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Post Info TOPIC: Allele
BeccaJune


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Allele
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I'll see if I can find what I had read before.  I had also mentioned it to my Gastro dr. and he had just been to a conference where they talked about it. He was very encouraged and they were convienced that there is something to it.

 I think it is called a IL-28B genotype status test.

 

 http://hepatitiscresearchandnewsupdates.blogspot.com/2012/01/il28b-genetic-polymorphism-testing-in.html

 

This is a pretty good (and long) article:

 

 



-- Edited by BeccaJune on Friday 20th of January 2012 11:13:21 PM

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Diagnosed Dec. 2008. Genotype 1b, enlarged liver.  Started triple tx with Incivek on August 12, 2011.
peanutbutter


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Thanks for posting that I never heard of that before. Interesting stuff. Science is ridiculous, in a good way. God bless Mike

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Diagnosed in 2008. Geno 1a. 6 month treatment of Incivek. UND at 4 weeks, and have remained that way as of 2 months POST treatment.
Cinnamon Girl


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Yes Becca I`m sure I`ve read that too, somewhere! 

Iris, there`s a bit about the test in the link I gave you - scroll down to `Testing for IL-28B`.  By the sounds of it, the test is still very expensive so not covered by most insurance companies, and therefore not widely used at present.  Who knows what the future may bring though? 

Love, Jill xx

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Iris Dragonfly


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Is there a specefic test to find this, or can they tell from the genotype (genome?)   ?????



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)
BeccaJune


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I have read that if you are CC type that your chances of successful tx are greatly increased.  If I remember correctly, they are doing clinical trials on CC types to see if 12 weeks total treatment with Incivek will cure the Hep C.  Things are looking promising because it may now be possible to customized based on your CC, CT, or TT type.

It could make a difference to some people as to whether they decide to treat or not based on the length of tx and their chances of success !  I know I read about this on the internet somewhere.



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Diagnosed Dec. 2008. Genotype 1b, enlarged liver.  Started triple tx with Incivek on August 12, 2011.
Cinnamon Girl


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Hi Iris, it refers to person`s genetic make-up, rather than that of the Hep C virus, and can be an indication of how well someone will respond to tx.

Here`s a link that explains it, scroll down to the section headed `IL-28B Genotypes` -

http://www.hepatitis-central.com/mt/archives/2010/12/differentiating.html

Hope that helps!

Take care, love from Jill xx

 



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Iris Dragonfly


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anybody?



__________________

in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)
Iris Dragonfly


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 Allele,....I have heard this term around here, (TT,CC etc.) what does it tell you?? and does it have anything to do with genome type?? How does this knowledge empower you or the dr.?  signed, curious george

PS. layman's terms pleaseevileye



__________________

in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)
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