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Hep C Discussion Forum -> On Treatment -> Would those taking off-label Sovaldi/Olysio with or without Riba mind posting here?
Post Info TOPIC: Would those taking off-label Sovaldi/Olysio with or without Riba mind posting here?
Audreyanna


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RE: Would those taking off-label Sovaldi/Olysio with or without Riba mind posting here?
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Well, finally got my 8 week viral load and it's the same as the 4 week. <15 detected! I have a bad feeling. :(



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Audrey

 

55 y/o, GT 1A, 1.4 million UI, cirrhosis, low platelets, enlarged spleen, high LFTs. Failed tx x2. 12 weeks Sovaldi/Olysio. Undetected end of treatment and 4 weeks after EOT!
Tig


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Hey Kurt,

Sorry to hear about your ticker, tocking an extra beat or two, but surprisingly enough, it happens more than some people are aware. They were concerned about my heart while I was on treatment and had a few EKG's during tx and even had to go in for another one last week because they continue to be concerned. So far, so good in that respect. My tx meds, in addition to some I was previously taking caused the concern in my case. Whether or not S/O can be the culprit, I don't know. But certainly medical treatment in general can have an affect on your overall health You need to not be terribly concerned because there are a number of things that can cause the condition, and they are easily controlled and/or corrected when they determine the likely cause. Many medications, including exhaustion can be triggers. Here's a list of common triggers that might be worthy of your thought. They will also check your blood work again if they haven't done a full screening recently. Of course, you can expect an EKG if they haven't done that already. Best to not sweat it and once they can determine what's responsible, you can plan on a quick resolution. Hang in there and rest easy my friend!

Tig

 

TRIGGERS OF ATRIAL FIBRILLATION

Emotional triggers

Physical exhaustion

Surgery or medical procedures

Dehydration

Sleep 

Hormonal influences

Caffeine 

Alcohol

Exercise

Medication



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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kurt


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While it may put my half marathon on hold I will wait to see what the doctor says. I'm not having any problems with it and didn't even notice it but they did a EKG during my yearly physical and caught it. It didn't show up during my pre biopsy EKG so it occurred in the last 4 months.Kurt



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61 yo male,genotype 1a for 20 yrs, undetected at 4 wks on sovaldi/olysio
Marypetrecz


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O Kurt......so sorry......but my mom was under a heart docs orders and procedures and she lived comfortable for decades,.....hoping it all works out for you.



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kurt


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My EOT labs came back with VL undetected and everything else normal. However it seems that sometime during treatment I've developed Atrial fibrillation and have to see a cardiologist next week. They've put me on a beta blocker and a thinner until then. So a good news , bad news type week for me. Kurt 



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61 yo male,genotype 1a for 20 yrs, undetected at 4 wks on sovaldi/olysio
Sara


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Congrats Caryn & Barnacle on EOT!  PW your lab results look great - you are probably UND as I type this  smile.

Greg I am saddened to read about your relapse.   The ups and downs of tx are grueling.  Don't give up!

 

 



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Sovaldi/Olysio/Riba 2 week vl 16 4 week vl UND! EOT vl UND! EOT+12 SVR!  EOT+24 SVR!!

 
Isiscat2011


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I sure hope you are right, Matt.  I just have a hard time believing that insurance companies are going to pay double (for 24 weeks) across the board for cirrhotics.

Even if the SVR rate for cirrhotics is 8 out of 10 the majority will achieve SVR with 12 weeks so why give them 24 weeks?  They are thinking about costs, and don't tend to think about what the individual is suffering.  Sadly, insurance companies know darn well that they won't be paying for liver transplants for most people, because there simply aren't enough livers to go around.  They will probably try to mitigate long term care costs by retreating only those who relapse. If some patients give up on treatment or die along the way, oh well.  Long term care costs will improve with SVR, but certainly will not be eliminated, for cirrhotics anyway.  That is the harsh reality of health care costs.

I do think this situation will improve as Rx costs decrease but there will be relapses, and other human suffering in the meantime, just as there has been suffering in the past 2+ years while Gilead refused to work with other pharmas to deliver a Sovaldi combo sooner.  This is about corporate profits--for pharma and for insurance companies--patients are incidental.  And our government is not protecting us as it should be against the corporate greed. 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Matt Chris


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Hey Isiscat

Appreciate yours thoughts but digging deeper into the breakout of Gt1a and GT1b along with cirrhotics we see that the the SVR rates are closer to 8 out of 10 .

