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Post Info TOPIC: why do some cirrhotic develop Dupuytren's contractures


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RE: why do some cirrhotic develop Dupuytren's contractures
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Hi Karen ,sorry about your foot.  My hand is not in pain in the effected areas Its always something. Looks like there are alot of us waiting for a different tx. Good luck and take good care of your self.  Michaele



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MDodrow


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Hi Michaele..this is an interesting post.

Last Sunday I was having dinner w/a friend, felt a sharp pain in my foot...looked down and had a knot in the bottom of my rt foot.  Since this time-I am unable to walk on the foot w/o pain.  Had an MRI and it looks like I have something similar only in my foot not hand...I thought it might be an age thing....crazy!!!

PS...I have not done tx as of yet-not sure when or if...and am delighted that I am still welcomed to this forum;)



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Geno Type A1- VL 16.2m - F1-F2 Moderate Fibrosis - Started treatment 4/16/13 Sofosbuvir/Ledipasvir 6 months -  UND week 4 (5/14/13) - EOT 10/1/13 - 12wk blood draw 12/20/13 UND - 24wk/final blood draw March 2014



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Hi  Jill, thanks for kind words. I'll have to live carefully and wait for an all oral Tx without interferon. Hope your doing well.  Michaele



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MDodrow


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Hi Michaele, please don`t feel bad about putting tx on hold for now, you`re right, it has to be your decision and if the time`s not right for you then you`re doing the best thing.   Don`t forget you`re still welcome here any time at all, this forum is for everyone effected by HCV, not just people doing tx, and it`s nice to have you around.

Sorry you`ve got another health problem to cope with now, hope you can get it sorted out. 

Keep us posted, take care, Jill  smile xx



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Jill 

(70 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Hi Michaele, you are correct, there is an increased incidence of Dupuytren's contracture in cirrhosis. However, not all patients with Dupuy. have cirrhosis, and only about 10% of cirrhotics develop Dupuy. The cause for this relationship is unknown. Liver fibrosis is a direct result of cytokines stimulating stellate cells to produce collagen (that leads to fibrosis) , so there is no association with the palmar fibrosis of Dupuy. Severe Dupuy. can be treated with surgery or radiotherapy. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Hi all, I feel like a deserter for not doing the Tx with all of you , but sometimes ya got to go with your gut, and the labs, too. I noticed some areas in my left palm that look callous. And also a small area on underside of finger. Well, it appears it may be Dupuytren's disease which can cause contracture of fingers. Ive just read there is a correlation between Dupuytrens and cirrhosis. But They dont know what causes it and it is benign except for the contractures. The contractures are caused by fibrotic cords that develop under the skin. So cirrhosis causes fibrosis of  the liver and the development of these cords in the hands. Does that mean if they figure out how to stop the cord growth in the hand they could figure out how to stop/ slow  it in the liver?   Hope your all safe and dry, and feeling as well as can be expected. Maybe Im a dreamer   Michaele



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MDodrow
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