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Hep C Discussion Forum -> General Discussion -> IL28B genotypes CC, CT or TT
Post Info TOPIC: IL28B genotypes CC, CT or TT
BeccaJune


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RE: IL28B genotypes CC, CT or TT
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Well, I guess if I had just waited until I finished all my googling, I would have found the answer.  It looks as though getting this test could help determine the success rate and length of tx in the future.

http://www.nature.com/ajg/journal/v106/n7/full/ajg201182a.html



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Diagnosed Dec. 2008. Genotype 1b, enlarged liver.  Started triple tx with Incivek on August 12, 2011.
BeccaJune


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I found this from another post by Lizard:

the CC allele is found when they do the IL28B test - it is part of your own personal genetic makeup, not the virus. It is an allele on (or near?) the genes we have that deal with our own interferon production (I think, please correct me if I'm wrong). At first it was believed that people with the CC allele's bodies handled HCV better, and they respond better to INF tx, which may explain why some achieve SVR and some don't. The TT allele did the worst and the CT allele did OK. But of course more studies are giving us more information. If you can get the test done, I would recommend it - knowledge is power, and may help decide what course of treatment to do.



__________________

Diagnosed Dec. 2008. Genotype 1b, enlarged liver.  Started triple tx with Incivek on August 12, 2011.
BeccaJune


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Posts: 371
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Has anyone been tested to see what IL28B genotype (CC, CT or TT) you belong to?  It seems this is a fairly new test only performed by some labs.  I see there is a new clinical trial to see if 12 weeks of total triple tx with Incivek will cure those with the CC type.  

Does anyone know if these all in the Genotype 1a or 1b family?

 

http://investors.vrtx.com/releasedetail.cfm?ReleaseID=617274

 



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Diagnosed Dec. 2008. Genotype 1b, enlarged liver.  Started triple tx with Incivek on August 12, 2011.
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