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Hep C Discussion Forum -> General Discussion -> Should I wait for Ledipasvir?
Post Info TOPIC: Should I wait for Ledipasvir?
suziq


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RE: Should I wait for Ledipasvir?
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I really think most of the new drugs will have excellent SVR rates.  I also think Riba will soon be a thing of the past as new trials are showing it does not make a difference in SVR rates.  Some are relapsing on the shorter length of time (8 weeks).  Since the new meds are pretty much side effect free then taking them a little longer should be no problem.  I did 18 weeks on my trial--which seemed a little over the top, but that was what I was assigned and I am SVR.  The extra six weeks made no difference in their data, so I suppose the new trials will be 8 or 12 weeks. 

It is entirely up to you about the drugs.  More data is available almost daily. 

Good luck on whatever you decide

SuziQ  



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Geno 1A  Age 82 Treatment naive Cirrhotic Told I had liver disease in 1966. Diagnosed as Hep C 1999.Started Merck clinical trial with Riba on 9/9/2013 Week 1 and 2 <25  Weeks 4, 8, 12,16,18 UND.  EOT Jan 14,2014  EOT +12 UND   JULY 1 2014 EOT+24= SVR
OldenSlow


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Why not wait, if your liver is in good enough shape? One pill regimen, no riba, potentially shorter treatment time, cure rates of close to 100%. I almost waited even given the cirrhosis. Thought I might be pushing my luck a bit too much, tho.  wink  



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66 y/o male - Geno 1b - F4 cirrhotic dx 2001 - 16 wk treatment w/ Sovaldi/Olysio/Riba - Und @ EOT+24 SVR

 
Tig


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Hi PW,

There's no doubt Sov/led is a blockbuster treatment! I guess it should be determined by your current need (urgency) for treatment. The treatment length has been trialed in 8 week increments with pretty impressive results. The problem exhibited in the Cosmos trials won't be a part of this roll out, because the ION studies went through full phase III trials. It will also be an approved treatment versus the current off label status shared by Sov/Oly. Here's a link to some information, take note of the graphs. Good luck!

http://hepatitiscnewdrugresearch.com/sofosbuvir-gs-7977ledipasvir-gs-5885.html

Tig



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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patiently_waiting


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As of this week I've been chomping at the bit to get started on either Solvadi/Olysio or maybe a Merck trial, but as I read more I'm wondering if I should wait for Ledipasvir.  Considering RAVs and the potential of having to take Ribavarin (which I'd really like to avoid), would I be better off waiting?  Also I think I read the Solvadi/Ledipasvir tx time is shorter?  Obviously I'll be discussing all this with my doc but I want to be as knowledgeable as I can before going in to see him.  If the target availability date is truly October, I want to be sure I'm not being too hasty here.



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42 yrs old: geno 1b, 23mil VL, ALT/AST 269/94 as of Apr '14.  Got HCV when I was 16.  Relapsed from Peg/Riba twice, last time in '08.  Completed Sol/Oly on 9/2/14, UND as of 10/7/14
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