Hep C Discussion Forum

Members Login
Username 
 
Password 
    Remember Me  
Chatbox
Please log in to join the chat!
Post Info TOPIC: Hep B Updates


Guru

Status: Offline
Posts: 3249
Date:
RE: Hep B Updates
Permalink  
 


They have really knuckled down on trying for better stuff for HBV. This (with Dr. Boci's name on it, Italy), and as well, earlier this year, "talk" from Dr. Gane, New Zealand about "Dicerna" -  About contracting HBV and HCV at the same time  -  I haven't caught anything new about Dicerna since  that post of January 29 - i wonder what's happening on that front as well? C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


Admin

Status: Offline
Posts: 8986
Date:
Permalink  
 

Good news on the HBV front!

 

Novel vaccine with Viread induces T cell immune response in chronic HBV

 

“HBV-specific T cells are deeply exhausted in untreated patients with chronic hepatitis B (CHB): reconstitution of their antiviral function represents a major goal of HBV immune therapies,” Carolina Boni, MD, from the University of Parma in Italy, and colleagues wrote. “Therapeutic compounds designed to restore an effective HBV-specific T-cell response represent promising tools for improving the rate of HBsAg loss and seroconversion in subjects with CHB compared with what is currently achievable with [nucleo(s)tide] alone.”

Boni and colleagues randomly assigned 195 patients to receive Viread (tenofovir disoproxil fumarate or TDF, Gilead Sciences) with GS-4774 (n = 168) or TDF alone (n = 27). While GS-4774 was originally engineered and evaluated to affect HBV surface antigen levels, the researchers found no significant differences between the two groups in HBsAg decline from baseline.

However, patients treated with the GS-4774 vaccine had significantly increased production of interferon gamma (IFNG), tumor necrosis factor (TNF) and interleukin 2 (IL2) by HBV-specific cytotoxic T cells at week 24 and week 48 compared with baseline. Patients treated with TDF alone showed no significant changes in immune response.

“Evolution of T-cell responses in patients treated with combined GS-4774 and tenofovir is well illustrated by hierarchical-clustering analysis of all data derived from all time points of therapy and from the reference acute hepatitis B control group for the definition of an efficient immune response able to control infection spontaneously,” the researchers wrote.

GS-4774 was generally well-tolerated. The most common treatment-emergent adverse events associated with injection site included pain, erythema and swelling, while other common events included fatigue and headache.

“Future combination therapies including vaccines should consider the sequential administration of drugs able to improve T-cell responsiveness to antigen stimulation by lowering the antigen load, such as, for example, silencing RNA compounds or capsid assembly inhibitors, or by inhibiting immune checkpoints or modulating T-cell metabolism, followed by T- and B-cell boosting through vaccination,” Boni and colleagues concluded. – by Talitha Bennett

Hep B Vaccine Advance

 



__________________

Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 5+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 

Page 1 of 1  sorted by
 
Quick Reply

Please log in to post quick replies.

Legal Disclaimer:

THIS FORUM, IT'S OWNERS, ADMINISTRATORS, MODERATORS AND MEMBERS DO NOT AT ANY TIME GIVE MEDICAL ADVICE AND IN ALL CASES REFER ANYONE HERE TO SEEK APPROPRIATE MEDICAL ADVICE FROM THEIR DOCTOR.