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Post Info TOPIC: I'm No longer Ranting I am finally on the Harvoni Train. Time to slay a Dragon.


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RE: I'm No longer Ranting I am finally on the Harvoni Train. Time to slay a Dragon.
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Thanks for that info, Bilbo.  I look into that more.  Fatigue was my major symptom and was diagnosed as "everything else" and "nothing" and finally as HepC!  I still struggle sometimes, but I'm impossibly determined.  Please give us updates as we are learning more all the time.  Our cumulative impute goes a long way.



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Bilbo,

Good information links you posted.

If we use the search function box and just type in "thyroid" as in (hyper/hypo/ism) a plethora of posts will be brought up, all kinds of folks have talked about various aspects of thyroid in the past here!

It is more popular a topic/query than perhaps people know! 

Cinnamon Girl, back in 2015 posted a good informational thing on the site, about extrahepatic manifestations of HCV (from hcvadvocate), which includes a small bit on the topic of thyroid, here ... Extrahepatic Manifestations of Hep C - Updated Fact Sheet  

As well, Tig posted on that thread, another helpful link (from Lucille Porter and hepmag) another resource where people may find info about many things to do with HCV and thyroid if they search it.

I am sorry your thyroid decided to give you trouble - I hope your treatment for it gets sorted well enough soon. I have heard the balancing of hormone level can take some juggling at first. C. 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Congratulations Cheddy. How am I feeling? Much better I guess.  I had lots of energy when I finished treatment.  Even more when I got the none detected 6 months afterward.  Then I started losing energy during so my Hepatologist   looked at my T3 and T4 counts and sent me to my PCP.  he looked at the result decided to run more tests but put me on .05 mcg of Levothyroxine and told me to get another test in 2 months.  His test showed no T3 or T4 in my system.  So I received a call from him asking if I ever had my Thyroid removed.  I said no I asked him and the group if Harvoni could lead to hypothyroidism nobody could find a connection.  2 Months mater I was put on .075 mcg of Levothyroxine. 2 months Then .088 mcg of Levothyroxine Then 2 months .075 mcg of Levothyroxine.  I was told to check again on 4 months they questioned how I was taking it I said first thing in the morning with a full glass of water and I wait an Hour before I drink or eat anything even Coffee as someone who started drinking coffee at 16 thats hard.  I was put back on .088 mcg of Levothyroxine 2 months check was given the third degree about how I was taking it again was .1 mcg of Levothyroxine Then 2 months. I have been on that dose for 3 weeks and the fatigue is going away. so I think there was just a bad test result in there somewhere.  Doing some research it seems there might be a connection between Hep C and Thyroid disease. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500622/
https://www.hindawi.com/journals/bmri/2017/2390812/
http://www.hepatitiscentral.com/news/many-with-hepatitis-c-have-abnormal-thyroid/



__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1



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hi Cheddy! long time no see! Hey thanks but everyone here is great, and thanks for the heads up on your progress it's good to see people feeling better. Swing by and say hi on my little journey over at "Harvoni beans and me" ! wheeeee!
see you soon, Blessings, Iris

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in the silence of the woods, you will not be alone- Chief Seattle

59 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=? (pending)



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Iris,

For some reason I found my way back to this forum.  I reported in "Am I going to feel better" how I have been feeling over 2 years hep free.  

Wow it took you a long time to get on treatment, it seems.  Thanks for hanging in and helping others.  You're a doll.

 



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Hi Bilbo and congratulations on one year free and clear, that must feel amazing!!

I wonder how you feel since completing? can you notice a difference in the last year?

So glad you came to check in, and thank you Canuck I was thinking about that blood thread, you found it. Maybe someday we can give blood.
BB, Iris

__________________

in the silence of the woods, you will not be alone- Chief Seattle

59 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=? (pending)



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Congratulations on your one year HCVersary! It's a good thing!



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Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, VL 4/8/12 weeks - UND, 90 day SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND at 13 weeks!

Club Zero Member.

