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Post Info TOPIC: Mavyret.2
Tig


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What in the world is that, Canuck? All that dancing wears me out, lol!



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Hey mpls,

CON-GRATS!!!!!!!!!!! Oh, it IS a good day! biggrin

Yes, me too, exactly - I too feel very grateful for these new wonderful drugs, and the good and hope they provide for so many.

I too felt a little tear that I gulped away (a tear of happiness for you), when you described how you felt when you read your SVR17 UND result! I started feeling relief right from the first announcement that I succeeded in getting into my trial, to that first pill past my lips, and then more all along the way through treatment, with every lab and VL!, and, beyond! The feeling of knowing, it's going to be alright now - it's very nice isn't it?

You did a stellar job getting through everything you did. Time to do some celebrating. Here is an example of the happy dancing I am doing for you today! wink

Mistro please ...    click here --->   Happy_(Pharrell_Williams_song_-_sample).ogg

  

 

Image result for happy dance gif

 

 

 

And that's just how we do it.  wink C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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woohoo MPLS !!! i am thrilled with you to see your results

all aboard the UND. train......yeehaw

5



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Gt:1a for 36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:Alpha 2-Macroglobs, Qn=400/high. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3,933,000

sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL now. 

Tig


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I forgot, the PCR Log is an old way of listing the viral load. It means the same thing as the PCR Quantification. Pay the Log no mind. You’re undetected, woot!



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Tig


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That’s FANTABULOUS!!! Congratulations is in order here.

HEAR YE, HEAR YE: Be it known that we have a new Dragon Slayer in the House!

SVR it is! Say goodbye to that pesky lizard, once and forever... Well done, Warrior!

F5E24F68-FC14-471F-B628-39DAD5123CB3.jpeg



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Congratulations mpls!!!!! Fantastic news. You must be feeling absolutely fantastic about now. I am so pleased for you. When those of us on treatment or waiting for treatment read something like this it makes us so positive that we will be joining you shortly. Thank you for sharing.



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65/F Contracted Early 80's First Diagnosed Early 2000's 2017 re diagnosis and referral for treatment

Gen 3a Fibroscan 8.6 Epclusa 12 weeks commenced 1 May 2018 ALT 72 AST 67

28 May 2018 4 weeks ALT 16 AST 23



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My results are in:

EOT 2/20/19. SVR17weeks 

PCR: NOT DETECTED!!!!

HepC PCR Quant. < 15 IUmL

HepC PCR Log < 1.18 (what does this mean?)

AST 21

ALT 11

Creatinine 125 and GFR 43, concerns me, but will talk to MD tomorrow at my appt. 

I cried when I read my results. 40 years of feeling stuck with no options, I can't believe it's gone!  I am so grateful for these new medications and am excited for the newcomers to this site who start their journey to get rid of Hep C. Success rates are looking good. 

Thank you Tig and Canuck for all your support. I appreciate your knowledge and sense of humor, you made me laugh every time I logged in. Bless your hearts for being helpful to everyone!  Also thank you to all of you who responded, gave support, and asked for support. I'm so glad you were here!!  

 

 



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62 y.o female HCV since 1977, (40 years). Genotype 1B, Dec 2017: ALT 53, AST 48, PCR 70,500. Fibroscan, very little scaring. Treatment naive. Mavyret: 8 weeks SOT 12/27/17, EOT 2/20/2018. EOT PCR Undetected!!! June 20, 2018 SVR 17 weeks Not Detected. 

Tig


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This is exciting! If they can do a PCR in two hours, I’ll be surprised, too. They did my last a couple months ago and it took several days. It wasn’t too many years ago it took weeks to get one back. I hope you get the good news tonight and if you do, I know we all want to hear the good news!



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Hey mpls,

How exciting and a long time coming eh (for your EOT+12 week labs?). Your EOT was UND, so will this be a beauty for you too. Good you asked for further labs - you are a good partner with your doc in taking good care of you! Hope everything is just perfect in your labs - I bet all will be. biggrin

Many people routinely have a "EOT+12 week" VL and LFT's drawn, and if your VL result from this test is UND, then this is your SVR12. Your "sustained" viral response (when one's VL is still undetected over the 12 week period from EOT).

In your case I am not sure about your dates tho (without scouring the thread again). Your EOT date was Feb 20, so EOT+12 weeks should have been about May 15?, and you are having your VL drawn now, well I can only conclude that this will be your EOT+17 week draw then. Maybe my dates or adding is wrong - never ask me to do math or count! But, if this is correct, then I guess the UND you will be celebrating soon will be your SVR17! 

