A game was created. A puzzle game. And thousands upon thousands of participants played and Did find out just Exactly how the HIV  unfolds .  Next is the Hep-c virus and with the new DAA and no doubt the help of the internet community that extends around the globe.

---

 That is beyond cool.

wow!!!!!  

3 shots left!!  I am not losing my mind this week.. lol 

  Science has not had this kind of upset since the Boson partial.  Advances in Hep-c treatment and HIV are due in part to the use of super computers like the famous KARKEN to model a single three dimensional virus core and mapping it.  With the HIV virus floating around in a modal on the screen we can see things that we never have seen before.  Scientist have now taken on the challenge of studying the behaviour of the virus at different stages in the replication process.  Now comes the hard part, when I say hard I mean near impossible.  What they found is that it unfolded it's self to form a kind of armour and if we could somehow cripple this process or prevent it all together.  But how does it unfold?  To figure this out science turns to Open Source.  A game was created. A puzzle game. And thousands upon thousands of participants played and Did find out just Exactly how the HIV  unfolds .  Next is the Hep-c virus and with the new DAA and no doubt the help of the internet community that extends around the globe.