PoloSilver



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Hi bilbo and lamassu,

Well now you've done it - you two have dredged up the endlessly unsolvable nail that can't easily be hit on the head. It wasn't just the other day we were (yet again) exploring, well, (more like lamenting) why can't we and when can we donate our parts/organs easily/freely. And again, (just recently) we were also talking about blood donations 

Donating Blood after Achieving SVR

 - reading back in the site (over the years) it seems this is a really big topic - it keeps coming up again and again (organ and blood donations). Of late, more and more articles are being posted here about HCV+organ donors and recipients. 

Until things get sorted further bilbo, i think you and your bro are doing a wonderful service just by getting people to donate blood. Countless people you will never get to know, appreciate and thank you for your endeavours. Helping people, in any way possible, is something we could all aspire to. smile C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Thank you for the response lamassu I realize that I was just hoping that someday they will adjust their guidelines.



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Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1



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Hi Bilbo,

AFAIK the blood banks only test for antibodies once that is positive they dump the donation. Your viral load may be below detection limits but you could still be carrying HCV under 10 IU/ml and possibly infect others. According to the American Red Cross guidelines:

If you ever tested positive for hepatitis B or hepatitis C, at any age, you are not eligible to donate, even if you were never sick or jaundiced from the infection.



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Male, 65, Dx 1990, GT 2a/2c. Pre-treatment VL 11,500,000, ALT 10, AST 18, Fibroscan F3, 12.4 kPa. Rx 12 weeks Epclusa, SOT Mar 8, 2018, EOT May 30, 2018. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19.



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Hey, hey Bilbo!,

Nice - we get 2 lovely posts from you recently (and all good news too) - just in case anyone missed the last back and forths between us ... 

Taking a class before starting Harvoni

Congrats on your well-won victory.

Nice what you and your bro do - drumming up blood! Very needed things.  smile C.

Let us know how you feel and about the ongoing battle with getting your thyroid levels in balance. 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Yesterday I passed my one year anniversary of taking my Last Harvoni.  So I celebrated by calling The Red Cross to find out if I can donate blood when I pass my one year clear test.  After all it says in the guidelines that you can't donate blood if you lived in the household with someone who has Hep C for 12 months. and I wouldn't have.  They said they haven't developed guidelines for people who have "undergone treatment"  I said "they call it cured" She repeated the statement. 

This is important to me since it is a family value to help others. My brother was excited when I got cured not only for me but he could start donating again because he was approaching his 20 gallon mark. I also ran blood drives in college and collected about 1,000 pints a year.

Keep going everybody for those of you who are thinking about treatment and those of you are undergoing treatment it is well worth it.  And for those of you who helped me during my treatment Tig, Canuck to name a few thanks for all the help it meant the world to me.



__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1



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Hi Bilbo,

Thanks for the info, but some dates would help in communicatons (you are man of so few words!) a refreshingly concise kinda guy heehee.

So, I assume this is your latest (pre-thyroid treatment) TSH result (42.50), up from a prior TSH of 41.50. Thanks for the update.

The UND (you posted yesterday), was that the "6" week one, that you already told us of, or, another one you have now had done?? No date mentioned yesterday.

If you had basic dates in your signature line (such as ... 8 weeks of Harvoni, SOT May 8 (or May 15?), EOT Jun 26 (or Jul 3?) - we would then be able to figure it out, peice together some of the other missing bits of info, such as what dates (which post-treatment week) your first or second UNDs were drawn on . ie at 6 weeks or 12 weeks post-treatment. We want to know what day is your "official" post-treatment 12 week UND SVR party to mark!

Regardless, I am so pleased you have been so well cured, and I hope you and your docs will now, next, get this thyroid thing figured and controlled. Glad you have noticed some improvements (comparatively) in how you are feeling now, now that you are HCV-less and finished with that treatment.

Do keep us posted - we, of course, would always be interested to know more.  : )  C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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THS 42.50 H range 0.30-5.0

 

Hepatitis C

 

(HCV), RT-pcr Quant ) 9:30

 

The Quantitative Range of this assay is15 IU/mL to 100 Mil

 

HCV Not Detected



__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1



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Hey bilbo,

Nice to hear from you, and your update.

