Hep C Discussion Forum

Members Login
Username 
 
Password 
    Remember Me  
Chatbox
Please log in to join the chat!
Hep C Discussion Forum -> General Discussion -> Triple Therapy works for GT-3?
Post Info TOPIC: Triple Therapy works for GT-3?
Omar


Member

Status: Offline
Posts: 25
Date:
Triple Therapy works for GT-3?
Permalink  
 

hepcinbama wrote:

dear omar thank you thank you thank you for posting that I am on solvaldi rib an peg pen an have hep c geno 3  I wonder what the success rate is for that combo?

 Sorry I had no access to internet for a couple of days...

I believe your queries have been very well answered by the forum experts (i am still a student of HCV knowledge)....

I wish you best of luck with your tx....

Kind Regards



-- Edited by Omar on Thursday 26th of June 2014 09:44:26 AM

__________________

Male 31 Years Old

Diagnosed with HCV GT-3a in June 2014

Sovaldi+Riba for 24 weeks started on 8 August 2015

 
hepcinbama


Member

Status: Offline
Posts: 39
Date:
Permalink  
 

tig thank you sooo very much for all the kind words you have been extremely helpful an knowledgeable thank you so much for your time an experience!



__________________

hep c geno 3     2,600,000 viral load   started 12 week tx of peg pen rib an solvaldi the wonder drug! first time being treated after living in Egypt for 6 years on a river called De-Nile!
Tig


Admin

Status: Offline
Posts: 9284
Date:
Permalink  
 

Hey Myke,

I took my shot on Thursday, no special reason though. I didn't have to work while I went through Tx (treatment) so I had it a lot easier than you working people! Typically, as you discovered, the first 24 hours after the injection can be the hardest. I can't say how it will go for you, but some adapt better to the SFX (side effects) as time goes on. I always took it later in the day, so I could go to bed and hopefully sleep off the flu like symptoms, including a low fever. If you notice something like that, you might try some Tylenol or ibuprofen before the shot and it will reduce any of those SFX. 

Its very important to remember that water is your friend while you're taking these drugs. 2-3 extra liters of good water daily, will keep many of the SFX at bay as well as providing the needed hydration during Tx. Eating a good balanced diet is very important as well. I found that eating several smaller meals per day were easier than 2 or 3 big ones. I lost over 50 pounds on Tx, so keep that in mind if you notice the weight dropping off. Nutrition will be an important part of your daily care, so plan for it.

I don't believe that your history of IVDU will have any impact on the outcome. While it may have introduced you to the virus, there won't be any similarities to those experiences. I'm glad you made the choice to change your life and leave that behind. It sounds to me like you've made some very important changes in your life and am very happy for you my friend. If there is anything I can do, just say the word. We have some very kind and knowledgable people here, just waiting to help! Good luck....

Tig



__________________

Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 
Tig


Admin

Status: Offline
Posts: 9284
Date:
Permalink  
 

Hey Liam,

Having gone through 7 months of an Interferon, Riba and Victrelis protocol, I understand the road that's ahead of you, and it can have some gnarly turns and rough patches. But while it can be tough, it's totally doable. I experienced some anemia that resulted from the  Victrelis. Since you will have Sovaldi as your third drug, I don't think you'll experience quite the anemia as I did and that alone will make it easier. The trial data shows very high rates of SVR for this combo. If you're ready to fight, I think the chances are quite good that SVR will be yours! Let us know what you decide, good luck!

Tig



__________________

Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 
Huey


Guru

Status: Offline
Posts: 678
Date:
Permalink  
 

Liamc wrote:

Hi Tig,

i can scrape enough money together for 3 months supply of Solvaldi, but not the 6 months,i can access the ribo/ interferon in thailand for a very cheap price and have a good GI, what do you think of giving this a try?

thanks

liam

 Four out of Five Voices in my Head say,""Go for IT!"



__________________

  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
Liamc


Veteran Member

Status: Offline
Posts: 97
Date:
Permalink  
 

Hi Tig,

i can scrape enough money together for 3 months supply of Solvaldi, but not the 6 months,i can access the ribo/ interferon in thailand for a very cheap price and have a good GI, what do you think of giving this a try?

thanks

liam



__________________

GT3a Age 61. Clinical trial sovaldi/riba 24 weeks. finished trial 17th April 2015 undetected. EOT+4 weeks undetected.24th July 2015 "SVR"

24 week SVR!!
hepcinbama


Member

Status: Offline
Posts: 39
Date:
Permalink  
 

wow just read that link if I read it right it looks like 97 % chance of clearing virus



