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Hep C Discussion Forum -> Clinical Trial Participants -> Abbvie trials for 3a?
Post Info TOPIC: Abbvie trials for 3a?
Matt Chris


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RE: Abbvie trials for 3a?
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Hey Liam & Malcolm

I would guess Abbvie realizes that had to many Ravs in their current versions compared to the newer / 2nd generations versions. I asked Abbvie about these new versions but as usual they are not saying a word.

I too, wonder if it will cause the FDA to scratch their head (introducing a better version of their drugs before the current ones are approved)

Liam, if you can get on this new trial go with it.

matt     



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61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
mallani


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Hi Liam,

Abbvie are messing with us. Their triple combo has been filed for approval, yet they introduce a new antiprotease (ABT-493) and a new NS-5A inhibitor (ABT-530). I didn't like the old antiprotease (ABT-450, boosted by Ritonavir), so are they telling us their new drugs are better? They are doing their best to fall even further behind Gilead.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Zlikster


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Hi Liam,

So you obtained information that Abbvie is sponsoring trial that has been offered to you?

could be this one:

http://www.clinicaltrials.gov/ct2/show/NCT02068222

it's Abbvie's Ritonavir (protease inhibitor mostly used for HIV) in combo with ABT-450 (protease inhibitor) and ABT-530 (new NS5A protein inhibitor) with and w/o Riba. I think they passed already Phase III with similar combo for GT1, they are prolly investigating another combo for GT3.

Ritonavir has a lot of sx on it's own, i would be careful with this one. Malcolm could know a bit more around Abbvie's Ritonavir and their HCV DAAs.

best

 



-- Edited by Zlikster on Monday 24th of February 2014 07:46:48 PM

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01-2016 Sof+Dac+Riba UND from w8, SVR24!
robertsamx


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www.clinicaltrials.gov/ct2/results
take a look

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 M-64) 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
Liamc


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Hi, has anyone heard of Abbvie trials for geno3a? Thanks in advance



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GT3a Age 61. Clinical trial sovaldi/riba 24 weeks. finished trial 17th April 2015 undetected. EOT+4 weeks undetected.24th July 2015 "SVR"

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