So, be patient with the thyroid therapy, they WILL try to get you back on an even keel, but sometimes it is a bit of an up and down adjustment period for a while when they first start these things. Should help if the ass-dragging is solely due to thryroid. Just make sure they go slow and careful with you until your get your dosing as right as it can be - be prepared to offer up your arms for as frequent bloods as they ask for, and as you can, (so you and they can all see how you are responding to thyroid therapy) aside from judging by how you are feeling.  

I hope it helps, it should - do you have any of those thryoid panel tests they did, to share?

Hey, wonderful if the tinnitus is from ear wax!!!!!!!!! Did it and the ear wax just disappear? They cleaned it out and no more tinnitus?

So, remind me again, why does it appear you had a EOT+6week blood draw, and what were the ALT/AST to go with that UND, and will you still get the EOT+12 week bloods?

Funny, we used to bame the cat for missing objects, moved things, glasses disappearing, chocolates bars gone, then she died, still happens, we figure a burglar or vandal, weird they would come over to your place and sleep? wink C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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So I went to my PCP today the Fatigue is probably Hypothyroidism like most of you deduced.  The Tinnitus is wax buildup since I wear Ear Plugs to bed.  Someone in the house snores and it isn't the cat.  I start Thyroid supplement treatment tomorrow. 



__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1



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Welcome to the zero club! 



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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Hi Bilbo,

Sorry I was a bit late for the party, just got back into town. Was on one of those medical toursim vacations.

Congrats on your hard won win!  

2 great big UNDS under your belt!! First UND at 4 weeks and now a EOT+6weeks UND. 

I hope you just continue to feel better and better.

Ya, I had the same question Tig did (often, they do bloods/VL) at EOT, but very most often we see them also done at EOT+12 weeks, and then again at EOT+24 weeks. EOT+12 weeks has been time frame most considered a "sustained" vrial response (SVR). But ... techinically, UND at EOT+6 weeks IS a SVR (but it has just been sustained for only 6 weeks versus 12 weeks) - it's just dif than when most people get a VL at EOT+12, to mark a EOT+12 week SVR, that's all. 

(If your EOT was about Jul 3, then for this 6 week VL, you must have had this blood draw about Aug 14? - is that right?).

Are you very sure they won't be doing another VL (after this EOT+6 week one), until 1 year from now? 

Being you responded SO wonderfully (with your first and early UND at only 4weeks, ALT nice and normal at 13, everything in your favour to win, a low F score, and pre-treatment load under 6 mil), and, as shown by being UND again at EOT+6 weeks, indeed you were an excellent candidate for ony 8 weeks of treatment. These conditions all bode well for nice sustained response, whether that be as early as EOT+6weeks, or 12/24 weeks or 1 year!

I am glad you will have your thyroid tests coming up next - hopefully we might see that has just vanished, all by itself! Maybe. I hope so. We'll see.

Do let us know how they find your throid now (now that you have been finished with the harvoni at least for a little while). Please do keep letting us know how you feel and how you are doing.

I am very happy for your EOT+6 week UND - looks good on ya!

What was your ALT and AST this time? C.

 

Image result for stylized letter U Related imageRelated image



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Congratulations! That's wonderful news. Why did they do a test at 6 weeks and not 12? I'm sure it will be the same, but the rule is to wait until EOT + 12 weeks to confirm SVR. The difference is miniscule so I wouldn't lose any sleep. 

The side effects from Harvoni should be gone by now. The fatigue and health issues related to HCV itself may take awhile. The improvements are going to come but people are always excited and hopeful they will get immediate relief. I wish I could say you will, but it took me an entire year to start to feel somewhat normal again. It'll come, but on it's schedule, not yours, unfortunately. Don't be discouraged though, the hard part is over, let the healing begin. You can help it out by living a healthy life, eating right and planning what you'll do with that new Hep C free liver!