There is the article that was released  on 6-27-14 about this very subject

http://hepatitiscnewdrugs.blogspot.com/2014/06/genotype-1-hcvinfected-cirrhotic.html 

This excerpt from the article explained further

-III ION-2 study of the same regimen in previously treated patients, cirrhotic individuals appeared to benefit more from the 24-week regimens than from 12 weeks of therapy (100% vs 82% to 86%, respectively). And in the phase III TURQUOISE-II study of the 3-drug regimen plus ribavirin in cirrhotic patients, previous null responders with genotype 1a infection also appeared to do better with 24 weeks of therapy compared with 12 weeks (93% vs 80%, respectively)

Also the lengthy articles from the NEJM on both studies concurred about the cirrhotic patients SVR results , primary focusing on GT1a cirrhotics with previous treatment the SVR goes from the low 80% on 12 weeks to almost 100% SVR for 24 weeks 

The cost factor will still be a wild card but its still less that all the expense with long term care and liver transplant, plus the price will moderate with all the new companies entering the market.

matt 



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Isiscat2011


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Matt Chris wrote:

really if insurance approved some of the off label S & O that many of you have been on that was not FDA approved why would you have no faith in the 24 weeks of SOF & LPV.    

It isn't really a question of faith.  It is a question of what is cost effective.  Based on clinical trials 12 weeks of the S/L combo will result in SVR in roughly 9 out of 10 people even when they have substantial liver damage.  Why pay for all cirrhotics to have 24 weeks when 12 weeks will be adequate for the overwhelming majority?  Adding the extra 12 weeks not only doubles the cost of the Rx  but increases incidences of adverse events, and therefore, increases medical and hospital costs related to tx. 

The gt3s are distinguishable.  They don't have 9 out of 10 odds with only 12 weeks of the Sovaldi/Riba combo.  Additionally, the Sovaldi/Riba combo is much less expensive than the S/L is expected to be.  

Hard to say how it will play out but I doubt 24 weeks will be the protocol for most even where they have substantial liver damage.  24 weeks may be a possibility but it will probably be a lottery that depends on the physician and the insurance company one happens to have.  Pretty much like what we are seeing now, at least until costs come down and there are enough relapses to justify the additional 12 weeks.  Wayne is right: unfortunately, there will be people in the US "falling through the cracks"--not receiving the individualized tx they need-- due to costs.  



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
maddie


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Greg, I am so sorry for the major disappointment.  Having this setback is just that...a setback.  You will be Hep c free one day soon. These newer medications are potent.  As a few people have said already, you might need to be on the medications for 24 weeks and maybe riba, but the virus can be beat with the right protocol. 

Also, as Matt mentioned, you need to have the VL repeated because there is always the chance of an lab error. 

We are all pulling for you, Greg. 

 



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Dx. 2005-liver bx.: stg 2/gr 1. at that time  - GT 1a multiple transfusions in 1981.  Started Sovaldi and Olysio 1/16/14  (No prior treatments) Q80K present.  UND week 4,8 and at EOT.   UND at wk 4EOT, Und at wk 8EOT  SVR 12!!!..SVR 24 :-)
Matt Chris


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OldenSlow wrote

 

Yeah, that's the way I see it playing out. There will be some very sick folks continuing to fall through the cracks due to ongoing bottom-line issues. Also, additional to Greg, Darkstar and Matt's AbbVie relapse, there have been a few others reporting in as having failed newer DAA trials, including one gentleman on the Electron S/L combo (forget his name). If memory serves, he was retreating with S/L + riba.

I believe your referring to RH and he was on the ION 3 trial with SOF & LPV for 12 weeks and relapsed and is now redoing 24 weeks of the same.  

The key for 24 weeks will be is if the FDA approves it like they did for GT-3 for 24 weeks , really if insurance approved some of the off label S & O that many of you have been on that was not FDA approved why would you have no faith in the 24 weeks of SOF & LPV. Most of the general HCV people and its community doubted that any off label use of S & O would ever be approved but hear we are and that thankfully never turned out.

