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TOPIC: All aboard the "Harvoni" Treatment Train


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RE: All aboard the "Harvoni" Treatment Train
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Tig wrote:

Welcome aboard! Sit back, grab your bucket of water and enjoy the ride. The EOT station will be the next stop on your way to SVRVille...  ALL ABOARD!!!!!

Harvoni Train 02.gif


this post is so cute! and cool ......... indeed , grabbing my bucket of water ..and dragging lots of water to work with me. went back to work tonite after 10days off to get started on Harvi. So far so good, a few weird feelings but thankful for the easy start.... and praying it keeps feeling ok. I keep imagining the colony getting smaller and new ones not reproducing-it's a beautiful picture when I think of it. My work is being so cool with me too, lots of ppl know and are cheering me on and letting me out early to keep me feeling well. I am blessed.smileaww 



__________________

GT1a for 36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off.

3.6.18:Alpha 2-Macroglobulins, Qn=400/high. A1 activity.  f3@60: fibrosur bloodtst. TumrMrk=norm. enz=mostly norm.VL=3,933,000 

.sot=5.1.18>Harvoni>8weeks>

Tig


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Welcome aboard! Sit back, grab your bucket of water and enjoy the ride. The EOT station will be the next stop on your way to SVRVille...  ALL ABOARD!!!!!

Harvoni Train 02.gif



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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All aboard the
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thank you to all the harvoni pioneers here and everywhere. I was an interferon pioneer and thankfully didn't have to do more than a few weeks of trial before they were good enough to take me off due to bad results.

I was sad and glad.

I started harvoni may 1st , 2018 and I feel so blessed to be on the harvoni train. looking forward to letting the virus go :)

__________________

GT1a for 36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off.

3.6.18:Alpha 2-Macroglobulins, Qn=400/high. A1 activity.  f3@60: fibrosur bloodtst. TumrMrk=norm. enz=mostly norm.VL=3,933,000 

.sot=5.1.18>Harvoni>8weeks>



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RE: All aboard the "Harvoni" Treatment Train
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Hello again Canuck --  Try to make that California trip --its good for one's overall well-being. It really helped mine in subtle ways that added up to letting go of old anxiety about why I felt the way I did physically for so long and the zombie's in my head. I am grateful for SVR! Amazing last year and am thankful for you, Tig, Wendy, everyone here on the board and your wealth of knowledge that kept me on track to SVR. Thank you, thank you!! Always grateful- biggrin

 

ps



__________________

 

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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Hey,

Glad you splained about the avatar - I was wondering, I showed the pic to my partner earlier today and but neither of us were sure, figured some sorta hawk or bird of prey - we're not really "up" on our birds (obviously) heehee. Good to know what it is, and what a neat shot for you to possess! Lucky you, to have those kinds of feasts for eyes, experience, and memory!

I am so jealous, I've been pining to drive the West coast all the way down along into Calif or further (or to just about anywhere of a warmer lattitude than here)! But Calif would suit me mighty fine! I went once as a child (from the Prairies no less), I only recall bits and pieces of that family trek. Recall I was astounded, mesmorized hitting Oregon as whole new "amazingly green" world unfolded before me, and then into the warmth Calif. I too remember seeing the Monarchs (but not hoards of them, just some gatherings). I was young, and was quite ill on that trip, so don't remember too many things. Will get there again eventually. I did fly in once as a young adult but it was a very short whirlwind kind of thing and did not get to spend any real quality time there, just a teaser, but knew I would return one day, fer sure

I'm so glad you went! Oh ya, Illinois! Right. Big brr. Well, doubly glad you got to Calif. then. Sounds wonderful. smile

Also very glad you gave us such a good peek into your brain, and how you are feeling. Very reassuring to us who have also struggled through fog and things to see others resolving. Really good, and I'm so glad for you. Gifts, meant to be. biggrin C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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also,,,my avatar is a picture I took of a peregrine falcon not far from seeing clusters of monarch butterflies in Eucalyptus trees...



__________________

 

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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Lindz & C --- sorry for the delay here! I have just returned from a month long trip to California of basking in the sun, hiking and feeling terrific!! The trip was something I did for myself since I am feeling so happy and healthy these days! I definitely had the encephal..effect in the brain from the HCV. Since treatment and SVR, the brain fog and fuzziness I felt for YEARS is quelled. My head is so clear and my energy level is much improved. I am in general feeling amazingly better than I have felt in many years,,,so a month in CA out of the cold weather of Illinois was a gift to myself. My partner and I explored Big Sur, Monterey and southern California...fantastic weather, swimming, sun,,all goodness.

