Yes you see the Ledi is combining with protein in your intestine just before it is adsorbed and the PH is critical as that is what releases the drug to do this in the first place. The Sovaldi gets adsorbed into the blood stream first then starts to combine with the protein.
I gather this from what i have read so far about the Harvoni from Gilead.
-- Edited by Huey on Wednesday 15th of October 2014 02:35:18 PM
Things like wild mushrooms might react like this,
The Amanita Muscaria "Edible" mushroom has cousins that are poisonous so if you alter the complex protean of this mushroom it may become a Toxin by mistake. You would get sick and not know why.
That is the kind of concern i have with this new Drug, Wile making it so one drug is adsorbed before the blood stream and the other after ;it makes it possible to put both in same pill, but the chemistry before the bloodstream is acted upon by many factors and can not be watched by blood test.
Be careful what you eat on this treatment is my advice.
Huey said
Oct 15, 2014
Yes you see the Ledi is combining with protein in your intestine just before it is adsorbed and the PH is critical as that is what releases the drug to do this in the first place. The Sovaldi gets adsorbed into the blood stream first then starts to combine with the protein.
I gather this from what i have read so far about the Harvoni from Gilead.
-- Edited by Huey on Wednesday 15th of October 2014 02:35:18 PM
suziq said
Oct 15, 2014
Hi All,
Just remembered the other no-no. I was not to take any antacids or tums, etc. It was feared they might interfere with the absorption of my HCV pills. That was on my list from Merck.
SuziQ
wmlj1960 said
Oct 15, 2014
Dzdayscomin wrote:
But it's important to tell them everything you take so they know what to advise against...in other words if your taking some funky supplement and you don't tell them you are taking it that doesn't make it OK to take it.
I agree with these very wise words!
wmlj1960 said
Oct 15, 2014
Huey wrote:
I suspect that the Ledi part of the Harvani is going to be effected by things like this.
I think the length and accuracy of a list of interactions for Ledi will grow and become more accurate with time. It's just too new right now. I haven't found any major interactions between the other Rx,s I take and Sovaldi, YET? So I suppose Harvoni will be approved to use with some other meds that an interaction may exist with, but has not yet been identified
I know grapefuit / juice has interaction warnings for most protease inhibitors used in HIV 'Antiretroviral Therapy' (ART). That includes Gilead's Viread (tenofovir) which is one of the Rx's that I currently take. Also there is an interaction with Zoloft which I take for bipolar disorder. The only other interaction I'm aware of from experience is Lipitor (atorvastaton) which is prescribed for cholesterol, but there are many more. So I suggest staying away from anything grapefruit until you've given it the attention it deserves concerning interactions. I haven't eaten grapefruit or drank grapefruit juice in many years because my HIV 'ART' always includes a protease inhibitor and although I did love grapefruit etc in my old non HIV+ life, I'm cool with living the last 20 years, basically asymptomatic, without it.
Another thing I've found with interaction list is that a 'Major' classification should always be investigated by your pharmacist and Dr., and a 'moderate' interaction should be discussed with your Dr. although the reason may seem minor. In my case I take several Rx's that have 'moderate' interaction warnings. But before I started HepC Tx, a change in my HIV Rx's was made due to a 'moderate' interaction. And in my case where my virus has become resistant to so many of the available 'ART' options, a change was the last thing we wanted to do, but the details of this 'moderate' interaction made it 'major' in my case, and required it.
And even OTC meds: I haven't been taking any OTC's except one-a-day multivitamin, until Aug 26 when my hepatologist wanted me to take ibupropen for back pain. But a major interaction was found between it and tenofovir (one of my current HIV Rx's) that could cause kidney failure, so my hepatologist put me back on my old pain med which is the only non-invasive option I have left.
-- Edited by wmlj1960 on Wednesday 15th of October 2014 06:11:25 AM
LC said
Oct 15, 2014
I should have been more specific. I'm not looking for general advice on what to eat, how to follow treatment guidelines, or how I should heed medical advice. While that is certainly good advice, I consider that a given. I am just looking for advice on what I should avoid, on the off chance there is some freaky little food that doesn't play well with my meds.
-- Edited by LC on Wednesday 15th of October 2014 06:03:47 PM
Huey said
Oct 14, 2014
Aloe Vera Juice is a wonderful anti-Oxidant , Vary strong herbal supplement is exactly what you don't won't, here is why.
#1. It can water down the meds you are taking to the point they can't work.
#2. The virus puts itself to sleep and stops replicating when cretin free radicals are present and detected by the virus, If you flush out "these" free radicals it can wake the virus up and make it start replicating and I believe it can cause a relapse after treatment if someone was to try it immediately after treatment.
Huey said
Oct 14, 2014
I suspect that the Ledi part of the Harvani is going to be effected by things like this.
Tig said
Oct 14, 2014
Here are some articles that might make you sit up and take notice of what grapefruit is capable of when combined with certain medications. It's contraindications like these that make it so important to research the medications you take and the diet you are on. It seems apparent that the addition of a single medication may indeed require much more attention to detail. Details we never really considered before. Simple things, like your breakfast fruit have to be considered with these new and powerful medications before they become part of your daily routine. Pardon the number of links, but they're all quite informative.
