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Post Info TOPIC: Detailed Report of my Biopsy
Tig


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RE: Detailed Report of my Biopsy
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I agree Josh, those are good numbers! The exceptions are the items we would expect to see but they aren't grossly abnormal aside from your Thyroid. Your A2/F2 status doesn't indicate any hepatic crisis, so the F3/4 staging some have required for the off label S/O treatment protocol, might get in the way of approval. But with those numbers and biopsy result, you've got time to wait for the next silver bullet if desired. The next line of drugs are sure to be show stoppers!

Tig



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Josh Haynie


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 thanks :) i shall indeed request that screen ..... Thanks for spotting that Malcolm



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genotype 1  HCV 4,958,318 iu/ml    HCV Log updated soon  iu/ml------5'10 135lbs 9-15-83  genotype 1 since 2002----Pendleton,Oregon
mallani


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Hi Josh,

Pretty good set of numbers. I'd be asking my doctor about the TSH (Thyroid Stimulating Hormone). Yours is low, so I'd want a full thyroid screen. This is a common issue with HCV.

Biopsy results seem good, with you labelled a A2, F2. Keep truckin'.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Josh Haynie


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  Well....  Excellent posts in the last few days from you guys I read them.....lots of DAA coming out between now and prolly 6 months to year means im hopin and thinkin...Price reductions once competition heats up which should make insurance Reps.. more at ease ... ANYway on with the stuff i got in the mail today ... i should of just scand the documents but iLL spend the time to type all this Jargin out...its 9:07pm right now so lets see how long this takes....

Date Blood test 6-3-14 ex=external *=higher or lower then set range

 

ComponentValueRange
Hemoglobin A1C external4.9 
Creatinine ex0.690.6-1.135
eGFR,ex>6060-99999
LDL Cholesterol,ex109*100

Cholesterol Total,ex

179200
HDL Cholesterol,ex54*40
Triglycerides,ex8030-150
Cholesterol Total,Non HDL-C125130
TSH,ex0.098*0.27-4.2
ALT,ex114*7-52
AST,ex69*13-39
VLDL16 
CHOL/HDL RISK3.3 
NA137 
K4.0 
CL102 
CO228 
Anion Gap11 
Glucose93 
BUN11 
BUN/Creatinine Ratio15.9 
Calcium9.6 
ALK PHOS52 
Bilirubin Total0.5 
Total Protein7.3 
Albumin4.2 
Globulin3.1 
Albumin/Globulin Ratio1.4 
Total Protein7.3 
Albumin4.2 
Globulin3.1 
Albumin/Globulin Ratio1.4 
Bilirubin Total0.5 
Bilirubin Direct0.1 
Bilirubin Indirect0.4 
ALK PHOS52 
INR,ex1.0 
WBC,ex7.24.5-11
HGB,ex15.913.5-18
HCT,ex45.341-50
PLT,ex144140-440
RBC4.72 
MCV96.0 
RDW12.3 
MCH34.0*27.0-33.0 pg
MCHC35.0 
Neutrophils %37.8*39.0-80.0%
Lymphocytes %49.024.0-44.0%
Monocytes %11.3 
Eosinophils %1.5 
Basophils %0.4 
Prothrombin Time13.2 

lol that sucked filling in all that sh....you know...... all that is pretty meaningless but lets just call this the before snapshot 9:55pm took me awhile to get the columns right or figure it out........

7-30-14 Liver Biopsy Readout

ASA 2-mild systemic disease Mallampati Score II (fauces,uvula and soft palate)

INCYTE Diagnostics Liver Needle Biopsy

Mild Chronic Active Hepatitis (grade 2/4)

Mild portal and periportal fibrosis,negative for significant bridging cirrhosis (stage 2/4)

Negative for significant steatosis 

Negative for significant stainable Iron  

Comment: The histologic features are consistent with the history of viral hepatitis C

JVR:smh:C2NR

Gross Description 

two fragments of light tan tissue measuring 1.4x0.2x0.1 and 1.2x0.2x0.1 both fragments are submitted in the same cassette....

 

MICROSCOPIC EXAMINATION half the crap written in this  I need to look up .........a few words 

An H&E section shows liver parenchyma with expanded portal tracts containing lumphocytes and a few plasma cells. There is mild portal

interface activity and focal clusters of lymphocytes within the hepatic parenchyma. The portal structures are preserved. containing essentially

unremarkable appearing bile ducts and vasculature. The hepatocytes within the haptic lobules show no evidence of hepatocyte destruction.

special stains are performed with appropriate postive and negative controls. A trichrome stain reveals portal and periportal fibrosis without

significant bridging fibrosis. An iron stain is negative for significant stainable iron. A PAS stain shows uniformly glycogenated hepatocytes. A

PAS with diastase stain is negative for Alpha-1 antitrypsin globules. A reticulin stain shows preserved hepatic lobular architecture. 10:17pm

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

so hopefully i can get DAA for F2 ....  Thanks for Reading :) have a good night/day 



-- Edited by Josh Haynie on Tuesday 19th of August 2014 06:22:48 AM

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genotype 1  HCV 4,958,318 iu/ml    HCV Log updated soon  iu/ml------5'10 135lbs 9-15-83  genotype 1 since 2002----Pendleton,Oregon
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