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Post Info TOPIC: Epclusa for gt3 - Started May 27


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RE: Epclusa for gt3 - Started May 27
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Details, details JB!

Which toe, which bone, what kind of fracture? How bad is the break?

Are you required to work, you mentioned a desk?? hm, OK to sit at a desk but ... still, the foot ends up being dependant too long, if you are still having swelling/pain issues.

The ideal would be not to weight bear much on it, move it/use it/abuse it (the fracture line that is) at all, until you have sucessfully knitted the fracture intact again. Worst thing is to keep distrubing/disrupting/moving a fracture line while it is in that important initial process of trying to heal fracture. 

Now, if it we me? I'd book off work, get someone to carry me around, get to a beach (like that nice one in your avatar) for some R&R therapy, and make use of lolling around on floaty things in the water. smile C.

Image result for floating in pool cast on leg

 



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Ah darn it!  Broken toe = annoying pain. I guess the Universe wants you to take it easy while you kick dragon butt ...and is making sure you do. 



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60y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

2.5years...post tx... successful dragon slayer 



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Yes bummer JB....Broken toes are no fun...they are only little but by crikey they hurt. An arm or a leg once they put a plaster on the pain almost vanishes but with toes where they can't do anything. Hope the pain eases quickly for you...

Last month coming....Great. Pity the toe getting in the way, and what a way to break it! You poor devil. Thinking of you. nod.gif

 



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65/F Contracted Early 80's First Diagnosed Early 2000's 2017 re diagnosis and referral for treatment

Gen 3a Fibroscan 8.6 Epclusa 12 weeks commenced 1 May 2018 ALT 72 AST 67

28 May 2018 4 weeks ALT 16 AST 23

Tig


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OUCH!! 

I had a feeling it was fractured, bummer. Sorry you’ll have to put up with it, but at least you know why it hurts so much. Time to kick back, elevate the sore toe and catch up on some daytime TV!



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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JB


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Well, I went to the doc today for my toe... and its broken! Woo hoo! Nothing really to do but take it easy and wear a spacer between the big toe and my second toe. Not much else they can do about it. No boot or special shoe. Just my comfortable sneakers. Thanks for the support. Glad I got it checked out. Now, the focus of my last 30-days or so of the Epclusa. Blood work in another week or so for 8 weeks.

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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, U/S showed some fatty liver, Fibroscan showed Fscore of 3, Tx 12 weeks Epclusa, SOT May 27 - EOT Aug 18. MRI Jun 12 showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm.



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we're on our way over for rice and beans JB,  

guess we'll have to do the cooking and serving tho cos of your foot.. 

5



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Gt:1a for 36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:Alpha 2-Macroglobs, Qn=400/high. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3,933,000

sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL now. 



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OK, JB, rice and beans for everyone eh? wink C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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ok, now i want some rice.



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Gt:1a for 36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:Alpha 2-Macroglobs, Qn=400/high. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3,933,000

sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL now. 

Tig


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Glad you’re feeling better, John. That entire statin thing sounds like it was hard on you. Good thing you discovered that right away and didn’t suffer through weeks or months of it before figuring it out. Sadly, that happens to a lot of people while they figure out something that will work for any given condition.

JB, stay off that toe! Don’t keep ice on it too long. If the swelling doesn’t go down, you need to get it looked at. There are meds they can give you to help with any inflammatory processes, your doctor can advise you on them. It is unfortunate that just about everything we take is filtered by the liver and all cause varying degrees of hepatic stress. I‘m still a firm believer in that organ though. It’s a tough and has to be simply because of the job it was designed to do. It can take a lot of punches, but we have to help it dodge and weave as many blows as possible! How’s that for a boxing analogy? Ha, ha!



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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I will never take Tylenol again. I want to keep the meds my F3 liver has to clear as low as possible. On prescription I take one 50 mg tramadol daily for arthritis pain; two on the occasional bad day when I have significant pain. As well as a centrally-acting opioid analgesic tramadol also has anti-inflammatory activity (the mechanism underlying the peripheral anti-inflammatory effect of tramadol remains unknown.) Still cleared the virus at ten weeks.

6 more weeks before I check viral load again at EOT + 12 weeks. Very thankful for this forum. Thinking about buying a rice cooker now:) Canuck I'm feeling better as each week passes once that side effect problem I had with the Crestor incident passed. Sorry to hear about your toe JB hope you are feeling better soon.



-- Edited by lamassu on Saturday 14th of July 2018 11:48:14 PM

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Male, 65, Dx 1990, GT 2a/2c. Pre-treatment VL 11,500,000, ALT 10, AST 18, Fibroscan F3, 12.4 kPa. Rx 12 weeks Epclusa, SOT Mar 8, 2018, EOT May 30, 2018. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18.



