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Post Info TOPIC: Starting trial next week!!!


Senior Member

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RE: Starting trial next week!!!
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Hi Marcy.

If memory serves me, you've been trying to get into a trial for some time. I'm glad you've finally made it. I hope you're in that 75% too! I'm sure you're as anxious and apprehensive as I was to start.

Good luck Marcy.

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jimbob: 64 y/o, GT 1A, F1-F2, diagnosed 1996. Since 1970. SOT 3.5 mil VL on 3/10/14 with Sov/Rib/Peg for 12 weeks. Tx naive. UND @ week 4,8,12. EOT 6/2/14.



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Fantastic. This can only be good !

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57 Yr old, Diagnosed 1994 Geno 1a. 1995: Interferon 12 weeks.  1998: Int/Rib 10 weeks.  2014: VL 106,000. Peg Int, Ribavirin, Victrelis 48 weeks (commenced June 2014). UND after Peg/Int lead in week 4. Still UND at week 8, 24, EOT. SVR 12.



Guru

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Hi Marcy,

I presume this is Merck's Phase 3 Trial, called C-EDGE. You should do well, going on the C-WORTHY results- SVR rates were >90% even without Riba. Keep us informed. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Hi Marcy,

Congrats on getting into the trial.  I had my EOT+24 labs on Monday--results in a few days.  My Merck trial had two pills plus ribavirin. They had not combined the two drugs into one pill yet--and thank goodness it did not have a blind study.  Personally, I think a blind study is silly.  We all know that sugar pills don't cure Hep C.  Maybe it is something FDA requires.  The data has been great from Merck so I am sure you will do well.  I did have some stomach issues toward the end of the trial, but I did 18 weeks and had ribavirin.  I had to take my first dose at the trial center and was required to eat with it.  You might take a snack along just in case.  Good luck from another Merck trial participant !!!

SuziQ 



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Geno 1A  Age 82 Treatment naive Cirrhotic Told I had liver disease in 1966. Diagnosed as Hep C 1999.Started Merck clinical trial with Riba on 9/9/2013 Week 1 and 2 <25  Weeks 4, 8, 12,16,18 UND.  EOT Jan 14,2014  EOT +12 UND   JULY 1 2014 EOT+24= SVR



Guru

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Congrats, Marci!  I know you have been working on trying to get this for awhile and I hope all goes well for you.  That combo seems promising. smile



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.



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Got the call today to start meds next Thursday on the Merck 5172/8742 combo.  Its a 12 week, 1 pill day, double blinded placebo trial.  Of course I'm hoping I'm in the 75% not on placebo, but even if I'm not, I still get the real thing after 18 weeks.  Excited to finally have a hope of being free of this crap.  Excited!!!

biggrin



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Marcy

Long-term HCV, GT1a, IL28B C/T, T/G;  VL 2 mil.  Merck C-Edge Clinical trial  EOT 10/01/14. +24= UND

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