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Hep C Discussion Forum -> General Discussion -> if i failed on
Post Info TOPIC: if i failed on
mallani


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RE: if i failed on
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Hi Kathy, if you have failed treatment with the first generation protease inhibitors (PI's), you will had great trouble being accepted for a trial. Any trial using a second generation PI has previous Rx with Incivek or Victrelis listed as an exclusion. This is because of resistant mutations (RAV's). The only significant trial that does not use a PI is Gilead's (NS-5A and NS-5B blockers). Although this is a worldwide trial, places are very limited.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
TazKat


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thanks teddytrout.. love the little pic.. lol  i will try not to give up. am at stage 3 flirting with 4 as of 4 yrs ago. i hate the interferon & riba.l. just hate it!!!  i reeally don't know if nurse pract from that office would even prescribe me anything. she became a bitch.. :)



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TazKat Genotype 1A null responder x 3 riba & iterferon twice, relapsed from Incivek 2012 with only 12 weeks left to do. stage 4 mild cirrhosis 4/25/2014/ started sovaldi riba & interferon.. finished treatment 7/17/14  results 7/25  cleared..

 

 
TeddyTrout


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They are developing many new treatments and other protease inhibitors that attack this virus. They are developing treatments with out use interferon or ribavin . I wouldn't be to concerned at this point about it. You may be very receptive to the P.I. but a non-responder to interferon. So try not to put the cart before the horse, I would stay well focused in on how well this new treatment is going to be and keep a positive outlook going forward. Don't sweat the small stuff as it only leads to hair loss. Cheers

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Don't sweat the small stuff, it will only give you hair loss.
TazKat


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the protease inhibitor after 32 weeks of  triple/combo treatment can i never ever do the protease inibitor ever again? if not what pipeline drugs do i need to track. i have been on riba/interferon twice & the the interferon/riba/incivik once.. lots of toxic crap put in my body.. thanks for any in\fo..



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TazKat Genotype 1A null responder x 3 riba & iterferon twice, relapsed from Incivek 2012 with only 12 weeks left to do. stage 4 mild cirrhosis 4/25/2014/ started sovaldi riba & interferon.. finished treatment 7/17/14  results 7/25  cleared..

 

 
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