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Post Info TOPIC: An update on Victrelis


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RE: An update on Victrelis
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I read a early pdf on Incivek that said it wasn't as effective on relapsers or null responders. Victrelis probably a better choice.



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GT 1a Started triple tx with Incivek, Pegasys, and Riba 2-6-2013. UND at 4,6,12,23,& 24 wks EOT 7-26-2013. Probably had Hep C for 20-30 years. Don't really know when I got it.



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Hi Tig,

I can't find any data on the old monotherapy with Interferon 3 times a week. Like you, I had 12 months of monotherapy in 1998. I became PCR -ve after week 12 and was PCR -ve at 48 weeks. However I was back to PCR +ve 8 weeks after EOT. We didn't have Viral Loads back then, just a fairly crude PCR test which came out as +ve or -ve. Even my Lab. can't tell me what the sensitivity was way back then.

In 2000, I had a 6 month course of Interferon ( again x3 weekly) with Ribavirin. I was PCR -ve at week 6 and stayed PCR -ve at 4 months post Rx. My EOT + 6month PCR came back +ve.  In 2001, I was told the new SOC was to do 48 weeks of Interferon and Ribavirin and would I like to try again!!!!! I made the worst decision of my life and said no thanks, as I was still working long hours and the previous Rx had made me fairly anaemic. I suspect that I would have cleared the virus if I had taken that Rx offer, as at that stage I was not cirrhotic.

I think anyone who has had Interferon previously and has had an Undetected or a -ve PCR, can be classed as a partial responder at least. As your VL after 4 weeks was so low, you have an excellent chance.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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I'm a relapser and now they think they will start me on victrelis instead of incivek. Reading this makes me feel so much better.

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Type 1a. Had HCV my entire life via blood transfusion. Did peg & riba in 2000, relapsed. Did triple tx with sovaldi in early 2014 & I am now undetected 



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Sorry, but when I understand the study correctly, the svr is smaller than 71%.

I find it strange to ignore participants who have to stop the therapy due to medical reasons.



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That is impressive. Gives us relapsers more hope. Fingers crossed. Thanks for the info.



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58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~



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With all the new DAA's, it is easy to forget the first antiproteases. If you're not in the USA, have a read of the Victrelis results, recently reworked and re-presented. If you were a prior relapser to Peg and Riba, SVR rates of close to 100% can be expected. Sure, there are side effects, but these results are pretty impressive. If you're not in the USA, you've got more chance of being Geno 1b, which is even better.

 

http://www.natap.org/2013/DDW/DDW_02.htm



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm

Tig


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Is there a category for SVR % in patients that were partial responders to the original mono therapy? There doesn't seem to be much consideration anymore to those Pioneers or am I just missing it?






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Tig

66 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 8+ years!

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