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Hep C Discussion Forum -> On Treatment -> Sovaldi/Harvoni: Important facts and warnings
Post Info TOPIC: Sovaldi/Harvoni: Important facts and warnings
malekula man


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RE: Sovaldi/Harvoni: Important facts and warnings
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Wow, now I can see I'm not alone with higher heart rate...

BAS, do you have the peak of this reaction soon after taking the pill or later? For me, personally, it happens later - next morning (with 18-20 hours delay)

MM

__________________

G1b, stage 4, cirrhosis

Harvoni Tx: Jan-Jun 2015 for 24 wks, SVR12, SVR24

PrevTx : relapser, Sovaldi +Peg+Riba for 12 wks, Jun-Sep 2014

My thread
Tess


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Hi BAS,

I second what Tig wrote.  Maybe ask for an EKG and check with Gilead.  I did 12 weeks of Harvoni and I did have one episode when I felt really strange. I felt like BP was through the roof although I couldn't check it because I was at work. The feeling went away after a few minutes and I chalked it up to unrelated reasons (a missed lunch, etc.) but if it lasted longer or if it happened again, I would have followed up with the doctor or Gilead.  Never felt that way before or since and I miss lunch frequently so I still wonder what the cause was.  These drugs are so new, any unusual side effects that concern you should be checked.

Take care,

- Tess



__________________

HCV Gen 1a diagnosed 2001; Labs 11/13/14: VL 1.2 million IU/mL, ast 88, alt 111. Harvoni TX 12 weeks.  EOT - 2/18/15, VL UND & normal ast/alt.

4 wks after EOT, VL = UND; normal AST/ALT at 4, 8 and 14 weeks after EOT.  15 weeks after EOT = Undetectable!
Tig


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Hi BAS,

While there is no warning of adverse reaction secondary to propranolol, that doesn't mean it can't. Your doctor of course is your first go to person for advice, but until you can get in there I suggest you call the Gilead Support Path help line. That number patients can call is 1-855-7-MYPATH (1-855-769-7284) for assistance. They have all the information and can speak from experience and first hand knowledge of adverse effects. I would request an EKG when you see your doctor. It would be reassuring to have that done since you're having issues. Anytime something bothers you, have it looked into.

Tig



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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BornAgainSinner


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Can anybody decipher that for me?  Is the cardiac risk only for people who also take Amiodarone and Harvoni?  

I've been experiencing rapid heart rate and high blood pressure (while taking BP meds) since starting Harvoni.  I do not take Amiodarone but do take a beta blocker: Propranolol.  I went to my primary doc yesterday and the BP was high but she didn't think much of it.  I don't go back to see the liver guy until next week.



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Gen 1a, Cirrhosis (Stage 4/4), Previously failed TX:  RBV & Pegintron (2008), RBV & Pegasys (2009), RBV & Consensus (daily injections) INF (2010), Incivik, RBV, & INF (2011).  Started Harvoni March 2015.
Cinnamon Girl


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No problem, MM, better to have the information repeated than not posted at all!

Thanks for your vigilance and concern for others here, it`s much appreciated. 

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
malekula man


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Sorry CG, probably I missed this one. Told my doctor, they received the letter and I will pass ECG exam. Goiod luck to all

 

MM



-- Edited by malekula man on Thursday 2nd of April 2015 12:35:23 AM

__________________

G1b, stage 4, cirrhosis

Harvoni Tx: Jan-Jun 2015 for 24 wks, SVR12, SVR24

PrevTx : relapser, Sovaldi +Peg+Riba for 12 wks, Jun-Sep 2014

My thread
Cinnamon Girl


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Hi MM, we have had this information posted before but it doesn`t hurt to repeat it as it`s important for people to be aware of this.

If anyone on Sovaldi based treatment has any concerns relating to this, please talk to your doctor. 

Very useful, thanks! 

 



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
malekula man


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Hello all,

 

I would like to start new thread about important facts for HCV drugs based on Sobosbuvir such as Sovaldi and Harvoni.

The reason I do it is the letter sent by Gilead to Health Care Providers: "Serious and Life-Threatening Cases of Symptomatic Bradycardia as well as One Case of Fatal Cardiac Arrest Reported with Coadministration of Amiodarone With Either Harvoni® (ledipasvir and sofosbuvir fixed-dose combination) or With Sovaldi® (sofosbuvir) in Combination with Another Direct Acting Antiviral."

First Tx I had my heart rate higher then normal and my osteopath confirmed this during ours appointments.

Now, I'm on week 12 on Harvoni and two weeks ago I was mentioning some muscular pains in the chest and higher heart rate.

So, there are some links and attached file with Gilead's letter.

http://www.fiercepharma.com/story/gilead-warns-fatal-reaction-sovaldi-harvoni-and-heart-drug/2015-03-23

http://www.fiercepharma.com/press-releases/serious-and-life-threatening-cases-symptomatic-bradycardia-well-one-case-fa

 

I don't know if this site is a reliable source of the information. This information was sent to by one of my friends on another HCV-forum from Australia, he did Sovaldi+Peg+Riba in combination with heart drug and had some problems like a heart rate, pains etc...

 

I think this is important because the most of us are not so young...

 

MM

 



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__________________

G1b, stage 4, cirrhosis

Harvoni Tx: Jan-Jun 2015 for 24 wks, SVR12, SVR24

PrevTx : relapser, Sovaldi +Peg+Riba for 12 wks, Jun-Sep 2014

My thread
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