Lots of labs have really fast turn-arounds, but do not be disappointed if the PCR VL takes longer to come back than your other labs do, I'd hate to see you sitting glued to the computer, fingers pacing back and forth over the keys, if the VL is the last thing to surface. My PCR's sometimes took a long time to return. Pssst - start celebrating early, to kill some time. I have already started celebrating for you over here! wink biggrin C.

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Labs were taken today!!!!

Waiting for results, the phlebotomist said they may be in "my chart" in a couple of hours.

My appointment with my hep doc is Thursday June 21. Is it called SVR or SVR 12 or SVR 14. What is the correct acronym ?

My Hep doctor only wants to know if the Hep c is gone, so he ordered only 1 test.  I asked for CBC and Liver panel because i want to know my what my WBC is (which was super low at EOT labs) 

Anyhow, we should know in a couple of hours now..... I'll be checking My Chart and will let you know the news real soon!!



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62 y.o female HCV since 1977, (40 years). Genotype 1B, Dec 2017: ALT 53, AST 48, PCR 70,500. Fibroscan, very little scaring. Treatment naive. Mavyret: 8 weeks SOT 12/27/17, EOT 2/20/2018. EOT PCR Undetected!!! June 20, 2018 SVR 17 weeks Not Detected. 



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YAY!

     



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60y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

2.5years...post tx... successful dragon slayer 



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Thanks for the welcome MPLS!

I've read  your posts, as well, while I was still "lurking" here. It's so nice to have a place to visit where everyone is so helpful, and encouraging! I'm looking forward to having you all along for the ride with me!

You mentioned, that you're tired? I'd guess that could probably be partially from the Nicotine withdrawl?  I still don't sleep well, since I quit smoking, and weaned off the patches/gum. Maybe you should have your vitamin levels tested?? Or try taking a B vitamin...and maybe a D as well?? just a thought, but your family Dr can run those for you, it's a simple blood test.

Keep us posted on how your 12 wk goes! You know you have the biggest cheer section here! :)



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45, F, Dx2000, VL 5.3M, ALT 113, AST 45, F0 (Blood work), GT 2 (? Couldn't establish subtype??), treatment naive, type 2 diabetic, recovering addict 11/22/02

RX Mavyret, 8 wks. SOT: 6/5/18. Liver function blood work at the end of week 3, for my Family Dr.  ALT 50, AST 24.

5wk-UND

 



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Hey Heidi

Welcome to the 'on treatment' forum. I read your 'new here' note and I see you'll be starting Mavyret on May 17! Congrats. It will go fast. My big concern was wanting to work while on treatment and I was able to work the entire 8 weeks.  I had very few side effects.  I don't have any info on diabetics on Mavyret, but since you'll be checking it 3x per day, you will be able to monitor it closely.  Hopefully your BG's will stay stable! 

I'm post treatment 2 months now and i have been extremely tired now, more than ever, i don't get it. Unless.... I gave up Nicorette gum 22 days ago and maybe that's what's wiping me out! I have a follow up appt for my SVR 12 will be end of May early June. 

Looking forward to hearing back from you!!! 



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62 y.o female HCV since 1977, (40 years). Genotype 1B, Dec 2017: ALT 53, AST 48, PCR 70,500. Fibroscan, very little scaring. Treatment naive. Mavyret: 8 weeks SOT 12/27/17, EOT 2/20/2018. EOT PCR Undetected!!! June 20, 2018 SVR 17 weeks Not Detected. 



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Welcome to the SVR group RLS.  Some of us just need a little more time on the treatment train but it looks like we all get to where we want to go!!   You stuck to it (at it) and look at you now. Congratulations fellow dragon slayer!   RC



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 M-61 (3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017) On my way to SVR.    SVR-12. 3-13-18

Tig


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Congrats my friend!! I tell people to NEVER DOUBT THE MAGIC 8 BALL... It is wiser than the guy shaking it (me)!

Thanks for sharing your great news!

You are now known as a  

894F51F1-BE11-4D4A-84A0-5498AEBD03A3.jpeg



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Wonderful news RLS. - You give me HOPE!!! you are GT1b, like me.  Whew!!! Also, like you, they called it non A non B when I contracted it too.  We've come a long way! It's about time the found a med to kick it's butt!!! Thanks for all your support and encouragement on this site.  Have a fabulous weekend I'm glad the weight has lifted!!!! 



