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Post Info TOPIC: Hello
mallani


Guru

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RE: Hello
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Hi tsq,

Sorry your original post was interrupted by that troll!

I'll give you a link to the Gilead trial using sofosbuvir + Ribavirin in Rx experienced Geno 3's. As you see, the SVR rate is 61%. This may improve in further Trials using a longer Rx duration ( from 12 to 16 weeks).

It's up to you but if I had little response to previous Peg and Riba, I wouldn't do it again.

I haven't seen any other trials for Geno 3's but these may be announced. As Geno 1's are most common, they seem to get most attention.

 

http://hcvadvocate.blogspot.ca/2012/11/gilead-announces-sustained-virologic.html



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
tsg


Newbie

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Thanks everyone for your replies. DJ, I hope all goes well for you. It sounds like you are off to a good start. I just checked trials for 7977 with riba and or interferon, as well as combinations of other drugs being tested such as 5885. Only trials for 2/3s nulls, partials and relapsers is in Europe. All else geno 1. I don't know if anything else will come up. Abbott doesn't have anything for experienced 3s either. If anyone has any info on this please advise me. I am from Chicago and I am willing to travel 8 hours one way. I am trying to have a positive attitude, but I am struggling. I have been extremely depressed the past few days. I just need to fake it till I make it. I also need to remind myself that things could be much worse. I might be feeling like this due to the anxiety of upcoming tx. Thanks for letting me whine. I feel better already. It is nice to know that you all get it. Hard to explain these feelings to others who have not walked down this path. Mallani, you are quite the detective :). Wishing well to all, Tsg

__________________

Geno 3a April - July 2011 null-responder stopped tx after 14 weeks

April 4, 2014 began 2nd tx with Ribavirin/pegintron 

My plan this time is to just shove the sword down the dragons throat!

tsg
mallani


Guru

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Posts: 3398
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Carver6,

Your IP address shows you are from Pakistan. If you are going to pretend to be Australian, learn to spell 'Sydney'. Your IP is also on the banned list with APEWS. Please go away.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Cinnamon Girl


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Carver6 wrote:

Hey Guys my name is Carver.I am a newly join person on this forum.I search this forum through search engine.I am living in Australia.My hobby is playing snooker,riding bikes and also help poor and needy person.I shall do my best to participate in this forum for like a human.good luck!!

 Hi Carver, do you have Hep C yourself?  Do please feel free to give us some more details!  ~ Jill



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
DJ


Senior Member

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Posts: 306
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I am so sorry things did not work last time.  I am also Genotype 3 and just started last week with 1200 daily of Ribasphere (ribavirin) and Pegatron.  So far very few side effects for me (but it has only been 1 weekon Ribasphere and only 1 injection of Pegatron).  I hope all goes well.  I am glad to hear there are trials going on for Genotype 3.  Seems like everything is for Genotype 1. 



__________________

Genotype 3.  Treatment started on 1/11/2013 with Ribavirin and Pegatron.  Week 4 UND.  Week 12 UND.  Ended treatment on 6/28/2013.  Six months post treatment 12/04/2013 SVR.
Carver6


Newbie

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Posts: 2
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Hey Guys my name is Carver.I am a newly join person on this forum.I search this forum through search engine.I am living in Australia.My hobby is playing snooker,riding bikes and also help poor and needy person.I shall do my best to participate in this forum for like a human.good luck!!


__________________

We should learn from our mistakes and we should not commit the same mistake
JoAnneh


Guru

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Posts: 1077
Date:
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I second BiggyB's response.
Yet, some will and have made it.
Glad u found the forum. It's full
Of great info and support.

__________________

JoAnne

Genotype 1a, Triple therapy w/Invicek started May 19, 2012

DET 4 wk. UND 2,6,12,24 48 treatment. Achieved SVR 2013!
Biggyb


Guru

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Posts: 820
Date:
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Good luck TSG, we are all just rollin the dice here. Some make it some don't. I have lost the roll twice before. Hoping this time for a winning roll.



__________________

58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~
tsg


Newbie

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Posts: 4
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Hello everyone,

I am a geno 3 nullresponder.  I was taken off tx after 14 weeks.  I did not even have a 1 log drop.  I kinda ran away and stuck my head in the sand for over a year.  I was very bitter and knew there was nothing new available to retreat so I decided for my own mental health that I needed to distance myself.  So, basically, I just acted like I didn't have it.  I got my head together, brushed myself off and so I begin this journey again. 

I began seeing a new gi doctor and had a biopsy.  I felt like it was the time and I really needed to know what my liver condition was.  I am stage 3, grade 2.  Scares the crap out of me.  I think I picked it up in the mid 80s.  I am trying to get myself strong and ready for the next go around with the dragon.  I am still feeling some of the effects of the interferon.  I have never quite been the same since tx.  I go back to my doctor the end of January.  He is going to try to get me into a trial.  Phase 3 sofosbuvir with and without other DAA trials for geno 3 nullresponders, partials and relapsers are suppose to begin in March from what I have read. Unsure.  I am hoping for a trial, however, my doctor and I are ready to go back on SOC.  I will be going on 1200 Riba this time and change the interferon (last time I was on Pegasys, putting me on pegintron.}  I feel like it is a shot in the dark at this point to clear this, but it is better than doing nothing right now.  Crazier things have happened, right?  There is a chance that I can clear the virus on SOC and I am willing to roll the dice.  I am looking forward to a hepc free life  smile.

Thanks,

 

tsg



__________________

Geno 3a April - July 2011 null-responder stopped tx after 14 weeks

April 4, 2014 began 2nd tx with Ribavirin/pegintron 

My plan this time is to just shove the sword down the dragons throat!

tsg
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