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Hep C Discussion Forum -> Post Treatment -> 4 WEEKS STILL DETECTABLE
Post Info TOPIC: 4 WEEKS STILL DETECTABLE
cmerduran


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RE: 4 WEEKS STILL DETECTABLE
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yes mallani, i know...

I try to tell that no need to worry about 4th week results anymore it can be UND or 1000, this doesnt mean that you are going to live with hepc all life... more effective medicines, cures are coming soon, science is coming to end about hep c treatment. It will become simply treatable disease in 2 or 3 years.

for ex. we have a young friend here i cant remember his name( he has a graduation photo at his profile pic. :) )... He is also young but had a unsuccesfull treatment before but then he tried new coming medicine GS-7977 and he was undetected at week 2!! and now he is running to SVR!!

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Murat
28.07.12: HCV-RNA +, VL:7.1m, 1b
02.08.12: incivo-riba-pegasys started
24.07.13: HCV-RNA: WEEK 3, 12, 24, 36, 50 UND(SVR!!)
*all men have fears but the brave, put down their fears and go forward... sometimes to death, but always to victory.
mallani


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Hi Murat, Worrying about SVR rates is unproductive. The latest rates from clinical experience have superseded rates shown in the trials. It is nice to have a rough idea, but everyone has to struggle on, hope for undetecteds, and take what we get. We are all different. You are young with a low VL, have your undetected, and have an excellent chance of SVR. That's all we can hope for.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
cmerduran


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No need to discuss Brad,

Todays sceintific solutions are very close to beat hep c with %100 successful cures.. or maybe vaccination protection will come in 5-10 years..

At this point even you are non-responder or untreated no matter.. maybe you have to stop treatment at 4th week no problem..

Murat

__________________
Murat
28.07.12: HCV-RNA +, VL:7.1m, 1b
02.08.12: incivo-riba-pegasys started
24.07.13: HCV-RNA: WEEK 3, 12, 24, 36, 50 UND(SVR!!)
*all men have fears but the brave, put down their fears and go forward... sometimes to death, but always to victory.
krowdog


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I don't know.

Perhaps that was a subset of patients like either previous non-reponders, or cirrhotic patients?  Those groups have lower SVR rates.

Anyway, no big deal. 

You treat, you do your best, and you clear or you don't.  Then you live your life, and just do what you do ;))

Take care my friend,

Brad



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(Geno 1a, Incivek Triple Tx, 6 month post TX - 9/20/2012 = SVR!!!)
cmerduran


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http://www.iegm.gov.tr/Folders/KubKT/Yeni%20%C4%B0la%C3%A7%20%C5%9Eube%20M%C3%BCd%C3%BCrl%C3%BC%C4%9F%C3%BC/incivo%20kub_628d4f2.pdf

This file is Turkish i can't find its english version...

3rd page, highlighted paragraph: http://i45.tinypic.com/17aemg.jpg

During phase 3 studies:
at week 4,, 4 of 16 patients (%25) who has hcv-rna between 100-1000 IU/ml achieves SVR

at week 12,, 2 of 8 patients (%25) who has hcv-rna between 100-1000 IU/ml achieves SVR

--------------------------------------------------------------------------------------------------------------------

but again at same document, 29th page advanced study results are mentioned as yours...



__________________
Murat
28.07.12: HCV-RNA +, VL:7.1m, 1b
02.08.12: incivo-riba-pegasys started
24.07.13: HCV-RNA: WEEK 3, 12, 24, 36, 50 UND(SVR!!)
*all men have fears but the brave, put down their fears and go forward... sometimes to death, but always to victory.
krowdog


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 Hello Murat.

Where did you get that info? From what I can see it's 60%.

From the "Incivek Full Prescribing Information" site, page 17, here: 

http://pi.vrtx.com/files/uspi_telaprevir.pdf

the SVR results for non RVR (not undetectable @ week 4) were 60%.

It works like this:

58% had eRVR (UND@ wk 4), and 92% of those had SVR, for a total of 53% SVR

42% had no eRVR, and 60% of those had SVR, for a total 25% SVR

Add the 53%, and the 25%, and you get Incivek's 78% oveall "cure" rate.

I only mention this, so those without an eRVR don't get discouraged.  Their chances are much better than 25%.

Please note that other factors, like cirrhosis, previous non-responder, etc, will skew these numbers up or down, but all the info is on the site mentionioned above.

Brad

 

 



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(Geno 1a, Incivek Triple Tx, 6 month post TX - 9/20/2012 = SVR!!!)
cmerduran


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During incivek(Telaprevir) studies:

%25 of patients could achieve SVR, who had HCV-RNA 100-1000 at week 4 or 12.

Unfortunately, no patient could achieve SVR, who had HCV-RNA >1000 at week 4.



