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Post Info TOPIC: Where are you from? What Genotype?


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RE: Where are you from? What Genotype?
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Hello.

I am from California and have either GT1A or GT1B.



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53 yrs female, Northern California, GT1b.  Let it go for 10 years after first DX in 2007.  First Treatment:  8 Week Mavyret starting April 11th to June 5th, 2018.  Viral load was undetected after 4th week of treatment and after 3 months after treatment.  See Pre-Treatment Test Results in Bio.



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USA California Genotype 1A.

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53 yrs female, Northern California, GT1b.  Let it go for 10 years after first DX in 2007.  First Treatment:  8 Week Mavyret starting April 11th to June 5th, 2018.  Viral load was undetected after 4th week of treatment and after 3 months after treatment.  See Pre-Treatment Test Results in Bio.



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LamontCranston.....I like that map idea! 



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55 yo GT1A F1 minimal fibrosis HCV dd 1996 

3/16/17  HCV VIRAL LOG 6.529

6/21/17 started Viekira Pak and Riba 800 mg per day for 12 weeks 

as of 7/19/17 NOT DETECTED....Slaying mode!!! YEESSS!!!!

Miss Brenda



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New York
2b

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66 m asymptomatic for perhaps 45 years GT 2b Dx HCV 2/17 ALT 113 AST 67 VL 551K SOT 5/17 12 weeks Epclusa 4 week blood draw ALT24 AST 22 VL undetected


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Illinois and 1b

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Genotype1b . 2 million VL on june 5th now undetected july 6 th.


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3a

WA State

 



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 M-64) 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   



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Pennsylvania /GT 1asmile



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64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay



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Maybe we could create a map? Of our own, that is.

What I want to know is when did I go to West Africa or French Guiana? Type 2 and variants are clustered there. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303918/figure/fig02/

 



-- Edited by LamontCranston on Sunday 3rd of September 2017 04:10:38 PM



-- Edited by LamontCranston on Sunday 3rd of September 2017 04:38:08 PM

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Lamont Cranston "Only the Shadow knows."

70 years old, retired IT Network support 33 years continuous sobriety in AA, ,DX'd in '99 with MS, DX'd with HCV 2, 2b , F0-F1 3/17/2017 VL 5.7m Started EPCLUSA 7/28/17

No Virus Detected on November 20, 2017 3 months after EOT



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genotype 1a

southern California 

 



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55 yo GT1A F1 minimal fibrosis HCV dd 1996 

3/16/17  HCV VIRAL LOG 6.529

6/21/17 started Viekira Pak and Riba 800 mg per day for 12 weeks 

as of 7/19/17 NOT DETECTED....Slaying mode!!! YEESSS!!!!

Miss Brenda



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The map named

ViralCancer7.pdf is gone. :(

 

But, I found this article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303918/ 



-- Edited by LamontCranston on Tuesday 28th of March 2017 11:06:49 PM



-- Edited by LamontCranston on Tuesday 28th of March 2017 11:07:23 PM

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Lamont Cranston "Only the Shadow knows."

70 years old, retired IT Network support 33 years continuous sobriety in AA, ,DX'd in '99 with MS, DX'd with HCV 2, 2b , F0-F1 3/17/2017 VL 5.7m Started EPCLUSA 7/28/17

No Virus Detected on November 20, 2017 3 months after EOT



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San Francisco Bay Area, Northern California

2, 2b 

You would think that would be more common to the United Kingdom.



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Lamont Cranston "Only the Shadow knows."

70 years old, retired IT Network support 33 years continuous sobriety in AA, ,DX'd in '99 with MS, DX'd with HCV 2, 2b , F0-F1 3/17/2017 VL 5.7m Started EPCLUSA 7/28/17

No Virus Detected on November 20, 2017 3 months after EOT



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I live in the Seattle area (eastside) and am genotype 3.

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HCV genotype 3b, started my 12 weeks of Sovaldi/Daklinza on 10/15/16.
Probably infected 1 - 2 years ago, viral load 800,000, fibrosis stage 0.



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GT2a.  Pacific Northwest.



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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I'm from Louisiana. I think my genotype is 2

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HVC positive since 1967 cirrhosis also

AbbVie M14-172 study member week 3

 Geno type 1

HVC Free after Abbvie ABT 493 ABT 530 treatment



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xtra wrote:

Cinnamon Girl

Thank You

That is exactly what I am going to need help with. Understanding the Dr.'s view which are those lab test.

