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Post Info TOPIC: New Drugs Pipeline, overview from the Hep C Trust


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RE: New Drugs Pipeline, overview from the Hep C Trust
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I think that 3s may not escape interferon altogether, but on the upside, reducing treatment to 12 weeks is a blessing compared with 24 weeks. To compete with the huge competition that is arising, they will all work harder and faster to find better cures. Prices will reduce fast to get their drugs out there. I think these drugs will be wide spread before it is anticipated. 

It is always horrible and makes your heart sink when you read things are not as good as you hoped, but we all have that, hope. I am sorry for people that are so far progressed that they are sitting on a time bomb, it can happen to anyone of us that are currently not cured. But I do believe that the future is bright and at least there is something out there that is coming our way.....

 



__________________

Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 



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Hi Mena, it is not this reason like you said the drug dosage is adjusted to be more beneficial for 1b. My Dr. told me they treat all Hep c patients  by taking the twice daily dosing schedule with inviek only because it is easier to manage and less fat 
Keep fighting
 
hepCFREEwanab wrote:

Hi Lucy, just noticed that you are also Genotype 1b like my husband.  I remember the day the Dr. told us about 1b, I asked "Would that  make any difference in the treatment?"  He said " Yes, the drug dosage is adjusted to be more beneficial for the patient"!

Mena


 



-- Edited by lucy on Sunday 14th of July 2013 06:15:20 PM

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 1b, start triple treatment(incivek) on Feb 5, 2013.  UND@ 4,12,24 wks. EOT Aug 6, 2013



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Hi Lucy, just noticed that you are also Genotype 1b like my husband.  I remember the day the Dr. told us about being 1b, I asked "Would that  make any difference in the treatment?"  He said " Yes, the drug dosage is adjusted to be more beneficial for the patient"!

Mena



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Genotype 1b, V/L  0! Finally got rid of the Dragon after 24 wks. of Harvoni.

EOT 5/10/15   - 4 wks. UND, 12 wks UND, 24 wks. UND!!! 



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I took the twice daily dosing schedule with incivek and it does work well for me. I`m sure it makes things a lot easier. I need not having to eat so much fat, and also there are less pills to remember to take!

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 1b, start triple treatment(incivek) on Feb 5, 2013.  UND@ 4,12,24 wks. EOT Aug 6, 2013



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I doubt Gilead can overprice Sofosbuvir like that, cause other DAAs are pretty close in PhaseIII now. AbbVie's DAA combo got "breakthru" category from FDA rite? only hope, price wise, that competition will do it's job. 250k for Sofosbuvir, while the chemist behind it;s inventions is out of work? i hate this world ;-(



__________________

GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!




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I didn't notice much from having to eliminate the extra 20 gms of fat a day. To me it was more natural to take around the times I would be eating my usual meals anyway. I posted some information here in response to one of Kellies post before that said the duration not the dosage was more important.  I lost weight during Incivek anyway. About 20lbs.

 

I enjoyed seeing all the new drugs in the pipeline. Lots of them I have read about but the combinations were interesting. I myself hope some of the ones with less sx are not looked over by some insurance company's and country's with national healthcare programs to save cost. Generally there are lots of people who can't miss work due to sx and their out of pocket cost would be more if they did. 

 



__________________

GT 1a Started triple tx with Incivek, Pegasys, and Riba 2-6-2013. UND at 4,6,12,23,& 24 wks EOT 7-26-2013. Probably had Hep C for 20-30 years. Don't really know when I got it.



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I didn't mean to give the wrong impression, as the new DAA's show how Medical Research has reached fantastic levels.

My concern is the exorbitant cost. African and Asian countries have huge reservoirs of HCV but will never see these drugs.

Karen, HIV was completely different. The Medical Profession was united, they had a huge lobby group, Governments were pressured to fund, and HIV drugs were relatively inexpensive. There is still apathy in the Medical profession towards HepC, this 'drug-user's' disease, and the HCV virus has been expensive to research, and difficult to treat. When Gilead paid $ 11 billion to acquire Sofosbuvir, we knew what to expect. Peg/Riba and Victrelis costs about $100,000 per patient. I would not be surprised if the Gilead Sofosbuvir combo costs $250,000.

I probably worry too much.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Jill, that is the way Angelo is taking the Inciveck  /  3 pills 2x every 12 hrs.

Spoke to Inciveck Nurse who told me that during a study done the results were very promising from the drug being given 2x   instead of 3x

Actually it's better on the body because you are eliminating 20 additional gm of fat per day !

