Hep C Discussion Forum

Canuck · Canuck

A relatively "new?" NS5A - (formerly called PP1-668), now named Ravidasvir. Well, it's news to me anyway. Out of Egypt (where there are many GT4's to trial it on), but reading other articles about it tonight, it IS being touted as pan, coupled with sof, with some impressive results, and more interest...

Canuck · Canuck

https://hepatitiscnewdrugs.blogspot.com/2011/03/celebrities-with-hepatiti...

Tig · Tig

This slide set was published last year, but offers some interesting info for new and old members alike. I couldn’t locate it being brought here before and CCO is more often a physician only periodical most don’t have access to. It’s amazing to see the shear numbers affected by this disease globally an...

sleestak · sleestak

Thanks to the cultural mediator support, we explained to the patient the correct posology of each drug to take during the day consisting of 12 week SOF (400 mg daily) plus DCV (60 mg daily) regimen. He returned 13 days after for a programmed visit and we were surprised to learn that he had taken 3 pills o...

Canuck · Canuck

From: MedscapeNews > Reuters Health InformationExtrahepatic Manifestations of Chronic Hep C Improve With Sustained Virological ResponseBy Will Boggs MDMay 21, 2018 NEW YORK (Reuters Health) - Extrahepatic manifestations of chronic hepatitis C virus (HCV) infection improve or res...

Tig · Tig

EASL Paris 2018 Updates c/o Clinical Care Options - Hepatitis Review Capsules Summaries, download slides, and listen to audio commentary from expert-led Webinars covering critical studies on viral hepatitis and NAFLD/NASH from Paris. credit: Clinical Care Options

Tig · Tig

Gilead, Inc., The World Health Organization has established a goal of eliminating viral hepatitis (hepatitis B and hepatitis C) by the year 2030.In support of this target, Gilead’s Medical Affairs team has created the CHIME Program (Conquering Hepatitis via Micro-Elimination), offering r...

Tig · Tig

YOU'RE INVITED!ALF CT Liver Transplant ReBirthday PartyApril is National Donate Life Month. The American Liver Foundation recognizes the incredible gift of life through transplantation.The Liver Tranplant ReBirthday Party is a gathering to hear liver transplantation updates from Con...

Canuck · Canuck

There was a fair bit of "talk" in the Journals, about safety profiles, and "Shingrex" getting approved for use over the "live" Zostavax in 2018. Between 2015 and as late as 2017 studies were still being completed about the effectiveness of Hep B and Zostavax immunizations in folk in association wit...

Canuck · Canuck

Funny (not) how "real world" data takes so long to "come out"! Here is a recent publication (2018), all about "Viekirax" (ombitasvir/paritaprevir/ritonavir) and "Exviera" (dasabuvir) - also known as "OPrD" (similar to later and further formulations named Viekira Pak and then Viekira XR).B...

skewedButNotBroken · skewedButNotBroken

https://www.hepmag.com/article/HCV-Brain-Endothelium-21818-1287637502

Canuck · Canuck

Published in Gastroenterology - News · January 18, 2018Psoriasis Remission Described After Hepatitis C Virus TreatmentCase report: After initiation of ledipasvir-sofosbuvir, HCV RNA decreased, and skin lesions improvedHealthDay WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- A case of...

Canuck · Canuck

EDITORIAL - HCV Next, January/February - Dr. Ira M. JacobsonManaging the Fruits of HCV Cure: How Much Care do the Cured Need? The feature by Eric Lawitz, MD, very nicely encapsulates the revolutionary changes occurring within hepatitis C therapy over the past few years. As he explains, this ex...

Canuck · Canuck

Helio - HCV Next, January/February - Eric Lawitz, MD COVER STORYLooking Back on an Unprecedented Revolution in Medicine As we conclude another year now past the peak of hepatitis C research, HCV Next asked me to consider where we came from, where we are now, and where we're headed. They wanted me...

Tig · Tig

Time to thank all of you that continue to make our forum the best it can be! We have thousands of you to thank for being there for each other through our journey. We are just one of the support groups that have made a difference. A tip of the hat to each of them! Unsung Heroes

Canuck · Canuck

Tig found and posted this very interesting one - it's aptly under "clinical trials", but I don't want to loose track of this new NS5B, so borrowed Tig's find to be over here as well, so it can be seen as new "news" as well! Hope that's OK Tig. Janssen 2a trial

Canuck · Canuck

News about Abby's Pan 8 week Glec (NS3/4A) and Pib (NS5A). No SOF. Especially intersting for those with compromized renal function, TN/TE/cirrhotics. They are stiving for shorter treatment times for these Pans. FDA grants priority review for AbbVie's pan-genotypic HCV regimen - February 3, 2...