I know what the ALT 89 AST 72 stand for but are those levels high or medium high or low high? I suppose it requires more tests to give it meaning. Does it say anything about liver damage?

I am trying to set up a signature but I don't understand the terms yet. I suppose before this is over I will be Harvoning and SOVRing and ALTing right along :)

 


 Hi again MM,

Your ALT and AST (liver enzyme) levels indicate inflammation in your liver which is resulting from an ongoing infection, and they are roughly what we`d expect to see.  They aren`t particularly high considering you have Hep C but they are out of the normal range.  Most people find that within a few weeks of starting treatment their liver enzymes drop to within normal levels. (which are...ALT 5 - 40, AST 10 -40 U/L)

Apart from that, those numbers don`t tell us anything about the actual level of fibrosis (liver damage) and you would need to have further tests to determine that, as others have said.

Mike has given you some more detailed information, but I thought I would add a simple explanation as well. 

Feel free to ask as many questions as you like, we`re here to help, and it`s what we like to do.  smile

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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think your being very wise in getting to know exactly what the situation is before jumping into anything. the way these meds are developing am sure in the near future there will be a cure with nil side effects .all the best                                                                                                                                                                                                                                                  william



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 william.61 yo.lives in uk.geno 1b.started sol/dac/riba sept 2014 12wks.am now svr and now had liver transplant on 19/07/ 16



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xtra wrote:

I am trying to set up a signature but I don't understand the terms yet. I suppose before this is over I will be Harvoning and SOVRing and ALTing right along :)


 Yes you will be. I was confused by all the 'secret code terms' too when I first got here lol. smile Our very knowledgeable member mallani posted a thread with a definition for all the terms which can be found by clicking the following link:

http://hepcfriends.activeboard.com/t51085702/forum-abbreviations/

I'm no medical professional but from my understanding ALT / AST refers to liver enzymes that function inside liver cells primarily and are present in the bloodstream in small quantities. When there is something causing  injury to liver cells, these enzymes leak into the bloodstream in large quantities causing a high level result on your lab work. ALT 89 / AST 72 is above normal and indicative of a person who has a liver injuring condition such as excessive alcohol consumption or active untreated hepatitis, etc. For example, my enzyme levels were ALT 307 / AST 52 when I was first diagnosed fibrosis final stage (cirrhosis), at which time I stopped daily consumption of alcohol. Currently, after 2 yrs with no alcohol, 24 weeks of treatment last year (even though SVR was not acheived), and 11 weeks of subsequent  treatment so far this year, liver injuring activity was reduced therefore my latest results are much better - ALT 22 / AST 7.

As Tig 56 posted previously, a test needs to be done to find the extent of scarring that has occurred in your liver. This is referred to as fibrosis. This can be assessed by way of liver biopsy, or less invasive Fibroscan (also called transient elastography) or Fibrosure blood serum test. This result shows degree of liver damage therefore can determine the urgency of your need for treatment.

Talk to your doctor and ask him about genotype, viral load and about a test to determine fibrosis progression stage, and keep us up to date on the results. Hang in there MM. You'll get this taken care of. smile



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

Mike

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FourLocos

Thanks, it is scary. Any new drugs or treatments are. But so far, the treatments seem mild compared to chemo or as one friend I have who has diabetis, 5 shots a day. That makes Harvoni seem very mild indeed. Still, I want to be very informed before I talk to the doctors about treatment.

I am so glad I found this forum. It is exactly what I wanted. I have been reading the threads about treatment and now when I go the doctor, I will know what the treatments are, what the side effects are and how to get the insurance to pay for it all.

This forum has been a real treasure specifically tailored to the immediate needs of Hepatitis C people. Help deciphering blood tests and real people reporting on drugs and side effects.

I appreciate this very much.



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Hi xtra,

I just wanted to say that I am the most paranoid person when it came to medications.  I have driven doctors crazy with my inability to tolerate antibiotics or anything really.  So when I was blessed to be approved quickly (without any hesitation from Blue Cross) for Harvoni I sort of went into a tailspin.  Because I was way early gaining treatment not much was out there to read on the forums about side effects during or post treatment.  Either way I knew that I didn't want to die of liver failure.  I was having symptoms bad enough that I was fatigued and in pain.  That is what brought me to the doctor and how I found out that I had Hep C for about 40 years.  Luckily I never drank so I was at a F1-F2 level.  But what I thought was just aging and stomach problems was really the virus that I didn't yet know I had.  Bottom line is I treated.  Fearfully for sure but I did it.  And if I can anyone sure can.  One day at a time... with help from the lovely people here.  I might have issues from treatment still and perhaps forever but I am blessed.  And I am free of it.