-- Edited by cmerduran on Sunday 23rd of September 2012 01:40:26 PM

__________________
Murat
28.07.12: HCV-RNA +, VL:7.1m, 1b
02.08.12: incivo-riba-pegasys started
24.07.13: HCV-RNA: WEEK 3, 12, 24, 36, 50 UND(SVR!!)
*all men have fears but the brave, put down their fears and go forward... sometimes to death, but always to victory.
AlexNY


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my doctor says he hopes to see 2 log drop at week 4, meaning -00 from the end. My guess for ur husband if it was bad Dr would advise to discontinue tx, since he didnt I assume it goes well. Good luck



-- Edited by AlexNY on Friday 17th of February 2012 04:51:34 AM



-- Edited by AlexNY on Friday 17th of February 2012 04:51:56 AM

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I'm Alex. Diagnosed with hep c 12 years ago. Genotype 1a. Started tx on 1/31/12 Ironically, I'm an RN. VL 15.9 (!) mil.  Wk 5, 8, 12, 16, 20 - all UND :)
JLynch30


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What about a 3 log drop but still 5000 at week 4?  I want to continue.



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
John William


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I too came back posittive after 4 wks. As a result the tx were extended from 24 to 36 weeks and the Ribirvarin increased from 800mg/day to 1200mg/day. My tests came back UND (Negitive) after 8 weeks.

This is a slow process and not everyone responds or reacts the same. We are in the hands of our keepers and I try to maintain that a positive attitude goes a long way in a cure.

Hang in there!



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"my plan is to live forever.........so far so good"

Genotype 3a, started 2 X tx Aug 19/11on Rib/Peg 36 wk tx, VL <43 UND in wk 8, Enzymes were 78 now at 22.

August 31/12 alls good in the blood work!

November 5/12 SRV Obtained, YAHOO! YEEPEE!
BeccaJune


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With the inconsistancies in the PCR test, some of us could actually be detectable but below the range of the test, because like mine, they only measured to <43.  

I am assuming this test only detects a VL measurement as low as 43, so I could have a VL of 42, or 26, or 0, but nobody knows because the test I took doesn't go that low.

Just an observation.  I am not going to worry about it, though, because there is nothing I can do about it!  My doctor knows best, and he will tell me so when I question certain things he does!



-- Edited by BeccaJune on Wednesday 16th of November 2011 08:11:33 PM

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Diagnosed Dec. 2008. Genotype 1b, enlarged liver.  Started triple tx with Incivek on August 12, 2011.
ss


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Jime i new u 2 would hit it off his next visit Is nov 28 too enjoy ur Moosage

__________________

Harvoni Started - November 23 2014

Geno 1b  Cirrohsis started incivek October 13, 2011 ended incivek on January 5, 2012

 FAILED

6 months Undetectable! 

8 months UNDETECTABLE

Last Shot Sept 7 2012.

Last Ribo Sept 13 2012

Graduated now to Post Treatment

  

 

 

 

 
JIme


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No, not bad, good that he can keep going.  If VL is over 1000, you have to stop treatment.  Tell him I was @470 on day 27.  My Dr thinks I'll be fine.  See Deidre's post answering my ? about this last Saturday night.

I'm in for 48 weeks as long as I am under 1000 for my next blood work, which is on Nov 28. 

It's all good.  My liver needed a break after all these years.  Even if I have to stop I know there will be other treatments coming soon that might help me.  I'm confident I'll be clear sooner or later.  And I've proven to myslf that I can do the treatment so far.  It ain't that bad.  For right now we're doing the one day at a time routine. 

ps. tell Steve I'm going for a moosage tonight...lol



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jim

GT1a, St2 Lv2 last biopsy 2002, VL  11.4m,  start triple tx 9/30/11

VL 470 @4wks.....VL 22,000 @8wks  stopped tx

Round 2-  Started 3/16/12   PSI-7977, BMS-790052, Riba Undetectable day 14

Did 24 weeks Still UND 12 weeks post tx, SVR24!!!!!!! 2/14/13

 

 

 

 

 
ss


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HE IS DOING 48 WEEKS THE DR TOLD HIM BUT IS THIS BAD AT 4 WEEKS



__________________

Harvoni Started - November 23 2014

Geno 1b  Cirrohsis started incivek October 13, 2011 ended incivek on January 5, 2012

 FAILED

6 months Undetectable! 

8 months UNDETECTABLE

Last Shot Sept 7 2012.

Last Ribo Sept 13 2012

Graduated now to Post Treatment

  

 

 

 

 
jrc209


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This means he will have to do 48 weeks if on incivek

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Geno 1 A Started Tx 8-3-11, Viral Load  21.2 Million,  4 Week Lead of Soc ,9-1-11 <43 On Soc alone started victrelis 9-3 ,8 week pcr vL und.Week 12 Vl Und, Did Week 24 PCR Results UND @ Week 24!!! 1-11-12,End Of Tx 2-15-2012 !!
ss


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HI MY HUSBAND IS DETACABLE AT 4 WEEKS BUT VL AT 24 DOES THIS MEAN SOMETING DR WANTS TO SEE WHAT HAPPENS AT 12 WEEKS ANYBODY GETTING THE SAME ON FOURTH WEEK THANK YOU ALL



__________________

Harvoni Started - November 23 2014

Geno 1b  Cirrohsis started incivek October 13, 2011 ended incivek on January 5, 2012

 FAILED

6 months Undetectable! 

8 months UNDETECTABLE

Last Shot Sept 7 2012.

Last Ribo Sept 13 2012

Graduated now to Post Treatment

  

 

 

 

 
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