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Post Info TOPIC: SVR
Barbara Lee


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RE: SVR
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Thank you James. evileye



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I can do everything through HIM who gives me strength Phil 4:13

 Genotype 1a,(983,330- 7/26/11) (HCV not dectected on 4 week labs 10/24) started tx 9/23/11 Incivek, Riba & Pegasys.12/01/11 off all Hep C tx. VL as of 12/5 UND    UND on 4/5/12 labs!!!!!
James10500


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Sustained Virological Response

 

http://www.webmd.com/hepatitis/news/20070521/hepatitis-c-cures-now-common 
"Virus Wont Come Back 

Those treatments include a long-acting version of the drug interferon, known as pegylated interferon, and the antiviral drug ribavirin. 

The long-term follow-up study included 997 patients who achieved sustained virologic responses with pegylated interferon with or without ribavirin, meaning they had no evidence of the virus in their blood six months after treatment. 

All but eight of the patients were still free of the virus an average of four years after treatment. Some patients were followed for as long as seven years. 

Two of the eight patients showed evidence of a second HCV infection, and it was not clear if the remaining five relapsed or were reinfected. 

Virginia Commonwealth University Medical Center chief of hepatology Mitchell Shiffman, MD, presented the follow-up data Monday in Washington at Digestive Disease Week, an annual meeting of liver and gastric disease specialists from around the world. 

When we achieve sustained virologic responses, less than 1% of patients will get the virus back, he tells WebMD. We know the virus will not come back in a year or two or three. These patients are cured." 



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Diagnosed 4/13/10; Started Tx 8/13/10; SVR 7/27/11
Barbara Lee


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What does S V R stand for???? 



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I can do everything through HIM who gives me strength Phil 4:13

 Genotype 1a,(983,330- 7/26/11) (HCV not dectected on 4 week labs 10/24) started tx 9/23/11 Incivek, Riba & Pegasys.12/01/11 off all Hep C tx. VL as of 12/5 UND    UND on 4/5/12 labs!!!!!
Mano


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congratulations mate. im really happy for ya. and thanks for ur support too.

u made it :)



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29 co-infectedVL (28Feb)=140.000 / genotype 4/ fibroscan 6.2 / acute phase infected less 6 months
started 24 weeks treatment 180mg pegasys + 1000 riba 11th March 2011. UND at week 3
BJ


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Gidday James,

Don't know how I missed this, the 28th was my birthday so I was probably half cut blowing a million candles out and passing out:)  You've done really well mate and deserve this result full-on.  It's never easy doing tx and particularly now the "old" double combination tx in comparison to these new combination tx that are all the go now.

Like me you dragged out the days and weeks into the many months that tx is, and regardless of who did it the longest, we all get tested to the limit and you stood strong and defiant and won out against one of the most stubborn viruses going around these days.

You achieved UND much quicker than I did, and I am not normally as confident as I am in people overcoming stubborn viruses, as I am for you and I.  Overcoming the HepC virus in the manner that you and I have, was not only overcome by medication alone, but also required an amnestic response from our own immune systems to build a memory, to complement the meds and completely lay the virus dead in the aisle.

It is commonly understood amongst immunologists that the virus will not return unless people that have beaten it return to previous habits of excessive drug and alcohol abuse that also usually includes high risk activity. In the study by Shiffman I believe it was, at least two of those that tested positive two years after attaining SVR had returned to high risk heroin use.

I use to drink an awful lot of alcohol, and actually did right up to starting tx, probably because I was **** scared.  Now after doing the biopsy I admit I really regretted the final binge I had prior to starting tx, wondering how much that had affected my ability to fight he virus in say the first 12 weeks of tx.  Now that tx is over and I also have attained SVR now (you beat me by more than a week, but I was always fussy:) I did have a couple of beers with my birthday celebratory meal and some beautiful red wine with the meal, and this weekend I've probably had 1/2 dozen cans of mid strength beer in celebratory drinks folowing my SVR last Friday just gone (5th).  I don't intend to drink alcohol anything like I use to, and doubt if I'll even contemplate drinking spirits ever again, however I do intend to appreciate the odd bottle of fine red wine and probably one or two beers on Friday with the staff as is the norm.

I don't feel tempted to drink anything at all and certainly won't be making a habit of doing anything on a weekly "must-do" type of thing to be quite honest.  I've spoken to my gastro mate and he reckons that won't make any difference providing I don't slide down to my old bottle of whisky a day type of thing, which sadly was not uncommon in my not so long ago past.

I guess I am writing this to you because first of all because I was worried I hadn't seen your SVR announcement and wondered when it would be.  The second reason is because of the way you reacted to the brainless "I do hope it continues......" comment. Apart from the drugs, your body has mounted an amnestic response to the virus and should you be confronted with any residual virus antigen hidden away somewhere, that same response would clean it up.  So to the "I hope it continues" yes it will, but that response is only really guarenteed against the genotype "mixture" that brewed within your body, but doesn;t afford you immunity against catching HepC from someone else later down the track.  In regards to the "......." bit of the same comment I'd say try it and find out.

