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Hep C Discussion Forum -> On Treatment -> missed 1 dose of incevik
Post Info TOPIC: missed 1 dose of incevik
LanaiSurferGirl


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RE: missed 1 dose of incevik
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I cannot speak for all patients and know some go the boceprevir route too depending on their history and conditions...as we all know one drug may be more appropriate for one than the other.

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geno 1a, mother & brother also hep c +...mom got a blood transfusion and passed it along.  Started tx with incivik 11/23/11 and brother started 2/8/2012.  Both of us und. at 4,8,12 and me at 24.  I am going 36 wks and brother is going 48 weeks.
innerview


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LaniaSurferGirl, I wonder, do you know if your dr perscribes the double dosage for all his/her hep c 1A patients? 



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Peace, Mark

1A, stage 2/3, TT, began TX with Incivo 1/31/12, Week 4 VL<15, week 7 UND, week 12 UND, week 18 UND!!! End of Tx July 31 VL UND!!!  I had to do 26 weeks total and was on half Riba and half Interferon for most of Tx. 12 week post Tx VL UND!
innerview


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Thanks for the links SurferGirl! All the best to you.

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Peace, Mark

1A, stage 2/3, TT, began TX with Incivo 1/31/12, Week 4 VL<15, week 7 UND, week 12 UND, week 18 UND!!! End of Tx July 31 VL UND!!!  I had to do 26 weeks total and was on half Riba and half Interferon for most of Tx. 12 week post Tx VL UND!
LanaiSurferGirl


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I found some articles on the internet to support it but know my doc has access to the data from clinical trials as he works with the docs that administer them.  Here are some links...I tried to find the most current and up to date info:

http://hcvnews.blogspot.com/

 

scroll down to about the middle of this one for study c208:http://www.drugs.com/clinical_trials/new-clinical-data-support-broad-profile-telaprevir-patients-genotype-1-hepatitis-c-virus-hcv-6049.html

 

http://files.shareholder.com/downloads/VRTX/0x0x512797/e0e871cd-e475-4818-8434-848e48c84987/VRTX_News_2011_10_27_Webcasts.pdf



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geno 1a, mother & brother also hep c +...mom got a blood transfusion and passed it along.  Started tx with incivik 11/23/11 and brother started 2/8/2012.  Both of us und. at 4,8,12 and me at 24.  I am going 36 wks and brother is going 48 weeks.
innerview


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LanaiSurferGirl wrote:

My doc has me on the 3 pills every 12 hours and I was UND at 4 and 8....still rough treatment but I cannot imagine the 3x per day.  I sleep 12-13 hours per night on this stuff and would be a zombie waking up to eat and take drugs!

 oh yeah...  3 pills every 12 hours!   I like the sound of that!

Is there any more information on this protocal?  Anyone else with this schedule?  This would make life so much easier.

Peace all!



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Peace, Mark

1A, stage 2/3, TT, began TX with Incivo 1/31/12, Week 4 VL<15, week 7 UND, week 12 UND, week 18 UND!!! End of Tx July 31 VL UND!!!  I had to do 26 weeks total and was on half Riba and half Interferon for most of Tx. 12 week post Tx VL UND!
news


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Lucky rascal. Three pills twice a day sure beats two pills three times a day. Just coming up with something to eat with them, and being on time at 6AM, 2PM and 10PM has been a real chore. Many was the morning I would look at the clock and wonder how in the world am I going to get out of bed, make a fatty breakfast, eat it and take my pills when it felt so good to stay in bed. But somehow it worked out. I am almost done with week 11 and looking forward to putting this poison down. They just had to adjust my riba doseage because of low hematacrit readings in the latest labs, but my focus is on getting through the Incivek and then never taking it again. Powerful juju, but very obnoxious.

Alan



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Geno 1A  Started Pegasys/Ribavirin/Incivek Nov. 20, 2011 .  Completed July 28, 2012 (36 weeks). For a treatment history, see:  https://jshare.johnshopkins.edu/xythoswfs/webview/_xy-9921874_1

SVR on January 14, 2013!!
LanaiSurferGirl


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My doc has me on the 3 pills every 12 hours and I was UND at 4 and 8....still rough treatment but I cannot imagine the 3x per day.  I sleep 12-13 hours per night on this stuff and would be a zombie waking up to eat and take drugs!



