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Hep C Discussion Forum -> Knowledge/Info Section -> Found this
Post Info TOPIC: Found this
mallani


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RE: Found this
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Hi Isis,

The Forum member who relapsed twice on S/L was username 'HR'. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Isiscat2011


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mallani wrote:

They are very similar, with the same activity numbers and resistance profiles.

As Gilead are not marketing Ledipasvir separately, the cost of Sovaldi + Daclatasvir will not be competitive. BMS are flogging a dead horse with Daklinza (Daclatasvir).

Oh, Man. That does make sense because even if Sovaldi could be purchased separately Daclatasvir would have to be priced very low to compete with Harvoni.  I keep hoping that somebody is going to give Gilead a run for their money just to drive the costs down.  Maybe Abbvie will do it but I'm kind of stuck on favoring Sovaldi as the backbone and would like to see more people getting it.  

 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
mallani


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They are very similar, with the same activity numbers and resistance profiles.

As Gilead are not marketing Ledipasvir separately, the cost of Sovaldi + Daclatasvir will not be competitive. BMS are flogging a dead horse with Daklinza (Daclatasvir).



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Isiscat2011


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Malcolm:

Is it safe to assume that since Ledipasvir and Declatasvir are both NS5A inhibitors they are very similar with respect to efficacy and safety/side effects? How do they differ?



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Isiscat2011


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Thanks, Malcolm.  Excellent tip in figuring out the drug class by the name.  

The person I was thinking of did 12 weeks on S/L, relapsed, and then repeated S/L for 24 weeks and relapsed again.  I was very surprised.  He doesn't post often and his sn escapes me.  Matt would probably remember because I think he has been following the S/L patients closely too.



__________________

Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
mallani


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Sorry Isis,

Daclatasvir is a NS5A inhibitor, same as Ledipasvir. (all drugs ending in ...asvir are NS5A inhibitors, and all ending in .........previr are protease inhibitors).

In another thread, I think you were referring to Rockyfeller (Jim). He did 12 weeks of Sovaldi/ Peg/ Riba in July 2012. He relapsed 4 weeks after EOT.

He then did 12 weeks of Sovaldi/ Ledipasvir/Riba in Dec 2013. He has achieved SVR.

So, in his case, retreatment with Sovaldi was successful. Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
skewedButNotBroken


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Very informing---thanks!



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Diag. with hep c in 1992; A3:F2;  GT 1a; IL28B CT; VL 900k, ALT 150, AST 100 on 8/5/2014; SOT 9/5/2014  S/O ---VL 127 after 6 days; VL detected on day 18 but < 15.; --> UND @ EOT+ 1 year SVR!
Isiscat2011


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Very interesting, but it still doesn't answer the hard questions.  His treatment strategies do not include Harvoni or Abbive or any future combos specifically so they are of limited value. He recommends Sovaldi/Declatasvir for retreatment of those who have failed tx, where Sovaldi was the ONLY DAA used, which is your situation. This is probably because he is a European researcher and Declatasvir is potentially available in Europe but not yet in the US. 

Declatasvir is not in the same drug class as Ledipasvir.  Declatasvir is a PI while Ledipasvir is an NS5A inhibitor.  Don't know what impact that distinction would have but it is all theoretical at this stage.

The best source for information regarding Sovaldi and Ledipasvir is Gilead and they aren't answering these questions.



__________________

Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
JLynch30


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Good news

 

http://www.informedhorizons.com/resistance2014/pdf/Presentations/Pawlotsky_MAC_BERLIN-RESISTANCE.pdf



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
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