Yes, I was given a paper with those items on it from MERCK that said NOT to eat them during my trial. So I didn't. I was a little surprised at how many things contain apple juice (the paper said apples and/or apple juice). I also was allowed no over the counter supplements except b-12. But it was a phase 2 trial and I am sure they were being extra cautious. When I was screened for a Gilead trial (which I did not get) I was told no supplements for 28 days prior to starting trial. Don't know if later trials have the same restrictions.
SuziQ
Dzdayscomin said
Oct 14, 2014
Did your Dr. specifically say no apples?
I think some people may be going overboard on this stuff, If the Meds IFU says do not take with certain things fine, or YOUR dr. says to omit things that is ok too.
But it's important to tell them everything you take so they know what to advise against...in other words if your taking some funky supplement and you don't tell them you are taking it that doesn't make it OK to take it.
I think the best thing anyone can do is stop all supplements eat a healthy normal diet and take the meds as prescribed and you stand the best chance of success, I think there is a tendency for people to think they can self doctor themselves and increase their success rates by adding or deleting things in their diet un-necessarily.
Just my 2 cents
-- Edited by Dzdayscomin on Tuesday 14th of October 2014 07:27:57 PM
LC said
Oct 14, 2014
suziq wrote:
Hi LC,
I was not allowed grapefruit, apples, pomegranates, orange marmalade (oranges ok) and something else I can't remember while on my Merck trial. After I finished the trial, I went out and bought an apple pie. Just sort of a gesture of freedom. None of those things were important enough to mess up my chance for SVR. They did request that I take Vit B-12.
SuziQ
Hmm, I sure wouldn't have thought some of these. Especially apples! I like a pomegranate/cranberry juice, but it won't taste the same without vodka anyway. Sometimes I take a supplement called Focus Factor, which has some high concentrations of B vitamins, and it was ok with them at the screening. I bet by the time 2015 rolls around, I will be craving apples too. Nothing like forbidden fruit.
Dzdayscomin said
Oct 13, 2014
Yep B 12 is good, grapefruit has interaction with many meds so I would just eat a good balanced diet of healthy foods and follow the instructions on the meds. IFU (instructions for use) and ask your prescribing doctor because many pharmacists are not going to be armed with all the info right away.
suziq said
Oct 13, 2014
Hi LC,
I was not allowed grapefruit, apples, pomegranates, orange marmalade (oranges ok) and something else I can't remember while on my Merck trial. After I finished the trial, I went out and bought an apple pie. Just sort of a gesture of freedom. None of those things were important enough to mess up my chance for SVR. They did request that I take Vit B-12.
SuziQ
LC said
Oct 13, 2014
I talked to someone from the Abbvie company who is running the clinical trial I'm on, and asked her if there were any foods I should avoid while on treatment. She said not to eat grapefruit or drink grapefruit juice. My nurse told me now that I started treatment, to get a new toothbrush, nail clippers, and razor so I wouldn't come in contact with any old blood. I know I don't want to take Milk Thistle or a whole lot of iron. I was wondering if anyone had any other advice?
Things like wild mushrooms might react like this,
The Amanita Muscaria "Edible" mushroom has cousins that are poisonous so if you alter the complex protean of this mushroom it may become a Toxin by mistake. You would get sick and not know why.
That is the kind of concern i have with this new Drug, Wile making it so one drug is adsorbed before the blood stream and the other after ;it makes it possible to put both in same pill, but the chemistry before the bloodstream is acted upon by many factors and can not be watched by blood test.
Be careful what you eat on this treatment is my advice.
Yes you see the Ledi is combining with protein in your intestine just before it is adsorbed and the PH is critical as that is what releases the drug to do this in the first place. The Sovaldi gets adsorbed into the blood stream first then starts to combine with the protein.
I gather this from what i have read so far about the Harvoni from Gilead.
-- Edited by Huey on Wednesday 15th of October 2014 02:35:18 PM
Hi All,
Just remembered the other no-no. I was not to take any antacids or tums, etc. It was feared they might interfere with the absorption of my HCV pills. That was on my list from Merck.
SuziQ
I agree with these very wise words!
I think the length and accuracy of a list of interactions for Ledi will grow and become more accurate with time. It's just too new right now. I haven't found any major interactions between the other Rx,s I take and Sovaldi, YET? So I suppose Harvoni will be approved to use with some other meds that an interaction may exist with, but has not yet been identified
I know grapefuit / juice has interaction warnings for most protease inhibitors used in HIV 'Antiretroviral Therapy' (ART). That includes Gilead's Viread (tenofovir) which is one of the Rx's that I currently take. Also there is an interaction with Zoloft which I take for bipolar disorder. The only other interaction I'm aware of from experience is Lipitor (atorvastaton) which is prescribed for cholesterol, but there are many more. So I suggest staying away from anything grapefruit until you've given it the attention it deserves concerning interactions. I haven't eaten grapefruit or drank grapefruit juice in many years because my HIV 'ART' always includes a protease inhibitor and although I did love grapefruit etc in my old non HIV+ life, I'm cool with living the last 20 years, basically asymptomatic, without it.
