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Hep C Discussion Forum -> On Treatment -> Optimal timing for triple tx drugs to peak together in the body.
Post Info TOPIC: Optimal timing for triple tx drugs to peak together in the body.
Tio


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RE: Optimal timing for triple tx drugs to peak together in the body.
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Thanks everyone, for your information on this.  I sould be starting the Victrelis this week-end.



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news


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The lady from the pharmaceutical company told us (at our new patient briefing) that you could take the ribavirin with the morning and mid-day doses of Incivek, to "get it out of the way". So that's what I did. One riba at the 6AM dose, and one at the 2PM dose. None at night. Because the riba lasts so long in the body it doesn't really matter as long as you spread them out and take them all. I am not sure about the daily schedule for Victrellis, but the riba schedule could be worked in with it any way you want.

Alan



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Geno 1A  Started Pegasys/Ribavirin/Incivek Nov. 20, 2011 .  Completed July 28, 2012 (36 weeks). For a treatment history, see:  https://jshare.johnshopkins.edu/xythoswfs/webview/_xy-9921874_1

SVR on January 14, 2013!!
jwmaher


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Most of the time I take Victrelis and ribaviron together. Is that o.k.? I try to do them around the same time, give an hour or so. Am I doing this right?
Mike

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Tio


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Has anyone heard that it is best to take Victrelis a few hours before or after interferon or ribavirin so that the drugs can peak at the same time in the body?



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krowdog


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Hi Tio.

Considering the ribavirin "multiple dose half life" is almost 2 weeks, and the interferon is pegylated, so it breaks down slowly, over several days, it shouldn't matter.

The real important one is your protease inhibitor, Victrelis, which has a half life of only about 3 1/2 hours (mean pooled study results).

You really DON'T want to miss-time doses of that drug.

I was on the other protease inhibitor Incivek.  I was told the doses of the three drugs could be timed independently of each other.

Brad

 

(Incivek triple TX, UND @ wks 4,8,12 & 16.  Just shot # 20 of 24)



-- Edited by krowdog on Thursday 1st of March 2012 04:49:53 AM

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(Geno 1a, Incivek Triple Tx, 6 month post TX - 9/20/2012 = SVR!!!)
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