__________________

hep c geno 3     2,600,000 viral load   started 12 week tx of peg pen rib an solvaldi the wonder drug! first time being treated after living in Egypt for 6 years on a river called De-Nile!
hepcinbama


Member

Status: Offline
Posts: 39
Date:
Permalink  
 

tig you have been sooooo very helpful can I please ask you a few more questions ?1} what should I watch out for or be aware of ? I just wanted to be cured I heard the peg pen treatment would be ruff  but the second week I took my shot Thursday night I was very very tired an achy an about by sunday I was feeling better Monday morn I was good to go for work but did notice a shortness of breath ,I think this week I will take my shot on Friday so I don't miss any work an just stay in bed.the doc wanted me to do the triple combo  because he said in three months I should clear this virus . I just want to be aware of what I should watch out for as a former drug addict I can help people deal with recovery because I have been there jus like the people in this forum my doc hasn't ever takin these drugs so he wouldn't know  TIG again thank you thank you thank you for all your time an help! I checked out your hep tattoo page very interesting



__________________

hep c geno 3     2,600,000 viral load   started 12 week tx of peg pen rib an solvaldi the wonder drug! first time being treated after living in Egypt for 6 years on a river called De-Nile!
Tig


Admin

Status: Offline
Posts: 9284
Date:
Permalink  
 

Hi Myke,

A recent report from the AASLD provided results from two phase 2 clinical trials, the Proton and Electron studies. Those results while short number were high in SVR results.

"The combination of sofosbuvir plus PEG/RBV has been evaluated in patients with genotype 3 infection. In 2 phase 2 clinical trials, PROTON and ELECTRON, 38 of 39 (97%) treatment-naive patients with genotype 3 infection achieved SVR with sofosbuvir plus PEG (4 to 12 weeks of therapy)/RBV. (Gane, 2013b) For many patients with genotype 3, the adverse effects and increased monitoring requirements of PEG make this less acceptable than the recommended regimen of sofosbuvir plus weight-based RBV."

http://www.hcvguidelines.org/full-report/initial-treatment-hcv-infection-patients-starting-treatment

Tig



__________________

Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 
hepcinbama


Member

Status: Offline
Posts: 39
Date:
Permalink  
 

omar I have been taking the peg pen for 2 weeks now it is not unbearable!



__________________

hep c geno 3     2,600,000 viral load   started 12 week tx of peg pen rib an solvaldi the wonder drug! first time being treated after living in Egypt for 6 years on a river called De-Nile!
hepcinbama


Member

Status: Offline
Posts: 39
Date:
Permalink  
 

dear omar thank you thank you thank you for posting that I am on solvaldi rib an peg pen an have hep c geno 3  I wonder what the success rate is for that combo?



__________________

hep c geno 3     2,600,000 viral load   started 12 week tx of peg pen rib an solvaldi the wonder drug! first time being treated after living in Egypt for 6 years on a river called De-Nile!
Omar


Member

Status: Offline
Posts: 25
Date:
Permalink  
 

Zlikster wrote:

Hi Omar,

did Gilead made same price for Pakistan as it did for Egypt? 300$ per bottle (99% discount)? Gilead won't be giving any discount to Bosnia & Herzegovina (1k$ per pill it is!), so i am trying to find it in other countries or get generic one from India when it becomes available.

cheers

 Hi Zlikster

I have confirmed from my hospital in Pakistan that the medicine will be available for a total price of USD 3000 (approx) for a 24 week course. However, the medicine is only for the Pakistani nationals and one has to prove his identity before registering for the medicine. 

I wish you good luck and hope your government be able to make a deal with Gilead for a discount like Egypt.

Regards

 



__________________

Male 31 Years Old

Diagnosed with HCV GT-3a in June 2014

Sovaldi+Riba for 24 weeks started on 8 August 2015

 
Zlikster


Guru

Status: Offline
Posts: 791
Date:
Permalink  
 

Hi Omar,

did Gilead made same price for Pakistan as it did for Egypt? 300$ per bottle (99% discount)? Gilead won't be giving any discount to Bosnia & Herzegovina (1k$ per pill it is!), so i am trying to find it in other countries or get generic one from India when it becomes available.

cheers



__________________

GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
Omar


Member

Status: Offline
Posts: 25
Date:
Permalink  
 

Isiscat2011 wrote:

Hi GT3s:

Keep in mind that the all oral 12 week combo of Sovaldi/Ledipasvir/Riba had a 100% cure rate in clinical trials.   That is half the tx time of the S/R combo.  

http://www.hepmag.com/articles/ELECTRON2_SOF_2501_25458.shtml

 That's definitely a fantastic news for GT-3 patients

The question is when it will be approved and the cost.... unfortunately in UAE, HCV treatment is not covered by insurance for the people with work permit (only UAE nationals are entitled to free treatment).

