Man, what a blog! How does someone have the time to write such drivel. Take some half-truths, distort them, then twist them around to support a personal point of view.
I like this one: in one Trial of Sovaldi, two patients died but in the corresponding Trial with Peg/Riba, only one patient died. Therefore Sovaldi is twice as dangerous as SOC!
The internet can be a dangerous place.
That's a major reason I like this forum.. Bad info is corrected quickly.
P.S. You asked specifically about the liver, Dex, but it is important to note that HepC is also linked with other extrahepatic conditions (such as Type 2 diabetes, autoimmune disorders, fibromyalgia, etc. etc). SVR will improve or even eliminate those conditions for many people. The indirect benefits of SVR are numerous.
Isiscat2011 said
Jul 25, 2014
drexelpbp wrote:
Thanks for the Reply Isiscat
My question for you or anybody that knows the answer is:
When you say that "achieving SVR will not save all people who suffer from hepc, but it will save some," do you mean that the virus still continues to cause damage even though its not detected or do you mean that for those that SVR does not save their liver was already too far gone?
Thanks
I mean the latter. Once a person achieves SVR the virus will not continue to assault his/her liver. There will still be people who are far into the disease process who will die from liver related complications or HCC (liver cancer) but the numbers will be significantly reduced.
SVR will also create indirect benefits. For example, it will reduce the need for liver transplants and consequently free up livers for transplants for those who need them. It should also give others more time as the science of liver regeneration progresses. Moreover, SVR will impact quality of life issues.
There are no guarantees but the alternative--allowing HCV to progress in the individual and even spread to others--is far worse.
Huey is right that this area of medicine is about the needs of the many outweighing the needs of the few. This fact saddens me deeply but it is a harsh reality. Having said that, there will come a point where tx is so safe and effective that people will not be placed in harm's way by treating the virus and the virus will be virtually eradicated. I believe the all orals are a paradigm shift that represent the beginning of that new reality.
drexelpbp said
Jul 25, 2014
Thanks for the Reply Isiscat
My question for you or anybody that knows the answer is:
When you say that "achieving SVR will not save all people who suffer from hepc, but it will save some," do you mean that the virus still continues to cause damage even though its not detected or do you mean that for those that SVR does not save their liver was already too far gone?
Thanks
Huey said
Jul 25, 2014
Isiscat2011 wrote:
Hi Drex:
Looks like a blogger who has an agenda. Not only does this person misstate facts but he/she deceptively takes facts out of context to support an agenda. I view this as dishonest argument. It certainly isn't objective.
I'm highly critical of big pharma but that doesn't mean every drug scientists invent is useless or bad. Medical breakthroughs do occur and imagine where we would be without them (still dying of infected teeth). I expect pharma to present their drug in the light most favorable to them while minimizing the down sides. However, I try to separate my personal disdain for profiteers of human suffering from the drugs the PHDs and MDs invent in labs.
We have to be realistic which means we have to view the good with the bad. Realistically, achieving SVR will not save all people who suffer from hepc, but it will save some, and it will give others a better quality of life. Some people will be worse off for treating but many others will be better off and I am satisfied that the tx is in fact improving. There are no absolutes nor are there universal truths about hepc tx that will apply to everyone. It is all about risk vs benefits. That's medical care in a nutshell: the possible risks vs the possible benefits.
"The Needs of the many - Outweigh the Needs of the Few" (Spock)
Josh Haynie said
Jul 25, 2014
mallani your July HCV article link thingy thing dosnt work :( i click on it and it goes nowhere ... not a big deal even though i bet it was good info.....
I concur sounds like whoever wrote that article was ragn on the fact oh woe is us drugs cost so much money blah blah .... the deal is do they work or do they not ... ya there expensive and i proably couldnt get m if didnt have this 5 star odumba care but meh ..... i hear good things about sovaldi im an optamist who has never been on any treatment of any kind ... ... here is the question of the day right here and iLL post it on the forum general disscusion ...
mallani said
Jul 25, 2014
Hi drexel,
Man, what a blog! How does someone have the time to write such drivel. Take some half-truths, distort them, then twist them around to support a personal point of view.
I like this one: in one Trial of Sovaldi, two patients died but in the corresponding Trial with Peg/Riba, only one patient died. Therefore Sovaldi is twice as dangerous as SOC!
The internet can be a dangerous place.
Isiscat2011 said
Jul 24, 2014
Hi Drex:
Looks like a blogger who has an agenda. Not only does this person misstate facts but he/she deceptively takes facts out of context to support an agenda. I view this as dishonest argument. It certainly isn't objective.
I'm highly critical of big pharma but that doesn't mean every drug scientists invent is useless or bad. Medical breakthroughs do occur and imagine where we would be without them (still dying of infected teeth). I expect pharma to present their drug in the light most favorable to them while minimizing the down sides. However, I try to separate my personal disdain for profiteers of human suffering from the drugs the PHDs and MDs invent in labs.
We have to be realistic which means we have to view the good with the bad. Realistically, achieving SVR will not save all people who suffer from hepc, but it will save some, and it will give others a better quality of life. Some people will be worse off for treating but many others will be better off and I am satisfied that the tx is in fact improving. There are no absolutes nor are there universal truths about hepc tx that will apply to everyone. It is all about risk vs benefits. That's medical care in a nutshell: the possible risks vs the possible benefits.