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62 y.o female HCV since 1977, (40 years). Genotype 1B, Dec 2017: ALT 53, AST 48, PCR 70,500. Fibroscan, very little scaring. Treatment naive. Mavyret: 8 weeks SOT 12/27/17, EOT 2/20/2018. EOT PCR Undetected!!! June 20, 2018 SVR 17 weeks Not Detected. 



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WONDERFUL RLS,

Just earlier tonight I was pining away to hear some good news from you, and here you are!, you did not disappoint.

aw, so nice - CON-GRATS! - after all this time, all that work, the many years, the prior disapointments - but to know you have finally done it now - must be the best feeling in the world to know you are officially SVR 12, you were so lucky to get the Mav.

Never say never! You "came with" and carried a very brave and positive attitude going through all of this. You so deserve a permanent rest from this 26 year burden. Enjoy this new found freedom, I know you thought you had the deed done in the past, but really and truly you have beat it now, forever.  

YOU are the one who has brought encouragement and positiveness here, by act and deed. It couldn't have happened to a nicer guy! I am very, VERY pleased for you. (understatement) biggrin  C. 



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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That is fabulous RLS! CONGRATULATIONS! I'm sure you're going to find that your 24 weeks will be clear as well! Any lingering effects?? I see my GI on the 17th, and I'm counting down the days!



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45, F, Dx2000, VL 5.3M, ALT 113, AST 45, F0 (Blood work), GT 2 (? Couldn't establish subtype??), treatment naive, type 2 diabetic, recovering addict 11/22/02

RX Mavyret, 8 wks. SOT: 6/5/18. Liver function blood work at the end of week 3, for my Family Dr.  ALT 50, AST 24.

5wk-UND

 

RLS


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It has been over 26 years since I was told I had non A/non B hepatitis (right around the time they named it hep C). Ribo/interferon didn't work and neither did Harvoni. I really thought I had a strain of this virus that just wouldn't go away.

I am happy to say that 16 weeks of Mavyret has finally eradicated the virus and I am officially SVR12! I'm meeting with my doc on the 14th and I know he wants to repeat the viral load test after 24 weeks from EOT.

Thank you everyone for your encouragement and positive thoughts!

RLS



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Male 54, DX 1992, GT 1B

2005 - Rib/Peg Relapse

2016 - 12 Week Harvoni Relapse

Mavyret (16 weeks), BOT 10/16/17, EOT 2/2/18. SVR 12 5/3/18



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Ah ha! Tig's Magic 8 ball - it has NEVER been wrong RLS! biggrin C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

RLS


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Well, some of my blood is now in tubes and on its way to the labs. Thank you for the good wishes and I'll report back next week.



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Male 54, DX 1992, GT 1B

2005 - Rib/Peg Relapse

2016 - 12 Week Harvoni Relapse

Mavyret (16 weeks), BOT 10/16/17, EOT 2/2/18. SVR 12 5/3/18

Tig


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Hey RLS,

Good luck with your blood work today! My Magic 8 Ball says you have nothing to worry about. I know the anxiety of this test, but I also know how effective these treatments are. You got this one in the bag!

 



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Hi RLS -- Thinking bout cha and sending kind thoughts and good vibes your way today!!! 



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62 y.o female HCV since 1977, (40 years). Genotype 1B, Dec 2017: ALT 53, AST 48, PCR 70,500. Fibroscan, very little scaring. Treatment naive. Mavyret: 8 weeks SOT 12/27/17, EOT 2/20/2018. EOT PCR Undetected!!! June 20, 2018 SVR 17 weeks Not Detected. 



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Hey RLS!

You mentioned (on a dif. thread) that you are going for your SVR 12 draw tomorrow! Yay! We need some more good news around here, and that's just what we are all going to get, when your results come back! We'll be waiting, right here, for blow by blows. Be excited, not nervous, you've done it this time! Can't you just feel it? Never mind, I AM positive you have. Your SVR 12 milestone is coming right up for you. Good thing you are keeping us straight on your testing timelines. We never want to miss out on partying for a SVR12. biggrin

How does everything else feels now, still got the GI trouble, hope that eased off. Wshing you a fast and easy draw tomorrow. C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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RLS,

