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Hep C Discussion Forum -> On Treatment -> Week 24 Labs Arrived - UNDETECTED
Post Info TOPIC: Week 24 Labs Arrived - UNDETECTED
alohaKim


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RE: Week 24 Labs Arrived - UNDETECTED
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Hooray, Phil!

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Genotype 1a, non responder to Peg/Riba in 2005. Started triple therapy 1-27-12 with Victrelis.  UNDETECTABLE as of 8wk labs (after 4 weeks of Victrelis) 4-3-12. UND at week 8, 12, 16 & 20 of tx. Completed triple therapy Oct 2012. relapsed 10/2012
LanaiSurferGirl


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yay!! :)



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geno 1a, mother & brother also hep c +...mom got a blood transfusion and passed it along.  Started tx with incivik 11/23/11 and brother started 2/8/2012.  Both of us und. at 4,8,12 and me at 24.  I am going 36 wks and brother is going 48 weeks.
Sunrise747


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Way to go Phil!  And not bad on that HGB reading.  Best I can seem to muster on my reduced Riba (600mg) is 10.4  Too high to allow Procrit and too low to have much energy to do anything.



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Geno 1B Relapser 2001. Started Incivek 12-16-11. 57 yr old male.  Last biopsy 2000 -stage 3 fibrosis. UND Wk4, 12, 18, 26.  Did 34 weeks.  Still UND at 12-wks post.
mallani


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Congrats Phil- another one for Victrelis. Having my 12 week bloods done today.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
krowdog


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Phil, I can't say it any better than Allan did, so I'll repeat it:
news wrote:

The UND is the best part, but running in close second is the "two more shots" part. You rock. Pure and simple.

 

Keep it up!

Brad

 

 



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(Geno 1a, Incivek Triple Tx, 6 month post TX - 9/20/2012 = SVR!!!)
Margo


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Great news!!!

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Geno 1b, relapsed in 2009 a week before my treatment was to be over. Started triple therapy on April 28th, 2012. UND at week 4,8,12,24,3 months post tx.
krowdog


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Judy S wrote:

  Although mine also says:  Roche Cobas Ampliprep/Cobas Taqman HCV test.  I guess the difference is in how it's assayed??  Not sure I'll ever fully understand, LOL.

The heptimax is a 2 part test.

The first part of the Heptimax is the same PCR test.

Then it adds a TMI type test, which acts as a confirmation of the first, and improves resolution.

If the first PCR showed a (false) "detectable, but below quantifiable limits", and the more accurate tmi showed negative, it would indicate a test or a testing problem (possible false positive). 

Brad



-- Edited by krowdog on Monday 4th of June 2012 05:45:19 AM

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(Geno 1a, Incivek Triple Tx, 6 month post TX - 9/20/2012 = SVR!!!)
news


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Yeah, when I went to see my GP recently, she asked a few questions about my treatment, for her files. As we went along, I noticed the questions became more and more detailed and technical in nature. After a bit she said "You have become quite knowledgeable about all this, haven't you?" . All I could do was nod and smile. Alan

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Geno 1A  Started Pegasys/Ribavirin/Incivek Nov. 20, 2011 .  Completed July 28, 2012 (36 weeks). For a treatment history, see:  https://jshare.johnshopkins.edu/xythoswfs/webview/_xy-9921874_1

SVR on January 14, 2013!!
kr


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pretty amazing that we get so familiar with the science of all of this (assays, genotypes, etc etc) - this disease is definitely not one of the simpler ones



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JoAnneh


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Phil, Great news! So happy for u
Joann

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JoAnne

Genotype 1a, Triple therapy w/Invicek started May 19, 2012

DET 4 wk. UND 2,6,12,24 48 treatment. Achieved SVR 2013!
Judy S


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Thank you Roberta!  Although mine also says:  Roche Cobas Ampliprep/Cobas Taqman HCV test.  I guess the difference is in how it's assayed??  Not sure I'll ever fully understand, LOL.



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Geno 1a; VL 4.7 million in Feb 2012. Started PegIntron & Ribavirin 3-9-12. Added Victrelis 4-6-12. UND since Week 8. Stopped tx Wk 23. UND 4 Wks post-tx. Relapsed 12-weeks-post.

52 y/o F, started Epclusa 11-10-19, F0/F1.  EOT 2-1-2020. UND. All liver function tests normal.
kr


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I get the Heptimax test and here's what it said the last few times - I sure hope it keeps saying this.  When mine was 26, 25 and 19 they did not call that UND but i am not sure what test that was. 

 HEPTIMAX (R) HCV RNA EZ

HEPTIMAX(R) HCV RNA <5 <5 IU/mL

HEPTIMAX(R) HCV RNA <0.70 <0.7 LogIU/mL

The range of the HEPTIMAX (TM) assay is 5 IU/mL

to 69,000,000 IU/mL.

Because the HCV RNA level was below 43 IU/mL

using the Real-Time PCR method, the sample was

assayed using the Transcription-Mediated

Amplification (TMA) method.

This test was developed and its analytical

performance characteristics determined by Quest

Diagnostics Nichols Institute. It has not been

cleared or approved by the U.S. Food and Drug

Administration. The FDA has determined that such

clearance or approval is not necessary.

