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Post Info TOPIC: I need your advice
nym


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RE: I need your advice
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Thanks,Zlikster & greenqueen for your advice.



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Zlikster


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Well, Malcolm (Mallani) can get you best advice, since he has most experience in the medical field

In my personal opinion,i would opt in for clinical trial (it's short, compared to 1year of normal interferon based therapy)....and if you do not respond to it, you can awalys opt in for traditional therapy. Of course before any clinical trial or standard therapy u will have to redo Fibrosure (if u plan to avoid biopsy).

best



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
nym


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Thanks ,Zlister & Mallani.



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nym


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Thanks,Zaklister.

Clinical trial with Abbot for 3 months.

They will give you 1. HCV protease inhibitor +ritonavir+HCV NS5A inhibitor.( comes in one pill)

                          2.HCV polymerase inhibitor

                          3.rivavirin

 

I can take part in another trial from other company.P' sceening is over for this trial.

I did fibrosure( first & last) in 2006 & found to be normal.Biosy never done before.

I was about to participate in trial & my friend told me to think about standard treatment.

 

 



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mallani


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I've moved this to New Members section.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Zlikster


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for GT 1 as i know, dual therapy (PegInterferon+Ribavirin) SVR rate 50-60%, triple therapy (PegInterferon+Ribavirin+DAA like Telaprevir) 70-80%

Some people on this forum passed clinical trials (Gilead's GS-7977) and achieved SVR.

Have you done any liver tests other than blood liver enzyme levels? biopsy, Fibroscan or Fibrotest?

New meds without Interferon are couple of years before FDA approval (hence clinical trials), if your liver is healthy and you feel no symptoms from hep c, you could wait for few years with some diet restrictions...

me personally would opt in in case of several particular DAA meds that are in clinical trials phase 3 now





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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
Zlikster


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Do you have more information on what pharma is behing clinical trial and what medicine are they testing?

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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
nym


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One more question.What is the cure rate of inj interferon (what percentage?)for genotype 1
(? 1C)

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nym


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I was dignosed with hep c in 2004 on routine lab test.Genotype 1.Never took treatment before.My liver function test 9 months ago was normal.My hepatologist advised to take part in clinical trial of 3months.One of my friends,a dr. who is practising here advised me to take standard treatment with interferon & rivabirin.Should i participate in clinical trial or take standard treatment for 1 year?

 

 

 

 



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greenqueen


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Hi nym,

Since it's been 6 years since your fibrosure test, you could do with a more up to date test to assess the condition of your liver. As for any decisions about clinical trials versus SOC treatment, I would advise you to make yourself as fully informed as possible and get your liver condition checked out first. Have a chat with your Hepatologist and ask for another fibrosure or a biopsy.

There is a lot of info in the Knowledge Base and you can also use the search box at the top of the page for any specific info. Please be aware we are not a medical forum and can only offer opinions.

All the best

Steff xx



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Geno 3a. 24 wks tx 20/10/05 - 06/04/06. Achieved SVR.
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