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Hep C Discussion Forum -> On Treatment -> Neutropenia
Post Info TOPIC: Neutropenia
JLynch30


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RE: Neutropenia- what do you think of this?
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NEUTROPHILS %, AUTOMATED COUNT42.0 - 75.0 %35.5
LYMPHOCYTES %, AUTOMATED COUNT20.0 - 51.0 %51.3
MONOS %, AUTO1.0 - 12.0 %11.0
EOSINOPHILS %, AUTOMATED COUNT0.0 - 10.0 %2.2
BASOPHILS %, AUTOMATED COUNT0.0 - 1.0 %0.0
RBC NUCLEATED AUTO COUNT, BLD<=0.0 %0.0
NEUTROPHILS, ABSOLUTE, AUTOMATED COUNT1.8 - 7.7 x1000/mcL1.0
LYMPHOCYTES, AUTOMATED COUNT1.2 - 3.4 x1000/mcL1.4
MONOCYTES, AUTOMATED COUNT0.1 - 1.0 x1000/mcL0.3
EOSINOPHILS, AUTOMATED COUNT0.0 - 0.7 x1000/mcL0.1
BASOPHILS, AUTOMATED COUNT0.0 - 0.2 x1000/mcL0.0


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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
Zlikster


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RE: Neutropenia
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I went down to 0.2 Neu. So since insurance wouldn't cover me Neupogen, i obtained it on my own. Was taking one shot weekly. Combined sx from Neupogen+Interferon wasn't that ez (bone ache from Neupogen), but it was bearable. I wish my hepa pushed me for few more shots :/

cheers



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
Ginny


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Tks for your reply. I don't seem to have any"extra" side effects. Mine is down to 0.9



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dustbear


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Hi Ginny,

My neutophils were low from the get-go, as low as 0.3, for most of 45 weeks. Cant say I can attribute any one side effect to it, had so many. They dont pay for neupogen here so I just stayed away from people! Been almost 6 wks sine EOT and its almost normal bur not quite yet.

 

 

 

 



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Geno 1A, since 1981. SOT 1/2013   TX stopped 11/2013 in week 45/48 due to Myositis & Interstitial Lung Disease. Completed 94% of Peg-Inter dbl TX, UND since week 4.  SVR 4/2014!  Still SVR after 4+ yrs!

"Day by day, step by step, breath by breath"
CodeNameBleu


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Hi Ginny,

I think a lot of people on Rx for Hep C experience this, so try not to worry. Am sure your doctors are keeping a watchful eye on your levels. I am currently neutropenic, i have had mine between .4 and .5 for the last couple of months. if it falls back to where i was, last year June which was .1, then i know there is a laid out protocol for me. I am super cautious because am susceptible to a lot of infections atm. Am sure your doc will advice you accordingly, but in the meantime take good care of yourself.

Best wishes!



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Diagnosis:2012. Tests Results: GenoType 1/ Viral Load 51,000/ Liver Normal.

Rx started: 10.06.2013 Copegus (Ribavirin) 200mg + Peg Interferon 180mcg . Down to

Peg Interferon 135mcg 3 months later. No Virus Detected (NVD) result to date. Rx duration: 48wks.
Tig


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Ginny, I also had low white counts and was prescribed Neupogen twice a week. It worked very well and really didn't cause additional SFX. As Bob mentioned, you might notice some achy bones initially but it's quite tolerable. The important thing is, it works and it works fast. My white count returned to safer levels rapidly. Good luck!



-- Edited by Tig56 on Tuesday 10th of December 2013 05:44:54 PM

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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Biggyb


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Hi Ginny, i was on Neupogen the last couple months of TX. It's no big deal.I took 2 shots a week for awhile then down to 1. It really works well. No side effect of that drug. Just a little sore bones.



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58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~
mallani


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Hi Ginny,

Low neutrophils are common during triple Rx, and are mostly due to Interferon. You really don't want to drop your Interferon dose unless absolutely necessary. As Jill said, Neupogen usually brings the level up. Normal range is 1.5-6.5, and mine dropped to 0.7.  They stayed at this level until I finished Rx at 48 weeks, and were back to normal within a month.  Risk of infection increases when they drop below 0.5, so can you let us know your level? Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Cinnamon Girl


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Hi Ginny, having a low neutrophil count isn`t that unusual with interferon based treatment and you`re quite a long way into treatment now. 

Do you know what your neutrophil lab results are?  If they fall below a certain level then your doctor might want to prescribe `Neupogen` which comes in the form of an injection and acts to stimulate the bone marrow to produce more white blood cells.  Many of our members have needed to use Neupogen at some point during their treatment.  Try not to worry!



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Ginny


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Hello,

my last two lab results show that I've got neutropenia.  im in week 17 of 48.  I would be interested in hearing others experiences with this side effect.  Is week some early for this sort of problem?  

 



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