This test was performed using the COBAS(R) AmpliPrep /

COBAS(R) TaqMan



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Judy S


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Phil, that's exactly what Jeremy said, too.  He and I both posted pics of our results here:   http://hepcfriends.activeboard.com/t49273219/und-to-detected-to-und/

All 3 of ours say COBAS Tagman test but the machine being used is different on mine.  It doesn't state the detection limit of 7 on mine.  Once I understood that it's detectable at 7 but quantifiable at 43, I asked my dr about it.  He said this is the same test that was used during the trials and when it's less than 43 at 6 months post tx, you are considered SVR.  I don't know if that is accurate, but that is what my dr said.

A friend mentioned that he knows of pts who have tested <43 at 6 months post tx and have achieved SVR.  He said it's known as false positive.

Yours reads a bit differently than mine.  I have gotten a few "Not Detected" and one "Detected <43".  But never "<43 Not Detected."  I wish they would all read identically.  The less confusion the better.  My last one read Not Detected......let's keep those going!!   biggrin



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Geno 1a; VL 4.7 million in Feb 2012. Started PegIntron & Ribavirin 3-9-12. Added Victrelis 4-6-12. UND since Week 8. Stopped tx Wk 23. UND 4 Wks post-tx. Relapsed 12-weeks-post.

52 y/o F, started Epclusa 11-10-19, F0/F1.  EOT 2-1-2020. UND. All liver function tests normal.
Phil G


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Thanks all. Means a lot.

Judy - I go to Quest for labs. I paid attention to the notes at the btm of the report this time. They use the COBAS Tagman test kit with a lower detection limit of 7.1 and a lower limit to quantify of 43. Paraphrasing, if between 7.1 and 43, it will be reported as <43 DETECTED. If below 7.1, <43 NOT DETECTED.



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Geno 1A, VL 1.9 mm, SOT 12/2/11 - Pegintron/Ribavirin/Victrelis, UND since wk 8, EOT 6/15/12 (28 wks), SVR 11/30/12
news


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Phil, I've been grinning all weekend. The UND is the best part, but running in close second is the "two more shots" part. You rock. Pure and simple. Alan

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Geno 1A  Started Pegasys/Ribavirin/Incivek Nov. 20, 2011 .  Completed July 28, 2012 (36 weeks). For a treatment history, see:  https://jshare.johnshopkins.edu/xythoswfs/webview/_xy-9921874_1

SVR on January 14, 2013!!
Judy S


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Awesome news, Phil!  I love to hear news like this!!!

You have the same lab that Jeremy and I have for our testing.  For us, <43 means UND.



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Geno 1a; VL 4.7 million in Feb 2012. Started PegIntron & Ribavirin 3-9-12. Added Victrelis 4-6-12. UND since Week 8. Stopped tx Wk 23. UND 4 Wks post-tx. Relapsed 12-weeks-post.

52 y/o F, started Epclusa 11-10-19, F0/F1.  EOT 2-1-2020. UND. All liver function tests normal.
chatterbox


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CONGRATULATIONS!  Wonderful news.



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Debra

 

Geno type 1a1b

Began Peg/Rib 4/16/2012  

Began Victrelis May 14, 2012            4 week and 8 week labs undectable

12 weeks und. 16 weeks und. Week 17 Cut peg, added Neopogen 5+months und.!
Cinnamon Girl


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Nice one Phil, congrats to you!  thumbsup.gif 

~ Jill xx

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
greenqueen


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Congratulations Phil! smile

Love Steff xx



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Geno 3a. 24 wks tx 20/10/05 - 06/04/06. Achieved SVR.
innerview


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Congrats, brother! Great news indeed! I'm happy for ya!

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Peace, Mark

1A, stage 2/3, TT, began TX with Incivo 1/31/12, Week 4 VL<15, week 7 UND, week 12 UND, week 18 UND!!! End of Tx July 31 VL UND!!!  I had to do 26 weeks total and was on half Riba and half Interferon for most of Tx. 12 week post Tx VL UND!
mallani


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Hi Phil, Great news! Gives me the strength to carry on



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
K2


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3 words Phil ' SUPER, SUPER, SUPER'!!

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genotype 1a. started pegasus and riba on 25/03/2012 added victrelis after 4 weeks, treatment naive. CHC. 4 weeks UND & continue to be so far. Finish tx 6/10/12. Fingers crossed for SVR.
Shep


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Yahoo Phil!! I am so happy for you--now you can just slide right though to the end!!

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Diagnosed 1996 genotype 1b VL alot tx starting 12/23/11 Victrelis UND week 8!!! 28 weeks of tx

Completed tx 7/6/12--still UND!!!!
Iris Dragonfly


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Hi Phil,....this GREAT news! Almost therebiggrin Keep it up. Blessings, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naďve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)
davesf


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Fantastic!  We've been anxiously waiting with you to hear this.  Now it's down the home stretch for you.

Best, Dave



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All Done Poisoning the Dragon that Used to Poison Me

Genotype 1b  Incivek Combo
Phil G


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Came in the mail today (8 days), and it is UNDETECTED. Thanks for all the reassurances. Wish I could listen better. Last 7 weeks on reduced riba (1000 mg to 600 mg). HGB up to 11.3 from low of 9.4. Two more shots to go!

Labs say the following:

HCV RNA, Quantitative Real Time PCR    <43 Not Detected



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Geno 1A, VL 1.9 mm, SOT 12/2/11 - Pegintron/Ribavirin/Victrelis, UND since wk 8, EOT 6/15/12 (28 wks), SVR 11/30/12
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