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GT 1b first time treating with Harvoni 8 weeks.  4 weeks UND 8 week UND.  8 weeks after treatment UND.

 12 weeks SVR.  Reached 24 weeks SVR!



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Cinnamon Girl

Thank You

That is exactly what I am going to need help with. Understanding the Dr.'s view which are those lab test.

I know what the ALT 89 AST 72 stand for but are those levels high or medium high or low high? I suppose it requires more tests to give it meaning. Does it say anything about liver damage?

I am trying to set up a signature but I don't understand the terms yet. I suppose before this is over I will be Harvoning and SOVRing and ALTing right along :)

 



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Hello MM, welcome from me too!

Yes, you`re right that Hep C is still very poorly understood, and I`m glad you found us.  Sounds like you`ve been looking after your health and your liver, and I think it`s very sensible to avoid over the counter medicines whenever possbile.

Do keep in touch and let us know when you have any more information or lab results.  We`ll do our best to help explain anything you need help with. 

Wishing you all the best of luck with getting your treatment plan in place.  smile

(Ps - You`re welcome to start your own new thread whenever you like, just click on `Start a New Topic` at the top right hand side of the reply box.)



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Thanks,

I am entering strange territory. I will be glad to get some help understanding the Dr.'s view of this disease.

Many people don't know they have this chronic condition until they get sick. I have been lucky because I know that I have to stay healthy because even a bad cold, for me, can have the unusual symptoms of vomiting and nausea, the first tip off that the hep has kicked in. So I have lived a very active healthy life.

I don't know about anyone else but I am extremely wary of medicine. For me the local drug store is the equivalent of a candy store to a diabetic. I have taken a lot of good natured kidding about my baby aspirins from the grown ups who eat Tylenol and Aleve like penny candy. I say, "I have hepatitis" and I am regaled with stories about "Oh, I had that from drinking the water in a foreign country."

Now, if I go to the drug store for cold medicine. I come out with a big box of chocolate. I feel instantly much better.

That goes double for Dr.'s. I have noticed lately that Dr's when I tell them I don't take drugs, seem to think I am going to refuse antibiotics. This is the first Dr. I have been to who reacted to the information that I had Hep C. Or maybe the Dr.s heard it loud and clear, but no treatment, next subject. I am extremely wary of medicine. Nuff said.



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Hi MM and welcome from me also. Although still not 100%, SVR rates with the latest medicines are showing excellent results. There are many more success cases than failures. And side effects are much easier to live with than treatments just a few years ago. Make yourself at home here and ask any questions you have. We have several knowledgeable members who can  give you answers. Please keep us up to date on any additional lab test results you get and which treatment protocol your Dr decides to put you on.  smile



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

Mike

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Tig


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Hi MM,

Welcome to the group! Thanks for sharing your story with us. Your bio sounds very familiar to many here, but you seem to have both suffered and triumphed throughout the years. That's going to change though. These new treatments are nothing like the old days and your chance to rid yourself of this disease have never been better.

The additional testing your doctor will do should tell you what genotype (strain) you have and a viral load or count that tells you the viral quantity. Those two items determine what type of treatment and the length of time is needed to destroy it for good. Have you had your fibrosis stage evaluated recently? That needs to be done too.

There will be others along soon to welcome you, so have a look around and if I can be of assistance, just ask. Here is some helpful info that will explain our lingo around here and how to set up an informative signature line if desired. I'm glad you're here! 

http://hepcfriends.activeboard.com/t58862021/forum-abbreviations-link-and-help-with-creating-your-signatu/



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

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Welcome MM, you've found a great place. Special people here who care and have been through some of what you're dealing with.  It's a great time to start treatment.  Take some time and read through threads here.  Lot's of good information and shared knowledge.  Your labs will give indication of your liver's status and possible courses of action.  Please keep us posted on your results. Folks here look forward in helping to make your journey as easy as possible.   Be well :)



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.