Lets keep the hope out there and thinking positive we all need it.

 

matt    



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Audreyanna


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Thats so sad Greg.  But didn't you have the same thing happen earlier in your treatment and when you talked to the dr. he confirmed you were still undetected?  Something about the lab results were wrong or confusing or something?

 I'm awaiting my 8 week bloodwork - got it all today except the viral load.  I get mine online also and was kind of freaking out when it was the only test not there.  Its making me nervous as my 4 week was almost but not quite undetected (15, which is the cutoff).  My ALT and AST are still slightly elevated and platelets came up slightly but still 90 and low normal is 140.  

Anyway, hang in there until you talk to the dr.  Maybe it's ok!



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Audrey

 

55 y/o, GT 1A, 1.4 million UI, cirrhosis, low platelets, enlarged spleen, high LFTs. Failed tx x2. 12 weeks Sovaldi/Olysio. Undetected end of treatment and 4 weeks after EOT!
patiently_waiting


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I'm sorry to hear that Greg.  I know from experience what a big kick in the gut it is to get that news.  You have the better meds coming to look forward to.  Also at the very least you gave your liver a break from the HCV for 12 weeks which can't hurt.  I hope things turn out ok with your job & insurance.  I'm familiar with that stress too.  I'll be pulling for you.



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42 yrs old: geno 1b, 23mil VL, ALT/AST 269/94 as of Apr '14.  Got HCV when I was 16.  Relapsed from Peg/Riba twice, last time in '08.  Completed Sol/Oly on 9/2/14, UND as of 10/7/14
OldenSlow


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Isiscat2011 wrote:
I expect insurance companies will balk at 24 contiguous months.  

Yeah, that's the way I see it playing out. There will be some very sick folks continuing to fall through the cracks due to ongoing bottom-line issues. Also, additional to Greg, Darkstar and Matt's AbbVie relapse, there have been a few others reporting in as having failed newer DAA trials, including one gentleman on the Electron S/L combo (forget his name). If memory serves, he was retreating with S/L + riba.



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66 y/o male - Geno 1b - F4 cirrhotic dx 2001 - 16 wk treatment w/ Sovaldi/Olysio/Riba - Und @ EOT+24 SVR

 
Matt Chris


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Hey Isiscat & Greg

Depending what your liver condition is and which DAA's you have been exposed to and how long you have been on treatment goes into each doctors recommendation. My my case all three of my Doctors, one ID, and two Hepatologist  concurred 24 weeks plus riba so every situation has to be looked at individually, The doctors recommendation is what has the most convincing power along with FDA approved dosing protocols, so lets hope they have a 24 weeks allowance for particular hard to treat patients.

matt     

 



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Isiscat2011


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Tig56 wrote:

You're the first in our group that I'm aware of to relapse on this protocol. 

Well, Darkstar relapsed.  He was positive for the Q80K and had used first gen PIs, though.  Also, he is a 1a.  

My doc didn't suggest either riba or 24 weeks for the S/L combo and I'm a bit concerned about that.  Still a bit early to say what the protocol will be in 3 months, though.  I expect insurance companies will balk at 24 contiguous months.  



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
OldenSlow


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Discouraging news, Greg. Not much I can say that hasn't been said, but my heart goes out to you. I'm with others in thinking you should press for longer tx time on the next go around. Some of us aren't going to fit so easily into conventional treatment timetables. And I've yet to see enough data to convince me riba can be excluded in all cases. Hopefully it can.

Be as healthy as you can be and press on. We'll be here.

wayne



-- Edited by OldenSlow on Tuesday 1st of July 2014 04:45:53 AM

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66 y/o male - Geno 1b - F4 cirrhotic dx 2001 - 16 wk treatment w/ Sovaldi/Olysio/Riba - Und @ EOT+24 SVR

 
Matt Chris


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Hey Greg

It truly was disappointing to read of your relapse, your doc will likely have you re-checked because it has happen that reading can be wrong. If not, your a candidate like myself for Gilead's new combo of SOF & LPV but try to get it for the 24 weeks as the percentage of SVR then will go to about 99%.

I know its depressing but better days are coming and not very long to wait.

matt    



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Isiscat2011


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Hi Greg:

I'm so sorry to hear this but try not to be disheartened.  Whatever happens with your job you should be able to get coverage under the Affordable Care Act and there will be patient assistance programs. You know there are some great combos coming soon and I have no doubt you will be able to get in on one.