Waiting IS hard! Yours IS a dif kind of wait (from this), but regardless, I link you to this thread about "waiting" (to start). I cannot tell you the relief I obtained (from my wait), just to simply hear those official words "your in" (accepted into my trial), the relief from waiting was so profound, intensified proportionately to the amount of angst experienced while waiting. If I had only accomplished getting into my trial, and had not even not achieved my cure, I think I would have been riding high on that accomplishment alone, until my next try. We all feel a little boxed into a corner (understatement), when we first find out we need to be treated, not wanting to have to be treated in the first place, with drugs unfamiliar to us -  but the relief we experience in the trying, knowing we have made our best choices, and then winning, is hard to explain to others who have not "been there". I hope that your win is going to feel very much larger than the angst you have gone through thus far. You should be feeling very proud of yourself for both your good choices and efforts in creating the cure you wait for. You WILL get your reward. I am always very proud of the folk who have had to try so hard and have had to pull themselves up from their bootstraps repeatedly until they are successful. You are already a success story, even without the Mav and it's undoubted cure of you. smile C.

Waiting, waiting, waiting

 

PS - while waiting, light reading is far less dangerous than hanging your head out a train window while going 200 mph. 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Hey RLS,

You‘re in the final leg of your journey. If you weren’t on the Mav Bullet Train, I’d tell you to open a window and smell the flowers. Probably not a good idea to open the window doing 200 mph, lol! You got it Brother, this is the time you’re going to finally tell this fire breathing lizard goodbye. 3 more weeks, you can do that standing on your head. If you try that, please send pictures, ha, ha! Seriously, the last month took forever to go by for me, too. Just know the odds are really in your favor. Chin up and enjoy that 200 mph view, it’s the last time you’ll be on this train...

Life is good  



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Tig


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Hi Dandi,

Sounds like you‘re ready to get this done! The final leg of this journey is often the most straining, but you sound committed and I’m confident this is your time to shine! It must’ve been dreadful to get that news of relapse after your Harvoni treatment. Like Canuck mentioned, your current protocol was designed just for your situation. You’ll do it this time, I feel it!

Keep pounding that water!! Glug, glug, gag and all that, but as they say, JUST DO IT! All of these fun and some not so fun side effects are your Dragon’s way of trying to go out on it‘s terms. You need to keep showing it who’s Boss wink

Onward to success! Good luck... 



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Hey, hey!

I love all the added comments "keeping the faith" (DL), "staying positive" (RLS)!, aside from your updates. biggrin. All good to hear. And from Angel too, ... "everything is good"!

You should all be feeling VERY positive about your progress/outcomes, excellent labs shown as you go, everything going to plan, all because of a new DAA which is leaps and bounds more effective than your prior DAA.

It's an especially hard thing to go through, the devastating disappointment you 3 have had to work your way through when a treatment did not work for you the first time around, it automatically can put you over in a hard to shake confidence deficit zone, but, it has also made you VERY strong to have rallied and come again with justfied hope to the newer and newer (ever more potent/effective) DAA's, like Mav, where you WILL find your ultimate success. Nowadays, we are seeing bitter disappointments less and less for people, it is now VERY, VERY rare indeed that this would ever happen to you now, again, especially now with likes of Mav under your belt! Mav (and Vosevi) were created and designed JUST for folk like you! And the bonus beauty of these drugs is also their "pan-ness", so they happen to be ideal for everyone else too. 

So, no more doubts, all of you have done it with Mav, wiped that beast out once and for all, forvever! 

Sorry about the divertic bout right now RLS, and for your fatigue DL. Ya, how i envied people who felt some improvement(s) while on treatment, but I was always glad to hear about those who did! (Kinda like you DL, I too did not get a sense of feeling "better" while on treatment with my Vosevi, aside from feeling thrilled to bits that i could see I was getting cured - I recall the coma state well)! But boy did I ever enjoy and revel in the dribs and drabs of regressions and resolutions that occurred for me after I finished treatment, and long after, no matter how slow they were to come, or how small they might have appeared to others, they felt huge and amazing to me, they still do!, and they are still coming! 

So, you are right ... keep the faith, stay positive, everything WILL be good! wink C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hey C, 

The finish line is up ahead. I'm in my 14th of 16 weeks on Mavyret and hanging in there. I have more fatigue than ever, headaches, and brain fog, but the water helps. I was UND at 4 and 8 wks, and had LFT's within normal range a month ago and am hoping to see better numbers when I get labs at EOT. I'm waiting until 4 wks post EOT for my next viral load. When I was on Harvoni 3 years ago I was UND at 4, 8, and 12wks. What a surprise the 4 week post was at 650000. Keeping the faith here. 

