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Post Info TOPIC: Does VL tests pick up mutations?


Guru

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Does VL tests pick up mutations?
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Just a quick one. I've been asked a few times about whether mutations will show up in our VL tests.  The answer is 'YES' , for all Roche PCR tests. The 'target' used is a stable strand of RNA transcripted to DNA , present in all genotypes and in all viral mutations.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm

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