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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So I just had my 6 week post Blood test Not detectable.  Yeah  He wants to see me in a year because he dose not expect any changes.  Yeah.   I am still somewhat fatigued and still have some tinnitus. I am getting my brain less foggy and my dexterity is coming back.  I am seeing my PCT next week since my thyroid levels are still high. When do the side effects end?



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Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1



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Ah Bilbo,

A no nonsense man of few words, so succinct, concise, to the point. I aspire to be like you.

All in two words ... "I'm done"!

Surely, you could have splurged and wasted a few more like ... " yay, yipee, wow, yes I DID do a great job, didn't I!!" ?

Never mind, we'll take care of that!

CONGRATS!!!! I am SOOOO happy you are finished!!!! Now, I highly reccommend a happy dance, I've been practising a few of these moves just for occasions like these. biggrin wink C. 

https://www.youtube.com/watch?v=CNI7c9n4HJ8&list=RDV9Xm82IleF8&index=5

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Bilbo626 wrote:

I took my last pill last night I'm Done


 Congrats Brother!

I would like to comment further on the accuracy of the HCV RNA Test.

Personally I feel this is where the "Sustained" aspect of SVR comes into play. 12 weeks from last night, (84 days from now) you will take another blood draw. When that one comes back UND that will establish a Sustained response to treatment allowing the Medical Records to reflect Cured.

I believe they will continue to drop the time required EOT to Cure =?

The incredible short life of the Virus is to me the obvious key. You can only be <12 for so long and then it is impossible for the virus to reemerge. The Dragon quickly replicates or it ceases to be.

Have you ever wondered how the Dragon stalks us?

  http://www.epidemic.org/theFacts/hepatitisC/lifeCycle/

To me this is a fascinating short read. I am one of those, "if you are going to do something TO me, I am going to study you." Kind of guys.

In my Home The Dragon is Dead. You know if I were to say... "the dragon was mortified." Most folks would think, the Dragon was thoroughly embarrassed. That is kind of how we use the term today. The term is used to signify shame.

no Nope.

It means "To Kill". Just play with the term mortal a bit and it becomes clear.

I am not seeing folks that are UND at EOT having a relapse on Harvoni. Further I would even be so bold as to say those folks that are UND at SOT = 4 weeks have MORTIFIED the Dragon, provided they continue the mop up to EOT.

At any rate it does not matter what I say. You are going to second guess things for the next 12 weeks. Trust me and remember I said this... We all did the same thing. wink

 

Again, Congrats.

JimmyK



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."



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I took my last pill last night I'm Done



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Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1



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Generally hep "tests" are very accurate, but there are dif "hep" tests, just "initial" antibody detection, and/or "qualitative" and "quantitative" tests. There can be situations/conditions where antibodies might not be detected, at first, when your disease is in "progress", or in transit (so to speak). In hep c testing, if you show a pos antibody test, you can count on it being accurate, that they have found the c antibody in you, then the only question left is whether you have chronic hep c, or, whether you beat the infection off by yourself in the past. (Someone will still show pos for hep c antibodies after they are cured with hep c drugs, or if they were one of the lucky ones and successfully defeated their hep c infection all by themsleves.) A "first" positive hep c antibody test then requires further testing, usually the PCR (RNA) "quantitative" test (your VL) to confirm whether an infection is active or not. It's "complicated" to explain.

(In general, in my book, it is not unwise/unreasonable to "re-test" when ANY blood test (not just hep c) is "questionable" as a pos or a neg, or not the expected result, appearing too high, too low; false pos's and false neg's can and do occur in varoius lab tests, or may "appear" that way, sometimes for a myriad of reasons! - so, in some cases, repeat testing although it may be expensive, inconvenient or redundant, can be helpful info. The adages apply ... can't count chickens before they hatch; measure twice, cut once; the safer than sorry rule of being surer about things.)

It would help to know what kind of first test you had (that was "neg") and the second test you had that was pos (after your heart procedures) and the timelines of same.

What were all your heart procedures (over time)? Just being nosey, as I can't really recall you mentioned much of this before.