Cheers,

Dandy



__________________

F, 67, HCV since1980, GT 1b, Semiannual LFTs, Ultrasounds. First treatment Harvoni, SOT 1/2/2015, relapsed June 2015. Fibroscan F0-F1, LFTs only slightly elevated. Second treatment Mavyret 16 wks, SOT 1/2/2018, EOT 4/24/2018.

RLS


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Hey Canuck, as Petty said, the waiting is hardest part. Will get my 12 well testing in 3 more weeks. Generally feeling good but had a bout with diverticulitis which sucks. Staying positive! rls

__________________

Male 54, DX 1992, GT 1B

2005 - Rib/Peg Relapse

2016 - 12 Week Harvoni Relapse

Mavyret (16 weeks), BOT 10/16/17, EOT 2/2/18. SVR 12 5/3/18



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Calling all Mavs! biggrin We need some feedback 'round here. How ya all doing? Akemi, RLS, mpls, N.W. and ALL. How ya'll doin' and making out? Hope all is going swimmingly. Got any new news, or even any old news?

New Mavers are still arriving here, it always so nice to keep them up to date on how one is feeling (from those who may be further along in the Mav process than they may be). Nice to keep them and all of us posted on every little thing, sharing and comparing notes always helps, everyone!

If ya don't post regular we'll have to call ya Mavericks, hee hee. wink C. Hey, I mean that only in the nicest way! If you go by the definition for Maverick, it says "free" spirited, which i think appropo, for it is the miraculous Mav which has (will) free you! smile C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

RLS


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Congrats Akemi on starting treatment. I recently completed my Mavyret treatment and will be retested in five weeks to see if has been eradicated. Other than a few occasional headaches (probably due to not enough water intake), I had no other symptoms. The new treatments are far better than prior and more invasive treatments.

Keep us posted on your progress and test results. The forum is a great place to share news and ask questions.

rls



__________________

Male 54, DX 1992, GT 1B

2005 - Rib/Peg Relapse

2016 - 12 Week Harvoni Relapse

Mavyret (16 weeks), BOT 10/16/17, EOT 2/2/18. SVR 12 5/3/18



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Welcome,

Glad you discovered your HCV and are getting rid of it.  I know they worry of getting little ones tested (and the huge relief of them not having it), so yay for that.

I had it for almost 20 years without knowing it, made, delivered, and breastfed 3 children and neither my husband or kids got it from me. Id agree with Tig, you should encourage your husband to get tested, and if he has it, start treatment lickedy split.

Water is your best protection against headaches, ginger tea can help with digestion.

A



__________________

60y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

2.5years...post tx... successful dragon slayer 



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Hi Akemi,

Welcome. Glad you have been reading the Mav threads here, meeting other Mav people and all of us. It's always good for all of us to have each others experiences to share, to compare to, and advice to draw on.

Fire away if you have any burning questions.

Tig has brought up important points for you, drinking lots of water and taking every dose on time.

Like mpls's doc, too bad your doc is not planning to do a viral load (VL) test on you until the end of your treatment. Some docs do that. That is how confident they are in these potent new DAA's we have at our disposal nowadays. But it is always nice to see your numbers start to go down while on treatment, often makes people fret less to see their progress.

So, reading "between" the lines of your posts, we can piece together some of your important background data, but if you could try to create a "signature line" that would be very helpful in conversations. (See how we all sport sig. lines at the bottom of our posts?) There are instructions (via the link in Tig's sig. line) in how to create one for yourself - you can create your sig. on the same page where you first put your bio when you became a member.

I do not think you have mentioned yet what your genotype (GT) is, or what your viral load (VL) is. It's real helpful for everyone to have a sig. line for "info at a glance", instead of scrolling through posts searching for key data. If you have troubles figuring out how to do the sig. line just let us know and of course we will try to assist.

I have questions for you - about your F3 - was that determined by a blood test or by a "fibroscan", just wondering? Also wondering if you had been given an abd. ultrasound (U/S), and if you had your hep A/B immunization checked prior to your Mav start?

So, could I suggest a sig. line for you, something that contains info like ... Sex, Age, GT, dx 3 years ago, VL, ALT/AST (and any other abnormal labs you want to post), U/S result (if one was done), fibroscan kPa number and fibroscan Fscore (if fibroscan was done), and/or the name of the blood test you had that determined your F3 Fscore, rx 8 weeks of Mavyret, start of treatment date (SOT) and end of treatment date (EOT), hx of gastric issues. So far, the underlined bits are what we know.