Canuck · Canuck

Hm, we have entered into this topic before ... what about those of us who, out of medical necessity and via deemed "best practices" of the times, received not transfusions per say, but various forms of "immunoglobulins" , see (U.K. Tainted Blood Inquiry), see (Viet Nam era veterans/ They gave us t...

Tig · Tig

Looks like Merck is going after different markets and dropping out of the HCV drug business. Zepatier is their last. Not a bad finish! It has cured a lot of people. Merck‘s Out

Canuck · Canuck

Nonprofit challenges Gilead's patents on sofosbuvir October 27, 2017 - HelioInitiative for Medicines, Access & Knowledge - a U.S.-based nonprofit also known as I-MAK - filed a set of patent challenges against sofosbuvir, according to a press release from the organization. According to...

Tig · Tig

If you would like to educate yourself or have something to share with others, this organization has an informative website that will help. HepCHope Official Site

Canuck · Canuck

-https://clinicaltrials.gov/ct2/show/record/NCT02429583

Canuck · Canuck

Updated ACIP Recommendations Nix LAIV, Expand HBV VaccinationDiana Swift - February 06, 2017 The final 2017 adult vaccination schedule has been issued by the Advisory Panel on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention (CDC).Published in the February 6...

Canuck · Canuck

Fatty Liver Disease Fastest-growing Reason for Transplants in Young U.S. Adults By Carolyn Crist - October 18, 2017(Reuters Health) - Nonalcoholic fatty liver disease and its more aggressive form, nonalcoholic steatohepatitis, have become the fastest-growing reasons for liver transplan...

Canuck · Canuck

Apparently they have recently inserted some updates, including recommendations for re-treating TE (treatment-experienced). https://www.hcvguidelines.org/

Tig · Tig

This is wonderful news! All you coffee drinkers can rejoice!!Increased coffee consumption lowers mortality risk in HIV/HCV coinfection Carrieri MP, et al. J Hepatol. 2017;doi:10.1016/j.hep.2017.08.005.September 26, 2017Elevated coffee consumption of three or more cups per day halved...

Tig · Tig

Here's a professional article on the various options used to determine levels (stages) of liver fibrosis. It includes the pros and cons of each. It's a 5 page article and may require free registration. I believe you will find it very informative. Assessing Fibrosis

Canuck · Canuck

I was a little disappointed with this news, not in a treatment plan for kids, nor in use of ledi, but with the age/size caveats - must wait until age 12 and weigh 35kgs (there is a lot of food for thought in that scenario). More so I am troubled and would be conflicted in only being able to offer sofa/riba to m...

wendyo · wendyo

Avella HCV Mobile App Received email today about Avella's HCV mobile app and there is some good info in the tabs so thought I would share. I shortened the URL, Wendy! -- Edited by Tig on Thursday 10th of August 2017 05:18:31 PM

Tig · Tig

HCV News Alerts > Grazoprevir + Ribavirin linked to rapid SVR in GT1: Grazo+Riba SVR > FDA places RG 101 on clinical hold: RG-101/FDA Healio articles may require a free registration