Great your family doc (or hep doc?) has ordered your fuller thyroid panel, you are right, you and he may just need to follow this well, test and wait and see what is found and what is required in response. Like Tig, maybe your thyroid blood work will just right itself, by itself?

How's it going today? Are you trying to get more time off, for more rest?? Hint, nudge. I am thinking you are not getting enough time off to do nothing, smell the roses, or to savour that UND! smile C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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My Doctor ordered a full thyroid panel TSH, free T3, free T4, reverse T3, thyroid antibodies and thyroglobulin antibodies. I wont take action until I'm off Harvoni. From what I've read, Some people have had their thyroid effected by treatment only to go back to normal after.  Regarding The HCV test how definitive does that show? I remember after my third heart surgery when they suspected this the first test came back undetected then they did a second more comprehensive test that found it?



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Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1



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Bilbo,

Don't fret (yet) about your thyroid test! Yes, convey the thyroid test result (and ALL your lab results) to your family doc (like the hep doc said to). Your family doc will probably order you a "repeat" TSH blood test, and, likely (I hope) some other thyroid blood tests as well. Your family doc may order these right away, or, he may wait, until you have finished with your HCV treatment first.

It could just be a one-off, who knows, but it should be checked out further, and repeatedly to see if any abnomalities persist. It's possible your thyroid system could be sputtering about in defense of itself, reacting to demands, but it should be established if this is indeed continuing, to what degree, and why, to suss what exactly is wrong, if the bloods continue to indicate something is out of wack. 

If it was me, yes I would definitely want a "repeat" TSH, after I had been finished with the HCV treatment, but along with the TSH I would definitely also want the "whole panel" of thryoid tests (more telling) - there are (at least) 6 further parts to a whole "thyroid panel" ... TSH, free T3, free T4, reverse T3, thyroid antibodies and thyroglobulin antibodies.

You wrote ... "THS 41.50, H, range .30 - 5.0",  (I am assuming typo?, and you mean TSH). My book lists a similar "normal reference range" for TSH, .40 - 5.0 mU/L.

If your family doc does not want to do a "full panel", or, if he is not comfortable dealing with endocrine/thyroid work-up things, then get him to refer you to a thyroid specialist. Endocrinologists do this kind of assessing and work-up in their sleep.

It could just disappear! But, maybe not, so, I would have it checked out, thoroughly AND repeatedly, to be sure it is out-of-wack. There's always something, eh! Just keep relishing that big ole UND! biggrin (BTW - what were some of your pre-treatment ALT/AST's to compare to? These ones below are sure lookin' mighty fine!) C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Test Results Hepatic function panel, CBc w/diff, TSH, Uric Acid. 

White Blood Cell 6.1

Red 4.4

Hemoglobin 13.4

Hematocrit 41.5

Mcv 94

mch 30

mchc 32

Platelets 198

mpv 9.5L

Rdw-cv 15

Neutrophils 53

lymphocytes 35

Monocytes 10

Eosinophilis 2

Basophilis 0

Neutrtropil count 3.3

Lymphocyte count 2.2

Eosinophil count 0.1

Basophil Count 0.0

Uric Acid 6.2

Hepatic Function panel

Total Protein 6.6 

Albumin 4.5

AST (SGOT) 23

ALT (sgpt)13

Alkaline Phos 68

Total Bilirubin 0.8

Direct Bilirubin <0.2

TSH 41.50 H range 0.30-5.0

Hepatitis C

(HCV), RT-pcr Quant ) 9:30

The Quantitative Range of this assay is15 IU/mL to 100 Mil

HCV Not Detected



-- Edited by Bilbo626 on Thursday 15th of June 2017 09:44:56 AM



-- Edited by Bilbo626 on Thursday 15th of June 2017 09:46:55 AM

__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1



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Greetings,

I was all set for 24 weeks and at 12 they cut me off. In retrospect I am glad they did. The 12 cured me.

The 8 week course is very effective.

Yes contact the Doctor. He will decide if there are reasons to push for the 12 weeks.

Best of luck and NO Worries.

JimmyK



__________________

Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."

