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Hep C Discussion Forum -> General Discussion -> VL and RAV's
Post Info TOPIC: VL and RAV's
Tig


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RE: VL and RAV's
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Hi C,

How about you read this one and you pretend I explained it clearly enough? You may need an account if you don't have one. If you can't gain access, let me know and I'll highlight it. The SVR rates (graph) look quite good to me....

 

Short-Duration Sofosbuvir/Velpatasvir + GS-9857 for Genotype 1 or 3 HCV: Safety and Resistance



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

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Canuck


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ooh, ooh, good'un's tig!! Glad you posted this - has pics and an' everything!

I kinda had forgotten our prior "skimming over" of that whole big thing about the scary "fitness" of these varmits. 4 years, phttt!

Now ... could one of you carefully, and very slowly, explain to me every nuance and re-interpretation of all the important bits of these 2 pdf's to me, until I fully understand?

I'll wait right here.

Oh, and to make this easier for you, just focus in (of course) on only how it applies to me (GT3a/velpa/gs9857). Cause we all know the world only revolves around me, right? biggrin

Good material you post. C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

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Tig


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Here's some information from the good doctor and is quite informative. If he checks in I'm sure he will expound on this.

RAV'S

One more:

RAV PERSISTENCE + RESISTANCE



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

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JimmyK


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So are you saying my very stupid question may have moved into the category of excellent question?

OK now THAT was a stupid question I know.no

Yeah I can't find data on it. Now given these are resistant variants it may be a moot question in that once you are off meds there is nothing to resist. "RESISTANCE IS FUTILE" on the other hand gives these little lizards more credit than they are due.

 

I will see if anyone else chimes in.

 

Thanks lill Sis.  wink 



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

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Canuck


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X-cellent question!! 

I tried looking it up in my mallani rav book whilst trying to study up on microwaving hcc.

The rav answer is either .... definitely yes, or definitely no, or ... maybe/sorta?

Usually with these things, all I ever come up with - are more questions! If load is gone, are ravs gone? If HCV replication ceases (absolutely) forever and ever, then one would assume NO Rav's could be found to type? Our basic "comes with the package" genetic info, such as, whether you are a cc, ct, or tt can never be "gone", so ....?

I hope you get it figured out for me.

catgtgcaaatcggctatcgacaaccgggtttata (code for love, Sis)

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
JimmyK


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Greetings,

This may be one of the all time stupid questions ever but in that I do not know the answer I am going to ask anyway.

If one fails treatment, and it is determined they have RAV's, then they go on to re-treat and are found to be UND say during the second treatment, are the RAV's gone or assumed to be?

wink



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
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