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Post Info TOPIC: Please someone answer my questions
britlitkaren


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RE: Please someone answer my questions
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God BJ! You're marevelous! I'm learning sooo much on this site n it gives me so much hope. Ok. Crying again. Nap time.

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Diag 8-10. 1st VL 600,000. Gen 1a. Grade 4 Stage 4 cirrhosis w/ Esophogeal varices level 2. Viral load 1,750,000 7/12/10. Triple Therapy w/ Telaprevir began 7-15-11
BJ


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Gidday Mate,

Exactly why your doctor has chosen one over the other is only one he can tell you.  It may be because there is a trial opening available or that he has links to the company, or perhaps simply because he believes it's better for you, you'll have to ask him to get a true answer.

From a treatment point of view both drugs are successfully coming up with excellent outcomes for people taking them, and while both attack the virus's life cycle, they do do that in slightly different ways.  Victrelis is otherwise a drug called boceprevir (Bocep.) and Incivek is otherwise called telaprevir (Telap.). 

I was happy to take Bocep. but developement was too slow and I needed to do tx as I WAS getting sicker every week, so I went ahead without it and ended up doing 72 weeks !!.  Bocep. has been very successful and has had great success.  Telap. was developed later than Bocep. by a matter of 6 months or so and both now have US FDA approval and both are protease inhibitors that disturb the HepC life-cycle in such a manner that it disables the virus.  The SOC drugs Interferon and Ribavirin need to be taken in concert with these protease inhibitors, whereby one disables the virus and the other makes sites that the virus would otherwise seek to settle in unsuitable for colonisation respectively.  I'm a Pathobiologist and have tried to make this as easy to understand as possible here, if you still have any difficulty let me know and I'll break it down a bit more.

Either way I believe you are in good hands, however, if you have any medical queries I firmly suggest you approach the physician who has suggested this path of treatment, and I'm sure he'll put you straight on why he has chosen one path over the other.  Remember, because one drug differs from what others are currently taking here means nothing, we have had members on here who flew through tx with Bocep and finished before 18 weeks and are still SVR.

Good luck with tx, not that you'll need it. Please talk to your doctor.

Cheers,

Brendan.

Please note:- I am a clinical microbiologist, not a doctor -  and you should only take this advice as that of a friend.  Always seek appropriate medical advise before making any decisions in regards to your actual tx.



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Geno 1b 72wk tx (Sept '09- Feb '11) Tx sucks, Sx's suck, but no one quits on my watch.   Pre-tx VL - 7.6 Million - Wk 4 - 480,000 - Wk 12 - 19,000....Wks 24, 36, 48 and 72 PCRs were all - negative :-))))Achieved SVR August 2011 

britlitkaren


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I can only tell you what my dr said. I was given the choice. The longer treatment (Bocevik?) has less side effects. They were going to write my script for it and I had a million questions since I had been to classes for Incivek. The transplants Dr's nurse oversees my tx. She talked to me for 15 min about that alone. She made me promise that no matter how bad my skin got that I would stay the course w Incivek. I cried in their office for the first time and made her look me in the eye. It felt like a like or death decision suddenly. (my alcoholic dad died from esophageal varices bleed out n I have varices also) She said, "If it were my body, I would feel equally confident in either choice." I'm wondering if perhaps there is a better outcome for 2nd time patients w Bocevik? I was also given the impression that Telaprevir was a once in a lifetime shot. Somebody else may have more exp or wisdom on this. All that said from emo girl who survived 2nd shot last night.. Lol - is to encourage you that it's a drug you can have confidence in. I'm happy for you to get a second chance. I tried to read an article for info but am pretty foggy. See if you find anything.. Lemmeno. Rxlist has some good trial outcome studies for 2nd time around. Stay cool, Karen

__________________
Diag 8-10. 1st VL 600,000. Gen 1a. Grade 4 Stage 4 cirrhosis w/ Esophogeal varices level 2. Viral load 1,750,000 7/12/10. Triple Therapy w/ Telaprevir began 7-15-11
jrc209


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My Dr told me i will be on victrelis and soc for up to24- 48ks!

Anyone have exp w/ victrelis? Why did he chose this over incivek?

 

30 yrs old   type 1a tumor marker 1.6 (normal) Vl 20 million  ultrasound norm  no symptoms

 

I asked him and all he said was "You will be using victrelis" However i read my odds are better w/ incivek



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Geno 1 A Started Tx 8-3-11, Viral Load  21.2 Million,  4 Week Lead of Soc ,9-1-11 <43 On Soc alone started victrelis 9-3 ,8 week pcr vL und.Week 12 Vl Und, Did Week 24 PCR Results UND @ Week 24!!! 1-11-12,End Of Tx 2-15-2012 !!
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