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heehee JB, I LOVE rice! Reminds me of my cousin when we were kids, being served supper by my Mom, cous says ... "what's THAT"! ... "rice" my Mom says, cous being an Prairie Orangeman farmers daughter I guess and never eating anything but good ole spuds, informs my Mom, "we don't eat rice" ... my Mom informed her that ... "here you will eat rice and you will like it!" hahaha. Oddly enough, in the end as it turned out, she did like it! 

You are not alone in the toe dept JB! It seems to me that we have had a few here with the very same or very simlar unfortunate nocturnal mishap, some just to do it in the dark of the night, with the help of pets, or furniture we swore had mysteriously aligned itself to show it's not known before hardest corner, or just blame it on a urinary urgency race, but all had to do with being on hep c treatment. A temporary occupation hazard it seems. I guess be glad you did not do a header as well. 

4 grams, 3, 2, 1 or 0 grams of tylenol (or, more often than not) no drugs or sups of any kind while on treatment or when you have liver disease is a call lots of people make all by themselves, all on their own, and, right or wrong, folk often just naturally decide they do not want to add anything to the mix of having a body that is already busy dealing with a systemic disease - can't blame them either, but nor do we want to see anyone suffer for lack of a little medication - it all boils down to common sense, and perhaps a little advice when one is unsure or unfamiliar, and your doc preferences. Good you had already cleared tylenol use with your doc aforehand, as you and he know the most about you - to ask ahead of time, that was the wise thing to do.

If we must nuance tylenol opinions/studies, then I agree with Dr. Eric Yoshida, the evolution of extra-strength 500 mg tablets versus 325 mg tablets and other OTC acetaminophnen products at least present a problem as far as overdosing. Seems a person jes kint be too kareful these days! I agree with you JB in the lament about how it is too bad about tylenols lack of anti-inflammatory properties. Aspirin will always have it's place of honor at the table too, when deciding on choosing a safe and appropriate med for what ails ya. Some docs forbid aspirin-based (acetylsalicylic acid) ones, others do not, and for their own good reasons. Common sense consensus is the thing.  wink  C.

PS - I always love gazing at your avatar, how did you get an advance booking/seat at the exclusive Club Zero, which umbrella is yours? Soft warm sand between the toes will be good rehab/phisio. 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

JB


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Thanks everyone! I've taken Canucks' advice and am eating lots of RICE. Thank you! I enjoy brown - a bit healthier.

On a more serious note, I appreciate everyone's concern. I did confirm that my doctor did state initially that I can take Tylenol as needed for pain. I took one yesterday evening and it helped. Too bad Tylenol doesn't help with the swelling, though. As you all know, I was advised not to take any NSAIDS. I'm not in so much pain, though (knock on wood). It is just uncomfortable when I walk and feels very stiff. 

I had to work yesterday (at a desk) - so I stayed off my feet and iced it and elevated it when I could. When I got home I didn't get off the bed - and have my foot elevated and am icing it. I applied some tape today to stabilize it and that seems to help as well. I cancelled all my weekend plans and will just be taking it easy. No 10,000 steps for me for the next several days. 

If it is not better on Monday, I'll go to the doctor for x-rays. However, there is not much to do for a broken or sprained toe. Lots of doing what I'm doing now - RICE. 

Thanks again, guys! 

JB

 



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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, U/S showed some fatty liver, Fibroscan showed Fscore of 3, Tx 12 weeks Epclusa, SOT May 27 - EOT Aug 18. MRI Jun 12 showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm.

Tig


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willbb wrote:
Always best to discuss any medication with your physician

 Exactly! As much as we would like to advise people on what medications to take, we can't do that. That's my rule here. The references are always welcome, but you're right, Will, people should always consult with their physician before adding any new medications. Especially while they're on treatment with these DAA's. My niece OD'd on Tylenol, by accident and her liver suffered greatly from it. I always get a bit nervous when I see people taking large doses of Tylenol when they are already experiencing a hepatic injury or disease.

Good article!



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Hello JB,

I negated to reference(which is always a good idea) one of the  "many" peer-reviewed articles(inclusive of exerts from the CDC,American Liver Foundation and the FDA) on pain mgmt. in patients with chronic liver disease,when I commented(not advised)on your statement: I'm pretty sure I can take 2000mg. of Tylenol per day".

Always best to discuss any medication with your physician

https://www.practicalpainmanagement.com/treatments/pharmacological/non-opioids/safe-usage-analgesics-patients-chronic-liver-disease-review.

