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Hep C Discussion Forum -> On Treatment -> OK! I need some help in understanding something!!
Post Info TOPIC: OK! I need some help in understanding something!!
TazKat


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RE: OK! I need some help in understanding something!!
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i tested undetectable at 4 weeks 12 weeks & 24 weeks. i am reducing my riba dose myself. i have never relapsed.. i didn't respond the dual therapy of interferon & riba back in 2005. it bothes me that i can't be treated if i relapse on any of the new meds that are coming out because of this prtease inhibitor.. wonder if it working me down inside on something else.. like my brain cells.. :)

 

amen mc99!!!!!!!!!!



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TazKat Genotype 1A null responder x 3 riba & iterferon twice, relapsed from Incivek 2012 with only 12 weeks left to do. stage 4 mild cirrhosis 4/25/2014/ started sovaldi riba & interferon.. finished treatment 7/17/14  results 7/25  cleared..

 

 
Sunrise747


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If you are a true relapser (completed combo treatment as undectable but later had the virus return) AND you test negative at 4 and 12 weeks while on Incivek then you are likely to only need 24 weeks of treatment.  Has your doc lowered your Riba dose?  Many of us are now on 600 mg which is much easier than 1,200.  And recent studies say that dosage works just as well for most.  Talk to your doctor.  And definitely hang in here for as long as you can.   Did you test negative at 4 and 12 weeks?



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Geno 1B Relapser 2001. Started Incivek 12-16-11. 57 yr old male.  Last biopsy 2000 -stage 3 fibrosis. UND Wk4, 12, 18, 26.  Did 34 weeks.  Still UND at 12-wks post.
mc99


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Try to hang in there Taz, I just finished 28 weeks with victrellis and I know its tough. I think with incivek if you are a relapser you are suppose to tx for 48 weeks I believe you can check the prescribing info to be sure, it would have been the same for victrellis I think. I am wondering if I should go a few more weeks myself because my liver biopsy is a little sketchy at best, It looks like stage 2 to 3 but the pathogist wrote early cirrhosis at the end of the report, so Im having second thoughts about whether or not to keep going. I will have to make up my mind by tomorrow in order to get the meds on time. I certainly do not want to keep going because I can tell the interferon is taking its toll on me.

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nohcvforme


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I think Incivek is for genotype 1s who are previous non responders or are being treated for the first time. I agree that Xanax would be good to get you through treatment- 4 weeks is a long time to be so distressed. Or maybe decrease meds temporarily to ease symptoms?

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TazKat


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was the incivek mainly for the non responders? or what?  i have been doing treatment for 30 weeks. i had a meltdown saturday. i quit taking the riba's. doc tells me today that i must try to do the 48 weeks. well number 1 i have a tooth that broke off into the gum about a month ago & i know it is not tgoing to survive til sept 6. she said if i relapsed that there is no other treatment out there for us that has been on the protease inhibitors. in another words if u relapse that new treatments can't be done because of doing the inhibitors.?? so i guess i will try reallllllly hard to do at least another 4 weeks or so. my nerves are shot, my legs are scarred up from picking at rash, arms too. so i wish she would give me a few xanex. i have had the thought cross my mind to f***ing give up!! this interferon & riba is rough as ****. i thought it would be wasy sailing after the incivek was done. boy was i wrong!!!!  



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TazKat Genotype 1A null responder x 3 riba & iterferon twice, relapsed from Incivek 2012 with only 12 weeks left to do. stage 4 mild cirrhosis 4/25/2014/ started sovaldi riba & interferon.. finished treatment 7/17/14  results 7/25  cleared..

 

 
krowdog


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Hi Taz

They use the Protease inhibitors (Incivek or Victrellis) on all Geno 1's, including those  who didn't respond to the SOC (interferon and Riba only) TX.  They don't re-use it due to viral resistance.

Also note, non reponder is very different than relapser.

However, there is another TX, in clinical trials now, that the 3 drug non-responders can use.  It appears effective with little or no side effects.  It uses a polymerase inhibitor.

One person on here, Jime, is on that trial after failing the triple TX.  He is posting his ongoing trial and results on the "Re: 7977 journal" here on the forum.  The stuff looks great so far.

Don't know when it may get FDA approval.  You might want to see if there are any trials about to start, "just in case"

Also, for me, I felt better when I finished the incivek, but discovered most of my itch was from the ribavirin, which I had to put up with for 12 more weeks... I know how you feel! :((

It appears that a moderate reduction in ribavirin does not change SVR much if you have a cEVR (complete early viral response) which you have.  Please check with your doc, hopefully the reduced dose will be all you need.

Best of luck,

Brad

 

 



-- Edited by krowdog on Wednesday 2nd of May 2012 02:29:28 AM



-- Edited by krowdog on Wednesday 2nd of May 2012 04:06:01 AM

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(Geno 1a, Incivek Triple Tx, 6 month post TX - 9/20/2012 = SVR!!!)
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