Thanks to everyone here who has supported myself and others through this slaying of the dragon. I love being a part of this fabulous Club Zero...I've always been a basically optimistic person, even though I had not felt 'quite right' for a long time. It seemed to be taking a toll on me the last 17-18 years, because it was becoming harder and harder to keep up with day to day living and now I am free of HCV!! Hoorah!! My biggest benefit as a result of SVR is the brain fog and energy level,,,wow. 

Thanks to all!! 

Cheers!

PS



__________________

 

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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Yes, Polo - absence does makes the heart grow fonder - but, we know (fondly) you are always around and with us! Lovely, isn't it, that we have been sharing in LM's recent celebrations. ALL us "UND people" (collectively) are getting to be one very large, happy, cured group!

So, during your treatment you never had much oppportunity to let up on your work comittments - is it still the same - work a lot, travel, then a bit of time off and repeat?

I'm wondering "how you feel" now, comparatively (with some retrospect under your belt), being that you are getting well past SVR12 (biggrin!) I recall one of your worst beginnng worries was fog, and that sometime along the way, some of this trouble dissipated a bit for you. How does it seem now, with more time transpiring?  Anymore thoughts about retiring one day?

Let us know how things seem to be going for you now. I forget your exact locale again, but I do recall you have been having some "winter" too! Hope you're not having to contend with work-driving/flying too much in incliment conditions. 

Keep us posted on your progress! smile C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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PS -Where are you?  I'm missing you!  It's been way too long since you've checked in with us here!



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64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay



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Thanks LZ, Dragon Slayed Tig, Slurp! Canuck!

 

ps biggrinbiggrinbiggrin



__________________

 

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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Image result for 12 scoops of icecream

Now, were talkin'! I got you 12 scoops to celebrate. 

So glad you are official now. What weird and wonderful trip you have been on eh.

Time to kick your shoes off a bit, loosen the belt, revel in the saiety value of this day. The rest is cream. biggrin C. 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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That’s OUTSTANDING!! SVR, has a nice ring to it, congrats! smile

1BF06468-0471-412E-9306-F5D759A86461.jpeg



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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YIPPEE PS!!  So very happy for you!!  Congratulations!!



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64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay



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I have SVR, no VL detected at 90 days! Hoorah! Hoorah!



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Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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Hi Tig & Canuck -- yes, I think they simply checked boxes when I told them I had HCV and completed treatment ~90 days ago. I had copies of all the tests that were run previously, but I think checked boxes, not reading the information or listening to me.

LZ - Yes, I panicked for a few minutes when I got the call and they said I was REACTIVE to HCV...I'm sure my face drained and I felt a dizzying moment.

Robert --you make a good point, I don't think they even were testing my LE's! I need to call them in the morning...

Wow, hope for no VL and another Party here!



__________________

 

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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Hi polos, As Tig mentioned, the LFTs -ast-alt tell a lot about virus activit. My numbers averaged 200 to 400 all the time. Todays blood work has me at 7 and 21. 

My EOT was Dec 18 2017, and each week since EOT I have had blood work and the LFTs have always been in the  12 to 27 range. So I would say keep an eye on your LFTs, its a very inexpensive test. My cardiologist has a finger prick test that spits out lipid results and LFTs results. I will wait until 6 week post to check load/count. In the first two treatments I was always relapsed at 4 weeks post treatmen. God I hated getting those phone calls, they knock you off your feet. I am 23 days out post treatment with LFTs of 7 and 21- Dragon Dead I would say!!   RC

 



__________________

 M-61 (3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017) On my way to SVR.    SVR-12. 3-13-18



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Poor ps!!  I'm so sorry you had that unnecessary scare!!  I'm so glad it was nothing but I do get frustrated with some of these medical professionals who just don't seem to know much about HepC.  Hopefully, that will improve in time.  I have no doubt your news will be good but please be sure to let us know when you get your results so we can celebrate with you! 



__________________

64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay



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Hey Polo,

I was out of town, but back tonight to ponder your new clinic.