I'm particularly interested in any comments in regards to following from the article:
"As we noted earlier, the two real randomized controlled trials of sofosbuvir did not assess its effects long term, even though it is a drug meant to treat a chronic disease, and particularly did not assess whether it affect clinical outcomes, that is, reduce rates of cirrhosis, liver failure, or liver cancer. In fact, there has never been a controlled trial meant to assess whether any treatment of hepatitis C affects these outcomes. Furthermore, while the first author of the case-series above, and many others have claimed the Sovaldi cures hepatitis C, it has never been shown that SVR equals cure. As Gluud et al wrote in a letter to Lancet,(5)
The claim of cure rests solely on sustained virological response (SVR). Since some patients who achieve SVRs still go on to develop end-stage liver disease and might die from the interventions, this concept is not correct and might even be wrong in principle.
That's a major reason I like this forum.. Bad info is corrected quickly.
Hi Josh,
Here's the amended link you were looking for:
JulyNewsletter
wayne
P.S. You asked specifically about the liver, Dex, but it is important to note that HepC is also linked with other extrahepatic conditions (such as Type 2 diabetes, autoimmune disorders, fibromyalgia, etc. etc). SVR will improve or even eliminate those conditions for many people. The indirect benefits of SVR are numerous.
I mean the latter. Once a person achieves SVR the virus will not continue to assault his/her liver. There will still be people who are far into the disease process who will die from liver related complications or HCC (liver cancer) but the numbers will be significantly reduced.
SVR will also create indirect benefits. For example, it will reduce the need for liver transplants and consequently free up livers for transplants for those who need them. It should also give others more time as the science of liver regeneration progresses. Moreover, SVR will impact quality of life issues.
There are no guarantees but the alternative--allowing HCV to progress in the individual and even spread to others--is far worse.
Huey is right that this area of medicine is about the needs of the many outweighing the needs of the few. This fact saddens me deeply but it is a harsh reality. Having said that, there will come a point where tx is so safe and effective that people will not be placed in harm's way by treating the virus and the virus will be virtually eradicated. I believe the all orals are a paradigm shift that represent the beginning of that new reality.
Thanks for the Reply Isiscat
My question for you or anybody that knows the answer is:
When you say that "achieving SVR will not save all people who suffer from hepc, but it will save some," do you mean that the virus still continues to cause damage even though its not detected or do you mean that for those that SVR does not save their liver was already too far gone?
Thanks
"The Needs of the many - Outweigh the Needs of the Few" (Spock)
mallani your July HCV article link thingy thing dosnt work :( i click on it and it goes nowhere ... not a big deal even though i bet it was good info.....
I concur sounds like whoever wrote that article was ragn on the fact oh woe is us drugs cost so much money blah blah .... the deal is do they work or do they not ... ya there expensive and i proably couldnt get m if didnt have this 5 star odumba care but meh ..... i hear good things about sovaldi im an optamist who has never been on any treatment of any kind ... ... here is the question of the day right here and iLL post it on the forum general disscusion ...
Hi drexel,
Man, what a blog! How does someone have the time to write such drivel. Take some half-truths, distort them, then twist them around to support a personal point of view.
I like this one: in one Trial of Sovaldi, two patients died but in the corresponding Trial with Peg/Riba, only one patient died. Therefore Sovaldi is twice as dangerous as SOC!
The internet can be a dangerous place.
Hi Drex:
Looks like a blogger who has an agenda. Not only does this person misstate facts but he/she deceptively takes facts out of context to support an agenda. I view this as dishonest argument. It certainly isn't objective.
I'm highly critical of big pharma but that doesn't mean every drug scientists invent is useless or bad. Medical breakthroughs do occur and imagine where we would be without them (still dying of infected teeth). I expect pharma to present their drug in the light most favorable to them while minimizing the down sides. However, I try to separate my personal disdain for profiteers of human suffering from the drugs the PHDs and MDs invent in labs.
We have to be realistic which means we have to view the good with the bad. Realistically, achieving SVR will not save all people who suffer from hepc, but it will save some, and it will give others a better quality of life. Some people will be worse off for treating but many others will be better off and I am satisfied that the tx is in fact improving. There are no absolutes nor are there universal truths about hepc tx that will apply to everyone. It is all about risk vs benefits. That's medical care in a nutshell: the possible risks vs the possible benefits.
Has anybody seen this article?
http://hcrenewal.blogspot.com/2014/07/sovaldi-quantum-leap-backwards-to-days.html
I'm particularly interested in any comments in regards to following from the article:
"As we noted earlier, the two real randomized controlled trials of sofosbuvir did not assess its effects long term, even though it is a drug meant to treat a chronic disease, and particularly did not assess whether it affect clinical outcomes, that is, reduce rates of cirrhosis, liver failure, or liver cancer. In fact, there has never been a controlled trial meant to assess whether any treatment of hepatitis C affects these outcomes. Furthermore, while the first author of the case-series above, and many others have claimed the Sovaldi cures hepatitis C, it has never been shown that SVR equals cure. As Gluud et al wrote in a letter to Lancet,(5)