 



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Sorry JB - I just need to say hello to willbb on your thread for a second, as he seems to have no thread of his own. smile 

 Hi again willbb!, i see this is your your second "advice" post of today .... umm, when are you going to introduce yourself ? Jes wondering who we are talking to?  No intro, no hx, no sharing about who you are, your hepc experience, treatment(s) done, bio, signature line (or anything!) since January - makes you a newbie mystery man. Soon? confuse C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Tylenol is generally safe to take, but we don’t like to advise anyone on what types of medication they should or shouldn’t take in a situation like this. Tylenol, taken on a routine basis is hard on the liver, so keep that in mind. Better get the approval of your doctor. If you have a fracture or severe sprain, the discomfort will get worse over the next day or two. Find out what you did and seek the advice of your doctor. You don’t want to delay treatment if there’s an injury in need of attention! Follow Canuck’s suggestion and ice it periodically and elevate it to reduce swelling. Rest is always a good idea. Good luck!



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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hi JB, you can always call the pharmacy. we were taking ibuprophen with their blessing.

so sorry to hear about your ankle; so now you will be resting it and your body more and that's ok



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Gt:1a for 36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:Alpha 2-Macroglobs, Qn=400/high. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3,933,000

sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL now. 



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I'm pretty sure I can take 2000mg of Tylenol per day, but just wanted to be sure. Any negatives to taking Tylenol while on Epclusa?

----------------------------

Thats correct JB. It has been proven in research that up to 2000mg of Acetaminophen is safe to take over a 24hr. period  for those with liver disease (including chirrosis).

The FDA prescribing info. has no contraindications with taking it with Epclusa.

Good luck with the toe.



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oh! OW!! RICE is a priority, hope you have already been on it - the rest, ice, compression, elevation! Especially important to do so the first minutes, first hours and the first 24 hours to prevent too much microscopic bleeding, bruising, swelling at the injured area. 

I sure hope you do not have to be on your feet with this new toe injury, it's very much worth it staying OFF your foot and most importantly keeping that injury elevated (above the level of your heart) - hope you can (stay off it and elevate it). Next, please do go seek an opinion on whether it is fractured or damaged/sprained. They may well have some helpful advice/devices for you depending on what you have done - from taping to splints to supports to walking air cast thingies - devices can sometimes make a huge difference in getting along with and getting over a foot injury. 

A large obvious fracture will show up right away on xray. If it is a tiny fracture somewhere in there, sometimes an immediate xray might not show it up, a repeat xray days later often can help to show up a tiny fracture previously not imaged, as re-calcification starts to become apparent within days. But even just a physical exam by someone with experience, a clinic or ER doc, will likely provide you a good guess on the likelihoods.

That is a large amount of tylenol you are talking about possibly taking! Yes, if you have pain you can take a single dose of tylenol, but see if that single dose will do it for you and how long it lasts, see if a single dose cuts the pain enough, if not you can always take one more single dose - but if you are on your way to a doc for an opinion about your injury (which I think you should do) you can be sure to ask how much pain meds (tylenol or whatever he recommends) would be the smallest amount you could do and it still be minimal and effective.

To take your mind off your toe, just imagine and envision what hell and pain and death throes you have just put your virus through, and wash it all down with lots of lovely water. biggrin Hope the toe stops hurting soon, go seek some advice for it please.  C.

Image result for elevating and icing a foot injury

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

JB


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Been waking up a lot at night to go to the bathroom with so much water consumption. I am usually pretty discombobulated - especially today around 4 a.m. Then, my alarm went off, I panicked and think I missed the side table to turn it off ... and fell out of bed. Yes, I fell out of bed. So hard that I think I sprained or broke by big toe! What the heck is wrong with me?! I'm pretty sure I can take 2000mg of Tylenol per day, but just wanted to be sure. Any negatives to taking Tylenol while on Epclusa?



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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, U/S showed some fatty liver, Fibroscan showed Fscore of 3, Tx 12 weeks Epclusa, SOT May 27 - EOT Aug 18. MRI Jun 12 showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm.

Tig


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Good job!

 

 



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61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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yay JB

i like stl's idea of half baked.hahahahahaha, and her with only 15 beans to go

 

99 magic beans on the wall, 99 magic beans, take one away and whadda ya got? 98  magic beans on the wall......... and so fort

it's supposed to be bottles of bear



-- Edited by 5-1-18 on Sunday 8th of July 2018 05:50:42 AM



-- Edited by 5-1-18 on Sunday 8th of July 2018 05:51:36 AM

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Gt:1a for 36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:Alpha 2-Macroglobs, Qn=400/high. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3,933,000

sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL now. 



