Hep C Discussion Forum

Canuck · Canuck

Another "new?" NS5A - "Ruzasvir" - Info from drug study discussed at recent Nov 2106 Boston Meeting.We have heard a lot about Zepatier (elbasvir/ grazoprevir) a NS5A and a NS3/4A respectively (given with or without riba, and sometimes with sof), but I (personally) did not know about this (new to m...

Canuck · Canuck

Published in GastroenterologyJournal Scan / Research · May 20, 2019Resistance Analysis of Genotype 3 HCV Indicates Subtypes Inherently Resistant to Nonstructural Protein 5A InhibitorsHepatology (Baltimore, Md.)TAKE-HOME MESSAGEThis is an interesting study wherein the authors eva...

Canuck · Canuck

California health officials battle state's largest hepatitis A outbreak in 2 decadesHelio - July 21, 2017The California Department of Public Health is working with local health officials in San Diego and Santa Cruz counties to contain the state's largest hepatitis A outbreak in 2 decades.As of J...

Canuck · Canuck

We have discussed the use of AFP's (many times, all over this site) but of late in particular about how an AFP may be used to possibly herald other kinds of cancers developing, aside from liver cancer, and it lead us to discuss not only the good ole familiar AFP, but the less US-used one, the AFP-L3 (this o...

Tig · Tig

This is very good news for those of us keeping an eye on our blood glucose levels! SVR brings improvements in areas we might not realize. It takes time to see some of these changes, but knowing it happens, is good news for all! A1C Reductions

jagad001 · jagad001

I ran my own company for several years, and I was always on the go. Sometime around 2010 or later, I began to feel tired all the time. I went to doctors, and they kept ordering lab tests, such as checking for diabetes. They couldnt find anything wrong with me for a year or two, so eventually I stopped going t...

Canuck · Canuck

I think it was "dharmabum" who first raised the early alarm about some sort of "recall" going on with a med (that I think she was on), Losartan (perhaps it was some other Losartan formula name she mentioned), but I do believe this Losartan drug was the one she referred to and was concerned about (I looked...

Cheddy · Cheddy

HEY NEW MEMBERS, IF HE CAN DO IT, SO CAN YOU! WE'VE MADE SO MUCH PROGRESS! NEWS RELEASEJanuary 16, 2019For immediate releaseRegions 1st hepatitis C heart-transplant recipient is curedAnacortes, Wash., man opted into UW Medicine protocol to receive infected donor heart and then had virus eradi...

Canuck · Canuck

Not that in North America we have seen Dacla (a NS5A) and Asunaprevir (a NS3/4A) being used as a double, but in Japan they have made use of this double. Multiple Japanese studies have fairly recently been coming out about the prevalent use of this combo and various notes they are making about it. This st...

Tig · Tig

I found this recent article on our favorite topic, HCV. I found it to be a good description of it and the many issues that accompany it. It’s easy to understand and could be a good tool for us to present when asked about the disease. See what you think. I give it a 9 out of 10... Everything You Need to Know: HCV...

Canuck · Canuck

From "Contagion Live - Infectious Diseases Today": ARTICLE Hepatitis C Treatment Time Could Be Cut in Half in Some Patients: A Proof of Concept Study NOV 14, 2018 | EINAV KEET A personalized medicine technique may shorten the duration and reduce the cost of treatment for hepatitis C virus infecti...

dharmabum · dharmabum

http://time.com/4996657/heart-transplant-hepatitis-c/

Tig · Tig

The AASLD and IDSA HCV Guidance Panel has released updated guidelines for the treatment of hepatitis C virus infection, according to newly published data in Hepatology. You will note that they continue to recommend the use of 12 weeks of Sovaldi/Peg Interferon/Ribavirin in GT 3's that are able to...

Canuck · Canuck

So, this article/take-home message, about the study (and the study itself) I found interesting - and, oh of course, they just had to study the costs savings! The part that was interesting to me was that group of liver transplant people who were studied and followed between 1998 and 2015, who WERE tole...