Mwna



__________________

Genotype 1b, V/L  0! Finally got rid of the Dragon after 24 wks. of Harvoni.

EOT 5/10/15   - 4 wks. UND, 12 wks UND, 24 wks. UND!!! 



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Hi Jill-Thanks for sharing the article...Interesting to read - How quick the progress...

Hi Malcolm, You are right, this was worth reading.  

I am feeling a bit more optimistic that the near future will be bright for all of us.  The real focus of finding better treatment options has not been going on that long.  Being a geno 1a, I choose not to treat with peg/riba; my chance of success was low, treatment was brutal and the chance of coming out with another illness to contend with was high. I can remember my doctor telling me I would have been better off if I were geno 2 or 3...that was not long ago.

The lack of awareness and stigma of this disease has played a huge part in getting the world to wake up...I believe that is changing.  There is progress being made in the areas of treatment, awareness..., at an amazing pace. I see this story similar to that of hiv/aids...the bigger it gets the more progress it will make.  I think the time to show concern is when these kinds of articles cease and all goes silent....!



__________________

Geno Type A1- VL 16.2m - F1-F2 Moderate Fibrosis - Started treatment 4/16/13 Sofosbuvir/Ledipasvir 6 months -  UND week 4 (5/14/13) - EOT 10/1/13 - 12wk blood draw 12/20/13 UND - 24wk/final blood draw March 2014



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hepCFREEwanab wrote:

Jill, that is the way Angelo is taking the Inciveck  /  3 pills 2x every 12 hrs.

Spoke to Inciveck Nurse who told me that during a study done the results were very promising from the drug being given 2x   instead of 3x

Actually it's better on the body because you are eliminating 20 additional gm of fat per day !

Mwna


 Hi Mena, yes, the twice daily dosing schedule that Angelo is doing has been shown to be just as effective.  I`m sure it must make things a lot easier, mainly because of not having to eat so much fat, and also because there are less pills to remember to take!  smile

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Hi Malcolm, I can understand you worrying about the potential cost of these new drugs.  There has been so much progress made over the last few years and we`re all impatient to see as many people as possible benefit from newer and more effective treatments.   At the same time, it`s very exciting to see so many new drugs and combos in the pipeline.  Things are moving forward at an astonishing pace, thank goodness, and I guess we`ve just got to be patient while it all rolls out!



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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I agree, Malcolm, the future of Hep C treatments is looking very promising on the whole, although it`s a different story for people living outside the USA, with many countries not even having widespread access to incivek and victrelis yet.  And still more clinical trials needed which include cirrhotics or people coinfected with HIV/HCV, who should be given much higher priority as they are in the greatest need of effective treatment.

Over here in the UK there`s about 40-50% of the Hep C infected population with gen 3, but at least most of them still have a good chance of a successful treatment outcome with the current standard peg/riba combo.  Extremely frustrating for those who fail tx though, especially if they have cirrhosis, as they have very limited options as it currently stands.

Interesting point about making victrelis into a single pill, that would make the treatment much easier to adhere to.  People on incivek now have the option of a twice daily, rather than three times daily dose, and the pill burden is so much greater with victrelis. 

 

 

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Hi Jill,

This is a useful overview and well worth a read.  I think the last paragraph is the most important. If countries can't afford to fund the new treatments, what's the point? The difficulty in treating cirrhotics and the Geno 1a's has also been glossed over. Apart from the USA, I think it will be 5-10 years before these drugs are used in other countries. How many cirrhotics will die before then?

Victrelis and Incivek have not been mentioned. These will be the front line drugs for many years in most countries, and all research into them appears to have ceased. These two drugs work, and surely they deserve more attention, particularly with a view to make the treatment regimes more simple, and to minimise Sx.  I'm sure Victrelis could be made into a single pill (instead of 3), and probably is just as effective twice daily.

As usual, Genotype 3 receives little attention. This is fairly rare in the USA, but in Australia, ~ 40% of HCV have this Genotype. My Hepatologist has many cirrhotic Geno 3's who have failed Peg./Riba, waiting for a new Rx. They will wait in vain.

The near future may look exciting, but only if you live in the USA, are not cirrhotic, and not Geno 1a or 3.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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You`ll be fine, Zlikster, don`t worry!  smile



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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cheers Jill "GT3 is the new GT1" yay!

__________________

GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!




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New Drugs Pipeline

See article...

http://www.hepctrust.org.uk/News_Resources/news/2013/July/New+drugs+pipeline

 

 



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 

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