Topic		Started By	Replies	Views	Last Post
	A "new?" NS5A - "PP1-668" (Ravidasvir) (Preview) A relatively "new?" NS5A - (formerly called PP1-668), now named Ravidasvir. Well, it's news to me anyway. Out of Egypt (where there are many GT4's to trial it on), but reading other articles about it tonight, it IS being touted as pan, coupled with sof, with some impressive results, and more interest...	Canuck	11	4911	Oct 23, 2018 by Canuck
	2011 HCV Blog News (Preview) https://hepatitiscnewdrugs.blogspot.com/2011/03/celebrities-with-hepatiti...	Canuck	0	805	Sep 9, 2018 by Canuck
	Clinical Care Options: Tools for HCV Care (Preview) This slide set was published last year, but offers some interesting info for new and old members alike. I couldn’t locate it being brought here before and CCO is more often a physician only periodical most don’t have access to. It’s amazing to see the shear numbers affected by this disease globally an...	Tig	2	1146	Aug 26, 2018 by Tig
	SVR 24 Two Weeks After a Tripled Dose of Daclatasvir in an HCV Genotype 3 Patient (Preview) Thanks to the cultural mediator support, we explained to the patient the correct posology of each drug to take during the day consisting of 12 week SOF (400 mg daily) plus DCV (60 mg daily) regimen. He returned 13 days after for a programmed visit and we were surprised to learn that he had taken 3 pills o...	sleestak	3	1536	Jun 18, 2018 by Canuck
	Extrahepatic Manifestation Improvements After SVR (Preview) From: MedscapeNews > Reuters Health InformationExtrahepatic Manifestations of Chronic Hep C Improve With Sustained Virological ResponseBy Will Boggs MDMay 21, 2018 NEW YORK (Reuters Health) - Extrahepatic manifestations of chronic hepatitis C virus (HCV) infection improve or res...	Canuck	1	1309	May 23, 2018 by Tig
	EASL 2018 Updates: Paris (Preview) EASL Paris 2018 Updates c/o Clinical Care Options - Hepatitis Review Capsules Summaries, download slides, and listen to audio commentary from expert-led Webinars covering critical studies on viral hepatitis and NAFLD/NASH from Paris. credit: Clinical Care Options	Tig	3	1389	May 5, 2018 by Canuck
	Conquering Hep B/C via Micro-Elimination (Preview) Gilead, Inc., The World Health Organization has established a goal of eliminating viral hepatitis (hepatitis B and hepatitis C) by the year 2030.In support of this target, Gilead’s Medical Affairs team has created the CHIME Program (Conquering Hepatitis via Micro-Elimination), offering r...	Tig	0	1317	Apr 23, 2018 by Tig
	ALF CT Liver Transplant ReBirthday Party (Preview) *YOU'RE INVITED!ALF CT Liver Transplant ReBirthday PartyApril is* National Donate Life Month. The American Liver Foundation recognizes the incredible gift of life through transplantation.The Liver Tranplant ReBirthday Party is a gathering to hear liver transplantation updates from Con...	Tig	2	1618	Mar 29, 2018 by Canuck
	Herpes Zoster Vaccination - "Shingrex" versus "Zostavax" (Preview) There was a fair bit of "talk" in the Journals, about safety profiles, and "Shingrex" getting approved for use over the "live" Zostavax in 2018. Between 2015 and as late as 2017 studies were still being completed about the effectiveness of Hep B and Zostavax immunizations in folk in association wit...	Canuck	5	2079	Mar 11, 2018 by Canuck
	Viekirax and Exviera (OPrD) - Real World Data (Preview) Funny (not) how "real world" data takes so long to "come out"! Here is a recent publication (2018), all about "Viekirax" (ombitasvir/paritaprevir/ritonavir) and "Exviera" (dasabuvir) - also known as "OPrD" (similar to later and further formulations named Viekira Pak and then Viekira XR).B...	Canuck	2	1495	Mar 7, 2018 by Tig
	Hep C crosses the brain barrier (Preview) https://www.hepmag.com/article/HCV-Brain-Endothelium-21818-1287637502	skewedButNotBroken	4	1601	Jan 24, 2018 by LamontCranston
	Harvoni SVR and then case of psoriasis remission (Preview) Published in Gastroenterology - News · January 18, 2018Psoriasis Remission Described After Hepatitis C Virus TreatmentCase report: After initiation of ledipasvir-sofosbuvir, HCV RNA decreased, and skin lesions improvedHealthDay WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- A case of...	Canuck	3	1648	Jan 22, 2018 by Canuck
	"Following" after SVR - Dr. Ira M. Jacobson (Preview) EDITORIAL - HCV Next, January/February - Dr. Ira M. JacobsonManaging the Fruits of HCV Cure: How Much Care do the Cured Need? The feature by Eric Lawitz, MD, very nicely encapsulates the revolutionary changes occurring within hepatitis C therapy over the past few years. As he explains, this ex...	Canuck	2	1192	Jan 22, 2018 by Canuck
	Looking Back ... on HCV Treatment - Dr. Eric Lawitz (Preview) Helio - HCV Next, January/February - *Eric Lawitz, MD* COVER STORYLooking Back on an Unprecedented Revolution in Medicine As we conclude another year now past the peak of hepatitis C research, HCV Next asked me to consider where we came from, where we are now, and where we're headed. They wanted me...	Canuck	0	1152	Jan 21, 2018 by Canuck