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I had hepatitis 50 years ago. I had all the classic symptoms then it went away. Except it didn't. It recurred periodically over the years. In 1992, I was diagnosed with Hep A. The two together were classic liver failure. It never occurred to me to get medical treatment for all the symptoms. I did what I have always done, take good care of myself and wait for it to calm down. I was delusional for a few days but I recovered after a while.

There wasn't any treatment when I contracted the disease and I lived with it. Talking to this new Dr. about this chronic condition, I was surprised how aware and protective I am of my liver. I guess it is the habit of a lifetime. Second nature without a second thought

The Dr. did some blood tests. Creatinine was low, 9  The AST is 72. The ALT is 89. I don't know what that means. The hematocrit was 47.2. No other abnormalities.

The Dr. is doing tests for RNA and for B which was non-reactive.

This isn't something I ever talk about. There was never any treatment although I see there are some which, reading the boards, fail as often as not.

It looks like my liver is going to become an issue with the Dr. so I would like to join the group to help me interpret the way the rest of the world views this condition which is now so much a part of my life, it is like the color of my eyes.

When the Dr. said, you have Hep C, I said, "I know." And I know a whole lot more about it than that.



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Try this one.

 

 

https://hcv.lanl.gov/components/sequence/HCV/geo/geo.comp?organism=HCV&region=nam&region=us&form=all&show=Show&prev_region=us&filo=



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Born in Stockholm, Sweden in 1980, genotype 1b. Most likely infected through a blood transfusion as a newborn. But have lived the last 15 years in NYC, so who knows...



-- Edited by kickingit on Wednesday 3rd of June 2015 06:27:28 PM



-- Edited by kickingit on Wednesday 3rd of June 2015 06:27:43 PM

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Gen 1b, 35yo. woman. Started 12wk Viekira Pak (no Ribavarin) on 5/28/2015.
F1-2
 
Before treatment: AST 35 ALT  33 VL: 2 million IU/ml
4 weeks treatment: AST 19 ALT 11 VL: <1.18 IU/ml detected
 


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Hi Kristen,

I haven`t been able to locate a map which shows what you`re looking for, only a global distribution one.  If you come across one, please would you post it here, please? 

For general interest, here`s a link to the global distribution per genotype...

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303918/figure/fig01/

As well as another map I came across...

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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I know there are statistical maps for Genotype breakdowns per country but if anyone comes across one per state in the US please send it to me. I'm curious.



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Born HepC + in 1983 ... diagnosed @ age 13 ... GT2 ... 12 wks of Sovaldi/Riba from 2/11/14 to 5/5/14  #ribazombie

1/30/14 - Starting VL 1,922,967 * 3/11/14 - UND @ 4 wks * 7/29/14 - SVR12 * 11/6/14 - SVR24 * May 2015 - SVR52 * MAY 2016 - STILL UND * FEB 2018 - STILL UND

 



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Born and raised and living in Michigan. Genotype 1a. I Believe I acquired the virus after a blood transfusion in Panama in 1989, although I'm sure the U.S. Army was using American blood. Started treatment with Viekira Pak+ Ribavirin on 3-5-15. Beginning viral load 21.8 million ml. Undetected after 4 weeks.



__________________

55 yo male-Genotype 1A  Started treatment 3-5-15 Viekira Pak+Ribavirin 12 weeks. Less than stage 1 fibrosis.  Previously treatment naïve. VL- SOT-21.8 million/ml  Log 10IU/ml-7.34, VL-4wks-UND, VL-7wks-UND

Greg



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Hello Im from Washington and I have GT 3a.

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Relentless


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Born in Brooklyn N.Y. Genotype 2b

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God bless Larry


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Hello, My name Roger Blood, genotype 1a. I'm going to take my first Harvoni tablet tonight at 8 PM pacific time. I'm looking forward to the day that I'm declared undetectable! From Wa. State



-- Edited by rblood on Saturday 17th of January 2015 01:55:50 AM

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Another Army brat here. Born in Japan and grew up all over the place but mostly in Oklahoma. Now in Oregon.

Genotype 1a

 



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UNDETECTED 5/4/15 - 16 weeks after EOT, 1st treatment - Sovaldi and Olysio, Geno 1a, 67 year old with compensated cirrhosis, over 40 years with HCV.



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Born in Mississippi and for the last 17 years have lived in south Florida. Geno-type 1a.



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Diag. with hep c in 1992; A3:F2;  GT 1a; IL28B CT; VL 900k, ALT 150, AST 100 on 8/5/2014; SOT 9/5/2014  S/O ---VL 127 after 6 days; VL detected on day 18 but < 15.; --> UND @ EOT+ 1 year SVR!