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Yay JB - 42 magic beans done for you! : )

Image result for 42 beans

And only 15 more for STL!

You and STL running good, and ever closer to that finsh line ... I keep hearing this distant drumroll, heehee ... 

https://www.youtube.com/watch?v=62erF1TM6_E

Before ya know it, you'll both be sitting pretty at Club Zero - we have a special spot reserved just for folk like you at the exclusive velpa club. biggrin C.

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Yea JB your half baked then ROFL....cake.gif Your doing great. I have 15 to go! teamwork.gif



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65/F Contracted Early 80's First Diagnosed Early 2000's 2017 re diagnosis and referral for treatment

Gen 3a Fibroscan 8.6 Epclusa 12 weeks commenced 1 May 2018 ALT 72 AST 67

28 May 2018 4 weeks ALT 16 AST 23

JB


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Just realized today was bean #42... half way done!

 



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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, U/S showed some fatty liver, Fibroscan showed Fscore of 3, Tx 12 weeks Epclusa, SOT May 27 - EOT Aug 18. MRI Jun 12 showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm.



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Today I think I will watch Forrest Gump. JB has kicked off his leg braces and is not looking back.    RUN JB RUN  

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Hi JB,

I think it is fine to do what you feel capable of doing, you felt capable of doing the 10k and did it so I think thats all good. It made you feel good to achieve it and I think that is good. Far better than sitting home wishing you had tried it.  We need a positive attitude, and if a good walk run makes us feel good that is good. I have been big on walking too as you know. I started a few years ago when I started working to lose weight. At my age and given the size I was I initially I wasn't capable of much but I improved. Before I got my pup I was doing 5k at least in one go more often 7 - 10 but since she is little and has little tiny legs so I don't do more than 5 k these days. I don't find it hard to do and I enjoy my walks. It is good for me. My liver specialist noticed my excess skin and asked about weight.  I told her I usually do at least a 5k walk a day and had done 9 the day before,  I generally do 12-20,000 steps a day and  she didn't find that a problem. She just said if you don't feel up to it, don't force yourself while on treatment. Good diet, whatever exercise you feel capable of doing, make sure you stay well hydrated and plenty of rest are whats important at this time so I have not changed any of that. These days its more likely the weather that will stop me walking rather than being on Epclusa. Of course I wont know if the dragon is dead until late Oct.



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65/F Contracted Early 80's First Diagnosed Early 2000's 2017 re diagnosis and referral for treatment

Gen 3a Fibroscan 8.6 Epclusa 12 weeks commenced 1 May 2018 ALT 72 AST 67

28 May 2018 4 weeks ALT 16 AST 23



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hi JB, mainly it's important to know what your body needs. 

i work so i had to save my energy for work.

i'm glad you feel well and are drinking lots of water



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Gt:1a for 36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:Alpha 2-Macroglobs, Qn=400/high. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3,933,000

sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL now. 

JB


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I get what you are saying Tig, however, I did not run the full 10k. Lots of walking and I wasn't in it to win it - just finish it. I've been feeling good - surprisingly better than before I was on the meds. I'm eating better, I'm walking every day, etc. I felt that since I have been walking 10,000 steps per day, I could do this. I did feel good enough to run some of the race, so I did. I didn't push myself beyond my limit (although my legs are very sore today). Should I not be walking 10,000 steps every day? I was told to exercise, eat healthy and live my ordinary life. Now I feel like an idiot for doing the 10k yesterday. I don't want to cause any problems for the meds and my fight with the dragon.

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, U/S showed some fatty liver, Fibroscan showed Fscore of 3, Tx 12 weeks Epclusa, SOT May 27 - EOT Aug 18. MRI Jun 12 showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm.



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Wow 10K JB onya!!!!!! I try to still do my 10,000 walking but have to admit some days are just "no b bo'd" type days (can't be bothered) - days where I am lucky to get 7/8000. I did get a 20,000 day on the 22 May but not in one big walk. A 10k run without treatment is some achievement and on treatment you are amazing clap.gif I don't run.



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65/F Contracted Early 80's First Diagnosed Early 2000's 2017 re diagnosis and referral for treatment

Gen 3a Fibroscan 8.6 Epclusa 12 weeks commenced 1 May 2018 ALT 72 AST 67

28 May 2018 4 weeks ALT 16 AST 23

Tig


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JB,

Congrats on finishing the 10K! You know, you should probably be taking it easy and not pushing those kind of limits, right? Use that energy for fighting that Dragon. There’s plenty of time ahead of you for marathons and the like! The new treatments are so different than what I experienced. I was so sick and weak, it was work just to go into the kitchen for food and drink. I’m glad you’re able to accomplish such things. Don’t push it, you’re taking some incredibly powerful drugs and they are assaulting your metabolism in harsh ways, whether you’re feeling it or not! Slow and steady, Bro...