 



__________________

Male 31 Years Old

Diagnosed with HCV GT-3a in June 2014

Sovaldi+Riba for 24 weeks started on 8 August 2015

 
Omar


Member

Status: Offline
Posts: 25
Date:
Permalink  
 

Liamc wrote:

Hi Omar,

i am also a geno 3 and waiting. Are you expecting Solvaldi to be available in Pakiistan in 60 days?

thanks and good luck

liam

 Hi Liamc

Yes, it will be available in 60 days. The government hospital is registering the patients and the medicine will be allotted in the order of registration number.

Good luck to you as well. I wish sovaldi becomes available in Australia and other parts of the world soon.

 

 



-- Edited by Omar on Saturday 21st of June 2014 07:20:50 AM



-- Edited by Omar on Saturday 21st of June 2014 07:22:06 AM

__________________

Male 31 Years Old

Diagnosed with HCV GT-3a in June 2014

Sovaldi+Riba for 24 weeks started on 8 August 2015

 
Isiscat2011


Guru

Status: Offline
Posts: 1724
Date:
Permalink  
 

Hi GT3s:

Keep in mind that the all oral 12 week combo of Sovaldi/Ledipasvir/Riba had a 100% cure rate in clinical trials.   That is half the tx time of the S/R combo.  

http://www.hepmag.com/articles/ELECTRON2_SOF_2501_25458.shtml



__________________

Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Liamc


Veteran Member

Status: Offline
Posts: 97
Date:
Permalink  
 

Hi Omar,

i am also a geno 3 and waiting. Are you expecting Solvaldi to be available in Pakiistan in 60 days?

thanks and good luck

liam



__________________

GT3a Age 61. Clinical trial sovaldi/riba 24 weeks. finished trial 17th April 2015 undetected. EOT+4 weeks undetected.24th July 2015 "SVR"

24 week SVR!!
Loopy Lisa


Guru

Status: Offline
Posts: 895
Date:
Permalink  
 

Omar wrote:

Dear All

I was searching for Hep C related stuff and found the following:

Here are the recommendations for HCV treatment for all genotypes from the American Association for the Study of Liver Diseases (AASLD):

 AASLD HCV Treatment Recommendations
for treatment-naive patients who are eligible to receive interferon
 RecommendedAlternative
Genotype 1Sovaldi + ribavirin + pegylated interferon for 12 weeksSovaldi for 12 weeks + ribavirin + pegylated interferon for 24 weeks*
Genotype 2Sovaldi + ribavirin for 12 weeksnone
Genotype 3Sovaldi + ribavirin for 24 weeksSovaldi + ribavirin + pegylated interferon for 12 weeks
Genotype 4Sovaldi + ribavirin + pegylated interferon for 12 weeksOlysio for 12 weeks + ribavirin + pegylated interferon for 24?28 weeks
Genotype 5 or 6Sovaldi + ribavirin + pegylated interferon for 12 weeksribavirin + pegylated interferon for 48 weeks

 

I just want to know if somebody with GT-3 has gone for triple therapy (Peg-IN + Sovaldi + RBV). The treatment time is reduced 12 weeks and I was thinking to adopt the same. I will also discuss the same with my doctor in the next visit.

My only concern is whether the side effects will be severe and shortening the treatment will achieve SVR or not.

I will appreciate your input.

 Hi Omar, 

It depends on the person, for some 12 weeks of interferon is very doable, for others not. I did read it is a high percentage of SVR with both. Personally I will go for the 24 weeks of oral only. Good luck with your decision.



__________________

Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 
Omar


Member

Status: Offline
Posts: 25
Date:
Permalink  
 

Thanks a lot Huey for the advice

You may understand my current mental situation, I want to get rid of this virus ASAP...... That is why I want to adopt the quickest possible method.

Luckily i have a desk job and a supporting boss, but I would prefer to avoid the side effects of Peg-IN.

So I will take the longer but easier route i.e 24 weeks with Sov+RBV and will wait for Sovaldi to become available. I have been told that it will be available within next 60 days. Keeping my fingers crossed.....