Try not to be nervous, take your Mav with a meal, drink lots of water throughout the day, you'll be fine. I'm glad you got started, your 8 weeks of treatment will probably feel both long AND short!  smile C.

BTW - the 2 dif GERD drugs you mentioned ... ARE YOU currently on one of them, or not? "Protonix" (generic is pantoprazole) AND "Prilosec" (generic is omeprazole) are similar, they are both "PPI's". Some DAA monographs do recommend avoiding PPI's and using other GERD drugs instead while on DAA treatment, other DAA's you can be on PPI's - some people end up having to switch to other gastric drugs, H2 blockers, such as "Zantac" (ranitidine) or "Pepcid" (famotidine), but, if you read the Mavyret monograph - even though you can see "Prilosec"/omprazole IS mentioned (read section 7.4), and (section 12.3 - table 8), omprazole IS listed ONLY in that the interaction between Mav and omprazole IS NOT SIGNIFICANT

MAVYRET (glecaprevir and pibrentasvir) - RxAbbVie

https://www.rxabbvie.com/pdf/mavyret_pi.pdf

 

Note, also in the mongraph, (read sections 2.2), and (12.3 - table 6) about taking Mav WITH a meal.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Gah I knew the difference between cirrhosis and fibrosis but have been reading so much the last few days my brain got muddled haha. Thanks. I've just been nervous about the lover issue as I haven't been infected long and it's already fairly advanced. But this is the first step in fixing that!

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Tig


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Hi Akemi,

Welcome to the forum! Mavyret is the real deal and you will do well on it. There have been very few side effects mentioned by anyone on this treatment, so you shouldn't be concerned about that. Any that might pop up are generally just an indication that you're not hydrating well enough. If you concentrate on drinking at least one gallon of water every single day, you should have no problems at all. Headaches tend to be the most common when people fail to do that. Treat yourself right, get some rest and never miss a dose and you're going to be dancing in no time!

The reason you're doing 8 weeks is because F3, while considered advanced fibrosis, is NOT cirrhosis. That starts at F4. These are very effective drugs and I have no doubt you'll be singing the praise I've been listening to from others. I haven't met anyone here that hasn't been successful on it.

I'm happy to hear your baby tested negative and advise your husband to go ahead and get tested now. It's easy to find out and easy to treat. If he is positive, there's no reason you can't both jump on the Treatment Train together. At the very least, he can get all of the preliminaries done ahead of time and be ready to rock and roll when the time comes.

Others will be along to welcome you soon. We've got a great bunch of people here and loads of friendly suggestions and endless helpful advice. I'm glad you're here. 



__________________

Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Yup I had them check the two different ones I've used in the past, protonix and omepraxole, both are fine. My doctor also isn't testing me until the end of the 8 weeks. I'm a little nervous that maybe she should've prescribed 12 weeks as I am at f3 cirrhosis, but I only contracted it just 3 years ago and this is my first time being treated. Just took my first dose!

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Hello and welcome to the Mavyret club.  Good luck to you. My experience with 8 weeks on Mavyret was good. I had some anxiety the 1st week, just because of my uncertainty of what the 3 pink pills were doing to me. I had very few side effects. I had a mild headaches about 5 times, mild nausea about 5 times, mostly tiredness, but I was able to work throughout my treatment.  I work part time.  I was undetected after 8 weeks. I have read several posts that people were undetected after 4 weeks. My doctor wouldn't test me until the end. I have read several other posts where people handled the treatment well with very mild to no side effects.  So, I hope it goes well for you too. Keep us posted. Ask your doctor if you can continue to take your GERD meds. I'm excited for you!!! 



__________________

62 y.o female HCV since 1977, (40 years). Genotype 1B, Dec 2017: ALT 53, AST 48, PCR 70,500. Fibroscan, very little scaring. Treatment naive. Mavyret: 8 weeks SOT 12/27/17, EOT 2/20/2018. EOT PCR Undetected!!! June 20, 2018 SVR 17 weeks Not Detected. 



