the nurse definitely said it is Simeprvir. Her first patients start in 4 weeks. She indicated that the various treatment centres will be starting with 10 patients each.
mallani said
Sep 30, 2014
Hi Paul,
I presume you're referring to Olysio. This drug was FDA approved for use with Peg/Riba, but we haven't seen a single US patient on this. It's only been used off-label with Sovaldi.
Why should we use it? It's probably no better than Victrelis, and may be worse. Sure the pill burden is lower, but I'm sure it costs more than Victrelis(? double).
Victrelis is still being prescribed in Queensland and I haven't heard of anyone who is about to start Olysio. If I was waiting for treatment, I'd give it a miss. Cheers.
Paul B said
Sep 30, 2014
Hey Tig
I mentioned it in the opening post of the thread. No such luck with Solvadi here in OZ. Simeprvir is the new wonder drug for us.
Tig said
Sep 30, 2014
Okay Paul I'm going to bite! Which of the new drugs are you referring to? Sovaldi and ?
Tig
Paul B said
Sep 30, 2014
So my nurse informed me that she has drugs to start 10 patients at the end of October. At this stage drugs are being provided gratis by the pharmaceutical company. The expectation is that it will make the PBS by December.
hrsetrdr said
Sep 17, 2014
Victrelis did me right, peg/inf did weird things and Ribavirin made me crazy[er].
Thank God that the triple tx came available....now goodbye!
Paul B said
Sep 17, 2014
So I am into week 15 and for the last two days I have felt reasonably good... as opposed to totally smashed. Hope it continues as I need a little respite.
Paul B said
Sep 9, 2014
Dzdayscomin wrote:
I have to say this thread title gave me a good chuckle. ...I like that kind of creative humor.
Wishing the best to you Paul
Duane
Glad you appreciated the light side Toto.
Dzdayscomin said
Sep 9, 2014
I have to say this thread title gave me a good chuckle. ...I like that kind of creative humor.
Wishing the best to you Paul
Duane
Paul B said
Sep 9, 2014
Hi Mal
Well the word out of the horse's mouth says it is all go in October. So maybe I have a scoop for the forum !
Anyhow, as far as I am concerned, I have 13 weeks complete with great results so I think I would keep that over the unknown.
Cheers,
Paul
mallani said
Sep 9, 2014
Hi Paul,
Although Simeprevir has been approved by the PBAC, it actually hasn't made it to the PBS as yet. The mind boggles- the same group approved Simeprevir (~$66k for 12 weeks) but rejected Sovaldi (~$84k for 12 weeks), saying it was too expensive! The two drugs are like chalk and cheese.
Agreed the pill burden with Simeprevir is less, but the SVR rate for cirrhotics remains doubtful. You may even have the Q80K polymorphism. IMHO it's not much better than Victrelis, and is twice the price.
You're doing fine with dear old Victrelis, and as we discussed, you probably didn't need a DAA. Cheers.
Paul B said
Sep 9, 2014
And the telaprevirans too ! Had a discussion with my nurse today during which she informed me that she was ditching her old DAAs and commencing Simeprvir. Sometime next month apparently.
So had I known when I started Victrelis triple I could have waited and had a tx duration of 24 weeks rather than 48. And 1 pill per day as opposed to 12 (plus Peg/Rib)
Oh well. Can't do anything about that.
Best wishes to all those here in OZ who are fortunate enough to have timed it for the latest tx. Seems I will go down as one of the last to undergo the old Victrelis triple.
Hi Mellani
the nurse definitely said it is Simeprvir. Her first patients start in 4 weeks. She indicated that the various treatment centres will be starting with 10 patients each.
Hi Paul,
I presume you're referring to Olysio. This drug was FDA approved for use with Peg/Riba, but we haven't seen a single US patient on this. It's only been used off-label with Sovaldi.
Why should we use it? It's probably no better than Victrelis, and may be worse. Sure the pill burden is lower, but I'm sure it costs more than Victrelis(? double).
Victrelis is still being prescribed in Queensland and I haven't heard of anyone who is about to start Olysio. If I was waiting for treatment, I'd give it a miss. Cheers.
Hey Tig
I mentioned it in the opening post of the thread. No such luck with Solvadi here in OZ. Simeprvir is the new wonder drug for us.
Okay Paul I'm going to bite! Which of the new drugs are you referring to? Sovaldi and ?
Tig
So my nurse informed me that she has drugs to start 10 patients at the end of October. At this stage drugs are being provided gratis by the pharmaceutical company. The expectation is that it will make the PBS by December.
Thank God that the triple tx came available....now goodbye!
So I am into week 15 and for the last two days I have felt reasonably good... as opposed to totally smashed. Hope it continues as I need a little respite.
Glad you appreciated the light side Toto.
I have to say this thread title gave me a good chuckle. ...I like that kind of creative humor.
Wishing the best to you Paul
Duane
Hi Mal
Well the word out of the horse's mouth says it is all go in October. So maybe I have a scoop for the forum !
Anyhow, as far as I am concerned, I have 13 weeks complete with great results so I think I would keep that over the unknown.
Cheers,
Paul
Hi Paul,
Although Simeprevir has been approved by the PBAC, it actually hasn't made it to the PBS as yet. The mind boggles- the same group approved Simeprevir (~$66k for 12 weeks) but rejected Sovaldi (~$84k for 12 weeks), saying it was too expensive! The two drugs are like chalk and cheese.
Agreed the pill burden with Simeprevir is less, but the SVR rate for cirrhotics remains doubtful. You may even have the Q80K polymorphism. IMHO it's not much better than Victrelis, and is twice the price.
You're doing fine with dear old Victrelis, and as we discussed, you probably didn't need a DAA. Cheers.
And the telaprevirans too ! Had a discussion with my nurse today during which she informed me that she was ditching her old DAAs and commencing Simeprvir. Sometime next month apparently.
So had I known when I started Victrelis triple I could have waited and had a tx duration of 24 weeks rather than 48. And 1 pill per day as opposed to 12 (plus Peg/Rib)
Oh well. Can't do anything about that.
Best wishes to all those here in OZ who are fortunate enough to have timed it for the latest tx. Seems I will go down as one of the last to undergo the old Victrelis triple.