That could be one explanation, that the "new clinic" you had to go to (because of a change in your insurance provider) possibly may not know much about HCV testing?, thus why they did the PCR VL (that you were expecting to be done) but that they also did a "seemingly redundant" Hep C antibody test? 

I just can't fathom a guess as to why they did the antibody test, but, perhaps they have their own reasons?, perhaps it is stupidly somehow automatically done, on the same page, tick all the boxes, boxes ticked in error? But, it seems odd, as this is a "new clinic" to you, and I assume a "new doc" to you (that came with this new clinic you now deal with) ... yes? And, so, it is really up to your ordering doc to decide what bloodwork should be done on you. Why would he be wanting the antibody test at this stage? You should all have been on the same page - you were coming in for your EOT+12 week VL, to confirm your EOT+12 week SVR (right?) and general LFT's and anything else he thought important done. It's funny he had the antibody drawn, but as Tig says, maybe it does not cost much.

Gee, hope you get the VL results back fast, i could do with another good party bout now! But no ice cream for me eh, I just about made myself sick pigging out at DQ on the way home - thank goodness for good functioning livers! wink C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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If you've been charged for the antibody test, you tell the doctor's office that it should be on them. They should've known that it wasn't necessary. I don't think the antibody test is all that expensive anyway. They can do them now with a finger stick in some cases. The blood test is going to be higher. So remind them that it was their mistake, not yours. I haven't had a viral load in a couple years if memory serves me. I'm of the school of thought, that if I were to relapse at this late date, my first inkling of trouble would be elevated enzymes. Then I'd request or the doctor should recommend, another viral load. The odds are so low, that it doesn't even cross my mind anymore. Once cured, we typically stay that way, thank God.... Even then, the treatments are far, far easier than they were, so retreatment would be easy peasy. Once approved that is. We still have that hurdle sometimes, but it's getting better, too. 



__________________

Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Thanks Tig for responding. My health insurance provider changed this year, so I had to go to another clinic for my SVR test. They checked me for the HCV virus and for VL. They called today and said I was REACTIVE and for a minute it scared me...then I looked it up again. However, I had given them my information that I had HCV and was treated, etc, so now I wonder how much I'll have to pay for the HCV test. I realize they should not have checked me for that, since we know I had the virus. Obviously, the new clinic doesn't know much about HCV. 



__________________

 

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver

Tig


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I see you answered your own question, but I can confirm that yes, you will always be HCV antibody positive. It simply indicates that you had it at one time. It’s the same test that most, if not all of us had that alerted our doctors to our little friend. Some found out by having elevated liver enzymes, which in turn brought about the Hep C antibody test. 

Once we have cleared the virus, any elevation in our enzymes again warrants another viral load to confirm or rule out relapse. You should know that once SVR12 is achieved, the chance of relapse is <.5 (1/2) of 1%. It’s very, very rare. Once cured, we tend to stay that way, thankfully!



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Okay - never mind,,I just re-read old notes here and found that yes I will always show REACTIVE even though I have cleared the virus.



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Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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Hail to the Elite -- Tig - Canuck - other Gurus--

Will I always show REACTIVE for HCV even when the Virus is cleared?



__________________

 

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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Dragon be gone.....

 

glinda.jpg



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__________________

Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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Congratulations PS on that UND at end of treatment!  Now the wait begins for the first post R/X results. Seems all we do is wait for the next test results. Once you come back UND at your 4 week post blood test you can take a deep breath and relax . The waiting will be over!

                                                               NICE JOB POLOSILVER.      RC



__________________

 M-61 (3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017) On my way to SVR.    SVR-12. 3-13-18



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Oh Hurray PS!!!!

Knowing you are UND is simply wonderful. (But not surprising with those fantastic LFT numbers biggrin)

Alison



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57 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

2 year post tx- dragon slayer 



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Thanks for the happy wishes C & LZ!

I'm a marching warrior princess that is now doing a ruby slipper-ed happy tap dance! Fun!!

 

ps



__________________

 

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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HURRAY PS!!!  You are a warrior princess!  Congratulations on an amazing journey to the Land of  ZERO!  SO happy for you!

Well, I had a photo of a warrior princess but can't seem to paste it on here!  It's the thought that counts!biggrin



__________________

64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay



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UND-UND!

UND-UND-UND-UND-UND-UND - geez I like the sound of that - good rythym, catchy beat.

