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Post Info TOPIC: Getting Ready for a Re-Match


Guru

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RE: Getting Ready for a Re-Match
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Hi Alison,

Excellent thank you and congratulations.

Love and Light,
Greg



__________________

The mind is like a parachute it works best when it is open. "The Dalai Lama" My blog: http://greghcv.wordpress.com/
Genotype 1a, started tx 1st Feb 2011, for 48 wks. Week 24 PCR 26/07/11 Non-Responder
New TX start date 12th Sept 2016 Harvoni x24 weeks.  VL 7.4 Mil. Week 4 "Undetected"



Guru

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I echo Pablo,

the VLs can vary drastically. When I was deciding whether or not to do the old treatment, the Dr. ordered VLs and it was 7 million, then a few months later it was 3 million. (I thought it was because of meditation no

I had it tested a few years later and it was over 7 million, then just last year before this treatment it was only 7K.

Now it's UND. biggrin

Alison



__________________

61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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Hi Greg

RAVs are resistance associated mutations, bad copies of the virus that don't respond to the enzyme blockers in the DAAs.  They tend to lie behind most treatment failures, but they are rarely checked for in routine clinical practice.  I wouldn't worry about them though as sofosbuvir, which you'll be getting in Harvoni, is very resistant to RAVs.

Pablo



__________________

44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.



Guru

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Pablito wrote:

Hi Greg

VLs vary hugely so I wouldn't worry too much.  They do tend to go up after a treatment that didn't work but the new DAAs are so potent - a 2 log drop after once dose - that whilst it's reassuring to have a low VL and it might take a little longer to achieve UND than with a low VL you will go UND during treatment.

The real enemies are RAVs.  Did they do RAV testing after your last treatment?

Best of luck.

Pablo


Hi Pablo
Thanks for your quick reply, and your reassuring words. I'm unfamiliar with RAV, just had a quick google and no they didn't do that test after TX. But hopefully will be touching base with my specialist today and will discuss that subject.

Love and Light,
Greg



__________________

The mind is like a parachute it works best when it is open. "The Dalai Lama" My blog: http://greghcv.wordpress.com/
Genotype 1a, started tx 1st Feb 2011, for 48 wks. Week 24 PCR 26/07/11 Non-Responder
New TX start date 12th Sept 2016 Harvoni x24 weeks.  VL 7.4 Mil. Week 4 "Undetected"



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Hi Greg

VLs vary hugely so I wouldn't worry too much.  They do tend to go up after a treatment that didn't work but the new DAAs are so potent - a 2 log drop after once dose - that whilst it's reassuring to have a low VL and it might take a little longer to achieve UND than with a low VL you will go UND during treatment.

The real enemies are RAVs.  Did they do RAV testing after your last treatment?

Best of luck.

Pablo



__________________

44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.



Guru

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Thanks everyone once again for your support,

I have a quick question and must admit I am a bit concerned. Back in 2011 pre TX my VL was around 2Mil and went down to a couple of thousand. Now my latest VL is upwards of 7Mil. I know this is a question for my specialist who will get a call today hopefully. But I was wondering as I was a non-responder did the TX trigger off some sort of renewed rapid replication mechanism, or might other factors be in play? Look forward to your replies.

Love and Light,
Greg



__________________

The mind is like a parachute it works best when it is open. "The Dalai Lama" My blog: http://greghcv.wordpress.com/
Genotype 1a, started tx 1st Feb 2011, for 48 wks. Week 24 PCR 26/07/11 Non-Responder
New TX start date 12th Sept 2016 Harvoni x24 weeks.  VL 7.4 Mil. Week 4 "Undetected"



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Hi Greg.

 

I wasn't here when you first started, but I am really happy for you to be able to get rid of this awful virus once and for all!

Have a great time with your granddaughter! Those are special moments. 

 

Liz



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Guru

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Hi again, Greg!

Your little granddaughter`s birthday party is your first priority of course, and then you can get down to the serious business of taking on that Dragon again, and this time it will be for good! 

I`m so thrilled for you getting Harvoni at last, you`ve been waiting around for long enough and you`ll soon be on your way to SVR, my friend!! 

Oh, and happy birthday wishes to your granddaughter, have the best fun ever!!!    party.gif

  


__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Hi Greg, welcome back to the forum.  So glad to hear about your retreatment option.  These new drugs are so much better.  Looking forward to you slaying the dragon this time around.   Best Wishes!   Chris



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F 63,  1b  1974, no cirrhosis, fibro scan 5.8 F0-F1,fibro test .37 ,V/L 702987, ALT 90, AST 75.  ABBVIE Topaz II on 10-30-14 Viekira Pak no RIBA , EOT 1-22-15 SVR, ALT 37, AST 29, 4-15-15 SVR12 - fibro test .22,  1-21-16 SVR 52 ,  1-21-17 SVR 104! 1-21-18 SVR 3 years ,2020 5 years, 2022 7 years!