Tig


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You can try for an additional 4, and as Canuck mentioned, 8 weeks of treatment, with your pre treatment history, fit the current guidelines exactly. They have actually been working on reducing the length of treatment even further. 6 weeks has shown some spotty promise in trials, but the rates of success at 8 and 12 weeks are much better. 

In this day of bean counting, they are doing everything in their power to reduce costs. With your Hx and fast response to treatment, 8 weeks should do it though. Call your doctor and see if they discussed this before or after the initial treatment decision was made. If your doctor has any supporting evidence for 12 weeks, s/he will have to provide it to your insurance provider. Appeals can be drawn out, so get on it if you plan to submit one. 



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Hmm, I wondered if this was going to happen - 8 weeks versus 12 weeks.

You can try to ask your doc about the need for 12 weeks, but all of them (insur and doc), may deem an early crash in ALT with an UND at week 4, in a person with a low Fscore (no cirrhosis) and a VL under 6 million, may mean to them, that 8 weeks is a sufficient course length.

I cannot recall which test gave you your prior Fscore of F1, nor what your pre-treatment ALT's were (for comparative purposes), nor can I recall any ALT's during your first 4 weeks, to be able to "see" your ALT crash, but, your VL at 2.8 mil pre-treatment, now down to UND! at week 4, is definitely a nice early crash! Just what everyone wants to see.

8 week therapies work perfectly for many people. Many people, that fit the parameters, are routinely treated with 8 weeks of Harvoni and are perfectly cured. Bonus happens to be a short treatment time. 8 weeks versus 12 weeks is a decision only your doc can make.

Savour your nice early UND! biggrin I would ask, but you may not have any luck getting them to agree you need 4 more weeks. C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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I received a phone call today from my insurance today saying they only approved me for only 8 weeks should i call my doctor and fight for another month?

 



__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1



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Bilbo!,

The sound of your VL (and probably your ALT), crashing! - https://www.youtube.com/watch?v=p-U4p3r48BU, and, the sound we are all making for you, in response!  biggrin  heehee  https://www.youtube.com/watch?v=Jd-22sVAryY

Congrats on a very hard won and a very well-deserved Und! C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Congratulations of your first undetected viral load! It will be that way from now on, too. Once undetected, the odds of it ever relapsing is quite low. Stay on it and keep doing what you're doing, it's working!

There are reports on the web from others that experienced thyroid abnormalities on Harvoni, but the overall percentage of patients is pretty low. You can find reports of HCV drugs causing all sorts of maladies and side effects, and I'm not going to deny it happens to some, but endocrine problems aren't widely recognized as a stand out problem. I had some Thyroid trouble when I was on treatment, a lot of us did. It was common to experience those problems on the Interferon protocols. The doctors were aware of it and monitored it throughout treatment. They also felt that once I finished treatment and recovered, it would return to normal and it did.

If you look for complaints on any drug regimen, you're going to find it. Just watch an hour of TV and you'll hear enough to wonder how Big Pharm gets anything approved! It's that CYA thing... If you search for negative keywords, you'll find references to people that had issues on anything and everything.

The one thing to remember is, the percentage of people on treatment that experience a serious adverse reaction, is low. If we search for good reports on a drug's effectiveness, you'll find lots of those too. I wouldn't be worried about anything. Finish treatment, and allow yourself time to recover. Let your doctors keep your thyroid function monitored, you concentrate on killing that Dragon. It takes time, but destroying this virus will bring improvements in many areas and is far better than not treating it at all. JMHO...

When I hear of someone avoiding treatment in hopes of the next best wonder drug, I remember thinking the same thing, what if something better comes along. I didn't want to wait any longer and neither did my doctor. It was time. They R&D these drugs for years and then when they release them, someone has a negative experience and right away the rumors start. Some people are going to have problems, it's reality. For every 5 people that have a problem, 95 didn't. I would've preferred these new drugs to Interferon, anyday. Interferon did cause me long term problems, but my liver is doing nicely! I'm recovering slowly and that's better than having that virus continuing to destroy the rest of me on it's terms. smile



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Well I called my Doctor they said my thyroid levels are off and I might want to get my Primary care doctor to look at it. They also said my viral load is undetectable.  