Thanks for the Independence Day wishes!



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Today was a special day. I ran my first 10K (6.2 miles). I had no intentions whatsoever to run/walk it. However, I feel good. I've been averaging 10,000 steps per day (walking) and wanted to prove that I could complete a 10K. As I reached the finish line, I could only think of the symbolism as I near the end of this journey and start this new lifestyle of healthy living. It was only fitting that I finished just in time to take pill 39 after I crossed the finish line.

Thought I'd share...

... And for those of you in the USA, Happy Independence Day!

JB



-- Edited by JB on Wednesday 4th of July 2018 12:54:44 PM



-- Edited by JB on Wednesday 4th of July 2018 01:11:06 PM

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, U/S showed some fatty liver, Fibroscan showed Fscore of 3, Tx 12 weeks Epclusa, SOT May 27 - EOT Aug 18. MRI Jun 12 showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm.

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Hey JB,

If she wasn’t concerned about those numbers slightly elevated, nothing to worry about. If you know what they are, just list them and we can review them. As you said, if she isn’t bringing concern to them, don‘t be concerned. There tends to be some fluctuations in some numbers, but as long as the ALT and AST are headed in the right direction, you’re doing well.

4 weeks down and things are looking fabulous! Keep hydrating and you’ll be dancing on that Dragon in no time! Good luck



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Thank you all for the positive comments and for sharing my excitement in my blood work results.

I did decide to get 8 week blood work done. I let the doctor know today to go ahead and get them ordered. May as well. Canuck - She did talk to me about 12 weeks and then again at 24 weeks. So we're good on that.

I got my complete results today online. A lot of letters and acronyms that I don't know what's what and what the meaning of them are. Anything I should look for that shows liver function (aside from ALT and AST)? Most of the numbers were in the "normal" range. A couple were sliiiiightly high. But I imagine since she didn't mention anything else beside ALT/AST and VL, she isn't worried.

Hope everyone has a great weekend! Day 35 tomorrow.

JB

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, U/S showed some fatty liver, Fibroscan showed Fscore of 3, Tx 12 weeks Epclusa, SOT May 27 - EOT Aug 18. MRI Jun 12 showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm.



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Wonderful 4 week results JB!

If you are on a budget and have to pay out of pocket for 8 week labs, then it's up to you if you want to have LFT's and VL drawn again at 8 weeks (like your doc said), BUT, if it costs you nothing, then of course I would have lots of bloods done, I always like to see the numbers as I go along! BTW - were there any 4 week bloods they drew aside from ALT/AST and VL? 

I am betting you may routinely be given (at EOT or shortly before EOT) your EOT VL and LFT's anyway. 

You might phone the doc's office just to clarify with them IF they have planned for you to have a EOT VL, and then will also be getting a EOT+12 week VL, and then a EOT+24 week VL done.

If you ever get around to it, you could add/delete from your sig line

... " are you a 3a or a 3b, do you know? - BTW - now that you have the actual fibroscan data, we could update your sig line - and show you are F3 only (not F4), being that your kPa's were at 11.1 (thus just another nice indicator showing you are not, according to kPa's, in the F4 cirrhotic range), unless of course you had other tests or other seperate blood tests which were supporting a possible F4 range, then you should include all results, by all testing methods - and, maybe we could squeeze it into your sig. line, add to the sig. line, (after the MRI bit) that the MRI also showed (aside from no cirrhosis) that there is likely no fatty liver as well (as was first suspected via your U/S)." ...

- some of us alternately post our ongoing and updated lab record results in our bio's - like our 4 week labs, 8 weeks, EOT, or SVR12, SVR24 results, etc. 

I bet your doc is VERY pleased for you how stupendously the epclusa is working for you! So are all of us!  biggrin C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Congratulations JB. floating.gif Isnt it a wonderful feeling to know these Magic Beans really do work their magic.... How lucky we all are to have this opportunity to be free of this freeloader forever. They certainly are amazing drugs. The sun.gifwill finally shine again for all of us dragon slayers.