Tig


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Hi Greg,

You're going to be amazed at the effectiveness of these drugs. So completely different from the things we experienced with the old SOC's. You are blessed with a PBS that provides them, too. 

Enjoy that special day with your grand daughter . Some days are more special than others and that is one of them! Save us a piece of cake smile

Good luck, Mate!!



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Tig

66 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Hi Greg,

I am so glad you are getting a re-match with the dragon. This time will be a whole lot different for you. smile

my old Drs. pushed me to try interferon, riba in early 2000's but I researched a bunch and I was too scared of what people were going through to try it. 

Fast forward 15 years of research and have my daughter beg me to get the new drugs and I am now SVR. Our healthcare system would only pay for 8 weeks of harvoni, but my new Dr was worried with my cirrhosis I'd better do 12 weeks so I did the holkira  pak with the riba experience. but all good now. 

Anyhoo, I look forward to seeing your numbers drop this autumn. Have fun at your granddaughters birthday   

Alison

 



__________________

61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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Hi Cauck,

Thanks for saying G'day, yes I forgot to mention that I will be on Harvoni for 12 weeks at this stage, hopefully that won't change.  I could start now but have my granddaughter's birthday party this weekend and want that to be special for her then I'll tackle this beastie the following day. 

Cheers mate,

Greg

  



__________________

The mind is like a parachute it works best when it is open. "The Dalai Lama" My blog: http://greghcv.wordpress.com/
Genotype 1a, started tx 1st Feb 2011, for 48 wks. Week 24 PCR 26/07/11 Non-Responder
New TX start date 12th Sept 2016 Harvoni x24 weeks.  VL 7.4 Mil. Week 4 "Undetected"



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Hi Greg,

Glad to meet you! Glad for your new doc and the new drugs. We will all be happy to see you free. Is it Harvoni for you? And how long?

Happy 11th! smile C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hi Everyone,

So good to see so many old friends here and new ones too, thank you once again for your kind words and encouragement.  Iris the first dance is mine lovely lady.   Malcolm we are so lucky in this country to have this provided to us on the PBS, just amazing and thanks for thinking of me mate. My son and I are becoming members at the Gabba later this year so you might get an invite.

My new specialist was a complete opposite to my old one and a breath of fresh air who  was on the ball with everything, within 30 mins I had my scripts in hand.
I have some basic results below more to follow so stay tuned.

HCV Vir Load is 7.39 Mil 

Viral Log is 6.9

That's all I have at the moment, will be having my Ultrasound etc on the 20th of this month so will post the results as well. I will start TX next Sunday the 11th. Just wanted to mention a grateful thank you to Jime, one of our former members who was one of the first people to trail these wonderful new drugs and thanks to him, myself and many others are able to free ourselves of this horrible virus. I know you will be in there with me mate as the re-match begins. Like last time hitting below the belt is allowed. 

Love and Light to all,

Greg

 



__________________

The mind is like a parachute it works best when it is open. "The Dalai Lama" My blog: http://greghcv.wordpress.com/
Genotype 1a, started tx 1st Feb 2011, for 48 wks. Week 24 PCR 26/07/11 Non-Responder
New TX start date 12th Sept 2016 Harvoni x24 weeks.  VL 7.4 Mil. Week 4 "Undetected"



Guru

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Hi Greg,

i went back and had a look at some of those old Intreferon/RIBA posts and was filled with so much respect for what you all went through - most for 48 weeks!!! 

With the new DAAs this rematch will be over before you realise it's started.

Syd



__________________

Contracted Hep C 1969. Genome Type 2, treatment naive. Began 12 week RIBA/sof/Dac on 12/11/15. Cirrhosis. VL before treatment 4m. Treatment extended another 12 weeks without Riba. No virus detected at 9 weeks.



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 You're right Greg - that "dragon is going down" this time and compared to your last time you will barely know you are in a fight. Welcome back!  smile



__________________

60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

Mike

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Hey there sweetie! You didn't think you could sneak in here without a big hug from me! This is excellent news! Much congratulations to you. I hear the side effects are much less with the newer treatments. Do you know which one is your option yet?  Man, it's really good to see you. We should go spin some tunes on the juke box and dance! Just like the good ol days !....