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Hey all, I just joined the group today and have been reading through a lot of threads, mostly the recent ones about Mavyret. I just got my approval for it and my pharmacy mailed out 4 weeks worth yesterday so presumably starting tomorrow. This is my first (and hopefully only) course of treatment as we just found out 3 years ago I had HCV when I was pregnant. Thankfully at 18 months my daughter tested negative!! If all goes well my husband is going in after I'm done to be tested and treated as well. Anyways, any words of advice from anyone currently or recently taking Mavyret? I have different stomach issues (acid reflux, GERD, ulcers) so I'm preparing for most likely getting some nausea.

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Hey Waffle!

Glad to hear from you. : )

We are straddling 2 threads here (this "Mav.2" one, as well as posts over in "Mav.1"), regardless, I think you checked in last on the other "Mav.1" thread, back around the time of your 4 week UND results.

(Over in Mav.1) I was was trying to figure out how long your course was going to be.

Initially, (I guess maybe it was your doc who originally made this made this suggestion to you) that there was some possibility that you would only be doing 8 weeks of Mav, IF you were UND at 4 weeks?

I am still not sure how long your course is, (what date is your EOT?), I am assuming (now) that you ARE still continuing it, for it to be a 12 week treatment? So, your EOT treatment date would be about March 23?

IF you are on a 12 week course, your 8 week blood draw should have been drawn about Feb 23, and, so then, your 12 week EOT blood draw should be drawn about March 23? That is, if they are done "on time".

Please set me straight about your EOT date OK? I have always been of the mind that us GT3's should welcome longer treatments anyway, if and when offered.

Your next May "return" appointment (mid-May or late-May) doesn't make time-sense to me either - as you said it was for your "final" blood draw? ... if you were on an 8 week treatment then your "final" (EOT) blood draw should have been done around Feb 23, but if you were on a 12 week treatment, then your "final" (EOT) draw should be on about March 23??

After anyone's EOT blood draw (whatever that EOT date may be), then your next blood draw after that EOT one, should be 12 weeks after your EOT, (your EOT+12 week SVR blood draw). 

Gee, too bad your can't get a "verbal" on the phone, about what your 8 week blood draw results were! You must have the patience of Job!

Thanks for checking in and filling us in on all these things, hair, skin, having to do more maintenance! Pleased to hear you say **drinks water** though, that's a good thing!  Very good to hear from you.  biggrin C.

 

 

 

 

 

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hey guys. I took a blood test @ 8 weeks but I never got the results because I didn't want to drive back just to get them. I was scheduled for mid May for the final blood draw but I'll be going late May instead (scheduling error).

Side note. I noticed my face skin has been oilier than usual and I've had some hair fall. I've had to do a lot more maintenance than usual to not feel gross. I'm not going to say one way or another if Mavyret is the cause of it but thats that. *drinks water* :)

 

 

 



-- Edited by NorwegianWaffle on Monday 19th of March 2018 02:38:58 AM

__________________

 30 yo, f, geno 3a, diagnosed 2007, AST 55, ALT 106, 5.8 million, PLT 224 

Started MAVRET for 8 wks on 12 /19/ 17. @4weeks Mavyret Not detected AST 17 ALT 12

6/1/18 final "undetected"

RLS


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Great news mlps! I'm right with you waiting for SVR. I'll know at the end of April. Looking forward to a celebratory spring for both of us! rls

__________________

Male 54, DX 1992, GT 1B

2005 - Rib/Peg Relapse

2016 - 12 Week Harvoni Relapse

Mavyret (16 weeks), BOT 10/16/17, EOT 2/2/18. SVR 12 5/3/18



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Hey GREAT! mpls - you got your EOT UND results today, I'm so glad you did not have to wait any longer to find out your good news. The weekend would have felt loooong if you had ended up having to wait until Mon or Tues (as they had suggested it might take that long). Really nice you got your results today, and got to know today.

Congrats on a job well done! biggrin (Now, THAT feels better!, doesn't it, earning and now owning those lovely numbers.) What a wonderful drug era we live in, to be cured in a mere 8 weeks with these amazing new DAA's. Your liver will thank you for the rest of your life (as we can see it already is, just by your now normalized ALT and AST!)

"Offically" and technically your next EOT+12 week SVR blood draw should be on May 15, should they be suggesting a later date for your EOT+12 week SVR VL and LFT blood draw, then try to get them to change it/book it, for your blood draw to be as close a possible to May 15.

