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Post Info TOPIC: Lose or gain weight ?


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RE: Lose or gain weight ?
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Pablito wrote:

Tig hit it on the nail.  I developed a very sweet tooth on sofosbuvir and gained about 2 kilos.

However, a few years back when I was on ribavirin I lost weight, about 4kgs.  Now this may have been the interferon, or perhaps just because I felt wretched and consequently had less of an appetite.

My this very loose estimation sof + rib should cancel each other out!  

But it's more about what we eat rather than the medication.


 Ha ha Pablito,

You have such a ways with words and i like your thinking - by your math to drug ratio examples, it makes perfect sense!, sof + rib = 0 weight gain. Hee hee, I like your "loose" reckoning!. Late in life I have come to love math, well ... numbers really, especially ZERO! smile C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Thanks Dave. 

Hope with the heat dome hitting all over the US this weekend, everyone remembers sunscreen and hydrate!



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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Sorry to hear stress and lack of sleep are ongoing Wendy, you're doing all the right things to try to alleviate them, hope your doc helps you find the right combo to tame that a bit. Getting and keeping the blood pressure down is a biggie though so you're doin' good there.

Yes, TGIF ... have a nice relaxing weekend smile

 

Dave

 



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63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 



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you guys/gals crack me up between sweetie pervert and the dribbling creepy person. Could be a new horror or sci fi flick. 

John many of us talk about DQ in numerous threads. I feel as long as it is in moderation

Hey Cheddy! Yes I kept going to the gym but remember I was on harvoni so the sides were not as bad as the TX's many of you all were on with geno 2 and 3. I am doing ok today. Got the blood pressure under control, labs revealed no issues just work stress. Dealing with starting menopause and that SUCKS. For me the lack of sleep is the worst. But I take it a day as a time and know it is not the end of the world. Waiting on lab results to see what we can do to manage those sides. 

TGIF!

wendy

 



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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Thank you , I have those sweet tooth moments also. I try to control them but it is hard sometimes.haha  



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Genotype 3  f2     vl 18,216,000. Hcv 7.260.  Alt 232. Fibrosis score 0.56. Necroinfl score 0.89    necroinfl grade a-3   sot 8-17-16 epclusa



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Ivery.  I lost about 4 lbs when for a few weeks, but over all I stayed exactly the same.  When I wasn't doing much, I didn't feel like eating as much.  Can't say I had a sweet tooth.  I think eating healthy food helps a lot.

 

Nice work on getting healthy!!!!!!



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Whooooaaa Wendy.  You kept going to the gym?  I could barely make it up the stairs.  Good going.  How are you now, anyway?



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 

Tig


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Creepy person dribbling?? I'm not even going there.....   wink



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Tig56 wrote:

Sweetie Pervert??? LOL! biggrin


 Yeah, staring at them like a creepy person dribbling. :P



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VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 

Tig


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Sweetie Pervert??? LOL! biggrin



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Pablito wrote:

Tig hit it on the nail.  I developed a very sweet tooth on sofosbuvir and gained about 2 kilos.

However, a few years back when I was on ribavirin I lost weight, about 4kgs.  Now this may have been the interferon, or perhaps just because I felt wretched and consequently had less of an appetite.

My this very loose estimation sof + rib should cancel each other out!  

But it's more about what we eat rather than the medication.


 I have a terrible sweet tooth on my combo as well. I hit back full steam today training, I've no excuse not too. I must admit, I keep eyeing up candies like some sweetie pervert. :O



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Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 



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Tig hit it on the nail.  I developed a very sweet tooth on sofosbuvir and gained about 2 kilos.

However, a few years back when I was on ribavirin I lost weight, about 4kgs.  Now this may have been the interferon, or perhaps just because I felt wretched and consequently had less of an appetite.

My this very loose estimation sof + rib should cancel each other out!  

But it's more about what we eat rather than the medication.



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44 y.o. male, HCV G4 since 1996, F-scan score 9, F2, Failed prior I/R, finished sof/vel/vox 8 weeks 5/16, pre-treatment VL 2 million, EOT UND, EOT+4 UND, EOT+12 UND.



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Hi John,

Great job on the lifestyle changes! That's what it takes to make a big difference such as the very noticeable changes that your pictures tell. I just wrapped up my treatment using Sovaldi/ Ribavirin and my weight remained steady throughout. As others have pointed out, you may not feel as energetic and need to back off a little as the Ribavirin saturates your system but since you are now used to regular exercise you'll do great.

You will need to keep your water intake steady through treatment with a full gallon per day, extra important with exercise.

Glad to see you off to such a great start, you'll do great, if you do start to crave sweets, just aim for natural sweets such as fruits, raisins, carrots etc.

 

Be Well,

Dave



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63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 



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Wow, what a transformation John. No wonder you don't want to back slide. My weight remained constant during treatment. I agree entirely with Tig regarding different story effects of Sof and riba.

Take care,

Syd



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Contracted Hep C 1969. Genome Type 2, treatment naive. Began 12 week RIBA/sof/Dac on 12/11/15. Cirrhosis. VL before treatment 4m. Treatment extended another 12 weeks without Riba. No virus detected at 9 weeks.



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I was on a different TX but I continued to work out maybe one day less then pre TX and I maintained, no gain or loss. Keep doing what you are doing John, hydrate, eat smart and listen to your body. If I needed to rest and not go to the gym that is what I did. Take care of you!



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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I guess it depends how much fatigue you get. I have noticed that people whom sport have a lot less side effects and continue sporting verses people who do not. Looking at photo 2, I'd say you'll be fine. However, even if you gain a little its OK,  its just a temporary thing. You look very healthy and happy. :)



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Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 

Tig


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Looking good John! You look pretty healthy in picture #2. Keep up the great plan and you shouldn't have a thing to worry about! Good luck smile



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Today 



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Genotype 3  f2     vl 18,216,000. Hcv 7.260.  Alt 232. Fibrosis score 0.56. Necroinfl score 0.89    necroinfl grade a-3   sot 8-17-16 epclusa



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2 years ago 



-- Edited by Ivery on Wednesday 20th of July 2016 11:01:08 PM



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Genotype 3  f2     vl 18,216,000. Hcv 7.260.  Alt 232. Fibrosis score 0.56. Necroinfl score 0.89    necroinfl grade a-3   sot 8-17-16 epclusa



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Thank you, I exercise daily, jog and try to eat healthy.  At 1 time I was 295lbs. A drinking, smoking, fast food, unhealthy mess!! But I changed my lifestyle and now I'm 200lbs. It took saot of work to get here and I pray to stay here.



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Genotype 3  f2     vl 18,216,000. Hcv 7.260.  Alt 232. Fibrosis score 0.56. Necroinfl score 0.89    necroinfl grade a-3   sot 8-17-16 epclusa

Tig


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That's kind of a toss up with Sovaldi and Ribavirin. Sovaldi protocols have been known to cause the development of a sweet tooth. Ribavirin on the other hand, causes some anemia, which may lead to some fatigue, lack of appetite at times and may result in some weight loss. It will be determined by your own metabolism and how many banana splits you put away if that sweet tooth attacks!! 

If you concentrate on a healthy diet, stay active and hydrate properly, you shouldn't have a problem either way. You're in control, remember that!



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Will riba / sov tx cause weight gain or loss?



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Genotype 3  f2     vl 18,216,000. Hcv 7.260.  Alt 232. Fibrosis score 0.56. Necroinfl score 0.89    necroinfl grade a-3   sot 8-17-16 epclusa

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