Welcome to the final battle, my far away friend biggrin,  many blessings on your quest!

Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)



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Hi Greg,

Mate, it's good to hear from you. I thought you should get on the Australian PBS drugs.

My Hepatologist in Brisbane is working though all his old non-responders. ALL have been Undetected after 4 weeks.

I guess you'll be on Harvoni so keep us posted. You've got this.

Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Welcome back Greg,

Although I was not here when you initially posted here, the forum as you say is great and the members and moderators are great. They help so many people get through treatment and everything leading up to it and after it. 

New drugs as you know are here and very effective. This time is going to be a piece of cake I am sure.

Good luck and glad you will revisit this again.

SF



__________________

65 yo, GT1A, , Cirrhosis, F-Scan F4 33.5, TX Naive Harvoni 12 wks

SOT 2/9/16 / ALT 187 AST 114 VL 2.3M.    POSTS

EOT 5/2/16  ALT 35/ AST/25  platlets 126 C/B VL UND

EOT +12 7/26/16  ALT 25 /AST 22/ ALP 83  platlets 129 C/B VL UND

EOT + 24 10/18/16 ALT 27/ AST 20/ ALP 71 platlets 153 C UND

 * SVR *



Guru

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Hi everyone and thanks for the lovely warm welcome,
Feels great to be back, I can't wait to get started. Can't believe I said that after the last effort.  Just wanted to thank you all for your kind words.

Love and Light,
Greg



__________________

The mind is like a parachute it works best when it is open. "The Dalai Lama" My blog: http://greghcv.wordpress.com/
Genotype 1a, started tx 1st Feb 2011, for 48 wks. Week 24 PCR 26/07/11 Non-Responder
New TX start date 12th Sept 2016 Harvoni x24 weeks.  VL 7.4 Mil. Week 4 "Undetected"



Guru

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Man I love a good Re-Match! Seems like there is always some refinement to the first attempt.

Welcome back Home!

 

JimmyK



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."



Moderator

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Yeah Greg!  Down dragon coming up!!!



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



Guru

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Hi Greg,

You'll think this is a picnic in the park compared to the horror 48 week nightmare. I'm glad you'll be on the new treatment train, the success rates are amazing and although you'll have probably some sides, they'll be nothing to what you previously endured.

Looking forward to hearing u kick its ass to timbuckto!



__________________

Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 



Guru

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Hi Greg and welcome back.

I failed the same treatment back in the day and had success with Harvoni. Here's to your new dragon slaying and much success. 

Yes, this site and the family here is a blessing.

wendy



__________________

Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



Guru

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Hello Greg!

Great to see your news, my friend..   welcome back!   I remember what you went through last time around and thank goodness you won`t have to go through that again.  These new DAA treatments are a vast improvement on what people used to have to endure, and this time you`ll have a new and hopefully much more competent doctor in your corner!

Keep us posted... smile



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



Guru

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Hi Greg,

And welcome back, glad you are able to revisit Treatment, these new meds are extremely effective as I'm sure you well know.

Indeed this site has helped us one and all, it's a true pleasure to see you here now.

I'm sure Tig and others will be along shortly to welcome you back. We'll be here for the whole train ride, it's nice that you are well on your way to, as you say, plan an attack. We have an armory full of knowledge about us here, let us know if we can point you in any particular direction.

Keep us posted on how it's all going or just drop in any time to catch up on friends, folks and freedom HCV-Freedom that is, LOL

 

Dave (aka Linux)



__________________

63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 



Guru

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Hi Everyone,
It's been a number of years since I last posted, and a lot of great and wonderful things have happened to me since then. Now it's time for a re-match with my particular Dragon I am a non-responder finished TX back in 2011. I have a new Doctor the last one retired, (no great loss....a long story don't want to go there lol, if you must it's in my blog.) so armed with a new Doctor and the new Meds I like my chances of beating this bugger this time around. I have an appointment on the 18th of August so hopefully will have a plan of attack and more news.
I can't begin to tell you all how much this site and it's wonderful and very beautiful people helped me during TX last time. This Dragon is going down! 

Love and Light,
Greg

 



__________________

The mind is like a parachute it works best when it is open. "The Dalai Lama" My blog: http://greghcv.wordpress.com/
Genotype 1a, started tx 1st Feb 2011, for 48 wks. Week 24 PCR 26/07/11 Non-Responder
New TX start date 12th Sept 2016 Harvoni x24 weeks.  VL 7.4 Mil. Week 4 "Undetected"

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