Knocking back your viral load, even for a while, is a good thing.  For me it helped with some of my hepc extra-hepatic symptoms.  Also, my viral load still hasn't climbed back up to where it was (11 million) pre-treatment in >2 years.  

Hang in there, pal.  Everything will work out.  



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
jimbob


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Grouper,  I'm sorry to hear that news. I am interested to know what your doc suggests.  Txs are indeed changing for the better. I know it's easy for me to say, but try to stay positive. My hopes are with you GG.



-- Edited by jimbob on Tuesday 1st of July 2014 04:10:36 AM

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jimbob: 64 y/o, GT 1A, F1-F2, diagnosed 1996. Since 1970. SOT 3.5 mil VL on 3/10/14 with Sov/Rib/Peg for 12 weeks. Tx naive. UND @ week 4,8,12. EOT 6/2/14.
mallani


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Hi Greg,

Bad luck mate. Probably 12 weeks wasn't enough in your case. I'm not sure of your liver status. You mention 'bridging fibrosis' which is at least F3.

The good news is you can retreat with Sovaldi, probably with Ledipasvir. I hope you can get the Insurance sorted. Cheers, life's not meant to be easy!



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Dee Dee


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Just seen this post...thought I'd share

"ok lets get things straight I did not vote for the man but I am defiantly reeping the rewards of the Obama care ! I signed up  the first go round an immediately went to the doctor an got diagnosed with hep c my doc put in for solvaldi ribavirin an peg pen the blue cross blue shield went ahead an paid for it the first time an I had a 5 dollar copay the next month blu cross told me I had to use their pharm  I got same drugs this time no co pay ! sooooo I urge you get Obama care an get cured I could have never afforded it on my min wage good luck an I hope this helps many ! 



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G1a prior tx 2005 with peg & RIBA -quit due to bad side effects. Follow up visit showed it was back. Current tx Olysio/sovaldi 673,000 vl on 3/21/14. May 1st undetected vl. EOT 12 weeks undetected!
Dee Dee


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Happy to hear your on your way to a virus free life PW.. Best wishes to a happy and healthy life!



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G1a prior tx 2005 with peg & RIBA -quit due to bad side effects. Follow up visit showed it was back. Current tx Olysio/sovaldi 673,000 vl on 3/21/14. May 1st undetected vl. EOT 12 weeks undetected!
Dee Dee


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So sorry to hear the disappointing news Groupergetter.. It really is heartbreaking. Thank Goodness there are new meds on the horizon. Try not to be too sad, think of it as your liver getting a well deserved break .. Til the next treatment that will knock that virus for a loop once and for all.  



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G1a prior tx 2005 with peg & RIBA -quit due to bad side effects. Follow up visit showed it was back. Current tx Olysio/sovaldi 673,000 vl on 3/21/14. May 1st undetected vl. EOT 12 weeks undetected!
Huey


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The S/L combo will work for ya, you may need the riba too this time. but youll get it.

We are all in this together Keep your stick on the ice(Red Green Show)



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  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
Groupergetter


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Fireman Rob wrote:

Groupergetter,

Maybe the count will go back down UND as it's only week four? What did your doc say? Aw, man, my heart really goes out to you. This is devastating news just to read. Hang in there friend and let us know what the doc says and if nothing else, October is almost here!

Hang in there Friend!

Haven't talked to my doc.  Just got the results this evening.  Definitely disappointing. 



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.
Tig


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Hey Greg, 

Sorry to hear your news. You're the first in our group that I'm aware of to relapse on this protocol. What was your doctors response?  Right now I would recommend getting back on track and clearing yourself of these medications. Don't try and figure it out today, give yourself some time to recoup and recover. You'll be able to fight this again another day. You know that these protocols are going to get better and better. Your day is coming, that is something you need to believe. This isn't your fault, it's a failure of the medication, remember that. Hang in there...

Tig

 

PS: don't worry about the thread



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Fireman Rob


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Groupergetter,

Maybe the count will go back down UND as it's only week four? What did your doc say? Aw, man, my heart really goes out to you. This is devastating news just to read. Hang in there friend and let us know what the doc says and if nothing else, October is almost here!