Don't worry about beating the virus for one day mate, if you behave yourself and I'm sure you will, you stand a far better chance of that than me and I'm never catching anything like that again.

Revel in the fact that you sir, have defeated HepC.  Keep your nose clean up in those beautiful mountains you lucky bastard and you'll be screaming down the black runs for many a year to come. 

Well done mate, we've got to get together sometime (not on ski's my knees are shot) and share a nice beer over a barbie somewhere.

Cheers,

Brendan.



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Geno 1b 72wk tx (Sept '09- Feb '11) Tx sucks, Sx's suck, but no one quits on my watch.   Pre-tx VL - 7.6 Million - Wk 4 - 480,000 - Wk 12 - 19,000....Wks 24, 36, 48 and 72 PCRs were all - negative :-))))Achieved SVR August 2011 

Mashar


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Congratulations James!  Wow your news is great and puts me in a happy mood.  The wait must have been hard but now it was so worth it. biggrin  May each day in life just get better.

hugs,

Mary



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Geno 3a, started 24wk tx 2/24  und @ 8 wks ended up doing 32 wks but 6 mo pcr UNDETECTED :D

A positive attitude can go a long way!
zebb37


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fantastic news, well done! biggrin



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morgan


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James

thats great news mine 6 months is not till the end of nov,it must be a great feeling i cant wait to here that news myself so happy for you,keep doing the good work you do here you help me a lot during tx all the best.

 

                                                             Morganbiggrin



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Hep Me


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I know I already gave you congrats in a PM James, but was reading the posts and just had to say it again.
Thanks for posting that info explaining SVR by the way, I knew the signifigance of it but never have read that before. Printed it out for a friend waiting to start tx in a few months.

As always, take care.
Randy



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"Ah but I was so much older then, I'm younger than that now."  Bob Dylan
BeccaJune


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 James,

You are a hero to those of us that are just beginning this journey, and an example that it can be done.  I am so happy for you.  You have been given a new chance at a long healthy life.  Nothing to do now but make the most of every glorious day! 

Love and peace to you,

Becca



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Diagnosed Dec. 2008. Genotype 1b, enlarged liver.  Started triple tx with Incivek on August 12, 2011.
jrc209


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Congrats man you have been a big help for me just in the few times we spoke



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Geno 1 A Started Tx 8-3-11, Viral Load  21.2 Million,  4 Week Lead of Soc ,9-1-11 <43 On Soc alone started victrelis 9-3 ,8 week pcr vL und.Week 12 Vl Und, Did Week 24 PCR Results UND @ Week 24!!! 1-11-12,End Of Tx 2-15-2012 !!
Cinnamon Girl


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Congrats again James, you are a Hero and a Champion!!   winner.gif

You have always been a rock for a lot of us who went thro` tx with you, we all know how difficult it got at times but I don`t think you ever complained, always looking out for others. 

Wishing you a very healthy and happy life, get out there and LIVE  life to the full!  smilesmilesmilesmile

So very happy for you.  smilesmile

Lots love, Jill xxx



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Minerva


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Congrats again James!!  smile  Always great news and i'm happy to hear this.

All the best!!

Hugs

Heather xxx



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Finished TX 2005. Geno 3. Achieved SVR - Heather.

When You Are Up To Your Neck In It - Keep Your Chin Up!!

'Knowledge. Is knowing that a tomato is a fruit. Wisdom is not using it in a fruit salad'. My dad. X.
britlitkaren


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I'm all emo and I don't even know you. But I'm having a grateful out loud crying jag. Thank God you DID it! I didn't know the bit about VCU. They don't know you either, all those men n women who stubbornly sat in their laboratories day after day. I thank them too. You've got ur life back buddy. Go enjoy it with all the passion and zeal of one who has been set free. If you were here I'd give you a big hug and then hop around shouting. Congratulations James!!!! You did it!!!

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Diag 8-10. 1st VL 600,000. Gen 1a. Grade 4 Stage 4 cirrhosis w/ Esophogeal varices level 2. Viral load 1,750,000 7/12/10. Triple Therapy w/ Telaprevir began 7-15-11
dragonfly


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So very happy for you.  You fought a tough one. Dragonflyx



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PJ


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FANTASTIC news James!!! You are a warrior and you WON :))))))

Hugs, PJ

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Diagnosed in 2006. Probably infected in the late 70s or early 80s. Genotype 1B. Starting TX on 5/5/11 with the SOC and Teleprevir. 
Gnome gardener


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James, I am so very happy for you...yes, treatment is tough and this is wonderful news! Forget about hcv and enjoy every second of your new life. Hugs, J.

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Genotype 1b. Diagnosed in 1991. Stage 2 biopsy. Started treatment end of August 2010. Interferon 180 and Riba 1200/day. VL of 4,000,000 before treatment.UND since week 4 PCR. Did 44 weeks. Still UND 7 weeks after end of treatment.
greenqueen


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That's great news, James! smile :party

Wishing you a very happy and healthy future

Love Steff xx



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Geno 3a. 24 wks tx 20/10/05 - 06/04/06. Achieved SVR.
jan


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Great news to start the day with.  FANTASTIC.  Enjoy the rest of your life and put all this to the back of your mind.  YOU DID IT. X

Jan x



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James10500


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Iris saying "I hope it continues" makes a person consider whether it will our not. I REALLY don't mean to give you grief but you have to consider that this is the time for me to stop thinking about HCV. We all know that there is a very small chance that I won't continue to be UND. But do you think I want to think about that now ?