Canuck · Canuck

A relatively "new?" NS5A - (formerly called PP1-668), now named Ravidasvir. Well, it's news to me anyway. Out of Egypt (where there are many GT4's to trial it on), but reading other articles about it tonight, it IS being touted as pan, coupled with sof, with some impressive results, and more interest...

Canuck · Canuck

https://hepatitiscnewdrugs.blogspot.com/2011/03/celebrities-with-hepatiti...

Tig · Tig

This slide set was published last year, but offers some interesting info for new and old members alike. I couldn’t locate it being brought here before and CCO is more often a physician only periodical most don’t have access to. It’s amazing to see the shear numbers affected by this disease globally an...

sleestak · sleestak

Thanks to the cultural mediator support, we explained to the patient the correct posology of each drug to take during the day consisting of 12 week SOF (400 mg daily) plus DCV (60 mg daily) regimen. He returned 13 days after for a programmed visit and we were surprised to learn that he had taken 3 pills o...

Canuck · Canuck

From: MedscapeNews > Reuters Health InformationExtrahepatic Manifestations of Chronic Hep C Improve With Sustained Virological ResponseBy Will Boggs MDMay 21, 2018 NEW YORK (Reuters Health) - Extrahepatic manifestations of chronic hepatitis C virus (HCV) infection improve or res...

Tig · Tig

EASL Paris 2018 Updates c/o Clinical Care Options - Hepatitis Review Capsules Summaries, download slides, and listen to audio commentary from expert-led Webinars covering critical studies on viral hepatitis and NAFLD/NASH from Paris. credit: Clinical Care Options

Tig · Tig

Gilead, Inc., The World Health Organization has established a goal of eliminating viral hepatitis (hepatitis B and hepatitis C) by the year 2030.In support of this target, Gilead’s Medical Affairs team has created the CHIME Program (Conquering Hepatitis via Micro-Elimination), offering r...

Tig · Tig

YOU'RE INVITED!ALF CT Liver Transplant ReBirthday PartyApril is National Donate Life Month. The American Liver Foundation recognizes the incredible gift of life through transplantation.The Liver Tranplant ReBirthday Party is a gathering to hear liver transplantation updates from Con...

Canuck · Canuck

There was a fair bit of "talk" in the Journals, about safety profiles, and "Shingrex" getting approved for use over the "live" Zostavax in 2018. Between 2015 and as late as 2017 studies were still being completed about the effectiveness of Hep B and Zostavax immunizations in folk in association wit...

Canuck · Canuck

Funny (not) how "real world" data takes so long to "come out"! Here is a recent publication (2018), all about "Viekirax" (ombitasvir/paritaprevir/ritonavir) and "Exviera" (dasabuvir) - also known as "OPrD" (similar to later and further formulations named Viekira Pak and then Viekira XR).B...

skewedButNotBroken · skewedButNotBroken

https://www.hepmag.com/article/HCV-Brain-Endothelium-21818-1287637502

Canuck · Canuck

Published in Gastroenterology - News · January 18, 2018Psoriasis Remission Described After Hepatitis C Virus TreatmentCase report: After initiation of ledipasvir-sofosbuvir, HCV RNA decreased, and skin lesions improvedHealthDay WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- A case of...

Canuck · Canuck

EDITORIAL - HCV Next, January/February - Dr. Ira M. JacobsonManaging the Fruits of HCV Cure: How Much Care do the Cured Need? The feature by Eric Lawitz, MD, very nicely encapsulates the revolutionary changes occurring within hepatitis C therapy over the past few years. As he explains, this ex...

Canuck · Canuck

Helio - HCV Next, January/February - Eric Lawitz, MD COVER STORYLooking Back on an Unprecedented Revolution in Medicine As we conclude another year now past the peak of hepatitis C research, HCV Next asked me to consider where we came from, where we are now, and where we're headed. They wanted me...