Hang in there Friend!



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Age 33, Male. GT-1 for ten years. Diagnosed in March, 2014.

Treated with Sovaldi/Olysio: SVR 24 on February 16, 2015!
Groupergetter


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Well............ got my 4 week EOT labs back today.  Good news and bad.  Good news I'm still here, bad news no longer UND.  Viral load climbing, hoping it doesn't explode.  Guess the Sovaldi and Olysio didn't make it for me .  Truly hope others find better success.  I have concerns that the job I've for over 25 years is about end and I won't have coverage when the new combo's come out.  Tomorrow is another day.  For all those on treatment don't give up hope.

My apologies, if this should be in Post Treatment I can delete and repost.



-- Edited by Groupergetter on Tuesday 1st of July 2014 02:21:01 AM



-- Edited by Groupergetter on Tuesday 1st of July 2014 02:23:38 AM

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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.
patiently_waiting


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Of course you're all right.  I just wasn't thinking clearly - I'm kinda foggy today.  I know there have been lots of people that didn't respond nearly this fast and still got SVR.  I'm very happy and looking forward to the 4wk results next week.  Thanks all.



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42 yrs old: geno 1b, 23mil VL, ALT/AST 269/94 as of Apr '14.  Got HCV when I was 16.  Relapsed from Peg/Riba twice, last time in '08.  Completed Sol/Oly on 9/2/14, UND as of 10/7/14
Tig


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Hey PW,

I'm in complete agreement! I'm seeing more and more reports of the first undetectable's coming in at 4 weeks, many are out to 6 weeks. For you to show a multi log drop at 2 weeks is incredible! You're on your way my friend! You've every reason to be thrilled!

Tig



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Groupergetter


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Lookin good PW, you're on the way.  Happy and for you. These meds are great.  Not sure what's taking so long on my EOT 4 weeks.  Was drawn a week ago and no results  cry    Hoping and praying we all make it to SVR.  Be well.



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.
jimbob


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PW--That's great! Twenty-three mil to almost UND in 2 weeks! Can't ask for much more. Most expect UND in 4 weeks so you are on the way. Thumbs up!.



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jimbob: 64 y/o, GT 1A, F1-F2, diagnosed 1996. Since 1970. SOT 3.5 mil VL on 3/10/14 with Sov/Rib/Peg for 12 weeks. Tx naive. UND @ week 4,8,12. EOT 6/2/14.
OldenSlow


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Be happy, PW. That's a fantastic result! And all in only two weeks. You are responding exceedingly well to the meds. Probably UND as I type this. Get ready to be REALLY happy at your next check. wink

wayne



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66 y/o male - Geno 1b - F4 cirrhotic dx 2001 - 16 wk treatment w/ Sovaldi/Olysio/Riba - Und @ EOT+24 SVR

 
Fireman Rob


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PW,

I would be extremely excited to be that close to UND at two weeks! It doesn't get much better than that and your LFT's look great! I don't get a VL test til six weeks ). ; 

Great News!



-- Edited by Fireman Rob on Monday 30th of June 2014 09:33:01 PM

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Age 33, Male. GT-1 for ten years. Diagnosed in March, 2014.

Treated with Sovaldi/Olysio: SVR 24 on February 16, 2015!
patiently_waiting


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Hi All.  I just got my 2 week viral load test back.  My last result was 23 mil in Nov 2012.  At 2 weeks I'm <15.  Here's my results...how excited should I be about this?  At first I was very happy, but I want to see UNDETECTED don't I?

 

 7/5/20115/24/201211/28/20126/24/2014
HCV RNA IU/ML
 
6452239864394622938401<15 DETECTED
<15 IU/mL
HCV RNA, QUANTITATIVE REAL TIME PCR
 
6.816.947.36<1.18 DETECTED
<1.18 Log IU/mL

 

Also, btw, my ALT and AST were pretty high before and now they're back in normal range.  Here's my other results:

ComponentStandard RangeYour Value
GLUCOSE65-99 mg/dL102
Fasting reference interval
BUN7-25 mg/dL18
CREATININE0.60-1.35 mg/dL1.24
eGFR NON-AFRICAN AMERICAN> OR = 60 mL/min/1.73m271
eGFR AFRICAN AMERICAN> OR = 60 mL/min/1.73m283
BUN/CR6-22 (calc)NOT APPLICABLE
SODIUM135-146 mmol/L140
POTASSIUM3.4-4.8 mmol/L4.1
CHLORIDE98-110 mmol/L107
CO219-30 mmol/L21
CALCIUM8.6-10.3 mg/dL9.5
Protein Total6.4-8.4 g/dL7.7
ALBUMIN3.6-5.1 g/dL4.7
GLOBULIN2.2-4.0 g/dL (calc)3.0
ALBUMIN/GLOBULIN RATIO0.9-2.3 (calc)1.6
BILIRUBIN, TOTAL0.2-1.2 mg/dL1.9
ALK PHOS40-115 U/L36
AST10-40 U/L22
ALT9-46 U/L27


-- Edited by patiently_waiting on Monday 30th of June 2014 09:28:36 PM

__________________

42 yrs old: geno 1b, 23mil VL, ALT/AST 269/94 as of Apr '14.  Got HCV when I was 16.  Relapsed from Peg/Riba twice, last time in '08.  Completed Sol/Oly on 9/2/14, UND as of 10/7/14
Caryn


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I took my last dose as well!  Hoping for the best! 



-- Edited by Caryn on Monday 30th of June 2014 12:19:39 PM

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1a, CT. Incivek triple 1/2013, vl 810 @ 2 weeks, 610 @ 4 weeks, 3000 @ 8 weeks, tx stopped. 

4/2014 - tx with Sovaldi/Olysio/Riba. VL 39 mil. - VL 230 @ 1 week, VL 40 @ 3 weeks, 5 weeks UND, EOT - UND, EOT @ 4 weeks UND, EOT @ 12 weeks UND!
Barnacle


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All these success stories are so encouraging. Took my last pills the other day. Will get to the lab in a day or so for my post Tx viral load.
I have had 2 VL tests already during Tx. The other day the nurse said my lab results better than it had for years. Everything within normal levels except my hemoglobin which was still in the low normal range but reduced from the riba.

I'm feeling really good right now so many of my hepc symptoms have disappeared.

Once again I want to express my gratitude to the members of this forum. Without you guys I would have never heard of sovaldi and olysio or known to insist that was the treatment I wanted.

I will let you know when my labs come back.


__________________

57yo male gen 1a since '70s. Fib F3-4 VL >2M Tx started 5 Apr 14 Sov/Oly/Rib

wk 4 UND wk 8 UND, wk 12 EOT UND...keep em coming 24wks UND = SVR!
Cinnamon Girl


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Congrats to you, Gator Man, I`m just catching up on your news and so pleased for you!

Thanks for such a thoughtful and inspiring post, and I have no doubt your mother would be overjoyed and very proud of your determination to rid yourself of this virus and finally achieving your goal. 

I`m very glad you intent to stay around, your comments are always appreciated as well as the support you give to other members.

Enjoy every new virus free day, you`ve worked hard for it!  biggrin

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Gator Man


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Thank you everyone for the kind  thoughts and wishes. Besides my family, there is no one I wanted to share the good news with besides my fellow forum members.

I am convinced my positive results from tx can now be replicated for almost everyone suffering from Hep C. For those still waiting, the next DAA generation will be even better and I hope that we will soon achieve virtually a 100% "cure" for everyone treated. Matt, your day will come soon!smile

In the 1950's, my mother was a lab assistant studying infectious diseases for Jonas Salk at the University of Pittsburgh. Dr. Salk's efforts, along with the support of people like my mother, led to the eradication of polio, at least in the developed world. The number of people worldwide infected with Hepatitis C is staggering at an estimated 150-200 million, far surpassing AIDS and many of the diseases of the past like polio. If my mother were still alive, she would of course be ecstatic over my personal good fortune, but remind me that the work has just begun.

Everyone participating in this forum plays a part in that work by sharing their current or past struggles, and providing morale boosting support and information for those of us wading into this new tx landscape, especially if we have failed in the past. To respond to your comment Wayne (OldenSlow takes the prize for the best screen name, although Groupergetter is a close second), I don't plan on being a stranger. There are many members who still generously contribute their time, knowledge, and concern long after they have finished tx; I would like to be part of that group.

