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Post Info TOPIC: cirhosis treatments?


Member

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RE: cirhosis treatments?
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This is clearly of considerable interest to me.
So far, I
- drink lots of coffee
- reduce BMI
- saw that in an abstract for CROI conference, statins were looked at (Simon et al., a 551)
"In patients with chronic HCV infection, statin use appears to reduce the risk of fibrosis progression
and decrease the risk of incident HCC, in a dose-dependent manner. Atorvastatin and fluvastatin are each
associated with significantly reduced fibrosis progression to cirrhosis, compared to other types of statins.
Further prospective clinical studies with clinical and histological endpoints are needed."
So I will talk to my doc, maybe switch me from rosuvacard to one of these ...

Lastly, and there seems to be an age-old controversy about that, Metformin. Not my field, but a friend of mine (Oxford PhD, biochemist) told me about its diabetes and anti-aging potential. He says most elderly (I am afraid he includes me here) develop some insulin resistance, likely not good re cirrhosis. Well. Furthermore, a large trial is now underway to check the anti-aging hypothesis. Reported in nature.com, I guess these are serious people, "Anti-ageing pill pushed as bona fide drug". Another talking point with my doc ..

Any thoughts/comments?

Cheers, Tom
(yes, I may become a little obsessive, and should get out more)






__________________

M, 57 (@Dx, 2014)

7/14: VL 4E6, F0-2 MRI TE

8/15: biopsy, A2F4 (no good)

SOT 8/15 - Harv./RIBA 12 wks

12 wks post: UND, ALT 21, AST 21, GGT 23, platelets 206

5/19 (44 month post): UND, ALT 34(?), AST 24,  GGT 22, platelets 240 



Guru

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Hey Peter

That is fantastic news, it would be nice to know what are the factors in reversing cirrhosis, like Malcolm mentioned it can get better or in some cases get worse.

It would make common sense items like diet, staying active physically, getting good sleep and reducing stress all can aid in the recovery.

matt 



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 



Veteran Member

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Just got a fibroscan after about two years of SVR. Fibroscan score: 5.9 which puts me at F0-F1. My last test was a biopsy in 2008 whicch showed cirrhosis. Before that a biopsy around 2003 showed bridging fibrosis F3. 



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64 YO - HCV  45 years - GT 1b - F4  - starting VL 7,800,000 - AST 130 ALT 164  - started S/O 4-11-14 - week 2: - AST 37 -ALT 43 - wk 4 VL <40 - UND week 8, 12, eot, +4 +8 +12 SVR!!!  My Blog-Visit hepcstories.wordpress.com!



Guru

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Every time I read something like this, I just dream a bit and especially the part for cirrhotics since there are a number of us here.



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65 yo, GT1A, , Cirrhosis, F-Scan F4 33.5, TX Naive Harvoni 12 wks

SOT 2/9/16 / ALT 187 AST 114 VL 2.3M.    POSTS

EOT 5/2/16  ALT 35/ AST/25  platlets 126 C/B VL UND

EOT +12 7/26/16  ALT 25 /AST 22/ ALP 83  platlets 129 C/B VL UND

EOT + 24 10/18/16 ALT 27/ AST 20/ ALP 71 platlets 153 C UND

 * SVR *



Guru

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It appears that fibrosis reversal is most definitely possible. I was reading up on it myself, and some good signs are raising of platelets and lowering of AFP of which I've had both so am very hopeful. I would think lifestyle choices would play a role. Definitely no drinking and regular exercise, low stress and healthy eating would help with your chances. And now that cure is possible for most, the next studies will most definitely be on fibrosis reversal. Let's hope in ten years we are all living with healthy slightly scarred regenerated livers! It is the only organ who can regenerate so chances are great for us!



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  1. Gracie

1A. Previously treated non responder Rebetron in 2000 And Incevik in 2014 with a breakthrough at week 12. Fibroscan 15.5. VL 6,000,000. Finished 24 weeks harvoni on Dec. 19, 2015. SVR. Latest Fibroscan 8.8.



Guru

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John,

I understand there will be some updated data shortly.

As of now, the reports state that, after 3 years,  50% show improvement of 1 to 2 stages, 25% are unchanged and 25% show some worsening of the histological features. The research is directed at what factors play a part in these figures, and whether anti-fibrotic agents can help.

The problem now, is that many patients are followed up by FibroScan, Elastography or Biochemical markers, so there will be a bit of doubt.

Post-SVR cirrhotics have a reduced incidence of HCC. Two years ago, I was told my chance of HCC had dropped to twice the normal population incidence. Now that I'm no longer cirrhotic, I think my chances of HCC are only slightly more than the normal population.

It has been shown that, in all post-SVR cirrhotics, portal venous pressure dropped. In other words, if you didn't have varices before treatment, you won't develop them now. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



Senior Member

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Anyone know what the idea is on cirrhosis treatment? Prognosis for cirrhosis after SVR?



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 

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