__________________

65/F Contracted Early 80's First Diagnosed Early 2000's 2017 re diagnosis and referral for treatment

Gen 3a Fibroscan 8.6 Epclusa 12 weeks commenced 1 May 2018 ALT 72 AST 67

28 May 2018 4 weeks ALT 16 AST 23



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that is wonderful news JB

better liver panel and proof the magic beans are working.

to get the stick or not would be you wanting to know more sooner.

i got the 4 week but not the 8 week and waiting 3 months is ok with me.  STL is also waiting till oct. to find out the eot score.

for now just enjoy knowing your liver already feels better than in years and can actually get some rest as the beans clear out the virus. your immune system is now having a party cos it can finally get some work done without having to beat back the virus all by itself

 

rest and water friend. 5

 



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Gt:1a for 36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:Alpha 2-Macroglobs, Qn=400/high. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3,933,000

sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL now. 

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That’s fabulous, JB! They are excellent numbers, well within normal limits. That tells me the treatment is working and making for one happy liver and one pissed off Dragon! If the viral load wasn’t quantifiable but detected, it simply means the viral load must be below <15 IU/ml (<15 viral copies can only be detected, and not quantified). This isn’t uncommon at all. Many go through treatment with the same results. I have a friend that tested that way after treatment was completed, but was SVR12. These drugs work differently, so you have no reason to be concerned with this at all. By today I am certain that you would be undetected, were you to repeat the test. Congratulations! 

I‘m always a big fan of tests every 4 weeks. If your insurance covers them, do it. Mine covered them 100% as long as the doc ordered them. I know they’ll be as good or better in 4 more weeks and good news is always a huge morale booster.



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Hi everyone!

Doctor called with the blood work results and said I'm heading in the right direction. The ALT and AST were 28 and 27 which is good, I imagine. They were 201 (ALT) and 116 (AST) in March and 91 (ALT) and 58 (AST) in May.

She said the HepC is still detectible, but so low their wasn't even a viral load number they could provide to quantify it. Does that make sense?

She said 8 week blood work is up to me if I want to get it done. Thoughts?

JB

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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, U/S showed some fatty liver, Fibroscan showed Fscore of 3, Tx 12 weeks Epclusa, SOT May 27 - EOT Aug 18. MRI Jun 12 showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm.



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JB, i always have to look away when they stick me.... i keep one eye out at first to see where they're going then turn away

a little stick is ok when i know it's giving me good news

i'm glad you got yours done without fainting



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Gt:1a for 36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:Alpha 2-Macroglobs, Qn=400/high. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3,933,000

sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL now. 



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Oh it's working alright JB!, epclusa is a most powerful thing - lucky you, your virus is not long for this world. biggrin 

I am glad you remained upright for labs, you can be uptight, as long as you remain upright I say - nice lab etiquette. 

We can't wait for you to get some happy feedback in the right direction too! Betting you will see a much happier ALT by now in these labs.  : ) C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

JB


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Blood work went well. No feeling of faint. The nurse joked and said she thinks I just like to get myself worked up for nothing. Probably true.

The doctor said it's hard to say anything about the "thing" seen on the liver during the MRI until I get a second MRI in 3-6 months. If it grew, it'll be concerning. If it stayed the same, that's good and we'll keep an eye on it. If it's gone, well, that's great.

Regarding the "thing" on my back -- she suggested I see my primary care physician because it's not her area of expertise. However, it won't be the area of expertise of a primary care physician, so I'm not sure what to do. I think she feels like I can start with him -- and let him refer me to a spine specialist if he feels it is necessary.

Now -- wait a few days for blood results and pray the epclusa is working.

JB



-- Edited by JB on Monday 25th of June 2018 10:13:29 PM

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, U/S showed some fatty liver, Fibroscan showed Fscore of 3, Tx 12 weeks Epclusa, SOT May 27 - EOT Aug 18. MRI Jun 12 showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm.



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Hey JB,

Congrats - 1/3 done coming right up! biggrin

Woozy is worth it, for a 4 week draw. For finding out your VL and LFT's, and whatever routine bloods they may draw ... it's very worth knowing! A draw is the ony way you will find out where you are at, and with good news coming your way, look forward to it! Tell the lab person about your woozy hx ahead of time, don't watch the draw, bring muzak and those ear buddy thingies and ask if you can plug in, just before they do the deed to try and distract yourself from the task. If they say no, no muzak/ear buds, well then, I suggest you plan to hum (in your head) the most unexpected off the wall tune you can can come up with ... like ... (sorry UK, nothing personal! you just happen to be kinda far removed from the situ, but, stiff upper and all that, so i picked you!) ... https://www.youtube.com/watch?v=l65_1S3qNBw .  I would be surprized if the labby would object to you bringing and playing some kind of muzak via ear buds, but if they did, then I might be tempted to hum (out loud) for them " Rule Britannia" for their benefit! wink

Yes, I would fast 12 hours - but do NOT fast the water, drink lots of water the night before (we assume you ARE already drinking lots of water anyway) - being fully tanked up on water the night before, and on the morning of a draw, will only help the draw go well/easier. Stay warm the morning of your draw, don't get stuck in some dreadful cold waiting room parked in front of a A/C and get chilled/cold before the draw, bring a jacket or sweater with you. Keep yourself comfortably warm for your draw. Most people miss having their morning tea or java, so, on my fasting blood work days, I usually treat myself to a couple mugs of hot steamy boiling water instead for the morning of the draw - better than nothing and (oddly) surprizingly comforting.

