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Hep C Discussion Forum -> Hep C News -> Gilead Releases Phase 3 SVR Rates-Sovaldi/Velpatasvir (GS-5816)
Post Info TOPIC: Gilead Releases Phase 3 SVR Rates-Sovaldi/Velpatasvir (GS-5816)
Zlikster


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Gilead Releases Phase 3 SVR Rates-Sovaldi/Velpatasvir (GS-5816)
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Gilead signed long time ago a deal for volume licensing of Velpatasvir with indian companies that are already in deal for Sofosbuvir production. Can't wait for Sof/Vel single pill for cca 10$ :)

I wonder whats the plan with Gilead's clinical trials of Sof+Vel+GS-9857. Seems they are targeting even shorter tx (6w only?) with this potent DAA combo.



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
Cinnamon Girl


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Yes, excellent data from these trials.  Hopefully we`re slowly  moving towards a time when genotype testing will not be so relevant as more new treatments come out which are effective across all types.

Thanks for posting it,Tig.



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
mallani


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Great results from a great Company.

Now for FDA approval and the Geno 3's may join the party.

Please make it affordable.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
wmlj1960


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I read it yesterday and my thoughts were along the lines of about how quick they are making advancements in treatment of HCV in recent times and how it will likely be in the near future when 100% effective treatment will be common as well as a vaccination to prevent initial infection.  It gives me a confident feeling that HCV will be eradicated for our young as well as future generations. Thanks for the link Tig! smile



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

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Tig


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I was surprised there were no comments on this, so I'm bumping this up just in case it was missed yesterday. We've been waiting for these results, don't miss the promising news! This will be the next silver bullet from Gilead. If you're considering treatment in the near future, this may be your ticket on the next train to SVRville.



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Tig

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Tig


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Some very good news indeed!  WOOT!!

"FOSTER CITY, Calif.--(BUSINESS WIRE)--Sep. 21, 2015-- Gilead Sciences, Inc. (Nasdaq:GILD) today announced topline results from four international Phase 3 clinical studies (ASTRAL-1, ASTRAL-2, ASTRAL-3 and ASTRAL-4) evaluating a once-daily, fixed-dose combination of the nucleotide analog polymerase inhibitor sofosbuvir (SOF) with velpatasvir (VEL), an investigational pangenotypic NS5A inhibitor, for the treatment of genotype 1-6 chronic hepatitis C virus (HCV) infection"

Gilead Releases Phase 3 SVR Rates-Sovaldi/GS5816



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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