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Post Info TOPIC: Hep C crosses the brain barrier


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RE: Hep C crosses the brain barrier
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Well, as long it doesn't destroy the liver, and behaves itself.

Herpes virus hangs out in central nervous system, too, and can be a real MF when it gets to things that really matter.

Epstein-Barr another ratbastard that Ive known since high school. All it was good for was getting me out of the USMC after an 18 month stint, saving me another 2.5 years of getting screamed at by mean guys with severe mental issues. Much literature ties it to a whole host of nasty diseases.

Let's face it, "they" need to spend more resources developing cures and vaccines for these vicious virae (sp) and less on whatever they are spending on!

 

 



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Lamont Cranston "Only the Shadow knows."

65 years old, retired IT Network support 29 continuous sobriety in AA, ,DX'd in '99 with MS, DX'd with HCV 2, 2b , F0-F1 3/17/2017 VL 5.7m Starting EPCLUSA 7/28/17

No Virus Detected on November 20, 2017 3 months after EOT

Tig


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Hey Skewed,

We discussed this a few years back. There has been a lot of research into the possibility that the HCV virus could hide out in tissues not easily accessed by the treatment medications. Studies have proven that adequate perfusion and attention to the individual, as well as things like past treatment, cirrhosis, genotype, etc., are all considered to assure adequate exposure to these virus killing agents. Here’s an article from Lucinda Porter with additional information. You can also find our discussions here. Search “post mortem” using our search function. Mallani and Matt talked about it in length.

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”Unlike HIV, hepatitis C does not form a latent reservoir, so technically if hepatitis C is nondetectable, it should remain that way. One theory as to why it may act otherwise, is that hepatitis C hides out in the lymphatic system. However, a study by Formann and colleagues found that although hepatitis C might be present in certain cells of someone with an SVR, there is no evidence that hepatitis C infection will recur. 

Most of us have heard a story or two of someone who had an SVR, but hepatitis C returned. The likely explanations for this are lab mistakes and reinfection. However, viral load assays are much more sensitive now, so I rarely hear about anyone with an SVR later becoming viremic.“

 

Treatment and Undetected Viral Loads

 

 



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Tig wrote:

I think an individual that fails to clear the virus (active, chronic infection) during treatment or relapses within the 12 week post treatment period of time, then consideration of this could be made. However, I havent seen any current evidence of it. If the barrier protected the virus from the (all) larger molecule medications passing through it, that would preclude any chance of ever defeating the virus in the first place. Right? I think its another one of those explanations that might apply if Tx failure occurred. Rare in this age of blockbuster DAAs.


 Tig, what you state seems logical, but could it be possible that the virus could be trapped in the brain because the medication could not penetrate the brain barrier? I've read articles that that examined the hearts and brains of patients postmortem who had reached SVR but still had the virus in these organs.



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Diag. with hep c in 1992; A3:F2;  GT 1a; IL28B CT; VL 900k, ALT 150, AST 100 on 8/5/2014; SOT 9/5/2014  S/O ---VL 127 after 6 days; VL detected on day 18 but < 15.; --> UND @ EOT+ 1 year SVR!

Tig


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I think an individual that fails to clear the virus (active, chronic infection) during treatment or relapses within the 12 week post treatment period of time, then consideration of this could be made. However, I haven’t seen any current evidence of it. If the barrier protected the virus from the (all) larger molecule medications passing through it, that would preclude any chance of ever defeating the virus in the first place. Right? I think it’s another one of those explanations that might apply if Tx failure occurred. Rare in this age of blockbuster DAA’s.



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

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Hi all,

This article is from 2012, but it verifies what many of us already believed. In addition, it begs the question can we, who have achieved SVR, still harbor the virus in our brains? 

https://www.hepmag.com/article/HCV-Brain-Endothelium-21818-1287637502



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Diag. with hep c in 1992; A3:F2;  GT 1a; IL28B CT; VL 900k, ALT 150, AST 100 on 8/5/2014; SOT 9/5/2014  S/O ---VL 127 after 6 days; VL detected on day 18 but < 15.; --> UND @ EOT+ 1 year SVR!

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