Glad you get your labs and your doc visit as well on Monday - I know you have questions for your doc re: your imaging - and we'll be waiting right here, for you to share what more you find out. Knowledge is power, having your actual imaging reports now and being able to read them yourself (versus carrying around "verbals" only in your head), helps to better clarify things, subtle diffences between words, (semantics) broken blood vessel in back (not really) - hemangioma is the correct name for what the radiologist is best-guessing he sees at your vertebrae, and hemangiomas happen (generally) to be notoriously benign things, so, all good to know. I am sure you are going to have a better opportunity to suss things more now with your doc on Mon. 

No one likes having to have a blood draw, but I sure learned to appreciate them (and what news and info they brought me as I went through my trial and beyond)! I am pretty good at them now, and they usually go fairly well, using all the self defense tactics I have learned to muster up along the way - even having to get a needle can  have it's bright side! You are about the witness some "epclusa power" !

Hey, are you a 3a or a 3b, do you know?

BTW - now that you have the actual fibroscan data, we could update your sig line - and show you are F3 only (not F4), being that your kPa's were at 11.1 (thus just another nice indicator showing you are not, according to kPa's, in the F4 cirrhotic range), unless of course you had other tests or other seperate blood tests which were supporting a possible F4 range, then you should include all results, by all testing methods - and, maybe we could squeeze it into your sig. line, add to the sig. line, (after the MRI bit) that the MRI also showed (aside from no cirrhosis) that there is likely no fatty liver as well (as was first suspected via your U/S).

I like your docs' thoughts/terminology ... "artifacts"! Could be! Could be just minor nuisance dinosaur dung, just what similar unexplainable kind of shat/abnomalities came (and went) in some of my imaging, of "perhaps" some upset "lymph gland something" cruising by in my imaging, then, a "perhaps" calcified granuloma thingy (which has not been seen for a while) ... hide and seek/history ... it could be same for you too. Try not to fret, you need more time/assessing for full info. Good you had the MRI WITH contrast, sometimes they can first do them without, so, you are ahead in info on the imaging front. I like the sounds of your doc BTW! I am interested if she thinks she IS going to send you to somebody else about the vertebral thing.

Keep us posted. Can't wait to hear your good news 4 week lab results! biggrin C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Hi JB,

I do recommend that you fast after midnight. My lab suggests 8-12 hours before the blood draw. Generally they allow you to take required medications with a sip of water, but anyone using insulin related (diabetic) medications should discuss that ahead of time. I imagine you’ll be having a liver profile, CBC and maybe a PCR at week 4. Long story short, yes, fast after midnight. When they do the blood draw, think about them sucking the life out of that Dragon, not you, lol! You’re proving to both you and that Dragon who’s in charge. This is the eviction notice, go into it with Sheriff Epclusa by your side! (Okay, corny, but you get my drift, lol)

Woohoo is right! One down and two to go. You’re on your way, Bro!



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Hey guys! I've got my 4-week appointment on Monday. Today was day 27 - woo hoo - 1/3 done.

Question... I'm getting blood work done. Do I need to fast? My doctor didn't tell me anything about not eating or drinking for xx hours before. My appointment is at 8:30am, so it isn't a huge deal since that is when I'm normally starting to wake up. But, I just want to be sure. I get woozy with blood work, so...

JB

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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, U/S showed some fatty liver, Fibroscan showed Fscore of 3, Tx 12 weeks Epclusa, SOT May 27 - EOT Aug 18. MRI Jun 12 showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm.

JB


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Thanks, Tig.

My appointment with the doctor is next Monday, the 25th. That's when I'll also get my 4-week blood work done as well.

I'll keep you posted.

JB

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39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, U/S showed some fatty liver, Fibroscan showed Fscore of 3, Tx 12 weeks Epclusa, SOT May 27 - EOT Aug 18. MRI Jun 12 showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm.

Tig


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Hi JB,

Glad the name change worked! 