I don't want to be harsh, but next time someone in the forum SVRs just say congrats.

Have a good night,


James




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Diagnosed 4/13/10; Started Tx 8/13/10; SVR 7/27/11
Iris Dragonfly


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dearest James I am sad that you don't accept my well wishes, where did I doubt you? I simply wished that this will continue for you, and I still do. I'm sure that you went thru hell... why do you think I am scared to death to try? SVR means you are sustained, does that not mean you continue to be undetectable?  Honestly dear your breaking my heart,  I wish nothing but the very best for you. I just wanted to be happy for you as well, even though I wasn't here for your ordeal, please don't let whatever you don't like about me get in the way of well wishes. Do enjoy your good news, if I were you I'd be at the top of one of those gorgeous Rocky Mt's, screaming F-YES I did It.                                    Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)
James10500


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Thanks Beth, couldn't have done it w/o you !!!

 

xoxox

James



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Diagnosed 4/13/10; Started Tx 8/13/10; SVR 7/27/11
bethland


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Awesome James we did it .......yep it was dam hard ..far as i am concerned we are winners and are cured ..You have been a wonderful anchor on this board and a great help to me ..love ya to bits dont let anyone bring you down...Elizabeth smile.gif



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48 wks tx..23 feb 2010..vl 7 million/no scarring/Genotype 1
Detected@wk12(15 copies)UND@wk24UND@wk36..UND@wk48..Finished tx Jan 18th 2011..SVR JULY 2011

from the dark end of the street.........to the bright side of the road............
James10500


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Iris,

I really do not appreciate you raising doubt as to whether I'm cured of Hep C. I just went through the worst 15 months of my life, and I can't even enjoy the fact I achieved SVR for one day without you raising doubt !




-- Edited by James10500 on Friday 29th of July 2011 03:35:55 AM

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Diagnosed 4/13/10; Started Tx 8/13/10; SVR 7/27/11
James10500


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Evidence for a Cure In order for a sustained viral response to be called a cure, the inability to detect Hepatitis C six months after treatment completion must be permanent. Unfortunately, only time and repeated testing can confirm the permanence of viral absence. Hope for pegylated interferon and ribavirin therapy representing a Hepatitis C cure took root in the Spring of 2007. In a study led by Mitchell Shiffman, M.D., professor in the Virginia Commonwealth University (VCU) School of Medicine, and chief of Hepatology and medical director of the Liver Transplant Program at the VCU Medical Center, nearly 1,000 patients were followed for up to seven years after they achieved a sustained viral response. Their results were the most encouraging thus far that Hepatitis C is curable. According to Shiffman, "The use of peg-interferon alone, or in combination with ribavirin, points to a cure for Hepatitis C. This paper strongly suggests, for the first time, that Hepatitis C is a curable disease. After treatment, 99.6 % of the patients remained virus undetectable for over five years." In Schiffman's study, eight patients who achieved sustained viral response tested positive for Hepatitis C at an average of two years following treatment completion. However, it is unknown why this occurred.

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Diagnosed 4/13/10; Started Tx 8/13/10; SVR 7/27/11
James10500


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Iris do you know what SVR means ? No trying to be a jerk, just trying to help you understand what it is.


James

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Diagnosed 4/13/10; Started Tx 8/13/10; SVR 7/27/11
Iris Dragonfly


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Good news James, I do hope it continues....  Blessings, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)
ty


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     Congratulations again James!  You alsohave been a huge support to me through tx and the waiting afterwards.  No, it isn't any fun but you made it through.  Like you, I'm pulling for Greg and Dee to get the new stuff and beat this dragon as well.  Take care buddy, tysmile



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Genotype 2 - 24 week Tx - Start 10-8-2010 - 4 week PCR test UND, 12 week PCR test UND, 24 week PCR UND,  SVR Oct. 11 
Greg


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Hi James,

Congratulations mate well done, I'm so happy for you, now get on that bike and ride like the wind.
All the very best,
Greg and Cate



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The mind is like a parachute it works best when it is open. "The Dalai Lama" My blog: http://greghcv.wordpress.com/
Genotype 1a, started tx 1st Feb 2011, for 48 wks. Week 24 PCR 26/07/11 Non-Responder
New TX start date 12th Sept 2016 Harvoni x24 weeks.  VL 7.4 Mil. Week 4 "Undetected"
tobytucker


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Congratulations!!!! I am so happy for you!

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James10500


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I SVR'd this week...... To those on tx, it was tough, I hated tx ! But you can do it, and it's all worth it ! To those who were taken off tx Greg, and Dee you are the true heroes. The ones who are going to get up off the mat, take IP's and win ! Thanks to everyone here for your help, support, and understanding. I could not have done it without YOU ! Bless you all, James

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Diagnosed 4/13/10; Started Tx 8/13/10; SVR 7/27/11
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