Another thing I've found with interaction list is that a 'Major' classification should always be investigated by your pharmacist and Dr., and a 'moderate' interaction should be discussed with your Dr. although the reason may seem minor. In my case I take several Rx's that have 'moderate' interaction warnings. But before I started HepC Tx, a change in my HIV Rx's was made due to a 'moderate' interaction. And in my case where my virus has become resistant to so many of the available 'ART' options, a change was the last thing we wanted to do, but the details of this 'moderate' interaction made it 'major' in my case, and required it.
And even OTC meds: I haven't been taking any OTC's except one-a-day multivitamin, until Aug 26 when my hepatologist wanted me to take ibupropen for back pain. But a major interaction was found between it and tenofovir (one of my current HIV Rx's) that could cause kidney failure, so my hepatologist put me back on my old pain med which is the only non-invasive option I have left.
-- Edited by wmlj1960 on Wednesday 15th of October 2014 06:11:25 AM
I should have been more specific. I'm not looking for general advice on what to eat, how to follow treatment guidelines, or how I should heed medical advice. While that is certainly good advice, I consider that a given. I am just looking for advice on what I should avoid, on the off chance there is some freaky little food that doesn't play well with my meds.
-- Edited by LC on Wednesday 15th of October 2014 06:03:47 PM
Aloe Vera Juice is a wonderful anti-Oxidant , Vary strong herbal supplement is exactly what you don't won't, here is why.
#1. It can water down the meds you are taking to the point they can't work.
#2. The virus puts itself to sleep and stops replicating when cretin free radicals are present and detected by the virus, If you flush out "these" free radicals it can wake the virus up and make it start replicating and I believe it can cause a relapse after treatment if someone was to try it immediately after treatment.
I suspect that the Ledi part of the Harvani is going to be effected by things like this.
Here are some articles that might make you sit up and take notice of what grapefruit is capable of when combined with certain medications. It's contraindications like these that make it so important to research the medications you take and the diet you are on. It seems apparent that the addition of a single medication may indeed require much more attention to detail. Details we never really considered before. Simple things, like your breakfast fruit have to be considered with these new and powerful medications before they become part of your daily routine. Pardon the number of links, but they're all quite informative.
Grapefruit and Drugs
Grapefruit Juice and your Medications
Grapefruit Interactions
Juice Interactions
Here are some links that also include information that speak of the benefit grapefruit can provide:
Grapefruit benefits
Tig
Hi dzdayscomin,
Yes, I was given a paper with those items on it from MERCK that said NOT to eat them during my trial. So I didn't. I was a little surprised at how many things contain apple juice (the paper said apples and/or apple juice). I also was allowed no over the counter supplements except b-12. But it was a phase 2 trial and I am sure they were being extra cautious. When I was screened for a Gilead trial (which I did not get) I was told no supplements for 28 days prior to starting trial. Don't know if later trials have the same restrictions.
SuziQ
Did your Dr. specifically say no apples?
I think some people may be going overboard on this stuff, If the Meds IFU says do not take with certain things fine, or YOUR dr. says to omit things that is ok too.
But it's important to tell them everything you take so they know what to advise against...in other words if your taking some funky supplement and you don't tell them you are taking it that doesn't make it OK to take it.
I think the best thing anyone can do is stop all supplements eat a healthy normal diet and take the meds as prescribed and you stand the best chance of success, I think there is a tendency for people to think they can self doctor themselves and increase their success rates by adding or deleting things in their diet un-necessarily.
Just my 2 cents
-- Edited by Dzdayscomin on Tuesday 14th of October 2014 07:27:57 PM
Hmm, I sure wouldn't have thought some of these. Especially apples! I like a pomegranate/cranberry juice, but it won't taste the same without vodka anyway. Sometimes I take a supplement called Focus Factor, which has some high concentrations of B vitamins, and it was ok with them at the screening. I bet by the time 2015 rolls around, I will be craving apples too. Nothing like forbidden fruit.
Yep B 12 is good, grapefruit has interaction with many meds so I would just eat a good balanced diet of healthy foods and follow the instructions on the meds. IFU (instructions for use) and ask your prescribing doctor because many pharmacists are not going to be armed with all the info right away.
Hi LC,
I was not allowed grapefruit, apples, pomegranates, orange marmalade (oranges ok) and something else I can't remember while on my Merck trial. After I finished the trial, I went out and bought an apple pie. Just sort of a gesture of freedom. None of those things were important enough to mess up my chance for SVR. They did request that I take Vit B-12.
SuziQ
I talked to someone from the Abbvie company who is running the clinical trial I'm on, and asked her if there were any foods I should avoid while on treatment. She said not to eat grapefruit or drink grapefruit juice.
My nurse told me now that I started treatment, to get a new toothbrush, nail clippers, and razor so I wouldn't come in contact with any old blood. I know I don't want to take Milk Thistle or a whole lot of iron. I was wondering if anyone had any other advice?