Tig · Tig

Time to thank all of you that continue to make our forum the best it can be! We have thousands of you to thank for being there for each other through our journey. We are just one of the support groups that have made a difference. A tip of the hat to each of them! Unsung Heroes

Canuck · Canuck

Tig found and posted this very interesting one - it's aptly under "clinical trials", but I don't want to loose track of this new NS5B, so borrowed Tig's find to be over here as well, so it can be seen as new "news" as well! Hope that's OK Tig. Janssen 2a trial

Topic		Started By	Replies	Views	Last Post
	New Contenders?? NS5A Ruzasvir and NS5B MK-3682 (Preview) Another "new?" NS5A - "Ruzasvir" - Info from drug study discussed at recent Nov 2106 Boston Meeting.We have heard a lot about Zepatier (elbasvir/ grazoprevir) a NS5A and a NS3/4A respectively (given with or without riba, and sometimes with sof), but I (personally) did not know about this (new to m...	Canuck	8	3695	Jun 12, 2019 by Canuck
	GT3's - (and more so, maybe "certain" GT3 sub-types) - perhaps why we have most often been considered "hard to treat" (Preview) Published in GastroenterologyJournal Scan / Research · May 20, 2019Resistance Analysis of Genotype 3 HCV Indicates Subtypes Inherently Resistant to Nonstructural Protein 5A InhibitorsHepatology (Baltimore, Md.)TAKE-HOME MESSAGEThis is an interesting study wherein the authors eva...	Canuck	2	1335	Jun 4, 2019 by Tig
	Up-surge of Hep A in California (Preview) California health officials battle state's largest hepatitis A outbreak in 2 decadesHelio - July 21, 2017The California Department of Public Health is working with local health officials in San Diego and Santa Cruz counties to contain the state's largest hepatitis A outbreak in 2 decades.As of J...	Canuck	36	5522	May 26, 2019 by Cheddy
	HCC Detection - Using AFP, AFP-L3 and DCP (Preview) We have discussed the use of AFP's (many times, all over this site) but of late in particular about how an AFP may be used to possibly herald other kinds of cancers developing, aside from liver cancer, and it lead us to discuss not only the good ole familiar AFP, but the less US-used one, the AFP-L3 (this o...	Canuck	1	833	May 24, 2019 by 5-1-18
	Significant A1C reduction after SVR (Preview) This is very good news for those of us keeping an eye on our blood glucose levels! SVR brings improvements in areas we might not realize. It takes time to see some of these changes, but knowing it happens, is good news for all! A1C Reductions	Tig	1	1009	May 9, 2019 by Cheddy
	Cure of hepatitis C (Preview) I ran my own company for several years, and I was always on the go. Sometime around 2010 or later, I began to feel tired all the time. I went to doctors, and they kept ordering lab tests, such as checking for diabetes. They couldnt find anything wrong with me for a year or two, so eventually I stopped going t...	jagad001	6	1398	Mar 26, 2019 by Tig
	BP Med - Losartan (and recalls, and fibrosis) (Preview) I think it was "dharmabum" who first raised the early alarm about some sort of "recall" going on with a med (that I think she was on), Losartan (perhaps it was some other Losartan formula name she mentioned), but I do believe this Losartan drug was the one she referred to and was concerned about (I looked...	Canuck	0	1268	Mar 24, 2019 by Canuck
	Region's 1st HCV heart-transplant is Cured WOW (Preview) HEY NEW MEMBERS, IF HE CAN DO IT, SO CAN YOU! WE'VE MADE SO MUCH PROGRESS! NEWS RELEASEJanuary 16, 2019For immediate releaseRegions 1st hepatitis C heart-transplant recipient is curedAnacortes, Wash., man opted into UW Medicine protocol to receive infected donor heart and then had virus eradi...	Cheddy	2	1335	Jan 17, 2019 by Tig
