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Hep C Discussion Forum -> On Treatment -> Interpreting week 4 results
Post Info TOPIC: Interpreting week 4 results
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RE: Interpreting week 4 results
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Dottiesax, jrc makes a good point. When VL is real low, just a day or two can make a difference. You may get a very pleasant surprise when you retest this week. I sure hope so. For triple therapy it is a major deal to be UND at 4weeks. Alan

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Geno 1A  Started Pegasys/Ribavirin/Incivek Nov. 20, 2011 .  Completed July 28, 2012 (36 weeks). For a treatment history, see:  https://jshare.johnshopkins.edu/xythoswfs/webview/_xy-9921874_1

SVR on January 14, 2013!!
dottiesax


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 Thx, very helpful. yep, i'm on triple therapy and yep, am re-testing next week to confirm. I feel pretty positivebleh!



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krowdog


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If that was the heptimax 2-part test, the 2nd part, the TMA (Transcription Mediated Amplification), "less than 5" test will trump the "less than 43" PCR (Polymerase Chain Reaction) test. I would consider that Undetectable, but personally would want a re-test, especially if you are on a 3 drug Tx and the results could change your treatment time. 

If, for instance, you are cirrhotic and Genotype 1, it wouldn't matter since you'd be doing 48 weeks anyway.

Hey, congrats on making it over a month.  Hope your TX goes well, and you clear this virus crap,

Brad



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(Geno 1a, Incivek Triple Tx, 6 month post TX - 9/20/2012 = SVR!!!)
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There are a couple of different tests, and they seem to vary according to the VL expected. I think typically the first test (usually around four weeks) is a "coarse" sort of test, that has real trouble getting real numbers for very low readings. Future tests, however, will be able to say "undetectable", and mean it, since that is what you are expecting. The only problem I see with this is that recommended treatment calls for additional time for some patents that are not undetectable at four weeks, so the patent might wish he could get a better result. But the fact is, even the very first test would detect undetectable. It is yes or no. The trouble comes from trying to apply a quantity. So, since I'm getting kinda'wordy here, the very low numbers are just that.... very low numbers. If you were undetectable the test would have said so, unless there was an error. And since both tests agree almost exactly, there rob ably is no error. Alan

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Geno 1A  Started Pegasys/Ribavirin/Incivek Nov. 20, 2011 .  Completed July 28, 2012 (36 weeks). For a treatment history, see:  https://jshare.johnshopkins.edu/xythoswfs/webview/_xy-9921874_1

SVR on January 14, 2013!!
dottiesax


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Interpreting week 4 results. I had 2 viral load test at week 4, one came back detectable <43, the other undectable <5. what do you make of this?hmm



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jrc


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dottiesax wrote:

 Thx, very helpful. yep, i'm on triple therapy and yep, am re-testing next week to confirm. I feel pretty positivebleh!

 i would ask your doc to clarify also you should do the tests all at the same lab, also which test was done first and how far apart?  if the <43 was first  that means you had a few copies left and  then if you took the other test even a few days after you may have cleared them by then.



-- Edited by jrc on Sunday 15th of April 2012 12:53:05 AM

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Geno 1 A Started Tx w/ Victrelis  8-3-11, Viral Load  21.2 Million,  Und Weeks 4 Through 28 ,End Of Tx 2-15-2012 !SVR
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