Sounds like somebody walking proudly with their marching papers tucked under their arm!

https://www.youtube.com/watch?v=CrGCsZRUFkg

Hm, I think this occasion calls for more of a ... happy dance! 

https://www.youtube.com/watch?v=smwzk0-Nz0Q

But in your case my dear, I think you deserve to be wearing a lovely set of ruby red slippers, because dreams really do come true. 

You deserve every molecule of your hard won, well earned, rewarding EOT UND! Such a good job you did. biggrin C.

 

Image result for ruby red slippers

 

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Thanks for all the good wishes here for my low liver enzyme numbers, fabulous!!

I got better news today, an email with a link that informed me that my I AM UND at 13 weeks!! My next test for SVR is mid-January.

Dragon Slayed and a Club Zero member.



-- Edited by polosilver on Saturday 4th of November 2017 05:47:46 PM

__________________

 

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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Polo, those are some good/low LFTs. No doubt your load will come back UND. But its always nice and reassuring to see that on official paper!!  Are you having a 1 month post treatment V/L test?  RC



__________________

 M-61 (3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017) On my way to SVR.    SVR-12. 3-13-18

Tig


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PERFECT!!



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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ps-Woo  Hoo!!  Those are beautiful numbers!!  I have no doubt that your VL will be just as pretty!!  What a great ending to a long journey!biggrin  



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64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay



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Thanks Observer!

All -- I don't have the VL/UND info from my blood draw yesterday for EOT 12 weeks. I do have the LE's, here we go:

AST    20 U/L    15 - 37 U/L
ALT    23 U/L    12 - 78 U/L

 



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Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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I am super happy for you

 



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57 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

2 year post tx- dragon slayer 



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Thanks Saludahiker!

Cheers!

 



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Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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Congrats Polo! It was a good ride!



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57 yo M, GT 1A, Dx 2006 HCV, SOT 8/1/2017 Harvoni 8 weeks

ALT 63, AST 34, VL 710,000, 4 weeks ALT 18, AST 16, VL undetected, 8 weeks ALT 14, AST 14, VL undetected 



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Hi everyone! Yes, I am smiling!biggrinbiggrinsmilesmilebiggrin Kicking up a few heels too!

Thanks for all the congrats and smiles! Woohoo, I made it and thanks to everyone here for getting me to the SOT station!!



__________________

 

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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It's funny how we love to see you get on the train and then get crazy excited when you disembark. Congrats Polo!

Trains kinda empty with all these new DAA's.  And that's a good thing.



__________________

Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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Polo, 

The lovely thing that cured you.

imagefly.cgi?cid=72734365&width=300&heig

methyl N-[(2S)-1-[(6S)-6-[5-[9,9-difluoro-7-[2-[(1S,2S,4R)-3-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-3-azabicyclo[2.2.1]heptan-2-yl]-3H-benzimidazol-5-yl]fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptan-5-yl]-3-methyl-1-oxobutan-2-yl]carbamate;propan-2-yl (2S)-2-[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate

InChI=1S/C49H54F2N8O6.C22H29FN3O9P/c1-24(2)39(56-46(62)64-5)44(60)58-23-48(15-16-48)21-38(58)42-52-22-37(55-42)28-9-13-32-31-12-8-26(18-33(31)49(50,51)34(32)19-28)27-10-14-35-36(20-27)54-43(53-35)41-29-7-11-30(17-29)59(41)45(61)40(25(3)4)57-47(63)65-6;1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h8-10,12-14,18-20,22,24-25,29-30,38-41H,7,11,15-17,21,23H2,1-6H3,(H,52,55)(H,53,54)(H,56,62)(H,57,63);5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t29-,30+,38-,39-,40-,41-;14-,16+,18+,20+,22+,36+/m00/s1

YWRYBUCQWKGONV-CABNZSRHSA-N

Canonical SMILES:

CC(C)C(C(=O)N1CC2(CC2)CC1C3=NC=C(N3)C4=CC5=C(C=C4)C6=C(C5(F)F)C=C(C=C6)C7=CC8=C(C=C7)N=C(N8)C9C1CCC(C1)N9C(=O)C(C(C)C)NC(=O)OC)NC(=O)OC.CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

Isomeric SMILES:

C[C@@H](C(=O)OC(C)C)N[P@@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3.CC(C)[C@@H](C(=O)N1CC2(CC2)C[C@H]1C3=NC=C(N3)C4=CC5=C(C=C4)C6=C(C5(F)F)C=C(C=C6)C7=CC8=C(C=C7)N=C(N8)[C@@H]9[C@H]1CC[C@H](C1)N9C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC
 
What a nice picture . I hope you are smiling too.  biggrin C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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PS-  You did it!!!  