	The Unsung Heroes of HCV (Preview) Time to thank all of you that continue to make our forum the best it can be! We have thousands of you to thank for being there for each other through our journey. We are just one of the support groups that have made a difference. A tip of the hat to each of them! Unsung Heroes	Tig	8	2001	Jan 18, 2018 by Canuck
	A "new?" NS5B - "AL-355" (Preview) Tig found and posted this very interesting one - it's aptly under "clinical trials", but I don't want to loose track of this new NS5B, so borrowed Tig's find to be over here as well, so it can be seen as new "news" as well! Hope that's OK Tig. Janssen 2a trial	Canuck	7	3042	Dec 8, 2017 by Canuck
	Abby's - Pan 8 week Glec/Pib (Preview) News about Abby's Pan 8 week Glec (NS3/4A) and Pib (NS5A). No SOF. Especially intersting for those with compromized renal function, TN/TE/cirrhotics. They are stiving for shorter treatment times for these Pans. FDA grants priority review for AbbVie's pan-genotypic HCV regimen - February 3, 2...	Canuck	17	6850	Dec 3, 2017 by Canuck
	HCV and Tainted Blood Product Inquiries/Studies (Preview) Hm, we have entered into this topic before ... what about those of us who, out of medical necessity and via deemed "best practices" of the times, received not transfusions per say, but various forms of "immunoglobulins" , see (U.K. Tainted Blood Inquiry), see (Viet Nam era veterans/ They gave us t...	Canuck	0	927	Dec 2, 2017 by Canuck
	Merck Drops Out (Preview) Looks like Merck is going after different markets and dropping out of the HCV drug business. Zepatier is their last. Not a bad finish! It has cured a lot of people. Merck‘s Out	Tig	6	2136	Nov 11, 2017 by Canuck
	About Access to Sofa (Preview) Nonprofit challenges Gilead's patents on sofosbuvir October 27, 2017 - HelioInitiative for Medicines, Access & Knowledge - a U.S.-based nonprofit also known as I-MAK - filed a set of patent challenges against sofosbuvir, according to a press release from the organization. According to...	Canuck	1	1156	Oct 28, 2017 by Tig
	Hep C Hope - The Forgotten Virus (Preview) If you would like to educate yourself or have something to share with others, this organization has an informative website that will help. HepCHope Official Site	Tig	0	821	Oct 25, 2017 by Tig
	Trials - Hep B or Shingles Immunization - (if never immunized for these) and if you have HCV (Preview) -https://clinicaltrials.gov/ct2/show/record/NCT02429583	Canuck	0	756	Oct 22, 2017 by Canuck
	Have your HBV immunity level checked if you have HCV or any other chronic liver disease state(s) (Preview) Updated ACIP Recommendations Nix LAIV, Expand HBV VaccinationDiana Swift - February 06, 2017 The final 2017 adult vaccination schedule has been issued by the Advisory Panel on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention (CDC).Published in the February 6...	Canuck	0	723	Oct 19, 2017 by Canuck
	Fatty Liver Disease and Transplants in US Youth (Preview) Fatty Liver Disease Fastest-growing Reason for Transplants in Young U.S. Adults By Carolyn Crist - October 18, 2017(Reuters Health) - Nonalcoholic fatty liver disease and its more aggressive form, nonalcoholic steatohepatitis, have become the fastest-growing reasons for liver transplan...	Canuck	1	550	Oct 19, 2017 by Tig
	AASLD HCV Treatment Guideline Updates (Preview) Apparently they have recently inserted some updates, including recommendations for re-treating TE (treatment-experienced). https://www.hcvguidelines.org/	Canuck	0	651	Oct 7, 2017 by Canuck
	Healio/HCV Updates (Preview) This is wonderful news! All you coffee drinkers can rejoice!!Increased coffee consumption lowers mortality risk in HIV/HCV coinfection Carrieri MP, et al. J Hepatol. 2017;doi:10.1016/j.hep.2017.08.005.September 26, 2017Elevated coffee consumption of three or more cups per day halved...	Tig	0	831	Sep 30, 2017 by Tig
	Assessing Fibrosis in HCV (Preview) Here's a professional article on the various options used to determine levels (stages) of liver fibrosis. It includes the pros and cons of each. It's a 5 page article and may require free registration. I believe you will find it very informative. Assessing Fibrosis	Tig	2	1521	Aug 25, 2017 by Lindsmatt52
	HCV Drugs for Kids (Preview) I was a little disappointed with this news, not in a treatment plan for kids, nor in use of ledi, but with the age/size caveats - must wait until age 12 and weigh 35kgs (there is a lot of food for thought in that scenario). More so I am troubled and would be conflicted in only being able to offer sofa/riba to m...	Canuck	4	1692	Aug 24, 2017 by Tig
	Avella Specialty Pharmacy (Preview) Avella HCV Mobile App Received email today about Avella's HCV mobile app and there is some good info in the tabs so thought I would share. I shortened the URL, Wendy! -- Edited by Tig on Thursday 10th of August 2017 05:18:31 PM	wendyo	9	2443	Aug 13, 2017 by Canuck
	Healio Updates - HCV Alerts (Preview) HCV News Alerts > Grazoprevir + Ribavirin linked to rapid SVR in GT1: Grazo+Riba SVR > FDA places RG 101 on clinical hold: RG-101/FDA Healio articles may require a free registration	Tig	14	3309	Aug 5, 2017 by Tig
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