 



-- Edited by Omar on Friday 20th of June 2014 05:12:07 PM

__________________

Male 31 Years Old

Diagnosed with HCV GT-3a in June 2014

Sovaldi+Riba for 24 weeks started on 8 August 2015

 
Huey


Guru

Status: Offline
Posts: 678
Date:
Permalink  
 

Omar wrote:

Dear All

I was searching for Hep C related stuff and found the following:

Here are the recommendations for HCV treatment for all genotypes from the American Association for the Study of Liver Diseases (AASLD):

 AASLD HCV Treatment Recommendations
for treatment-naive patients who are eligible to receive interferon
 RecommendedAlternative
Genotype 1Sovaldi + ribavirin + pegylated interferon for 12 weeksSovaldi for 12 weeks + ribavirin + pegylated interferon for 24 weeks*
Genotype 2Sovaldi + ribavirin for 12 weeksnone
Genotype 3Sovaldi + ribavirin for 24 weeksSovaldi + ribavirin + pegylated interferon for 12 weeks
Genotype 4Sovaldi + ribavirin + pegylated interferon for 12 weeksOlysio for 12 weeks + ribavirin + pegylated interferon for 24?28 weeks
Genotype 5 or 6Sovaldi + ribavirin + pegylated interferon for 12 weeksribavirin + pegylated interferon for 48 weeks

 

I just want to know if somebody with GT-3 has gone for triple therapy (Peg-IN + Sovaldi + RBV). The treatment time is reduced 12 weeks and I was thinking to adopt the same. I will also discuss the same with my doctor in the next visit.

My only concern is whether the side effects will be severe and shortening the treatment will achieve SVR or not.

I will appreciate your input.

 Hi, I am  a geno 3a and have eight weeks left of 24 weeks.  Here are some things i have learned from my experience, yours may be different,

1/ Genotype 3 has a unique characteristic  the others don't have.  The virus itself causes insulin resistance !  This will show up in your blood test as elevated glucose .  and you feel it too. The first two weeks of treatment your VL drops vary quickly, and your sugar goes up just as quick.  The thing is that because of this, the first two weeks are going to be the worse time you have with side effects without Peg=IN ,  and with it you will have bad side effects for 12 weeks or more.  The 24 week Tx may cost more and take longer but on a side effects standpoint, taking the Alt Tx is not advised.  I have been able to work the whole time i have been taking Tx without Peg=IN , with it this would not have happened.  In conclusion your best bet is the 24 week Tx if you can get it ware you are. but if not and you are desperate enough the 12 week tx. would most likely work,

2/ Peg=IN has known long term conditions that are best avoided .  Problems with your vision and teeth for instance.

3/With other complications from other conditions. You are much more able to cope with the non= Peg=IN Tx. 

 

The Only logical  reason I can think of for the Alt TX. is rationing!  If you only have so many Sovaldi in a remote population and you had to make it go farther in  order to cure everybody.



-- Edited by Huey on Friday 20th of June 2014 04:07:42 PM

__________________

  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
Omar


Member

Status: Offline
Posts: 25
Date:
Permalink  
 

Dear All

I was searching for Hep C related stuff and found the following:

Here are the recommendations for HCV treatment for all genotypes from the American Association for the Study of Liver Diseases (AASLD):

 AASLD HCV Treatment Recommendations
for treatment-naive patients who are eligible to receive interferon
 RecommendedAlternative
Genotype 1Sovaldi + ribavirin + pegylated interferon for 12 weeksSovaldi for 12 weeks + ribavirin + pegylated interferon for 24 weeks*
Genotype 2Sovaldi + ribavirin for 12 weeksnone
Genotype 3Sovaldi + ribavirin for 24 weeksSovaldi + ribavirin + pegylated interferon for 12 weeks
Genotype 4Sovaldi + ribavirin + pegylated interferon for 12 weeksOlysio for 12 weeks + ribavirin + pegylated interferon for 24?28 weeks
Genotype 5 or 6Sovaldi + ribavirin + pegylated interferon for 12 weeksribavirin + pegylated interferon for 48 weeks

 

I just want to know if somebody with GT-3 has gone for triple therapy (Peg-IN + Sovaldi + RBV). The treatment time is reduced 12 weeks and I was thinking to adopt the same. I will also discuss the same with my doctor in the next visit.

My only concern is whether the side effects will be severe and shortening the treatment will achieve SVR or not.

I will appreciate your input.



__________________

Male 31 Years Old

Diagnosed with HCV GT-3a in June 2014

Sovaldi+Riba for 24 weeks started on 8 August 2015

 
Page 1 of 1  sorted by
 
Quick Reply

Please log in to post quick replies.
Hep C Discussion Forum -> General Discussion -> Triple Therapy works for GT-3?
Legal Disclaimer:

THIS FORUM, IT'S OWNERS, ADMINISTRATORS, MODERATORS AND MEMBERS DO NOT AT ANY TIME GIVE MEDICAL ADVICE AND IN ALL CASES REFER ANYONE HERE TO SEEK APPROPRIATE MEDICAL ADVICE FROM THEIR DOCTOR.