__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1

Tig


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Hey Tim,

Dude, you've been having nothing but trouble with Walgreens! I have had my problems with my local Rx too. They do their best to put you in a head lock and make you dance to their tune. I quit going there after the pharmacist starting berating me in front of a lobby full of people. I know times are tough, but the cost and profits made by some of these businesses, especially Big Pharm, leads me to believe they're probably doing better than most... 

Ask your doctor if they provide a patient portal for your lab results. I ran into the same problem with Quest. They have one, but your doctor has to either set it up for you or provide a PIN number to access the files. Your doctor or nurse can sometimes sign approval on the original request form. Then they just mail you one if the online portal isn't available. It's an unnecessary obstacle IMO, but some doctors want to deliver the news first. Seems fair, as long as they do it immediately upon receipt. Share the results when you can.

Congrats on bottle #2! Sorry about the reason for your work tardiness though. Better late than the consequences of not paying heed to the rumble in the nether regions... wink 

Good luck this week! Make sure you carry your sword with you when you strap on the armor! Let them know you mean business...



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Week 5 is done.  I was late for work twice since I had to run back in the house to hit the bathroom.  Hmm I wonder if that's why bathroom has a Black Eyeconfuse.  Yesterday we received a nasty-gram from our insurance company telling us that they would not pay for anymore specialty medication from a local Pharmacy only from Cigna's mail order pharmacy.  I called them and explained what happened.  The specialty pharmacy rep explained that when Walgreen's gets approval to fill it locally The Insurance company is in effect purchasing this Drug for you and you just pay the copay. This is why Walgreen's is being so grabby. It is loosing $10k-$15k in profit each refill.  I tried to get the testing lab to send me the results of Mondays test. They told me they could only release the results to a Doctors office any doctors office.  So I said let me get this straight, you can only release my test results on my blood to somebody other than me? Yes Sir that is correct.  So this week I get to put on my armor and get my test results from my doctor and tell Walgreens to back the hell off and  any refills of this prescription.



__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1



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I Just took the first pill of my second bottle. Blood test this week. Hepatic function panel, CBc w/diff, TSH, Uric Acid.

__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1



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Bilbo,

Gotta hand it to ya, you can sure muster through things, no matter how you are feeling! - you are doing so well, under trying times - especially noteworthy is your abilty to push yourself to work like you are - I have a feeling your business is VERY busy, and you are VERY motivated/dedicated to it? 

 ... "Wednesday was terrible. It seemed like everything inside wanted to exit as quickly as possible. My head and body and skin hurt. I Still had to go to work" ... 

Just because you have been able to keep working like you are, doesn't mean you should be pushing yourself this much. Is there not SOME way, some staff, something you can orchestrate, that will alow you a bit more "down time" at home.

It is good you are cooperating with the "program" showing up for all these time-consuming bloods, etc., but I am not sure (at all) that your "rest" factor is really being addressed - please think about it - how you could get a bit more rest in.

Not only did I have to go for VERY frequent bloods, (a very strict trial schedule) on that same day, I had to be examined by the doc and have other tests done, EVERYTIME! It was an "all day" event (the bloodletting and doc exam/appointment day), a five hour drive one way and a motel stay overnight, 5 hour drive back home the next day! Now, mind you I am retired and had no real demands being made of me, so was easier for me than you.  

I am not at all surprized they want to physically see you at the docs office, in my book they should be asking you to come in for appointments!, for good thorough following. 

My lab results never seemed to come fast enough for me! Good you asked for your last labs, you will get them, and you will get these 4 week ones as well - persevere.

You are doing a fine job of dealing with it all, including getting through that horrendously long delay at the start. Keep mustering. I hope some of these symptoms start decreasing more and more now. And, i hope you can figure a way to get some more rest/time off even if this is a busy time. 