Have you had the opportunity to talk about your results with your doctor? We’re not docs and aren’t able to interpret these reports. Sounds to me like they aren’t recommending anything except some repeat imaging in the near future. The radiologist will pass these results along to your liver specialist and you’ll be advised of the results and future tests. Anytime they recommend watching something in our livers, it’s important to do so. It can be nothing or something that needs to be investigated on a timely basis. This is why we all go through this stuff on a periodic basis and some of us will do it every 6 months for life. When do you get to speak with your doctor again? Let us know what his/her impression is.



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Tig

61 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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I received the official report of my MRI today and thought I'd share. Still pretty nervous about things. Glad there is no cirrhosis visible, but concerned about the other things. I don't know what much of this language even means, to be honest. 

Impression
1. No MRI evidence of cirrhotic hepatic morphology or sequela of portal
hypertension. Patent portal vein.
2. Query 1.4 x 0.6 cm arterial enhancing focus within the hepatic dome
versus volume averaging with the right hemidiaphragm; if a true lesion
this would be characterized as an LR-3. Recommend attention to this
finding on follow-up imaging within 3-6 months.
3. 1.5 cm vertebral body lesion at the thoracolumbar junction, likely
T11, as above. In the absence of a known malignancy, vertebral body
hemangioma favored. Attention on follow-up recommended.


PROCEDURE: MRI ABDOMEN WITH AND WITHOUT CONTRAST

HISTORY: Abnormal liver function tests. Chronic hepatitis C.

COMPARISON: None

TECHNIQUE: Multiplanar and multisequence magnetic resonance imaging of
the abdomen was performed both prior to and following the administration
of 13cc of MultiHance contrast. There were no reported immediate
complications.

FINDINGS:
Please note examination mildly limited secondary to patient respiratory
motion.

Lung bases are predominantly clear. Heart size normal, no pericardial
effusion. GE junction unremarkable.

MRI ABDOMEN WITHOUT CONTRAST:
No significant hepatic iron or lipid deposition.

MRI ABDOMEN WITH CONTRAST:
Liver normal in size/contour and homogeneous in enhancement. No evidence
of cirrhotic morphology. 1.4 x 0.6 cm focus of apparent arterial
enhancement within the hepatic dome image 8 series 10 is not identified
on any other sequence. Specifically, no evidence of washout or
associated T2 signal abnormality.

Hepatic veins, portal vein, SMV, and splenic vein are patent.

No intra-/extrahepatic bile duct dilation. Gallbladder unremarkable. No
wall thickening or gallbladder calculi.

Spleen normal in size and without suspicious focal lesions. Bilateral
adrenal glands normal.

Pancreas demonstrates preserved precontrast T1 signal intensity and
normal enhancement. No suspicious focal pancreatic lesions or pancreatic
ductal dilation.

The kidneys enhance symmetrically. No hydronephrosis, solid enhancing
renal lesions, or perinephric fluid collections. 6 mm cyst inferior pole
left kidney image 8 series 2 and image 26 series 3.

No abdominal aortic aneurysm. No ventral abdominal hernia. No free or
organized abdominal fluid collections. No pathologically enlarged
abdominal lymph nodes.

Imaged loops of abdominal large/small bowel are nonobstructed and
without wall thickening.

1.5 x 1.5 cm T2 hyperintense enhancing focus near the thoracolumbar
junction image 6 series 5 and image 6 series 2.



__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, U/S showed some fatty liver, Fibroscan showed Fscore of 3, Tx 12 weeks Epclusa, SOT May 27 - EOT Aug 18. MRI Jun 12 showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm.



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Some labs, depending (on where you are and where the lab is located), go by 8 OR 10 ng/mL - yep, yer AFP looks really good and low to me and lamassu, and as any kind of "marker" it is a handy, good "rough" guide to use, but it is not the "be all and end all", all of you is taken into account wholistically by your docs (from ALL of your labs/tests, to your imagings, to your physical exams with them). 

These labs tho always drive me batty, complicated language they use and tests to understand, and then they always seem to be changing things up or down too! Like the cut-offs and such! Calling sometthing one thing in one country and another in an other! Using dif measurements. sigh. But luckily, AFP levels and measurements are pretty universal - and a fairly useful tool at times too! wink C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hi JB1407,

Canuck posted as I was typing this. An AFP level of less than 10 ng/mL is normal for adults. An extremely high level of AFP in your blood: greater than 500 ng/mL could be a sign of liver tumors. So your AFP is great. Once the Hep C virus is cleared we have members who have seen their kPa decrease in 6 months as liver inflammation decreases and repair begins.

 



__________________

Male, 65, Dx 1990, GT 2a/2c. Pre-treatment VL 11,500,000, ALT 10, AST 18, Fibroscan F3, 12.4 kPa. Rx 12 weeks Epclusa, SOT Mar 8, 2018, EOT May 30, 2018. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18.

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