You've done it! Wiped that nasty virus out. Keep taking really good care of yourself, eating well, rest and coddling, after all you just been through a big war and won! Reward your body, and above all, CELEBRATE! wink C.

 https://www.youtube.com/watch?v=3GwjfUFyY6M

 

 

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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The AST and ALT are your liver enzymes. Yours are a lovely shade of normal. The PCR Qnt is the viral load test. The test sensitivity was 15 and the log is another way they score it. Sometimes a test will come back with a result of <15 but Detected. That means the number of viral particulate was too low to count, but still detected. That happens ocassionally but not in your case. Undetected is a lovely word!



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Tig


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That’s fabulous! Let me say congratulations again. If you think you’re excited now, just wait a couple days. It gets better! Wait until you get the official SVR12, you’ll want to put them both in a frame and admire them for a year or two, lol!

I‘m so happy for you! I’d get up and click my heels for you, but I’d probably hurt myself. You’ll have to enjoy a lively Happy Dance! Jumping, not so much. Well done!

UNDETECTED

 



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Big news.. Good news...

I'm happy to share with you my successful results after 8 weeks on Mavyret:

Hep C PCR Not Detected.

Not sure what these mean: Hep C PCR Qnt < 15 and Hep C PCR Log <1.18

ALT 10 and AST 17.  



-- Edited by mpls on Friday 23rd of February 2018 10:15:20 PM

__________________

62 y.o female HCV since 1977, (40 years). Genotype 1B, Dec 2017: ALT 53, AST 48, PCR 70,500. Fibroscan, very little scaring. Treatment naive. Mavyret: 8 weeks SOT 12/27/17, EOT 2/20/2018. EOT PCR Undetected!!! June 20, 2018 SVR 17 weeks Not Detected. 

Tig


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WOOHOO!! Big congratulations are in order Mpls! That time went by quick, at least for me wink

We’ll be waiting right here for the final results. Your fan club and supporters will be on the edge of our seats. If we have to wait too long, please bring donuts and coffee. Apple Fritters (hint, hint)... smile

MPLS = EOT



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Congrats on finishing treatment and on those fabulous normal ALT and ASTs whoooo hoooo...let us know as soon as you find out your (presumably und) virus status.

 



__________________

60y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

2.5years...post tx... successful dragon slayer 



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Hey mpls,

Great news. All finished your Mav!! Congrats - and your EOT ALT (now 10) from prior 53, and your AST (now 17) from prior 48, are indeed beauties and herald that UND result you are waiting for. smile

I hope the PCR lab returns soon for you. That WAS a long wait you had (with NO VL draw, nor LFT's during your 8 week treatment)! I wish they would not do that, I like to see people getting testing 4 weeks in to their therapy (or in your case 1/2 way through treatment, but, even though your arm was willing your doc was not!

I do find it even odder still, of him, that he seemed relucatant to do LFT's with this EOT VL that you just had done!!confuse Weird in my books. But VERY good you specifically requested them to be done. 

Do the same for your next set of follow-up labs (which should be aprox 3 months) REQUEST LFT's along with your VL (if he again seems to want to leave them out) -  your "official" SVR is normally done at EOT+12 weeks, (generally not at EOT+16 weeks confuse).

Humph, what kind of budget is your doc on?!

Nevermind, just keep advocating for yourself, and do ask for GOOD follow-up and care (in all and any of your health matters in future). 

Great news - can't wait to see you post your first UND! biggrin C.

 

 



-- Edited by Canuck on Friday 23rd of February 2018 02:30:54 AM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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I finished my 8 weeks of Mavyret on Tuesday this week.  My blood draw was Wednesday. No PCR results yet, they said Monday or Tuesday, but ill check my chart tomorrow. My ALT was 10 and AST 17. It's the first time in years that they are in normal range. Whooo Hooo! My doctor wasn't even going to check my ALT & AST, I had to ask him.  They want to see my SVR in 4 months. He said if I'm clear after 3 months that i probably will be cleared for good. They still don't have much data on the success rate, because it's new. They did remind me that it's not 100% effective. I will post my results as soon as i know.  Thanks for all your knowledge and support!!! Be back soon!



-- Edited by mpls on Friday 23rd of February 2018 01:42:34 AM



-- Edited by mpls on Friday 23rd of February 2018 02:00:21 AM

__________________

62 y.o female HCV since 1977, (40 years). Genotype 1B, Dec 2017: ALT 53, AST 48, PCR 70,500. Fibroscan, very little scaring. Treatment naive. Mavyret: 8 weeks SOT 12/27/17, EOT 2/20/2018. EOT PCR Undetected!!! June 20, 2018 SVR 17 weeks Not Detected. 

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