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Tig


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RE: Hi there
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Hi Sunny,

Tell me more about yourself. I’m curious, why did your doctor select an old treatment protocol, when there are better rescue options available? Ledipasvir hasn’t been referred to as GS-5885 in years and only during the Gilead trials. Who mentioned this to you? Something isn’t adding up. I’d like to know more about your history if possible. You mentioned a course of Interferon and Ribavirin in 99. Was that the old beta 3z protocol?



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Canuck


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Hi sunnyard,

Welcome here.

Thank you for introducing yourself. We are happy to meet you. All of us will offer company and support, as best as we are able.

I am not sure what country you hail from, but I am wondering if you and your doc have ALREADY made up your minds about what treatment would be best for you. If your doc insists that that IS the only and best treatment for you, and no other doctor can suggest another or better one for you, then so be it - but if it were me (given the hx you have shared here - being treatment-experienced, non-responder to int/riba, non-cirrhotic?) - I would exhaust of your doc (or another) if there is NOT a better treatment choice.

If you two have already decided on a re-treatment with Harvoni + riba, then I assume no other treatment choice was available to you to consider. GS-5885 is "ledipasvir" of which sof+ledi IS "Harvoni", and it "seems" in your case, because of your prior treatment-experience (non-responder) or perhaps for some other reason, riba as a third drug addition has been suggested.

Drug regime choice may be limited in some countries, thus, why I was trying to verify which country you were from.

If you are still at the "deliberating" stage, find out what other appropriate drug choices are available to you, if the decison has already been made, you can still ask your doc if there are any other choices before you start, and what they might be.

A Harvoni + riba regime (as a triple) has shown high cures in studies, but we do not see it being used much as a triple nowadays though. When possible, or when riba does not discernably improve cures rates by much, docs are less inclined to use riba as a third drug to add to a modern DAA double - one drawback with riba use are possible riba sides - riba may contribute sides and feel harsh compared to other modern DAA HCV drugs, I do not know how long you were on your prior treatment of int/riba but perhaps you noted sides on that treatment? I do not (generally) see riba being added to any of the current recommended list of double drug regimes in case of re-treatment (but maybe your doc knows more than we all do in your particular case) - please do inquire about riba use, period, and if there is any better double regime choice that may be best or available to you.

There are other drug treatments recommended in some countries, more so than sof/led/riba (for the known parameters you have outlined thus far - such as being treatment-experienced and non-cirrhotic), such as 12 weeks of Epclusa (sof/vel). Others may be Mavyret, or perhaps Zepatier.

Inquire.

Glad you joined us here. : )   C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

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Iris Dragonfly


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Oooo, I want to sleep 10 hours a day! LoL the Mr. Is too noisy to let me do so :(.

Welcome to the forum, tons of info here and lots of helpful folks! The magic beans abound! Keep reading, you'll see what I mean. See you around.

Bb, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)
5-1-18


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hi sunnyard, are you going to be taking one of the new daa's soon?

did you stay on the interferon for very long?

welcome to the forum and i hope to hear about your journey

 

5



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0
sunnyard5666


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I am a 57 years old female and was  diagnosed with HCV in 1999.

I contracted the virus from a blood tranfusion in 1977 in a bad car accident.

My health is excellent. Genotype 1A, minimal liver fibrosis and inflammation, ALT and other liver enzymes almost always normal, viral count usually 1-2 million.

I am slender and walk 40 minutes a day.

I failed interferon and ribaviran in 1999 and I am a null responder.

My only complaint is that I sleep 10 hours a night (yes, every night) if I can.

The interferon gave me a migraine every day so my dr recommends waiting for sofobuvir/GS-5885 with ribaviran. 

Great forum!



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