	Dacla and Asunaprevir (Preview) Not that in North America we have seen Dacla (a NS5A) and Asunaprevir (a NS3/4A) being used as a double, but in Japan they have made use of this double. Multiple Japanese studies have fairly recently been coming out about the prevalent use of this combo and various notes they are making about it. This st...	Canuck	0	1075	Dec 22, 2018 by Canuck
	HCV: Explained 2018 (Preview) I found this recent article on our favorite topic, HCV. I found it to be a good description of it and the many issues that accompany it. It’s easy to understand and could be a good tool for us to present when asked about the disease. See what you think. I give it a 9 out of 10... Everything You Need to Know: HCV...	Tig	0	1669	Dec 11, 2018 by Tig
	Shortening HCV Treatment Courses (Preview) From "Contagion Live - Infectious Diseases Today": ARTICLE Hepatitis C Treatment Time Could Be Cut in Half in Some Patients: A Proof of Concept Study NOV 14, 2018 \| EINAV KEET A personalized medicine technique may shorten the duration and reduce the cost of treatment for hepatitis C virus infecti...	Canuck	0	1367	Nov 24, 2018 by Canuck
	Organ Donors (Preview) http://time.com/4996657/heart-transplant-hepatitis-c/	dharmabum	5	2392	Nov 14, 2018 by Canuck
	AASLD/IDSA release updated HCV treatment guidelines (Preview) The AASLD and IDSA HCV Guidance Panel has released updated guidelines for the treatment of hepatitis C virus infection, according to newly published data in Hepatology. You will note that they continue to recommend the use of 12 weeks of Sovaldi/Peg Interferon/Ribavirin in GT 3's that are able to...	Tig	1	2329	Nov 5, 2018 by Tig
	Liver Transplant Article (Preview) So, this article/take-home message, about the study (and the study itself) I found interesting - and, oh of course, they just had to study the costs savings! The part that was interesting to me was that group of liver transplant people who were studied and followed between 1998 and 2015, who WERE tole...	Canuck	0	1053	Oct 27, 2018 by Canuck
	A "new?" NS5A - "PP1-668" (Ravidasvir) (Preview) A relatively "new?" NS5A - (formerly called PP1-668), now named Ravidasvir. Well, it's news to me anyway. Out of Egypt (where there are many GT4's to trial it on), but reading other articles about it tonight, it IS being touted as pan, coupled with sof, with some impressive results, and more interest...	Canuck	11	6606	Oct 23, 2018 by Canuck
	2011 HCV Blog News (Preview) https://hepatitiscnewdrugs.blogspot.com/2011/03/celebrities-with-hepatiti...	Canuck	0	1137	Sep 9, 2018 by Canuck
	Clinical Care Options: Tools for HCV Care (Preview) This slide set was published last year, but offers some interesting info for new and old members alike. I couldn’t locate it being brought here before and CCO is more often a physician only periodical most don’t have access to. It’s amazing to see the shear numbers affected by this disease globally an...	Tig	2	1491	Aug 26, 2018 by Tig
	SVR 24 Two Weeks After a Tripled Dose of Daclatasvir in an HCV Genotype 3 Patient (Preview) Thanks to the cultural mediator support, we explained to the patient the correct posology of each drug to take during the day consisting of 12 week SOF (400 mg daily) plus DCV (60 mg daily) regimen. He returned 13 days after for a programmed visit and we were surprised to learn that he had taken 3 pills o...	sleestak	3	2007	Jun 18, 2018 by Canuck
	Extrahepatic Manifestation Improvements After SVR (Preview) From: MedscapeNews > Reuters Health InformationExtrahepatic Manifestations of Chronic Hep C Improve With Sustained Virological ResponseBy Will Boggs MDMay 21, 2018 NEW YORK (Reuters Health) - Extrahepatic manifestations of chronic hepatitis C virus (HCV) infection improve or res...	Canuck	1	1862	May 23, 2018 by Tig