Image result for celebrate emoticon



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64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay

Tig


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Here’s the Station sign, time to de-Train!

                       



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Hello LM - Woohoo!!! Yes, Freedom is right!!! A Woodstock Freedom is the best!! Thank you! Thank you! 9PM tonight is the last of the Harvoni Magic.  Thanks for the toast and rememberance! You are coming up in less than 30 days yrself...biggrin

Hi Tig -- Amazing at how thrilled I was to get that Club Car seat 3 months ago and now I'm happy to let it go as I roll down the hill to SVR. Thanks!

 

 



-- Edited by polosilver on Thursday 26th of October 2017 06:10:43 PM

__________________

 

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver

Tig


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Time to pick up your belongings, Polo! The Harvoni Train is pulling into EOTville. Proceed to track 1 for the smooth ride to SVR Station....



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Hey Polosilver-  WOOHOO!!  Your last day, girlfriend!  I am thrilled for you and will toast you with a huge glass of water!biggrin  Here's a little inspirational song to celebrate your release!

 

https://www.youtube.com/watch?v=UcRWWC8wD-A



__________________

64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay

Tig


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Oh ya! We’ve got a lot of exciting results coming soon. I’m really pleased to have so many members (family) here that are so close to the end of treatment. Time to pack your bags and prepare to de-train. EOTville, next stop!

HYDRATE!!



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Hail all Harvonians and may you fare well,

Welcome SaltLyfe. Please do let us know a bit more about yourself, how you got diagnosed, your labs or anything you wish to share, and fire away if you have any questions.

Polo,

I still think it a "little" odd they don't do your EOT labs (exactly) on time, yes, better, that they bumped your lab day up to be a bit earleir, but still most of them try to do the EOT labs (all the labs really) on time. Oh well, it's not critical - your doc's office is (like all of us) probably sooooo confident of your result it matters not to know the result exactly on EOT day - but WE always want to know the result and hear that lovely und word again asap! So, that headache you got, after being on the "dry" side, was it a silent headache like you have had before or was it the full monty kind? How exciting, you're on your final countdown now girl.

How goes everything Saluda, GB site still feeling OK? Still working like a 2 headed octopus? You and Polo sound like you might dabble in workalholicism sometimes. As long as you are both feeling good and good enough to keep pullin'. We can only do what we can do, or, we only do what we need to do! Don't forget to keep watering your ponies.

Yup, these DAA's are truly lifesavers. biggrin C. 

Related image



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 62 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hi SaltLyfe, Welcome and congratulations on starting your treatment.  I recently finished my 8 week Harvoni treatment.  The HCV virus is undetected and my liver functions AST and ALT are now both 14.  Harvoni is a remarkable drug!  Good luck!



__________________

57 yo M, GT 1A, Dx 2006 HCV, SOT 8/1/2017 Harvoni 8 weeks

ALT 63, AST 34, VL 710,000, 4 weeks ALT 18, AST 16, VL undetected, 8 weeks ALT 14, AST 14, VL undetected 



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Hi Saltlyfe,

Congratulations on starting. I'm almost done with 8 weeks (Harvoni prescribed for 12 weeks). I was concerned about possible side effects before I began but have felt really fine. Drink the water everyone is suggesting you consume.  Good luck smile

 



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68 y/o; geno 1a; contracted from transfusion in 1972; Dx 1999; biopsies showed mild scarring and inflammation;  Harvoni - 12 weeks SOT 8/23/17; no prior treatment

Tig


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Hey Polo,

Glad you’ll be getting that important testing and information earlier than originally planned. I’m confident the results will be excellent. Almost time to call for the forum wide “Happy Dance”! 

Hi SaltLyfe,

Interesting screen name! Welcome to the forum. Are you a coastal dweller, fisherman or beach bum? All of the above, lol? Congratulations on securing Harvoni treatment and getting started tonight. It will go by fast and successful. Stay positive and concentrate on yourself. Getting through this will be far easier if you heed the recommendations of proper hydration. One gallon of water everyday, without fail. Stay in touch!



__________________

Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ

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