My special thanks goes to all the gurus who constantly support people like us that need a kindred spirit and an ear to listen. Your help has been invaluable to me personally, as I am sure everyone on the forum would agree. I also add an additional thanks to our Cinnamon Girl (Jill), who keeps this forum smoothly ticking in the background along with all the contributions she shares with it's members.

P.S. The World Cup has temporarily usurped Gator football as the center of the sports universe. My wife tells me that not everyone agrees with the part about Gator football. Although a rare occurrence, she is of course incorrect!

 



-- Edited by Gator Man on Friday 27th of June 2014 09:16:03 PM

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Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
Audreyanna


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Gator Man,

Such great news!, I'm so happy for you.  I know what you mean about not believing this would ever happen. Waiting on my 8 week into tx bloodwork. Was ALMOST UND at 4 weeks (15), down from 1-1/2 million.  So glad to see this great news. Congrats!!!



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Audrey

 

55 y/o, GT 1A, 1.4 million UI, cirrhosis, low platelets, enlarged spleen, high LFTs. Failed tx x2. 12 weeks Sovaldi/Olysio. Undetected end of treatment and 4 weeks after EOT!
Matt Chris


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Hey Gator Man

Another great day by another result from a very happy Gator Man, this is better than the Gators winning the national Championship.  This year 2014 will turn out to be an super Fantastic year for beating the H out HCV.

Looking forward to joining you later this year.

matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Dee Dee


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I sure hope we all get rid of this virus...seems to be the case .. Yeahhhh for all of us!biggrin

-- Edited by Dee Dee on Friday 27th of June 2014 04:06:11 AM

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G1a prior tx 2005 with peg & RIBA -quit due to bad side effects. Follow up visit showed it was back. Current tx Olysio/sovaldi 673,000 vl on 3/21/14. May 1st undetected vl. EOT 12 weeks undetected!
Peter M


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Way to go Gator Man! 



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64 YO - HCV  45 years - GT 1b - F4  - starting VL 7,800,000 - AST 130 ALT 164  - started S/O 4-11-14 - week 2: - AST 37 -ALT 43 - wk 4 VL <40 - UND week 8, 12, eot, +4 +8 +12 SVR!!!  My Blog-Visit hepcstories.wordpress.com!
Barnacle


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Great news. Here's hoping for the same for all here.

__________________

57yo male gen 1a since '70s. Fib F3-4 VL >2M Tx started 5 Apr 14 Sov/Oly/Rib

wk 4 UND wk 8 UND, wk 12 EOT UND...keep em coming 24wks UND = SVR!
Groupergetter


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G-man if you could see the big ole s'eatin grin on my face you'd be proud.  Excited and happy for you.  If you're coming to your old stomping grounds drop me a pm.  Would love to meet you and family.  Maybe get together for a cool one....I hear pine floats are pretty good biggrin   Congrats!



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.
mallani


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Hi Gator Man,

Congrats. Fantastic result. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Sara


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Congrats Gator Man!  Celebrate!



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Sovaldi/Olysio/Riba 2 week vl 16 4 week vl UND! EOT vl UND! EOT+12 SVR!  EOT+24 SVR!!

 
Isiscat2011


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Gator Man wrote:

When maddie started this thread for all of us just beginning the off label Sovaldi/Olysio combination, there were a lot of unknowns. I think we definitely have "better treatment options" with even more promise on the horizon. If you had asked me a year ago, I wasn't confident that I would ever see this day.

 

         ___________________________________________________________________________________________________________

So true and the clinical trial data on the S/O combo was very limited.  My hepa doc told me that in practice they are seeing really fine across the board results with this combo.  It is doing an especially bang up job with the 1b gt even with cirrhosis.  Great news, Gator Man.  smile



__________________

Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Caryn


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I am so happy reading all of these great results!  Congrats GM!!!



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1a, CT. Incivek triple 1/2013, vl 810 @ 2 weeks, 610 @ 4 weeks, 3000 @ 8 weeks, tx stopped. 

4/2014 - tx with Sovaldi/Olysio/Riba. VL 39 mil. - VL 230 @ 1 week, VL 40 @ 3 weeks, 5 weeks UND, EOT - UND, EOT @ 4 weeks UND, EOT @ 12 weeks UND!
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