Ah, the lovely sound of only one or two pills rattling around inside a near-empty bottle! smile C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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They want me to set an appointment with the doctor

__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1

Tig


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Just tell them you're smarter than their average patient and will wait while they prepare your copy. They can't deny you a copy, you paid for it and have a right to it. Perhaps they could educate their patients about the results, instead of keeping them wondering. That can be more stressful than anything. I have yet to see any of these new DAA's provide anything but promising and morale boosting test results. Regardless of the length into treatment!

Congrats on the end of bottle #1 smile 



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Update for the last week I have had little or no side effects other than mild headache and fatigue which seemed to for the most go away with water. I have found one sports drink a day helps with fatigue. I put a propel drink mix in my water at the beginning of the day and as I fill it up every half hour it just gets more diluted. It helps refills the electrolytes since I owe once or twice an hour. Wednesday was terrible. It seemed like everything inside wanted to exit as quickly as possible. My head and body and skin hurt. I Still had to go to work since my Garden center was still restocking from Memorial Day weekend. Today I called my doctor's office to find out my results from my blood draw they said they normally don't share the test results until my treatment is done. They said it confused people. Monday when I get my 4 week blood draw I will go demand a copy, Then check the little box on the blood draw paperwork to send me a copy of the results. Two more ð pills in my first bottle.

__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1

Tig


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You both realize you have been carrying on for an entire day, about getting or having been high. Do I need to be concerned? biggrin lol

Each day is a better day, make it so...

 



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Nice, when you get to day 20 or so, it's a special sound, that sound of only the last few remaining pills rattling around in a "near-empty" bottle isn't it? Accomplishment!

Then, the bolstering feeling, of that next nice brand-new shiny bottle of harvoni re-inforcement, "army in a bottle", at the ready and waiting to keep backing you up!

Aw, so nice when we have partners like that - she "smiling and nodding" whilst allowing you expressions of your harvoni high! My partner still does that for me!! But, nothing to do with drugs in my case today as to why I go on and on!

There were periods during treatment where I was as lively and as mobile as a one ton piece of lead, but the brain was sputterring around uselessly in some kind of frenetic-quality mis-firing overdrive - both at the same time - felt weird. But, my drugs were completely dif than yours, I have no idea what a harvoni high feels like. 

Won't be long now! - and you will get to go for your 4 week blood draw soon, and perhaps get your first bits of good news, even tho it is "early" days . Let us know BTW (when you know) what your last LFT's (ALT/AST) were, from your week 2 draw. 

Good job, Bilbo, yer killin'it! smile C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Walgreens got the business they want it that bad they can have it. I might write corporate when this is done. Putting in a prescription that I didn't need to test the insurance is fraud.

__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1

Tig


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I guess my mind is going south on me. I see where you started now, so what happened with the two pharmacies? You must've gotten one bottle before they started battling for your business. I'm easily lost... 

You're going to have those weird moments sometimes. Seems all of these drugs, even the stuff I took, would make me speedy one day and a slow mess the next. I think you're getting this under control. 2-3 weeks is about average. Good job!



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Just took day 20. 64 to go

__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1



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On the plus side today's side effects were just some sneezing and fatigue. But my wife says the Harvoni High kicks in and I start talking a nonstop monologue of what happened in my day. Every detail. She just sits there smiling and nodding. So I think I have crested the hill and my body has just given into having this in my system.

__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1

Tig


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Alright, you're good to go! When do you drop the first Nuke? Get hydrated well beforehand and keep it up!  



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Oh I agree.

Let them work the politics.

We have Dragons to whoop.

JimmyK



__________________

Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."



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Well I received the meds at 8 this morning. They can mess around all they want. I think something shady is going on. But at this point I don't care. I think it is about the money. I just need one more bottle and then Smaug is dead and Harvoni is my ring of power. Then Harvoni will help me throw Hepatitis C into the crack of mount doom.

__________________

Harvoni 12 weeks

51yo Cont 1983 by Blood Trans Diag 2003

viral load test 2.8mil

Geno type 1A

TB Test Neg

Eye and Retna Norm

Liver function test. F1

ultrasound of my liver F1

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