	EASL 2018 Updates: Paris (Preview) EASL Paris 2018 Updates c/o Clinical Care Options - Hepatitis Review Capsules Summaries, download slides, and listen to audio commentary from expert-led Webinars covering critical studies on viral hepatitis and NAFLD/NASH from Paris. credit: Clinical Care Options	Tig	3	1975	May 5, 2018 by Canuck
	Conquering Hep B/C via Micro-Elimination (Preview) Gilead, Inc., The World Health Organization has established a goal of eliminating viral hepatitis (hepatitis B and hepatitis C) by the year 2030.In support of this target, Gilead’s Medical Affairs team has created the CHIME Program (Conquering Hepatitis via Micro-Elimination), offering r...	Tig	0	1699	Apr 23, 2018 by Tig
	ALF CT Liver Transplant ReBirthday Party (Preview) *YOU'RE INVITED!ALF CT Liver Transplant ReBirthday PartyApril is* National Donate Life Month. The American Liver Foundation recognizes the incredible gift of life through transplantation.The Liver Tranplant ReBirthday Party is a gathering to hear liver transplantation updates from Con...	Tig	2	2178	Mar 29, 2018 by Canuck
	Herpes Zoster Vaccination - "Shingrex" versus "Zostavax" (Preview) There was a fair bit of "talk" in the Journals, about safety profiles, and "Shingrex" getting approved for use over the "live" Zostavax in 2018. Between 2015 and as late as 2017 studies were still being completed about the effectiveness of Hep B and Zostavax immunizations in folk in association wit...	Canuck	5	2751	Mar 11, 2018 by Canuck
	Viekirax and Exviera (OPrD) - Real World Data (Preview) Funny (not) how "real world" data takes so long to "come out"! Here is a recent publication (2018), all about "Viekirax" (ombitasvir/paritaprevir/ritonavir) and "Exviera" (dasabuvir) - also known as "OPrD" (similar to later and further formulations named Viekira Pak and then Viekira XR).B...	Canuck	2	1914	Mar 7, 2018 by Tig
	Hep C crosses the brain barrier (Preview) https://www.hepmag.com/article/HCV-Brain-Endothelium-21818-1287637502	skewedButNotBroken	4	2188	Jan 24, 2018 by LamontCranston
	Harvoni SVR and then case of psoriasis remission (Preview) Published in Gastroenterology - News · January 18, 2018Psoriasis Remission Described After Hepatitis C Virus TreatmentCase report: After initiation of ledipasvir-sofosbuvir, HCV RNA decreased, and skin lesions improvedHealthDay WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- A case of...	Canuck	3	2131	Jan 22, 2018 by Canuck
	"Following" after SVR - Dr. Ira M. Jacobson (Preview) EDITORIAL - HCV Next, January/February - Dr. Ira M. JacobsonManaging the Fruits of HCV Cure: How Much Care do the Cured Need? The feature by Eric Lawitz, MD, very nicely encapsulates the revolutionary changes occurring within hepatitis C therapy over the past few years. As he explains, this ex...	Canuck	2	1468	Jan 22, 2018 by Canuck
	Looking Back ... on HCV Treatment - Dr. Eric Lawitz (Preview) Helio - HCV Next, January/February - *Eric Lawitz, MD* COVER STORYLooking Back on an Unprecedented Revolution in Medicine As we conclude another year now past the peak of hepatitis C research, HCV Next asked me to consider where we came from, where we are now, and where we're headed. They wanted me...	Canuck	0	1418	Jan 21, 2018 by Canuck
	The Unsung Heroes of HCV (Preview) Time to thank all of you that continue to make our forum the best it can be! We have thousands of you to thank for being there for each other through our journey. We are just one of the support groups that have made a difference. A tip of the hat to each of them! Unsung Heroes	Tig	8	2575	Jan 18, 2018 by Canuck
	A "new?" NS5B - "AL-355" (Preview) Tig found and posted this very interesting one - it's aptly under "clinical trials", but I don't want to loose track of this new NS5B, so borrowed Tig's find to be over here as well, so it can be seen as new "news" as well! Hope that's OK Tig. Janssen 2a trial	Canuck	7	3645	Dec 8, 2017 by Canuck
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