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Originally from NY and living in Tennessee.  Geno 2b.

 



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Type 2b, 3485370 IU/mL VL, sovaldi/ribavirin-12weeks, treatment end 11/15/14 SVR-UD, SVR-5-UD, SVR-14 & 32-UD. (64 yr old with hepc since 1970s)

 



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Originally from Texas but am an Air Force brat so lived all over. Home for last 20+ years is Kauai. Genotype 2, docs always tell me I got lucky with that cause it's not that common in USA. But then again, I've lived overseas and Kauai is multicultural big time. Probably contracted it through drug usr



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genotype 2 completed sovaldi and ribavirin on 6/4/14. SVR on 12/3/14



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Privet Sergey i dobro pozhalovat'!

Vancouver Island, Canada. Genotype 2b. Infected in Montreal, Quebec in the 70's most likely from IV use.



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60 yo (2013), genotype 2b, started 28 week tx Sept.14, 2013. Triple Therapy (ribavirin, victrelis, peginterferon), VL 235k prior to tx, UND right through. EOT March 29, 2014. EOT24 Sept. 15, 2014 and EOT + ONE YEAR April 1, 2015 UND.... SVR!

 



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Hello !2000 year -hepatit b +c+d , 2012,2013YEAR -RNA HCV-not detected,Russia ,Cheljabinsk



-- Edited by sergey74rus on Saturday 6th of December 2014 07:50:37 PM

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2000 year -gepatit b+c+d ,2012,2013-RNA HCV -not detected


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From Baton Rouge, LA

Genotype 1a ; VL 165,000; ALT 400 ; AST 300. Have had HCV for about 25 yrs.



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Rene M DeRouen


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From New Zealand - 3a and would have got it when in Australia back in the 70's and 80's. Only just found out last year and now been on treatment for a week - int/rib.

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Genotype 3a ; VL 4 million; ALT 168 ; AST 185. recently diagnosed but had it 25 plus years.

02/05/2015 - EOT - 24 weeks of Peg/Riba. VL - und at week 8 . ALT - 26.

Fibroscan - F3

16/05/2015 ; EOT VL Undetected. ALT - 20 ; AST - 35



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I tested non-A and non-B back in early 1970's from drug use in Oklahoma.
GT1a
I live in Oregon now.
I was treatment naive until I started Sovaldi and Olysio in October 2014.

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UNDETECTED 5/4/15 - 16 weeks after EOT, 1st treatment - Sovaldi and Olysio, Geno 1a, 67 year old with compensated cirrhosis, over 40 years with HCV.



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From Northern California, Geno 1a. Have had it since at least the 80s, possibly as early as the 70's (as a child from blood products). In 1984 I was told my liver was 'enlarged', in 89 that I had non AB, and then in 2006, HCV.



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From Los Angeles but live in Missouri now. I'm genotype 2b contracted in 1998 from my ex-girlfriend and I.V. drug use 



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34yr male Dx 1998 G.T.2b V.L. 2.5 million no current Tx 



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From Angel,London. Type three, got this in about 1985(though only recently diagnosed). I can actually pinpoint the two people that I could have caught this from...Why o why was I so stupid? What makes this worse for me is I am not stupid...I have no excuse,I just took a crazy risk.

 



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Kay


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1A I got in Texas from IV drug use or also had a blood transfusion in 1987/88 waiting for the one pill a day interferon free regimen.



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This is 100% accurate info



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A. M. Turner


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I live in Brooklyn, NY. GT 4c...how I got it?  Unsure...Either from previous IV drug use or my ex-husband who received a blood transfusion...



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DJ...dx 2005...geno 4c...twice interferon/riba failure....completed 24 weeks Sovaldi & Riba on 10/18/14....SOT VL 600,000 after 16 days VL <43. Day 45 <43 again. Day 59...8 weeks UNDETECTED.

Happy and grateful to God for new life....



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I am in Australia. About to start treatment for the third time. Genotype 1a.

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57 Yr old, Diagnosed 1994 Geno 1a. 1995: Interferon 12 weeks.  1998: Int/Rib 10 weeks.  2014: VL 106,000. Peg Int, Ribavirin, Victrelis 48 weeks (commenced June 2014). UND after Peg/Int lead in week 4. Still UND at week 8, 24, EOT. SVR 12.

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