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geno 1a, mother & brother also hep c +...mom got a blood transfusion and passed it along.  Started tx with incivik 11/23/11 and brother started 2/8/2012.  Both of us und. at 4,8,12 and me at 24.  I am going 36 wks and brother is going 48 weeks.
Anna Christie


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Hi. I was worried because around week 6 I got very nauseated and one hour after taking 6am Incevik threw up. Then for 2pm dose could not eat anything but a bit of fat. Still UDT at 12 weeks. I have read on another forum serverl posts where several people missed one dose of Incevik and still were undetectable at 4 and 12 weeks. They are studying dosing it three pills every 12 hours also. You will be OK. One less thing to worry about. Sounds like you got a great plan to prevent it in the future. 



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jrc209


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no problem, in the future do your best to take all meds and on time@

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Geno 1 A Started Tx 8-3-11, Viral Load  21.2 Million,  4 Week Lead of Soc ,9-1-11 <43 On Soc alone started victrelis 9-3 ,8 week pcr vL und.Week 12 Vl Und, Did Week 24 PCR Results UND @ Week 24!!! 1-11-12,End Of Tx 2-15-2012 !!
robert d


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Thanks  for your input I needed to here it I was scared  when I missed my dose. i'm Glad you had that information to share it help me calm down. Thank You for your research and support. 



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Geno 1a diog 2005 vl 1500000 stage 1&1, 2011 stage 2 to 3 fib stage 3 infl. Started triple x 11/16/2011 VL 15,000,000
robert d


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Thats good advice this is new meds and I'm sure their still learning a lot about it. I ate my meal in prep for med then got distracted.Now besides alarm I made spead sheet of my meds day and time and check them off when i take them just something to help me remember. I know the drug co. know the best way to use their meds and to deveate from that thinking it will be all right would not be wise. Very good point.



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Geno 1a diog 2005 vl 1500000 stage 1&1, 2011 stage 2 to 3 fib stage 3 infl. Started triple x 11/16/2011 VL 15,000,000
Isiscat2011


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Excellent, Robert.  No need to stress about it now and I really think you are A-OK with one missed dose at this stage.

I was going to post the info about 80% compliance, which is a general rule regarding prescriptions, but I personally would not rely on that for this drug because there are many uncertainties still.  Point is 100% compliance is best so anybody thinking 80% is okay as a target point please be careful. 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
robert d


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That helps with my stress  level, sure hate to mess this up.



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Geno 1a diog 2005 vl 1500000 stage 1&1, 2011 stage 2 to 3 fib stage 3 infl. Started triple x 11/16/2011 VL 15,000,000
jrc209


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You will be fine , the svr rates are based on 80% compliance.

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Geno 1 A Started Tx 8-3-11, Viral Load  21.2 Million,  4 Week Lead of Soc ,9-1-11 <43 On Soc alone started victrelis 9-3 ,8 week pcr vL und.Week 12 Vl Und, Did Week 24 PCR Results UND @ Week 24!!! 1-11-12,End Of Tx 2-15-2012 !!
Isiscat2011


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The incivek folks anticipated a possible missed dosed and wrote instructions in the rx inserts on how to handle it. When to dose next depends on whether you discovered it in 4 hours or less.  If you don't have this info post back and I'll get it for you.

I think one missed dose is not a serious problem under your circumstances--UNDs all the way. 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
robert d


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One day left week 11 on 3x and brain fog one dose of incevik I been und since before week 4 and still was und at week 10 does any one know if this will be serious mistake. I called my dr. but just got recording you know how that goes. no



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Geno 1a diog 2005 vl 1500000 stage 1&1, 2011 stage 2 to 3 fib stage 3 infl. Started triple x 11/16/2011 VL 15,000,000
jrc209


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Did i say 80% was ok? No , also i wasnt speaking about general drugs i was speaking of triple thereapy, If you look at studies of triple therapy the facts state 80% compliance is what i was based on i didnt pull that out of the air lol . And no i dont agree with settling for 80% i was simply stating the facts. Im on week 27 and have done allot of research on all of this thanks though.On a bright note ive been 110% compliant even through a surgery and being hospitalized during tx i told dr id leave if i couldnt take meds>

-- Edited by jrc209 on Friday 3rd of February 2012 01:30:21 AM

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Geno 1 A Started Tx 8-3-11, Viral Load  21.2 Million,  4 Week Lead of Soc ,9-1-11 <43 On Soc alone started victrelis 9-3 ,8 week pcr vL und.Week 12 Vl Und, Did Week 24 PCR Results UND @ Week 24!!! 1-11-12,End Of Tx 2-15-2012 !!
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